公开(公告)号：EP2834333A1

公开(公告)日：2015-02-11

申请号：EP13772671.7

申请日：2013-03-06

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  HASSAN, Aziz ,  ANTHONY, Rayford G.

IPC: C11B1/00 ,  C11B3/16

CPC classification number: B01F3/04 ,  A23D9/02 ,  B01F3/04531 ,  B01F7/00766 ,  B01F13/1016 ,  C11B1/00 ,  C11B1/02 ,  C11B1/10 ,  C11B3/00 ,  C11B3/14

Abstract: Herein disclosed is a method of processing oil, comprising providing a high shear device comprising at least one rotor and at least one complementarily-shaped stator configured to mix a gas with a liquid; contacting a gas with an oil in the high shear device, wherein the gas is an inert gas or a reactive gas; and forming a product, wherein the product is a solution, a dispersion, or combination thereof. Herein also disclosed is a high shear system for processing oil, comprising; at least one high shear device, having an inlet and at least one rotor and at least one complementarily-shaped stator configured to mix a gas with a liquid; a gas source fluidly connected to the inlet; an oil source fluidly connected to the inlet; and a pump positioned upstream of a high shear device, the pump in fluid connection with the inlet and the oil source.

公开(公告)号：EP2827982A2

公开(公告)日：2015-01-28

申请号：EP13764217.9

申请日：2013-03-19

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  HASSAN, Aziz ,  ANTHONY, Rayford G. ,  HASSAN, Alishah

IPC: B01J19/18 ,  B01F7/16

CPC classification number: C01B23/00 ,  B01F7/00766 ,  B01F13/1016 ,  B01J19/1806 ,  G21G5/00

Abstract: A system for converting a first substance into a second substance, the system including a mixing reactor configured to provide a reactant mixture comprising a first reactant, a second reactant, and a solvent; and a high shear device fluidly connected to the mixing reactor, wherein the high shear device comprises at least one rotor/stator set comprising a rotor and a complementarily-shaped stator symmetrically positioned about an axis of rotation and separated by a shear gap, wherein the shear gap is in the range of from about 10 microns to about 250 microns; and a motor configured for rotating the rotor about the axis of rotation, whereby energy can be transferred from the rotor to the reactants thereby inducing reactions between the first reactant and the second reactant to form a product.

公开(公告)号：EP2294296B1

公开(公告)日：2015-01-28

申请号：EP09773987.4

申请日：2009-06-02

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  ANTHONY, Rayford, G. ,  BORSINGER, Gregory ,  HASSAN, Aziz ,  BAGHERZADEH, Ebrahim

IPC: F02B45/10 ,  B01F3/00 ,  B01F7/16 ,  C10L1/32

CPC classification number: F02B43/00 ,  C10L1/32 ,  F02M29/02

公开(公告)号：EP2563426A2

公开(公告)日：2013-03-06

申请号：EP11777787.0

申请日：2011-04-08

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  HASSAN, Aziz ,  ANTHONY, Rayford G.

IPC: A61M5/14 ,  A61M5/142 ,  A61M5/168 ,  A61J3/00 ,  A61K9/10

CPC classification number: A61J3/00 ,  A61K9/0019 ,  A61M5/142 ,  B01F7/00766 ,  B01F7/008 ,  B01F13/1016

Abstract: In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 μm. In this disclosure, a system is also described wherein the system comprises a therapeutic gas source or a therapeutic liquid source or a combination thereof; a liquid carrier source; a high shear device (HSD) having an inlet, an outlet, at least one rotor, and at least one stator separated by a shear gap; and a pump configured to control the flow rate and residence time of a fluid passing through the high shear device.

公开(公告)号：EP2563338A2

公开(公告)日：2013-03-06

申请号：EP11777788.8

申请日：2011-04-08

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  HASSAN, Aziz ,  ANTHONY, Rayford G.

IPC: A61K9/16 ,  A61K9/08 ,  A61K9/107 ,  A61J3/00 ,  A61M5/14

CPC classification number: A61J3/00 ,  A61K9/0019 ,  A61M5/142 ,  B01F7/00766 ,  B01F7/008 ,  B01F13/1016

Abstract: In this disclosure, methods and systems for drug delivery utilizing high shear are disclosed. In an embodiment, a method comprises (1) subjecting a therapeutic fluid containing a drug to high shear; and (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug in nano-size. In an embodiment, a method comprises (1) subjecting a drug carrier and a therapeutic fluid containing a drug to high shear; and (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug carrier loaded with the drug. In an embodiment, a method comprises (1) applying high shear to a drug carrier and a therapeutic fluid containing a drug; (2) obtaining a processed therapeutic fluid, wherein the processed therapeutic fluid contains the drug-loaded carrier; and (3) modifying the drug-loaded carrier with a targeting moiety to obtain a modified drug-loaded carrier.

公开(公告)号：EP2401051A2

公开(公告)日：2012-01-04

申请号：EP10744351.7

申请日：2010-02-19

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  ANTHONY, Rayford G. ,  HASSAN, Aziz

IPC: B01D45/14 ,  B01D53/24 ,  B04B5/08

CPC classification number: B01D53/24 ,  B01D45/14 ,  B01D53/22 ,  B01D59/20 ,  B01D63/06 ,  B01D2256/24 ,  B01D2257/102 ,  B01D2257/504 ,  B01D2313/18 ,  B04B5/08 ,  B04B7/08 ,  Y02C10/10

Abstract: Herein disclosed is an apparatus comprising (1) a porous rotor symmetrically positioned about an axis of rotation and surrounding an interior space; (2) an outer casing, wherein the outer casing and the rotor are separated by an annular space; (3) a motor configured for rotating the rotor about the axis of rotation; (4) a feed inlet positioned along the axis of rotation and fluidly connected with the interior space; and (5) a first outlet, wherein the first outlet is fluidly connected with the interior space. Herein disclosed is a system, comprising at least one disclosed apparatus. Herein disclosed is also a method of separating a feed gas into a first fraction and a second fraction, wherein the first fraction has an average molecular weight lower than the average molecular weight of the second fraction.

