公开(公告)号：AU2003212459B2

公开(公告)日：2008-05-08

申请号：AU2003212459

申请日：2003-02-25

Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY

Inventor： BEWLEY CAROLE A

IPC: A61K38/00 ,  A61K38/16 ,  A61K39/00 ,  C07H21/04 ,  C07K14/195 ,  C12N1/21 ,  C12N15/74

Abstract: The present invention relates to a purified or isolated obligate domain-swapped dimer of CVN and a composition comprising the same.

公开(公告)号：AU2002236526B9

公开(公告)日：2008-05-01

申请号：AU2002236526

申请日：2001-11-15

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY

Inventor： KINGSLEY DAVID H ,  ZIMMERBERG JOSHUA

IPC: C07K14/01 ,  A61K9/127 ,  C07H21/04 ,  C12N15/88

Abstract: The present invention provides an isolated nucleic acid comprising the nucleotides set forth in the Sequence Listing as SEQ ID NO: 1. SEQ ID NO: 1 is an example of GP64-6His nucleic acid. The invention further provides polypeptides encoded by GP64-6His nucleic acids as well as the polypeptide encoded by SEQ ID NO: 2. The invention also provides liposomes comprising GP64-6His polypeptides as well as liposomes comprising GP64-6His polypeptides and biological molecules. The invention further provides a method of increasing the solubility of polypeptides comprising linking a 6His tag to a polypeptide and measuring the solubility of the 6His-tagged polypeptide, whereby an increase in solubility of the 6His-tagged polypeptide can be detected. The invention also provides a method of solubilizing a viral fusion polypeptide comprising linking a 6His tag to a viral fusion polypeptide. Further provided is a method of delivering a biological molecule to a cell comprising, administering the liposome comprising a GP64-6His polypeptide to a cell. This invention also provides a method of delivering a viral vaccine to a cell comprising administering the liposome comprising a GP64-6His polypeptide to a cell. Also provided is a method of delivering a DNA vaccine to a cell comprising administering the liposome comprising a GP64-6His polypeptide to a cell. Further provided is a GP64-6His polypeptide further comprising a binding site for a cell surface molecule. Also provided by this invention are chimeric proteins comprising GP64-6His.

公开(公告)号：AU2007286630A1

公开(公告)日：2008-02-28

申请号：AU2007286630

申请日：2007-08-23

Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY

Inventor： GREIG NIGEL H ,  MATTSON MARK P ,  HABERMAN FRANK ,  YU QIAN-SHENG ,  ARUMUGAM THIRUMA

IPC: A61K31/52 ,  A61K31/522 ,  A61P17/02 ,  A61P25/00

Abstract: Disclosed is a method of treating or preventing an oxidative stress-related disease in a mammal in need thereof comprising administering an effective amount of a compound of formula (I) to the mammal, wherein R 1 -R 4 and X 1 -X 3 are as described herein. Examples of the oxidative stress-related diseases are a neurological disorder, a cardiovascular disorder, and a wound.

公开(公告)号：AU2003269924B2

公开(公告)日：2008-01-24

申请号：AU2003269924

申请日：2003-07-24

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY

Inventor： BOYD MICHAEL R ,  GUSTAFSON KIRK R

IPC: C07D309/06 ,  C07D491/04 ,  C07D498/08

Abstract: A composition comprising a substantially purified compound of the formula: in combination with at least one additional therapeutic agent, and methods of preventing or treating cancer and a condition treatable by the inhibition of vacuolar-type (H+)-ATPase.

公开(公告)号：AU2007223093A1

公开(公告)日：2007-09-13

申请号：AU2007223093

申请日：2007-03-06

Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY

Inventor： ROSENBERG STEVEN A ,  PARKHURST MARIA R

IPC: A61K35/14 ,  C12N5/0783

Abstract: The invention provides a simple, cost-effective method of preparing a composition comprising natural killer (NK) cells useful for administering to a human. The method comprises (i) depleting CD3+ cells from a population of PBMCs comprising NK cells, and (ii) co-culturing cells from (i) with irradiated PBMCs that are autologous to the NK cells. Further provided by the invention are the compositions prepared thereby and methods of treating or preventing a disease or immunodeficiency in a host.

