公开(公告)号：ZA827844B

公开(公告)日：1983-06-29

申请号：ZA827844

申请日：1982-10-27

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: A61K8/00 ,  A61K8/49 ,  C07D295/10 ,  A61P25/04 ,  A61P29/00 ,  A61Q17/04 ,  C07C45/46 ,  C07C49/84 ,  C07C59/76 ,  C07C59/80 ,  C07D207/32 ,  C07D207/325 ,  C07D209/08 ,  C07D295/112 ,  C07D295/155 ,  C07D295/185 ,  C07D295/194 ,  C07D307/83 ,  C07D307/92 ,  C07D405/04 ,  C07D405/12 ,  C07D471/04 ,  C08K5/1535 ,  C07D ,  A61K

Abstract: The invention relates to novel furans, especially benzofuranones of the general formula (I) in which R1 represents hydrogen or an aliphatic radical, R2 represents an amino group di-substituted by a divalent hydrocarbon radical, and the aromatic ring A may be additionally substituted, and their salts and/or isomers, processes for the manufacture of compounds of the formula (I) and their salts and isomers, pharmaceutical preparations containing these compounds, and their use as the active ingredients of anti-inflammatory agents or analgesics and/or for the manufacture of pharmaceutical preparations.

公开(公告)号：ZA827840B

公开(公告)日：1983-06-29

申请号：ZA827840

申请日：1982-10-27

Applicant: CIBA GEIGY AG

Inventor： BREITENSTEIN WERNER ,  BAUMANN MARCUS ,  BOSSHARD HANS

IPC: C07C51/54 ,  C07D307/60 ,  C07C57/03 ,  C07C59/76 ,  C07C59/80 ,  C07D207/44 ,  C07D207/452 ,  C07D307/34 ,  C07D307/83 ,  C07D307/92 ,  C07D401/04 ,  C07D471/04 ,  C07D

Abstract: Compounds of the formula I (I) in which R, R1 and R2 are as defined in patent claim 1, can be prepared by a novel process, for example by treating a salt of imidazo[1,2-a]pyridin-2(3H)-one with fumaric acid, maleic acid or maleic anhydride, in the presence of a base, and converting the product to a salt of 3-(1,2-dicarboxyethyl)-imidazo[1,2-a]pyridin-2(3H)-one, in the presence of a strong acid, reacting the latter salt with a compound CH2=C(R1)(R2) and treating the intermediate obtained with glacial acetic acid and sodium acetate. The compounds (I) can be converted, in a manner known per se, to corresponding imides having functional groups suitable for polymerization reactions of polycondensation reactions. These imides can be used to prepare photocrosslinkable polymers. The anhydrides (I) can also be used, in some cases, to prepare pharmaceutically active benzofuranones and homosalicylic acids by reaction with salts of suitable amines.

公开(公告)号：GB2110664A

公开(公告)日：1983-06-22

申请号：GB8230354

申请日：1982-10-25

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: A61K31/34 ,  A61K31/343 ,  A61P25/04 ,  A61P29/00 ,  C07C59/76 ,  C07D307/83 ,  C07D471/04

Abstract: The invention relates to novel lactones, especially benzofuranones of the general formula (I) in which R1 represents hydrogen or an aliphatic radical, R2 represents an amino group di-substituted by two monovalent hydrocarbon radicals, and the aromatic ring A may be additionally substituted, and their salts and/or isomers, processes for the manufacture of compounds of the formula (I) and their salts and isomers, pharmaceutical preparations containing these compounds, and their use as the active ingredients of medicaments and/or for the manufacture of pharmaceutical preparations.

公开(公告)号：GB2110210A

公开(公告)日：1983-06-15

申请号：GB8230351

申请日：1982-10-25

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: A61K8/00 ,  A61K8/49 ,  A61P25/04 ,  A61P29/00 ,  A61Q17/04 ,  C07C45/46 ,  C07D295/10 ,  C07C49/84 ,  C07C59/76 ,  C07C59/80 ,  C07D207/32 ,  C07D207/325 ,  C07D209/08 ,  C07D295/112 ,  C07D295/155 ,  C07D295/185 ,  C07D295/194 ,  C07D307/83 ,  C07D307/92 ,  C07D405/04 ,  C07D405/12 ,  C07D471/04 ,  C08K5/1535 ,  A61K31/40 ,  A61K31/55 ,  A61K31/445 ,  A61K31/535 ,  C07D413/04

Abstract: The invention relates to novel furans, especially benzofuranones of the general formula (I) in which R1 represents hydrogen or an aliphatic radical, R2 represents an amino group di-substituted by a divalent hydrocarbon radical, and the aromatic ring A may be additionally substituted, and their salts and/or isomers, processes for the manufacture of compounds of the formula (I) and their salts and isomers, pharmaceutical preparations containing these compounds, and their use as the active ingredients of anti-inflammatory agents or analgesics and/or for the manufacture of pharmaceutical preparations.

公开(公告)号：AU8982282A

公开(公告)日：1983-05-05

申请号：AU8982282

申请日：1982-10-27

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: A61K31/34 ,  A61K31/343 ,  A61P25/04 ,  A61P29/00 ,  C07C59/76 ,  C07D307/83 ,  C07D471/04 ,  A61K31/365

Abstract: The invention relates to novel lactones, especially benzofuranones of the general formula (I) in which R1 represents hydrogen or an aliphatic radical, R2 represents an amino group di-substituted by two monovalent hydrocarbon radicals, and the aromatic ring A may be additionally substituted, and their salts and/or isomers, processes for the manufacture of compounds of the formula (I) and their salts and isomers, pharmaceutical preparations containing these compounds, and their use as the active ingredients of medicaments and/or for the manufacture of pharmaceutical preparations.

