公开(公告)号：KR1020110080984A

公开(公告)日：2011-07-13

申请号：KR1020100001448

申请日：2010-01-07

Applicant: 고려대학교 산학협력단

Inventor： 전태훈 ,  이한형 ,  임지영

IPC: A61K36/484 ,  A61P19/00 ,  A61P3/10 ,  A61P17/00

CPC classification number: A61K36/48 ,  A61K2236/331 ,  A61K2236/333 ,  Y10S514/885 ,  Y10S514/925

Abstract: PURPOSE: An inhibitor for immunocyte proliferation, containing mung bean extract is provided to suppress IL-2 and IFN-gamma secretion and to prevent and treat immune diseases. CONSTITUTION: An inhibitor for immunocyte proliferation contains mung bean extract as an active ingredient. The mung bean extract is isolated by a solvent selected from the group consisting of water, alcohol of C1-4 carbon atoms, ethyl acetate, chloroform, ether, hexane, and dichloromethane. The immune diseases are autoimmune diseases or graft rejection of organ or tissue. The autoimmune disease includes rheumatoid arthrisis, systemic lupus erythematosus, diabetes, atopic dermatitis, psoriasis, smallpox, asthma, aphthous stomatitis, chronic fibrous thyroiditis, ulcerative colitis, polymyositis, autoimmune encephalomyelitis, and fibrofascitis.

Abstract translation: 目的：提供含有绿豆提取物的免疫细胞增殖抑制剂，以抑制IL-2和IFN-γ分泌并预防和治疗免疫疾病。 构成：免疫细胞增殖抑制剂含有绿豆提取物作为活性成分。 绿豆提​​取物通过选自水，C 1-4碳原子的醇，乙酸乙酯，氯仿，乙醚，己烷和二氯甲烷的溶剂分离。 免疫疾病是器官或组织的自身免疫性疾病或移植排斥反应。 自身免疫性疾病包括类风湿性关节炎，系统性红斑狼疮，糖尿病，特应性皮炎，牛皮癣，天花，哮喘，口疮性口炎，慢性纤维性甲状腺炎，溃疡性结肠炎，多发性肌炎，自身免疫性脑脊髓炎和纤维性筋膜炎。

公开(公告)号：KR100922484B1

公开(公告)日：2009-10-20

申请号：KR1020070120614

申请日：2007-11-26

Applicant: 고려대학교 산학협력단

Inventor： 전태훈 ,  허유진

IPC: A61K38/16 ,  A61K38/17 ,  A61P9/08

Abstract: 본 발명은 서열번호 1의 아미노산 서열을 코딩하는 인간 파필로마바이러스 16형 E6 단백질(human papillomavirus 16 E6, HPV E6) 유전자 및 서열번호 2의 아미노산 서열을 코딩하는 인터페론 조절인자-1 단백질(Interferon Regulatory Factor 1, IRF-1) 유전자를 함유하는 신생혈관생성 억제용 약학적 조성물에 관한 것이다.
본 발명에 따르면, 본 발명에 따르면 서열번호 1의 아미노산 서열을 코딩하는 인간 파필로마바이러스 16형 E6 단백질(human papillomavirus 16 E6, HPV E6) 유전자 및 서열번호 2의 아미노산 서열을 코딩하는 인터페론 조절인자-1 단백질(Interferon Regulatory Factor 1, IRF-1) 유전자를 함유하는 신생혈관생성 억제용 약학적 조성물을 사용하여 신생혈관생성(angiogenesis)를 억제함으로써 암 전이를 감소시킬 수 있다.

公开(公告)号：KR100808925B1

公开(公告)日：2008-03-03

申请号：KR1020060095670

申请日：2006-09-29

Applicant: 고려대학교 산학협력단

Inventor： 전태훈 ,  김선수

IPC: C07K16/42 ,  C12N15/12 ,  A61K38/17

CPC classification number: C07K14/4702 ,  A61K47/6811 ,  C07K2319/00 ,  C07K2319/30

Abstract: Extracellular domains 1 and 2 of a porcine LAG-3 are provided to inhibit the activity of a human T lymphocyte during human-porcine immune reaction, thereby being usefully used for treating or preventing an acute graft-versus-host disease caused by xenotransplantation. A porcine LAG-3 gene includes a sequence coding an amino acid sequence of SEQ ID : NO. 2. A porcine LAG-3 protein includes an amino acid sequence of SEQ ID : NO. 2. A porcine LAG-3 fused immunoglobulin consists of extracellular domains 1 and 2 of a porcine LAG-3 having the amino sequences from 23rd to 247th of the SEQ ID : NO. 2 and a human immunoglobulin Fc fragment. A recombinant expression vector includes extracellular domain 1 and 2 genes of a porcine LAG-3 having sequences from 67th to 741st of SEQ ID : NO. 1 and a human immunoglobulin Fc gene. A composition for inhibiting the activity of a human T lymphocyte includes the porcine LAG-3 fused immunoglobulin as an effective ingredient.

Abstract translation: 提供猪LAG-3的细胞外结构域1和2以在人猪免疫反应期间抑制人T淋巴细胞的活性，从而有效地用于治疗或预防由异种移植引起的急性移植物抗宿主病。 猪LAG-3基因包括编码SEQ ID NO：1的氨基酸序列的序列。 猪LAG-3蛋白包括SEQ ID NO：1的氨基酸序列。 猪LAG-3融合免疫球蛋白由具有SEQ ID NO：23的至第247位的氨基酸序列的猪LAG-3的细胞外结构域1和2组成。 2和人免疫球蛋白Fc片段。 重组表达载体包括具有SEQ ID NO：67的第74位至第741位的序列的猪LAG-3的细胞外结构域1和2基因。 1和人免疫球蛋白Fc基因。 用于抑制人T淋巴细胞活性的组合物包括猪LAG-3融合免疫球蛋白作为有效成分。