AUTO-INJECTOR
    71.
    发明申请
    AUTO-INJECTOR 审中-公开
    自动注射器

    公开(公告)号:WO2012164390A2

    公开(公告)日:2012-12-06

    申请号:PCT/IB2012001150

    申请日:2012-06-04

    Abstract: Provided is an auto-injector for a syringe suitable for the injected delivery of drug to a patient. The auto-injector comprises a cassette unit arranged for receipt of a syringe. The cassette unit and/or syringe is movable from a rest position, in which the syringe needle tip is within the drive unit housing to a use position, in which the needle tip protrudes from a needle delivery aperture thereof. The auto-injector comprises a drive unit arranged for docking receipt of the cassette unit at a docking position and a drive arrangement. The drive unit is arranged for initial receipt of the cassette unit at an intermediate pre-docking position and for subsequent transport of the cassette unit to the docking position. In embodiments, the drive unit is arranged such that transport of the cassette unit to the docking position is permitted only following verification of an identifier at the intermediate pre-docking position.

    Abstract translation: 提供一种用于注射器的自动注射器,其适用于将药物注射到患者体内。 自动注射器包括布置成接收注射器的盒单元。 盒单元和/或注射器可从其中注射器针尖在驱动单元壳体内的静止位置移动到使用位置,在该使用位置,针尖从其针送出孔突出。 自动注射器包括驱动单元,该驱动单元布置成用于对接在对接位置处的盒单元和驱动装置的接收。 驱动单元布置成在中间预对接位置处初始接收盒单元,并且用于随后将盒单元传送到对接位置。 在实施例中,驱动单元被布置成使得只有在中间预对接位置的识别符的验证之后才允许盒单元传送到对接位置。

    MULTIVALENT ANTIBODIES
    72.
    发明申请
    MULTIVALENT ANTIBODIES 审中-公开
    多功能抗体

    公开(公告)号:WO2011061492A2

    公开(公告)日:2011-05-26

    申请号:PCT/GB2010002120

    申请日:2010-11-17

    Abstract: A multivalent antibody fusion protein comprising: a heavy chain comprising, in sequence from the N-terminal, a variable domain nominally VH1, a CH1 region and a further variable domain nominally VH2, a light chain comprising, in sequence from the N-terminal, a variable domain nominally VL1, a CL domain and a variable domain nominally VL2, wherein said heavy and light chains are aligned to provide a first binding site formed by a first variable domain pair of VH1 and VL1 and a second binding site formed by a second variable domain pair of VH2 and VL2, wherein there is a disulfide bond between a variable domain pair forming a binding site, and said fusion protein is conjugated to a PEG polymer.

    Abstract translation: 一种多价抗体融合蛋白,其包含:重链,其从N末端依次包含名义上为VH1的可变结构域,CH1区域和名义上为VH2的另外的可变区,轻链,其从N末端依次包含, 可变结构域名义上为VL1,CL结构域和名义上为VL2的可变结构域,其中所述重链和轻链对齐以提供由第一可变结构域对VH1和VL1形成的第一结合位点和由第二结合位点形成的第二结合位点 VH2和VL2的可变结构域对,其中在形成结合位点的可变结构域对之间存在二硫键,并且所述融合蛋白与PEG聚合物缀合。

    AUTO-INJECTOR
    73.
    发明申请
    AUTO-INJECTOR 审中-公开
    自动注射器

    公开(公告)号:WO2010146358A2

    公开(公告)日:2010-12-23

    申请号:PCT/GB2010001182

    申请日:2010-06-17

    Abstract: There is provided an auto-injector for a syringe that is suitable for use in the injected delivery of drug to a patient. The auto-injector comprises a housing defining a housing cavity and a needle delivery aperture, the housing cavity arranged for receipt of a syringe. The syringe is movable within the housing cavity from a rest position, in which the needle tip thereof is within the housing to a use position, in which the needle tip protrudes from the needle delivery aperture. The auto-injector further comprises a drive transfer element for transferring axial drive; and a first coupling for coupling said drive transfer element to said syringe barrel of the syringe. The drive transfer element communicates with said plunger of the syringe for transferring axial drive thereto. The first coupling is a friction clutch coupling arranged for decoupling by declutching thereof when the syringe moves to the use position.

    Abstract translation: 提供了一种用于注射器的自动注射器,其适用于将药物注射到患者体内。 自动注射器包括限定壳体空腔和针输送孔的壳体,所述壳体腔布置成用于接收注射器。 该注射器可以在该静止位置内在该容纳空腔内移动,在该静止位置,其针尖位于该壳体内至使用位置,在该使用位置,针尖从该针传送孔突出。 自动注射器还包括用于传递轴向驱动的驱动传递元件; 以及用于将所述驱动传递元件联接到注射器的注射器筒的第一联接器。 驱动传递元件与注射器的柱塞连通,用于将轴向驱动传递到其上。 第一联轴器是布置成当注射器移动到使用位置时通过其分离来解耦的摩擦离合器联轴器。

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