公开(公告)号：FI823640A0

公开(公告)日：1982-10-25

申请号：FI823640

申请日：1982-10-25

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: C07D295/10 ,  A61K8/00 ,  A61K8/49 ,  A61P25/04 ,  A61P29/00 ,  A61Q17/04 ,  C07C45/46 ,  C07C49/84 ,  C07C59/76 ,  C07C59/80 ,  C07D207/32 ,  C07D207/325 ,  C07D209/08 ,  C07D295/112 ,  C07D295/155 ,  C07D295/185 ,  C07D295/194 ,  C07D307/83 ,  C07D307/92 ,  C07D405/04 ,  C07D405/12 ,  C07D471/04 ,  C08K5/1535 ,  C07D

Abstract: The invention relates to novel furans, especially benzofuranones of the general formula (I) in which R1 represents hydrogen or an aliphatic radical, R2 represents an amino group di-substituted by a divalent hydrocarbon radical, and the aromatic ring A may be additionally substituted, and their salts and/or isomers, processes for the manufacture of compounds of the formula (I) and their salts and isomers, pharmaceutical preparations containing these compounds, and their use as the active ingredients of anti-inflammatory agents or analgesics and/or for the manufacture of pharmaceutical preparations.

公开(公告)号：FI823639A0

公开(公告)日：1982-10-25

申请号：FI823639

申请日：1982-10-25

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: A61K31/34 ,  A61K31/343 ,  A61P25/04 ,  A61P29/00 ,  C07C59/76 ,  C07D307/83 ,  C07D471/04 ,  C07D

Abstract: The invention relates to novel lactones, especially benzofuranones of the general formula (I) in which R1 represents hydrogen or an aliphatic radical, R2 represents an amino group di-substituted by two monovalent hydrocarbon radicals, and the aromatic ring A may be additionally substituted, and their salts and/or isomers, processes for the manufacture of compounds of the formula (I) and their salts and isomers, pharmaceutical preparations containing these compounds, and their use as the active ingredients of medicaments and/or for the manufacture of pharmaceutical preparations.

公开(公告)号：CA1084494A

公开(公告)日：1980-08-26

申请号：CA284420

申请日：1977-08-10

Applicant: CIBA GEIGY AG

Inventor： BOEHNER BEAT ,  BAUMANN MARCUS

IPC: C07D207/26 ,  A01N43/36 ,  A01N43/40 ,  A01N43/54 ,  A01N43/60 ,  A01N43/74 ,  A01N43/82 ,  A01N43/836 ,  A01N47/06 ,  A01N47/18 ,  A01N47/22 ,  A01N53/00 ,  A01N53/04 ,  A61K31/402 ,  C07D207/38 ,  C07D207/44 ,  C07D207/448 ,  C07D401/04 ,  C07D417/04 ,  C07D403/04 ,  A01N9/22

Abstract: The present invention relates to novel 3,4-dimethyl-Z-hydroxy-5-oxo-2,5-dihydropyrrole compounds substituted on the nitrogen atom, to processes for producing them, to their use in agricluture for combating animal and plant pests and also for regulating plant growth, and to compositions containing these novel pyrrole compounds. The novel 3,4-dimethyl-2-hydroxy-5-oxo-2,5-dihydropyrrole compounds substituted on the nitrogen stom correspond to the formula wherein A represents the hydroxyl group, a halogen atom or an O-acyl radical, and R represents an aryl radical, an aralkyl radical, or an heteroaromatic radical which has 5-6 ring members and which is bound by way of a carbon atom.

公开(公告)号：NZ247000A

公开(公告)日：1995-07-26

申请号：NZ24700093

申请日：1993-02-25

Applicant: CIBA GEIGY AG

Inventor： CAPRARO HANS GEORG ,  BAUMANN MARCUS

IPC: A61K31/555 ,  A61P35/00 ,  C07D487/22 ,  C07F5/00 ,  C07F5/06 ,  C07F7/00 ,  C07F7/08 ,  C07F7/30 ,  C07F15/00 ,  C07H23/00 ,  C07J43/00 ,  C07J51/00 ,  C08G65/32 ,  C07F7/18 ,  A61K31/58 ,  A61K31/695

Abstract: Naphthalocyanine chelate complexes of the formula I, which contain aluminium, gallium, indium, tin, ruthenium or, preferably, germanium as the central atom M, and wherein the other symbols are as defined in Claim 1. The complexes may be used, inter alia, for the photodynamic chemotherapy of tumours.

公开(公告)号：CA2090772A1

公开(公告)日：1993-08-28

申请号：CA2090772

申请日：1993-02-25

Applicant: CIBA GEIGY AG

Inventor： CAPRARO HANS G ,  BAUMANN MARCUS

IPC: A61K31/555 ,  A61P35/00 ,  C07D487/22 ,  C07F5/00 ,  C07F5/06 ,  C07F7/00 ,  C07F7/08 ,  C07F7/30 ,  C07F15/00 ,  C07H23/00 ,  C07J43/00 ,  C07J51/00 ,  C08G65/32 ,  C07C15/00 ,  C09B47/08 ,  A61K31/695 ,  A61K31/70

Abstract: 4-18996/A Chelate complexes and processes for their preparation Naphthalocyanine-chelate complexes of formula I (I) are described which contain as central atom M aluminium, gallium, indium, tin, ruthenium or preferably germanium and in which the remaining symbols are as defined in claim 1. The complexes can be used inter alia in the photodynamic chemotherapy of tumours.