公开(公告)号：US20170334755A1

公开(公告)日：2017-11-23

申请号：US15594919

申请日：2017-05-15

Applicant: Texas Tech University System

Inventor： Weile Yan ,  Yanlai Han

IPC: C02F1/70 ,  B09C1/00 ,  C02F103/06 ,  C02F101/36

CPC classification number: C02F1/705 ,  B09C1/00 ,  B09C1/002 ,  B09C1/08 ,  C02F2101/36 ,  C02F2103/06

Abstract: Methods, systems, and compounds for degrading chlorinated compounds in water. A facile aqueous-based surface treatment of zero-valent iron is provided to increase the reactivity of a zero-valent iron material for degrading chlorinated compounds in the water without the use of a noble metal catalyst. Such a facile aqueous-based surface treatment can be implemented as a surface sulfidation pre-treatment of iron to increase its reactivity towards chlorinated contaminants in water. The disclosed facile aqueous-based surface treatment increases reactivity utilizing sulfur compounds for use in the degradation of the chlorinated compounds in the water.

公开(公告)号：US09782351B2

公开(公告)日：2017-10-10

申请号：US14053091

申请日：2013-10-14

Applicant: Texas Tech University System

Inventor： Harvinder S. Gill ,  Shashwati Atwe ,  Yunzhe Ma

IPC: A61K9/16 ,  A61K39/00 ,  A61K39/07 ,  A61K39/12 ,  A61K39/39

CPC classification number: A61K9/167 ,  A61K39/00 ,  A61K39/07 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/542 ,  A61K2039/55588 ,  C12N2740/16034

Abstract: The present invention includes compositions, methods of making and using the compositions for modulating the immune response in a subject by providing a vaccine composition having a pollen/spore disposed in a pharmaceutical carrier for delivery to a subject, wherein the pollen/spore comprises multiple pores that connect an outer surface of the pollen/spore to an inner cavity and one or more antigens disposed on the outer surface, in the inner cavity, in the multiple pores, or a combination thereof, wherein the one or more antigens modulate an immune responses in the subject.

公开(公告)号：US20170283413A1

公开(公告)日：2017-10-05

申请号：US15513882

申请日：2015-09-25

Applicant: Texas Tech University System

Inventor： Ruiwen Zhang ,  Wei Wang

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: An SP-141 compound is a novel small molecule that can serve as a molecular-targeted chemotherapeutic agent. In one embodiment, the labeled compound can comprise SP-141, which comprises 6-methoxy-1-(naphthalen-1-yl)-9 H-pyrido[3,4-b]indote. The compound inhibits expression of oncogenes such as the Mouse Double Minute 2 protein. The compound can bind directly to Mouse Double Minute 2 to inhibit cancer growth including breast cancer growth.

公开(公告)号：US20170267968A1

公开(公告)日：2017-09-21

申请号：US15475286

申请日：2017-03-31

Applicant: Texas Tech University System

Inventor： Siva A. Vanapalli ,  Swastika S. Bithi ,  Meng Sun

IPC: C12M1/00 ,  B01L3/00 ,  G01N35/10

CPC classification number: C12M47/02 ,  B01L3/502784 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2300/088 ,  B01L2400/0487 ,  G01N35/1002 ,  G01N2035/1034 ,  Y10T29/49

Abstract: A microfluidic device includes a substrate comprising an inlet in fluid communication with one or more conduits and one or more parking loops in fluid communication with the one or more conduits. Each parking loop includes a bypass channel and a lower branch with a fluidic trap capable of retaining one or more drops of a sample solution, wherein the bypass channel has a smaller hydrodynamic resistance than the lower branch within the fluidic trap and a hydrodynamic resistance ratio (RT/RB) between the lower branch within the fluidic trap and the bypass channel is from 1.5 to 3.2. One or more outlets are in fluid communication with at least one of the bypass channels. A method for making the microfluidic device is also disclosed.

公开(公告)号：US09744212B2

公开(公告)日：2017-08-29

申请号：US15017856

申请日：2016-02-08

Applicant: Texas Tech University System ,  MandalMed, Inc.

