公开(公告)号：WO2012167350A1

公开(公告)日：2012-12-13

申请号：PCT/CA2012/000500

申请日：2012-05-25

Applicant: UNIVERSITY HEALTH NETWORK ,  ZHENG, Gang ,  LOVELL, Jonathan

Inventor： ZHENG, Gang ,  LOVELL, Jonathan

IPC: A61K9/127 ,  A61K31/704 ,  A61K47/22 ,  A61K49/00 ,  A61K51/12 ,  A61K9/14 ,  B01J13/02 ,  C12P17/18 ,  C12P41/00 ,  C07F9/6561

CPC classification number: C12P17/182 ,  A61K8/14 ,  A61K8/553 ,  A61K31/704 ,  A61K41/0071 ,  A61K47/544 ,  A61K2800/10 ,  A61Q19/00 ,  B01J13/02 ,  C07F9/106 ,  C07F9/6561 ,  C09B67/0097 ,  C09B69/108

Abstract: There is herein described a nanovesicle comprising a bilayer of porphyrin-phospholipid conjugates. Each porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain at one of the sn-1 or the sn-2 positions of one phospholipid. Further, the nanovesicle has a defined regioisomeric ratio of sn-1:sn-2 porphyrin-phospholipid conjugates.

Abstract translation: 本文描述了包含卟啉 - 磷脂共轭物双层的纳米囊。 每个卟啉 - 磷脂缀合物包含一个卟啉，卟啉衍生物或卟啉类似物，其共价连接到一个磷脂的sn-1或sn-2位置之一的脂质侧链。 此外，纳米囊具有定义的sn-1：sn-2卟啉 - 磷脂缀合物的区域异构体比例。

公开(公告)号：WO2012069965A1

公开(公告)日：2012-05-31

申请号：PCT/IB2011/055145

申请日：2011-11-17

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  BZDUSEK, Karl Antonin ,  ALLAIRE, Stephane ,  HARDCASTLE, Nicholas Gordon Lance ,  UNIVERSITY OF WISCONSIN ,  TOME, Wolfgang Axel ,  UNIVERSITY HEALTH NETWORK

Inventor： BZDUSEK, Karl Antonin ,  ALLAIRE, Stephane ,  HARDCASTLE, Nicholas Gordon Lance ,  TOME, Wolfgang Axel

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1038

Abstract: A radiation therapy planning system includes a planning module (20) which receives a first planning image set from a diagnostic imaging apparatus (10) and uses automatic segmentation tools (22) or manual segmentation tools (24) and a radiation therapy planning system (32) to generate a first radiation therapy plan. After the first radiation therapy plan has been applied for one or more therapy sessions, a second planning image set is generated. The planning module (20) uses a deformable image registration algorithm (30) to register the planning image set sand generate a corresponding deformation map which is applied to segmented objects of interest (OOIs) of the segmented first planning image set to propagate the objects of interest onto the second planning image set. The deformation map is corrected in accordance with deviations between the propagated and actual OOI locations in two steps: 1) manual and/or automated corrections of the propagated OOIs are performed, such as region of interest contour corrections and/or landmark point of interest positions; 2) a corrected global deformation map is generated from these local OOI corrections. The corrected deformation map is applied to the first radiation therapy plan and an accumulated radiation map depicting the radiation accumulated in each OOI during the therapy session(s) implemented with the first radiation therapy plan.

Abstract translation: 辐射治疗计划系统包括规划模块（20），其从诊断成像设备（10）接收第一规划图像集并且使用自动分割工具（22）或手动分割工具（24）和放射治疗计划系统（32） ）产生第一次放射治疗计划。 在第一次辐射治疗计划已经应用于一个或多个治疗会话之后，产生第二规划图像集。 规划模块（20）使用可变形图像配准算法（30）来注册规划图像集合砂，生成适用于分段的第一规划图像集合的分割对象（OOI）的相应变形图，以传播分割的第一规划图像集合的对象 感兴趣的第二个规划图像集。 变形图根据传播的和实际的OOI位置之间的偏差在两个步骤中被校正：1）执行传播的OOI的手动和/或自动校正，例如感兴趣的区域轮廓校正和/或地标点的兴趣位置 ; 2）从这些局部OOI校正产生校正的全局变形图。 校正的变形图应用于第一放射治疗计划和描绘在用第一放射治疗计划实施的治疗会话期间累积在每个OOI中的辐射的累积辐射图。

