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71.发明公开멜라닌 세포주 계대배양계 및 이를 이용한 노화 수준 판단, 미용 정보 제공, 또는 스크리닝 방법 审中-实审MELANOCYTE PASSAGED CULTURE CELL LINE系统，确定老化水平的方法，提供美容信息或使用其进行筛选
公开(公告)号：KR1020160065038A
公开(公告)日：2016-06-08
申请号：KR1020150167820
申请日：2015-11-27
Applicant: (주)아모레퍼시픽
Abstract: 본명세서에는신규한멜라닌세포주계대배양계가개시된다. 상기계대배양계는계대배양된전기멜라닌세포및 후기멜라닌세포를포함하는계대배양계를제공한다. 이에, 상기계대배양계는생체내 환경(in vivo)과유사한생체외(in vitro)환경을제공함으로써, 노화수준판단, 미용정보제공및 세포회춘유도물질을스크리닝하는데유용하다.
Abstract translation: 公开了一种新型黑素细胞株的亚文化系统。 亚文化系统包括经历前期和后期的传代培养的黑素细胞。 此外，亚文化系统提供体内类似的体外条件，从而可用于确定老化水平，提供美容提示和筛选细胞再生诱导物质。
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72.发明公开
公开(公告)号：KR1020160065035A
公开(公告)日：2016-06-08
申请号：KR1020150167771
申请日：2015-11-27
Applicant: (주)아모레퍼시픽
IPC: A61K31/352 , A61K31/353 , A23L1/30 , A61K8/49 , A61K9/00 , A61Q19/00
CPC classification number: A61K8/498 , A61K8/49 , A61K31/352 , A61K31/353 , A61K2800/78 , A61K2800/91 , A61Q5/00 , A61Q19/00 , A61Q19/08
Abstract: 본명세서에는제니스테인(Genistein), 에피갈로카테친갈레이트(Epigallocatechin gallate, EGCG), 이들의유도체, 이들의이성질체, 이들의약학적으로허용가능한염, 이들의프로드럭, 이들의수화물및 이들의용매화물의신규한용도가개시된다. 상기제니스테인, 에피갈로카테친갈레이트, 이들의유도체이들의이성질체, 이들의약학적으로허용가능한염, 이들의프로드럭, 이들의수화물또는이들의용매화물을포함하는조성물은, 멜라닌색소형성능증가관련인자의발현을감소시키고, 노화지표단백질의발현을감소시키며, 멜라닌색소형성관련효소의발현을조절함으로써, 멜라닌세포를포함하는세포의회춘효과를가질수 있다.
Abstract translation: 本发明涉及染料木素，表没食子儿茶素没食子酸酯（EGCG），其衍生物，其异构体，其药学上可接受的盐，其前药，其水合物和溶剂合物的新用途。 包含染料木素，EGCG，其衍生物，其异构体，其药学上可接受的盐，其前体药物，其水合物和溶剂化物的组合物减少与黑色素颜料形成性增加有关的因素的表达，减少老化的表达 状态蛋白并控制与黑色素形成相关的酶的表达，因此对于包括黑色素细胞在内的细胞的复原是有效的。
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公开(公告)号：KR1020140084808A
公开(公告)日：2014-07-07
申请号：KR1020120154702
申请日：2012-12-27
Applicant: (주)아모레퍼시픽
CPC classification number: A61K38/20 , A61K8/64 , A61K9/0014 , A61Q19/02
Abstract: The present invention relates to a composition for whitening the skin, wherein the composition contains interleukin 27 (IL-27). More specifically, the present invention relates to a skin external application composition containing IL-27 so as to control the chromogenesis of adult melanocytes in the skin so that the skin can be whitened and hyperchromatism including chloasma and lentigo can be treated.