Inventor： Maurizio Chiriva-Internati ,  Everardo Cobos ,  Constance John

IPC: A61K38/00 ,  A61P35/00 ,  A61K38/17 ,  A61K45/06 ,  A61K38/05 ,  A61K31/407 ,  A61K31/69 ,  A61K38/07

CPC classification number: A61K38/1732 ,  A61K31/407 ,  A61K31/69 ,  A61K38/05 ,  A61K38/07 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides a novel composition of matter useful for the treatment of neoplastic diseases. The novel composition is synergistic and comprised of galectin-3C in combination with a proteasome inhibitor, the combination having a pharmacologic activity greater than the expected additive effect of its individual components. Other embodiments of the invention provide novel synergistic compositions of galectin-3C with a proteasome inhibitor capable of reducing or overcoming resistance that develops to the proteasome inhibitor or reducing the adverse side effects from the proteasome inhibitor through increasing the therapeutic efficacy of lower doses.

公开(公告)号：US20170240899A1

公开(公告)日：2017-08-24

申请号：US15519359

申请日：2015-10-14

Applicant: Texas Tech University System

Inventor： Haoquan WU ,  Jang-gi CHOI

IPC: C12N15/113 ,  A61K48/00

CPC classification number: C12N15/1132 ,  A61K48/005 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/31 ,  C12N2310/3519 ,  C12N2310/51 ,  C12N2310/531 ,  C12N2330/51 ,  C12N2740/15042 ,  C12N2750/14142

Abstract: Nucleic acid molecules such as shRNA clusters and artificial miRNA clusters are disclosed, Also disclosed are methods of use, compositions, cells, viral particles, and kits relating to the nucleic acid molecules disclosed herein. The disclosure provides, at least in part nucleic acid molecules such as shRNA clusters encoding shRNA-like molecules and artificial miRNA clusters encoding modified pri-miRNA-like molecules. The shRNA clusters and artificial miRNA clusters disclosed herein can be used, for example, to produce artificial RNA molecules, e.g., RNAi molecules. Cells, viral particles, compositions (e.g., pharmaceutical compositions), kits, and methods relating to the nucleic acid molecules, e.g., shRNA clusters and artificial miRNA clusters, are also disclosed. The nucleic acid molecules (e.g., shRNA clusters and artificial miRNA clusters), artificial RNA molecules (e.g., RNAi molecules), cells, viral particles, compositions (e.g., pharmaceutical compositions), and kits and methods disclosed herein can be used to treat or prevent a disease, e.g., HIV infection and/or AIDS.

公开(公告)号：US09519056B2

公开(公告)日：2016-12-13

申请号：US13952606

申请日：2013-07-27

Applicant: Texas Tech University System

Inventor： John Schroeder ,  Brian Hirth ,  Jerry Guynes

IPC: G01S13/95 ,  G01P5/00 ,  G01S13/87 ,  G01S13/58

CPC classification number: G01S13/95 ,  F03D17/00 ,  F05B2270/32 ,  F05B2270/321 ,  G01P5/001 ,  G01S13/589 ,  G01S13/87 ,  G01S13/951 ,  G01S13/956 ,  Y02A90/18

Abstract: The present invention provides a system and method for obtaining data to determine one or more characteristics of a wind field using a first remote sensing device and a second remote sensing device. Coordinated data is collected from the first and second remote sensing devices and analyzed to determine the one or more characteristics of the wind field. The first remote sensing device is positioned to have a portion of the wind field within a first scanning sector of the first remote sensing device. The second remote sensing device is positioned to have the portion of the wind field disposed within a second scanning sector of the second remote sensing device.

Abstract translation: 本发明提供一种用于使用第一遥感装置和第二遥感装置获得数据以确定风场的一个或多个特性的系统和方法。 协调数据从第一和第二遥感装置收集并分析以确定风场的一个或多个特征。 第一遥感装置被定位成将风场的一部分置于第一遥感装置的第一扫描扇区内。 第二遥感装置被定位成使风场的部分设置在第二遥感装置的第二扫描扇区内。