公开(公告)号：WO2011123937A1

公开(公告)日：2011-10-13

申请号：PCT/CA2011/000366

申请日：2011-04-06

Applicant: UNIVERSITY HEALTH NETWORK ,  LAUFER, Radoslaw ,  PAULS, Heinz W. ,  FEHER, Miklos ,  NG, Grace ,  LIU, Yong ,  EDWARDS, Louise G. ,  PATEL, Narendra Kumar B. ,  PAN, Guohua ,  MAK, Tak W.

Inventor： LAUFER, Radoslaw ,  PAULS, Heinz W. ,  FEHER, Miklos ,  NG, Grace ,  LIU, Yong ,  EDWARDS, Louise G. ,  PATEL, Narendra Kumar B. ,  PAN, Guohua ,  MAK, Tak W.

IPC: C07D231/56 ,  A61K31/416 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

CPC classification number: C07D231/56 ,  A61K31/00 ,  A61K31/517 ,  A61K31/522 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The present teachings provide a compound represented by Strutural Formula (I): or a pharmaceutically acceptable salt thereof. Also described are a pharmaceutical composition and method of use thereof.

Abstract translation: 本发明提供由式（I）表示的化合物或其药学上可接受的盐。 还描述了药物组合物及其使用方法。

公开(公告)号：WO2010130053A1

公开(公告)日：2010-11-18

申请号：PCT/CA2010/000743

申请日：2010-05-14

Applicant: UNIVERSITY HEALTH NETWORK ,  THE HOSPITAL FOR SICK CHILDREN ,  WANG, C. Y., Jean ,  DICK, John ,  DANSKA, Jayne ,  JIN, Liqing ,  PRASOLAVA, Tatiana ,  THEOCHARIDES, Alexandre

Inventor： WANG, C. Y., Jean ,  DICK, John ,  DANSKA, Jayne ,  JIN, Liqing ,  PRASOLAVA, Tatiana ,  THEOCHARIDES, Alexandre

IPC: A61K38/45 ,  A61K38/16 ,  A61K47/48 ,  A61P35/00 ,  A61P35/02 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  A61K38/16 ,  C12Q2600/156

Abstract: The invention relates to modulating the SIRPα-CD47 interaction in order to treat hematological cancer and compounds therefor. In some embodiments, there is provided methods and uses of SIRPα polypeptides, fragments and fusion proteins for treating hematological cancer, preferably human acute myeloid leukemia.

Abstract translation: 本发明涉及调节SIRPa-CD47相互作用以治疗血液癌症及其化合物。 在一些实施方案中，提供了用于治疗血液癌症，优选人急性骨髓性白血病的SIRA2多肽，片段和融合蛋白的方法和用途。

公开(公告)号：WO2010102387A1

公开(公告)日：2010-09-16

申请号：PCT/CA2010/000324

申请日：2010-03-09

Applicant: UNIVERSITY HEALTH NETWORK (UHN) ,  BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  SIMINOVITCH, Katherine ,  AMOS, Christopher ,  HIRSCHFIELD, Gideon

Inventor： SIMINOVITCH, Katherine ,  AMOS, Christopher ,  HIRSCHFIELD, Gideon

IPC: A61K38/20 ,  A61P1/16 ,  C12Q1/68 ,  C30B30/04 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68

CPC classification number: A61K38/208 ,  C12Q1/6883 ,  C12Q2600/16 ,  C12Q2600/172 ,  G01N33/6869 ,  G01N33/6893 ,  G01N2800/085

Abstract: Primary biliary cirrhosis and related autoimmune disorders are characterized by polymorphisms in various loci including IL-12-related genes, and by reduced levels of IL- 12A transcripts. Methods useful to screen for these defects are described for use in diagnosing these conditions. Methods useful to treat subjects afflicted with these conditions are also described.