Abstract translation: 本发明涉及一种用于使皮肤美白的组合物，其中该组合物含有白细胞介素27（IL-27）。 更具体地，本发明涉及含有IL-27的皮肤外用剂组合物，以控制皮肤中成人黑素细胞的发色，从而可以使皮肤发白，并可以治疗包括黄褐斑和雀斑的过度色素沉着。
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公开(公告)号：KR1020140084806A
公开(公告)日：2014-07-07
申请号：KR1020120154700
申请日：2012-12-27
Applicant: (주)아모레퍼시픽
IPC: A61K31/4152 , A61K31/41 , A61K8/49 , A61P17/00
CPC classification number: A61K31/64 , A61K8/494 , A61K9/0014 , A61Q19/02
Abstract: The present invention relates to a skin external application composition containing SM-19712. More specifically, the skin external application composition exhibits excellent skin whitening effects by containing SM-19712, which is an antagonist of a substance P, as an active ingredient.
Abstract translation: 本发明涉及含有SM-19712的皮肤外用剂组合物。 更具体地，皮肤外用组合物通过含有作为P物质的拮抗剂的SM-19712作为活性成分，显示出优异的皮肤美白效果。
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公开(公告)号：KR1020140078973A
公开(公告)日：2014-06-26
申请号：KR1020120148356
申请日：2012-12-18
Applicant: (주)아모레퍼시픽
CPC classification number: A61K38/2086 , A61K8/64 , A61K9/0014 , A61Q19/02 , C07K14/5437
Abstract: The present invention relates to a skin whitening composition including interleukin 13 (IL-13), more specifically, to a skin preparation composition for an external use, wherein the composition comprises IL-13 to suppress a generation of a pigment and differentiation of an adult melanin cell on the skin, thereby providing a skin whitening effect; and is effective in curing hyperpigmentation skin diseases such as melasma or lentigo.
Abstract translation: 本发明涉及包含白细胞介素13（IL-13）的皮肤美白组合物，更具体地，涉及外用皮肤制剂组合物，其中所述组合物包含IL-13以抑制颜料的产生和成人的分化 皮肤上的黑色素细胞，从而提供皮肤美白效果; 并且有效地治疗色素沉着过度的皮肤疾病如黑斑病或雀斑斑。
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Patent Agency Ranking
公开(公告)号：KR1020130140318A
公开(公告)日：2013-12-24
申请号：KR1020120063582
申请日：2012-06-14
Applicant: (주)아모레퍼시픽
Abstract: The present invention provides a composition for skin whitening which contains wortmannin as an active ingredient. The composition for skin whitening which contains wortmannin as an active ingredient according to the present invention whitens skin by reducing melanin production, suppressing tyrosinase activation and reducing expression of melanogenesis-related gene and protein and can be widely applied to skin externals, cosmetic compositions, and pharmaceutical compositions by having stability not to have bad influence on cells.
Abstract translation: 本发明提供了含有渥曼青霉素作为活性成分的皮肤美白组合物。 含有渥曼青霉素作为本发明活性成分的皮肤美白组合物通过减少黑色素产生，抑制酪氨酸酶活化和减少黑素生成相关基因和蛋白质的表达来增白皮肤，并可广泛应用于皮肤外用剂，化妆品组合物和 稳定性不会对细胞产生不良影响的药物组合物。
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公开(公告)号：KR1020130140317A
公开(公告)日：2013-12-24
申请号：KR1020120063581
申请日：2012-06-14
Applicant: (주)아모레퍼시픽
IPC: A61K8/49 , A61K31/5377 , A61Q19/02 , A61P17/00
CPC classification number: A61K8/498 , A61K31/5377 , A61Q19/02
Abstract: The present invention provides a composition containing LY294002 for skin whitening. The composition containing LY294002 for skin whitening reduces the generation of melanin, suppresses the activity of tyrosinase, and reduces the expression of genes and protein related to the generation of melanin for whitening the skin. The composition containing LY294002 for skin whitening has stability which does not have bad influence to cells, and is capable of widely applied to a skin external application, a cosmetic composition, and a pharmaceutical composition.
Abstract translation: 本发明提供含有LY294002用于皮肤美白的组合物。 含有LY294002用于皮肤美白的组合物减少黑色素的产生，抑制酪氨酸酶的活性，并减少与产生黑色素相关的基因和蛋白质的表达，以使皮肤美白。 含有用于皮肤美白的LY294002的组合物具有对细胞没有不良影响的稳定性，并且能够广泛地应用于皮肤外用剂，化妆品组合物和药物组合物。
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