Methods of treating cartilage defects using soluble morphogenic protein complex
    74.
    发明专利
    Methods of treating cartilage defects using soluble morphogenic protein complex 审中-公开
    使用可溶性多形性蛋白复合物治疗消化不良的方法

    公开(公告)号:JP2013049716A

    公开(公告)日:2013-03-14

    申请号:JP2012267047

    申请日:2012-12-06

    Inventor: ENGELMAN DONALD

    CPC classification number: A61K38/1875

    Abstract: PROBLEM TO BE SOLVED: To provide methods of treating cartilage defects using a soluble morphogenic protein complex.SOLUTION: The methods of repairing cartilage tissue uses the soluble morphogenic protein complex comprising (a) a morphogenic protein, and (b) a morphogenic protein pro region isolated from a morphogenic protein, or a conservative substitution variant or a fragment of the pro region, wherein the pro region or variant or fragment is noncovalently linked to the morphogenic protein and wherein the complex is more soluble in an aqueous solvent than the morphogenic protein alone.

    Abstract translation: 要解决的问题:提供使用可溶形态发生蛋白复合物治疗软骨缺陷的方法。 软骨组织的修复方法使用可溶性形态发生蛋白复合物,其包含(a)形态发生蛋白,和(b)从形态发生蛋白分离的形态发生蛋白原区,或保守取代变体或 pro区,其中所述前区或变体或片段与形态发生蛋白非共价连接,并且其中所述复合物比单独的形态发生蛋白更易溶于水性溶剂。 版权所有(C)2013,JPO&INPIT

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