Abstract translation: 原发性胆汁性肝硬化和相关的自身免疫性疾病的特征在于包括IL-12相关基因在内的各种基因座的多态性，以及IL-12A转录物水平的降低。 描述了用于筛选这些缺陷的方法用于诊断这些病症。 还描述了用于治疗患有这些病症的受试者的方法。

公开(公告)号：WO2010099601A1

公开(公告)日：2010-09-10

申请号：PCT/CA2010/000282

申请日：2010-03-02

Applicant: UNIVERSITY HEALTH NETWORK ,  SCHIMMER, Aaron, D.

Inventor： SCHIMMER, Aaron, D.

IPC: A61K31/69 ,  A61K31/47 ,  A61P35/00 ,  A61P35/02

CPC classification number: A61K31/47 ,  A61K31/69 ,  A61K45/06 ,  A61K2300/00

Abstract: The disclosure provides methods and compositions for treating hematological malignancies. In particular, the disclosure provides methods and compositions for treating leukemia, lymphoma and multiple myeloma using bortezomit and 5AHQ (5-ammo-8-hydroxyqumolme) and related compounds that bind non-competitively to an alpha unit of 2OS proteasome and inhibit proteasome activity Kits and commercial packages are also disclosed

Abstract translation: 本公开提供了用于治疗血液恶性肿瘤的方法和组合物。 具体地，本公开提供了使用硼氢化酮和5AHQ（5-氨基-8-羟基喹啉）和与2OS蛋白酶体的α单位非竞争性结合并抑制蛋白酶体活性的相关化合物来治疗白血病，淋巴瘤和多发性骨髓瘤的方法和组合物 并且还公开了商业包装

公开(公告)号：WO2009146546A1

公开(公告)日：2009-12-10

申请号：PCT/CA2009/000776

申请日：2009-06-05

Applicant: UNIVERSITY HEALTH NETWORK ,  SCHIMMER, Aaron, D. ,  LI, Xiaoming ,  BATEY, Robert ,  WOOD, Tabitha ,  MAO, Xinliang

Inventor： SCHIMMER, Aaron, D. ,  LI, Xiaoming ,  BATEY, Robert ,  WOOD, Tabitha ,  MAO, Xinliang

IPC: A61K31/47 ,  A61P35/00 ,  A61P35/02 ,  C07D215/16

CPC classification number: A61K31/47 ,  C07D215/24 ,  C07D215/38

Abstract: The application relates to compositions and methods for treating hematological malignancies and proliferative diseases, disorders and conditions involving increased D-cyclin expression. In particular, the application relates to compositions and methods for treating the hematological malignancies acute myeloid leukemia (AML), lymphoma and multiple myeloma (MM) using 5-nitrogen substituted hydroxy quinolones as well as 7-bromo-5-chloro substituted hydroxy quinolones and 5-chloro substituted hydroxy quinolones.

Abstract translation: 本申请涉及用于治疗血液恶性肿瘤和增殖性疾病，紊乱和涉及增加的D-细胞周期蛋白表达的病症的组合物和方法。 特别地，本申请涉及使用5-氮取代的羟基喹诺酮以及7-溴-5-氯取代的羟基喹诺酮和/或治疗血液恶性肿瘤急性骨髓性白血病（AML），淋巴瘤和多发性骨髓瘤（MM）的组合物和方法 5-氯取代的羟基喹诺酮。

公开(公告)号：WO2008134878A1

公开(公告)日：2008-11-13

申请号：PCT/CA2008/000848

申请日：2008-05-05

Applicant: UNIVERSITY HEALTH NETWORK ,  MEDIN, Jeffrey, A. ,  MCCART, Andrea

Inventor： MEDIN, Jeffrey, A. ,  MCCART, Andrea

IPC: C12N15/85 ,  A61K39/00 ,  A61K48/00 ,  A61P35/00 ,  A61P37/04 ,  C12N15/86 ,  C12N15/867 ,  C12N7/01 ,  C07K14/47 ,  C07K14/705 ,  G01N33/574