公开(公告)号：US09518989B2

公开(公告)日：2016-12-13

申请号：US14178407

申请日：2014-02-12

Applicant: Texas Tech University System

Inventor： Maurizio Chiriva-Internati

IPC: A61K39/00 ,  G01N33/574 ,  C07K16/30 ,  C07K14/47 ,  C07K14/705 ,  C12N9/12 ,  A61K35/15

CPC classification number: A61K39/0011 ,  A61K35/15 ,  A61K2039/5154 ,  A61K2039/572 ,  C07K14/47 ,  C07K14/705 ,  C07K16/3023 ,  C12N9/12 ,  G01N33/57423 ,  G01N33/57488 ,  G01N2333/47 ,  G01N2333/705 ,  G01N2333/912

Abstract: The present invention includes compositions and methods for the diagnosis and treatment of lung cancer with a recombinant tumor-associated antigen loaded antigen presenting cell that generates a cytotoxic T lymphocyte specific immune response to at least one of SP17, AKAP-4, or PTTG1 expressed by one or more lung cancer cells.

Abstract translation: 本发明包括用重组肿瘤相关抗原加载的抗原呈递细胞诊断和治疗肺癌的组合物和方法，其产生对SP17，AKAP-4或PTTG1中的至少一种表达的细胞毒性T淋巴细胞特异性免疫应答 一个或多个肺癌细胞。

公开(公告)号：US20160339428A1

公开(公告)日：2016-11-24

申请号：US15135326

申请日：2016-04-21

Applicant: Texas Tech University System

Inventor： Jungkyu Kim ,  Ryan Howse

IPC: B01L3/00 ,  C23C16/04 ,  C23C16/30

CPC classification number: B01L3/502707 ,  B01L3/50273 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/126 ,  B01L2400/0406 ,  C23C16/04

Abstract: Disclosed is a device and method for forming a chemically patterned paper microfluidic device (cPMD) having controllable hydrophobic regions for purposes of providing a repeatable and versatile production with no temperature limitations similar or expensive printers, enabling point of care sensor devices. The disclosed invention comprises multilayer capability, including the ability for various biomolecules to be immobilized with charge interaction. The paper-based microfluidic platform as disclosed repeatable, versatile, cost effective, and allows for the creation of complex channels using the settling time calculated from calibration results. The disclosed system supports a wide variety of scenarios for testing, diagnostics and drug delivery, and related products and services.

Abstract translation: 公开了一种用于形成具有可控疏水区域的化学图案化纸微流体装置（cPMD）的装置和方法，用于提供无可重复和多功能的生产，没有类似或昂贵的打印机的温度限制，使得护理点传感器装置。 所公开的发明包括多层能力，包括各种生物分子用电荷相互作用固定的能力。 所公开的基于纸张的微流体平台可重复，通用，成本有效，并允许使用由校准结果计算的建立时间来创建复杂通道。 所公开的系统支持用于测试，诊断和药物递送以及相关产品和服务的各种场景。

公开(公告)号：US20160325491A1

公开(公告)日：2016-11-10

申请号：US15108217

申请日：2014-12-26

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： Charles B. Sweeney ,  Micah J. Green ,  Mohammad Saed

IPC: B29C67/00 ,  B29B15/14 ,  B33Y80/00 ,  B33Y30/00 ,  B33Y70/00 ,  B29C35/08 ,  B33Y10/00

Abstract: A microwave-induced heating of CNT filled (or coated) polymer composites for enhancing inter-bead diffusive bonding of fused filament fabricated parts. The technique incorporates microwave absorbing nanomaterials (carbon nanotubes (CNTs)) onto the surface or throughout the volume of 3D printer polymer filament to increase the inter-bead bond strength following a post microwave irradiation treatment and/or in-situ focused microwave beam during printing. The overall strength of the final 3D printed part will be dramatically increased and the isotropic mechanical properties of fused filament part will approach or exceed conventionally manufactured counterparts.

Abstract translation: CNT填充（或涂覆）聚合物复合材料的微波诱导加热，用于增强熔丝长丝制造部件的珠间扩散接合。 该技术将微波吸收纳米材料（碳纳米管（CNTs））纳入到3D打印机聚合物长丝的表面或整个体积上，以在印刷后的微波辐射处理和/或原位聚焦微波束之后增加珠间粘合强度 。 最终3D印刷部件的总体强度将显着增加，并且熔丝部分的各向同性力学性能将接近或超过常规制造的对应物。