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    71.
    发明专利
    未知

    公开(公告)号：SE366037B

    公开(公告)日：1974-04-08

    申请号：SE464471

    申请日：1971-04-08

    Applicant: HOECHST AG

    Inventor： RADSCHEIT K ,  STACHE U ,  FRITSCH W ,  HAEDE W ,  LINDNER E

    IPC: A61K31/70 ,  C07J71/00 ,  C07C173/04

    Abstract: 1315235 Bufapolyenolides FARBWERKE HOECHST AG 19 April 1971 [8 April 1970] 26359/71 Heading C2U The novel compound 3#-(α-L-rhamnopyranosyloxy) - 14,15# - epoxy - 14# - bufa - 4,20,22- trienolide is prepared from proscillaridin by successively acylating the three sugar hydroxy groups, dehydrating in the 14,15-position, adding hypohalous acid acoross the resulting # 14 - double bond, dehydrohalogenating the resulting 14#-hydroxy-15α-halo grouping, and lastly liberating the three sugar hydroxy groups by saponification. The novel compound is stated to be cardioactive and may be made up with carriers into pharmaceutical compositions for oral administration.

    77.
    发明专利
    未知

    公开(公告)号：FI46158B

    公开(公告)日：1972-10-02

    申请号：FI105169

    申请日：1969-04-10

    Applicant: HOECHST AG

    Inventor： KOHL H ,  RADSCHEIT K ,  STACHE U ,  FRITSCH W ,  HAEDE W

    IPC: C07J19/00 ,  B01J25/02 ,  C07C173/02 ,  C07C173/04

    Abstract: 1275421 Cardioactive medicines FARBWERKE HOECHST AG 28 April 1969 [27 April 1968] 21595/69 Heading A5B [Also in Division C2] Pharmaceutical compositions comprise a carrier and a cardioactive steroid of formula: wherein R is the broken line indicates an optional 4, 5- double bond, and Y is oxo or a hydrogen atom with an α- or #-(hydroxy or C 1-6 acyloxy) group which may be α-oriented in the 4, 5 #-dihydro compounds only. Routes of administration are not specified. Reference has been directed by the Comptroller to Specification 1,184,238.

    79.
    发明专利
    未知

    公开(公告)号：DK123711B

    公开(公告)日：1972-07-24

    申请号：DK242569

    申请日：1969-05-01

    Applicant: HOECHST AG

    Inventor： SCHROEDER H ,  FRITSCH W ,  RADSCHEIT K ,  STACHE U ,  HAEDE W

    IPC: C07J5/00 ,  A61K47/48 ,  C07C169/34

    Abstract: 1,271,159. Dimeric steroid carbonates. FARBWERKE HOECHST A.G. 5 May, 1969 [3 May, 1968], No. 22798/69. Heading C2U. The invention comprises compounds of formula wherein Q and Q 1 are each H or together represent an additional 1,2-bond or a 1α,2α- or 1#,2#- epoxy group; X is H 2 , oxo, (H, α-OH), (H, #- OH), (H, #-Cl) or (H, #-F); Y is α-H or α-F; or X and Y together represent an 11-hydrogen atom together with an additional 9,11-bond or 9#,11#-epoxy group; Z is H, α-F, #-F, α-Me or #-Me; Z 1 is H; or Z and Z 1 together represent an additional 6,7-bond or a 6α,7α- or 6#,7#- epoxy group; R 1 is an acyclic or cyclic alkylene group (which may be branched and/or interrupted in the carbon chain by one or more oxygen atoms), aralkylene or arylene; R 2 is α-H or α-OH; and R 3 is H 2 , =CH 2 , =CHF, =CF 2 , (H, α-F), (H, #-F), (H, α-Me) or (H, #-Me). Preparation of compounds I is by reaction of the corresponding monomeric steroid 21-ols with compounds of formula ClCOO-R 1 -OCOCl. Compounds I are interconvertible by 6/9/16- fluorination, 1,2/6,7-dehydrogenation and reduction of 11-oxo. The mixed carbonate (II) of flumethasone and diethylene glycol is prepared analogously. Compounds I and II are said to possess antiinflammatory activity, and may be made up with carriers into pharmaceutical compositions for topical and parenteral administration.

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