公开(公告)号：AU2002228722B2

公开(公告)日：2007-01-04

申请号：AU2002228722

申请日：2001-11-01

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY

Inventor： GRAGEROV ALEXANDER ,  FELBER BARBARA K ,  PAVLAKIS GEORGE N

IPC: C12N15/09 ,  A61K35/76 ,  A61K38/00 ,  A61K39/00 ,  A61K39/21 ,  A61P31/18 ,  A61P37/04 ,  A61P43/00 ,  C07K14/155 ,  C07K14/52 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/00 ,  C12N15/62

Abstract: The invention relates to nucleic acids (such as DNA immunization plasmids), encoding fusion proteins containing a destabilizing amino acid sequence attached to an amino acid sequence of interest, in which the immunogenicity of the amino acid sequence of interest is increased by the presence of the destabilizing amino acid sequence. The invention also relates to nucleic acids encoding secreted fusion proteins, such as those containing chemokines or cytokines, and an attached amino acid sequence of interest, in which the immunogenicity of the amino acid sequence of interest is increased as a result of being attached to the secretory sequence. The invention also relates methods of increasing the immunogenicity of the encoded proteins for use as vaccines or in gene therapy.

公开(公告)号：AU2003262426B2

公开(公告)日：2006-09-28

申请号：AU2003262426

申请日：2003-11-19

Applicant: ORTHO MCNEIL PHARM INC ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY

Inventor： KAFRISSEN MICHAEL E

IPC: A61K31/00 ,  A61K45/00 ,  A61K31/505 ,  A61K31/519 ,  A61K31/565 ,  A61K31/57 ,  A61P5/24 ,  A61P9/00 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00

Abstract: This invention provides folic acid-containing pharmaceutical compositions comprising either an oral contraceptive or a hormone replacement composition. This invention also provides methods of administering folic acid to a subject using the instant pharmaceutical compositions. Finally, this invention provides a drug delivery system useful for administering the instant pharmaceutical compositions.

公开(公告)号：AU2001277078B2

公开(公告)日：2006-04-27

申请号：AU2001277078

申请日：2001-07-23

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY

Inventor： GRONTHOS STAN ,  ROBEY PAMELA GEHRON ,  SHI SONGTAO

IPC: A61K6/00 ,  A61K6/838 ,  A61K35/12 ,  A61L27/00 ,  C12N5/077

Abstract: The present invention provides a culture of isolated adult human dental pulp stem cells that can differentiate into dentin/pulp tissue that can be used to produce a tooth in a human being. The present invention further provides a method of regenerating human dentin/pulp tissue.

公开(公告)号：AU2004284075A1

公开(公告)日：2005-05-06

申请号：AU2004284075

申请日：2004-10-22

Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY ,  MIDWEST RES INSTITUTE ,  SPIROGEN LTD ,  STARKS ASS

Inventor： THURSTON DAVID ,  LIU PAUL S ,  TURNER GREGORY ,  HOWARD PHILIP W ,  VISHNUVAJJALA B RAO ,  SNADER KENNETH M

IPC: C07D487/04

公开(公告)号：AU2004265280A1

公开(公告)日：2005-02-24

申请号：AU2004265280

申请日：2004-07-26

Applicant: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND A NOT FOR PROFIT CORP ,  THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPT OF VETERANS AFFAIRS

Inventor： VARGA JOZSEF ,  CAI REN ZHI ,  ZARANDI MARTA ,  SCHALLY ANDREW V

IPC: A61K38/00 ,  C07K20060101 ,  C07K14/60

Abstract: There is provided a novel series of synthetic antagonistic analogs of hGH-RH(1-29)NH 2 . These analogs inhibit the activity of endogenous hGH-RH on the pituitary GH-RH receptors, and therefore prevent the release of growth hormone. The analogs also inhibit the proliferation of human cancers through a direct effect on the cancer cells. The higher inhibitory potencies of the new analogs, as compared to previously described ones, results from replacement of various amino acids.