公开(公告)号：EP2379678A1

公开(公告)日：2011-10-26

申请号：EP10738908.2

申请日：2010-01-18

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  ANTHONY, Rayford, G. ,  BORSINGER, Gregory, G. ,  HASSAN, Aziz ,  BAGHERZADEH, Ebrahim

IPC: C10G47/00 ,  B01J23/40 ,  B01J23/74

CPC classification number: B01J23/85 ,  B01J23/24 ,  B01J23/28 ,  B01J23/30 ,  B01J23/40 ,  B01J23/70 ,  B01J23/72 ,  B01J23/74 ,  C10G49/002 ,  C10G49/04 ,  C10G49/06 ,  C10G49/12 ,  C10G2300/1025 ,  C10G2300/1033 ,  C10G2300/104 ,  C10G2300/1044 ,  C10G2300/1051 ,  C10G2300/1055 ,  C10G2300/202 ,  C10G2300/207 ,  C10G2300/40

Abstract: Herein disclosed is a method for hydrodesulfurization, hydrodenitrogenation, hydrofinishing, amine production or a combination thereof. The method comprises forming a dispersion comprising hydrogen-containing gas bubbles dispersed in a liquid feedstock, wherein the bubbles have a mean diameter of less than about 5 μm and wherein the feedstock comprises a mixture of petroleum-derived hydrocarbons and a naturally derived renewable oil. The feedstock comprises hydrocarbons selected from the group consisting of liquid natural gas, crude oil, crude oil fractions, gasoline, diesel, naphtha, kerosene, jet fuel, fuel oils, and combinations thereof. The method further comprises contacting the dispersion with a catalyst that is active for hydrodesulfurization, hydrodenitrogenation, hydrofinishing, amine production, or a combination thereof. The catalyst comprises homogeneous catalysts and heterogeneous catalysts. The catalyst may be utilized in fixed-bed or slurry applications.

公开(公告)号：EP2334353A2

公开(公告)日：2011-06-22

申请号：EP09818513.5

申请日：2009-10-01

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  ANTHONY, Rayford, G. ,  BORSINGER, Gregory, G. ,  HASSAN, Aziz

IPC: A61M5/14 ,  A61M37/00

CPC classification number: A61M5/142 ,  A61K9/0019 ,  A61M1/36 ,  A61M2206/16 ,  B01F7/00766

Abstract: Herein disclosed is a system for applying shear stress ex-situ to a fluid. In some embodiments, the system comprises a shear device; and at least one device configured for intravenous administration of the fluid to a patient, the devices defining a fluid passage configured to be sterilized and maintained sterile during use, the fluid comprising at least one therapeutic fluid, blood, or a combination thereof. The shear device of the system is in fluid communication with the at least one device configured for intravenous administration of the fluid to a patient. Herein also disclosed is a method of preparing a fluid for intravenous administration to a patient.

公开(公告)号：EP2158173A2

公开(公告)日：2010-03-03

申请号：EP08780991.9

申请日：2008-06-25

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  BAGHERZADEH, Ebrahim ,  ANTHONY, Rayford, G. ,  BORSINGER, Gregory ,  HASSAN, Aziz

IPC: C07C2/66 ,  B01J29/18 ,  C07C15/107 ,  B01F7/26

CPC classification number: B01J19/1806 ,  B01F7/00766 ,  B01F13/1013 ,  B01F13/1016 ,  B01J8/025 ,  B01J8/20 ,  B01J19/0066 ,  B01J2219/00006 ,  B01J2219/00779 ,  C07C2/68 ,  C07C2527/08 ,  C07C2527/10 ,  C07C15/107 ,  C07C15/02

Abstract: Methods and systems for the production of linear alkylbenzens are described herein. The methods and systems incorporate the novel use of a high shear device to promote dispersion and mixing of one or more olefins (e.g. propylene) with an aromatic. The high shear device may allow for lower reaction temperatures and pressures and may also reduce reaction time with existing catalysts.

公开(公告)号：EP2144873A1

公开(公告)日：2010-01-20

申请号：EP08771013.3

申请日：2008-06-13

Applicant: H R D Corporation

Inventor： HASSAN, Abbas ,  BAGHERZADEH, Ebrahim ,  ANTHONY, Rayford G. ,  BORSINGER, Gregory ,  HASSAN, Aziz

IPC: C07C409/10 ,  C07C39/16 ,  C07C37/00

CPC classification number: C07C409/10 ,  B01F7/00766 ,  B01F13/1013 ,  B01F13/1016 ,  C07C407/00

Abstract: Use of a high shear mechanical device incorporated into a process for the production of cumene hydroperoxide as a mixer/reactor device is capable of decreasing mass transfer limitations, thereby enhancing the cumene hydroperoxide production process. A system for the production of cumene hydroperoxide from oxidation of cumene, the system comprising a reactor and an high shear mixer the outlet of which is fluidly connected to the inlet of the reactor; the high shear mixer capable of providing a dispersion air gas bubbles within a liquid, the bubbles having an average bubble diameter of less than about 100 microns.