CPC classification number: A61K39/0011 ,  A01K67/0275 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/208 ,  A61K39/21 ,  A61K48/005 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/55522 ,  A61K2039/55538 ,  A61K2039/57 ,  A61K2039/575 ,  C07K14/5434 ,  C07K14/70503 ,  C07K2319/06 ,  C12N7/00 ,  C12N15/8509 ,  C12N15/86 ,  C12N2740/15021 ,  C12N2740/15034 ,  C12N2740/15043 ,  C12N2740/15071 ,  C12N2740/16043

Abstract: Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as colon cancer and prostate cancer. fold-induction

Abstract translation: 公开了用于递送免疫调节分子以产生治疗效果的组合物和方法。 组合物和方法使用稳定整合的慢病毒递送系统。 该方法可用于治疗和预防性治疗癌症如结肠癌和前列腺癌。 折叠式感应

公开(公告)号：WO2008006198A1

公开(公告)日：2008-01-17

申请号：PCT/CA2007/001209

申请日：2007-07-10

Applicant: UNIVERSITY HEALTH NETWORK ,  ISLAM, Mohammad, K. ,  NORRLINGER, Bernhard, D. ,  GALBRAITH, Duncan, M. ,  JAFFRAY, David, A. ,  HEATON, Robert, K. ,  SMALE, Jason

Inventor： ISLAM, Mohammad, K. ,  NORRLINGER, Bernhard, D. ,  GALBRAITH, Duncan, M. ,  JAFFRAY, David, A. ,  HEATON, Robert, K. ,  SMALE, Jason

IPC: G01T1/185 ,  A61N5/10 ,  G01T1/02 ,  G01T1/29 ,  H01J47/02 ,  G01T1/15 ,  G21K1/04

CPC classification number: H01J47/02 ,  A61N5/1042 ,  A61N5/1048 ,  A61N5/1067 ,  G01T1/185 ,  G01T1/2935

Abstract: Various embodiments are described herein for an area integrated fluence monitoring sensor that can be used to measure a radiation dose. The sensor comprises at least one Gradient Ion Chamber (GIC) comprising an ion chamber having a volume gradient across a length or width thereof, a gas or liquid located within the ion chamber and an electrode to detect ions generated within the gas or liquid when the at least one GIC is subjected to an ionizing radiation beam. Various embodiments are also described herein for an Integral Quality Monitoring system and associated method that can be used to measure and monitor the quality of radiation doses provided by a radiation treatment system.

Abstract translation: 本文描述了可用于测量辐射剂量的区域集成注量监测传感器的各种实施例。 传感器包括至少一个梯度离子室（GIC），其包括具有其长度或宽度的体积梯度的离子室，位于离子室内的气体或液体，以及用于检测气体或液体中产生的离子的电极 至少一个GIC经受电离辐射束。 本文还描述了可用于测量和监测由辐射治疗系统提供的辐射剂量的质量的整体质量监测系统和相关方法的各种实施例。

公开(公告)号：WO2007131345A1

公开(公告)日：2007-11-22

申请号：PCT/CA2007/000833

申请日：2007-05-14

Applicant: THE HOSPITAL FOR SICK CHILDREN ,  UNIVERSITY HEALTH NETWORK ,  PATERSON, Andrew, David ,  BORIGHT, Andrew, Pepler ,  AL KATEB, Hussam

Inventor： PATERSON, Andrew, David ,  BORIGHT, Andrew, Pepler ,  AL KATEB, Hussam

IPC: C12Q1/68 ,  A61K45/00 ,  C07H21/00

CPC classification number: C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: The invention relates to a composition comprising an isolated nucleic acid sequence that specifically hybridizes to at least one of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:9 and their complements. The composition is useful as a probe to detect the presence of at least one allele of three single nucleotide polymorphisms (SNPs) that are associated with renal disease, cataract, cardiovascular disease and longevity.

Abstract translation: 本发明涉及一种组合物，其包含与SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5，SEQ ID NO：7，SEQ ID NO：9和SEQ ID NO：7中的至少一个特异性杂交的分离的核酸序列和 他们的补充。 该组合物可用作探针以检测与肾病，白内障，心血管疾病和长寿相关的三个单核苷酸多态性（SNP）的至少一个等位基因的存在。