公开(公告)号：CA2661662A1

公开(公告)日：2008-02-28

申请号：CA2661662

申请日：2007-08-23

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  NAKATSURU SHUICHI

IPC: G01N33/574

Abstract: The present invention provides a method of identifying agents that inhibi t or suppress the binding between MPHOSPH1 and PRC1. Such agents are expecte d to suppress the proliferation of cell expressing MPHOSPH1 and PRC1, and fu nction as agents to prevent or treat cancer, such as bladder cancer.

公开(公告)号：AU2003263603A1

公开(公告)日：2004-04-23

申请号：AU2003263603

申请日：2003-09-17

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

IPC: A61K38/00 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/574 ,  C12N15/11 ,  C07K16/12

Abstract: Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.

公开(公告)号：AU2003260966A1

公开(公告)日：2004-04-23

申请号：AU2003260966

申请日：2003-09-12

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

IPC: A61K38/00 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/574 ,  C07K16/12 ,  C07K14/82 ,  A61K38/17 ,  C12N15/11

Abstract: Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.

公开(公告)号：AU2003253439A8

公开(公告)日：2004-04-23

申请号：AU2003253439

申请日：2003-08-12

Applicant: JAPAN PRESIDENT UNIV TOKYO ,  UNIV TOKYO ,  ONCOTHERAPY SCIENCE INC

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/574 ,  G01N33/50 ,  A61K35/00

Abstract: Objective methods for detecting and diagnosing Chronic myeloid leukemia (CML) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of CML-associated gene that discriminate between CML and normal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of CML, methods of treating CML and method of vaccinating a subject against CML.

公开(公告)号：AU2003253439A1

公开(公告)日：2004-04-23

申请号：AU2003253439

申请日：2003-08-12

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/574 ,  G01N33/50 ,  A61K35/00

Abstract: Objective methods for detecting and diagnosing Chronic myeloid leukemia (CML) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of CML-associated gene that discriminate between CML and normal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of CML, methods of treating CML and method of vaccinating a subject against CML.

公开(公告)号：CA2500861A1

公开(公告)日：2004-04-15

申请号：CA2500861

申请日：2003-09-22

Applicant: ONCOTHERAPY SCIENCE INC ,  UNIV TOKYO

Inventor： NAKAGAWA HIDEWAKI ,  NAKATSURU SHUICHI ,  KATAGIRI TOYOMASA ,  NAKAMURA YUSUKE

IPC: C07K14/47 ,  C12Q1/68

Abstract: Objective methods for detecting and diagnosing prostate cancer (PRC) or prostatic intraepithelial neoplasia (PIN) are described herein. In one embodiment, the diagnostic method involves the determining a expression leve l of PRC -associated gene that discriminate between PRC or PIN and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of either or both of PRC and PIN, methods of treating either or both of PRC and PIN and method of vaccinating a subject against either or both of PRC and PIN.

公开(公告)号：CA2500405A1

公开(公告)日：2004-04-15

申请号：CA2500405

申请日：2003-07-29

Applicant: ONCOTHERAPY SCIENCE INC ,  UNIV TOKYO

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/00 ,  A61K48/00 ,  A61P35/00 ,  A61K38/17 ,  C07K16/18 ,  A61K39/395 ,  G01N33/50 ,  C07K14/705 ,  C07K14/82

Abstract: The present application provides novel human genes RHBDF1 whose expression i s markedly elevated in CML and AML compared to normal peripheral blood cell, a nd lung adenocarcinoma compared to normal lung cell. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.

公开(公告)号：EP2362904A4

公开(公告)日：2012-04-18

申请号：EP09809506

申请日：2009-08-21

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  TOGASHI AKIRA

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K14/82 ,  C07K19/00 ,  C12N15/113 ,  G01N33/50 ,  G01N33/574

CPC classification number: C07K14/82 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/10 ,  C12N15/113 ,  C12N2310/14 ,  G01N33/5011

公开(公告)号：EP2356230A4

公开(公告)日：2012-04-04

申请号：EP09809510

申请日：2009-08-21

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： NAKAMURA YUSUKE ,  KATAGIRI TOYOMASA ,  FUKUKAWA CHIKAKO

IPC: C12N15/09 ,  A61K31/7088 ,  A61P35/00 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  A61K31/7088 ,  C12Q1/6809 ,  C12Q2600/136

公开(公告)号：EP2738255A4

公开(公告)日：2015-04-08

申请号：EP12820786

申请日：2012-07-27

Applicant: UNIV TOKUSHIMA ,  ONCOTHERAPY SCIENCE INC

Inventor： KATAGIRI TOYOMASA ,  TSUNODA TAKUYA

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/68

CPC classification number: C07K14/4705 ,  A61K31/138 ,  A61K38/00 ,  A61K38/1709 ,  C12N9/485 ,  G01N33/5011 ,  G01N33/57484 ,  G01N2333/4704 ,  G01N2333/95 ,  G01N2500/02

Abstract: Provided is a novel cancer-treating agent which can be used as a novel choice for the treatment of cancer. Specifically provided are: a peptide that inhibits binding of ERAP1 polypeptide to PHB2 polypeptide, which comprises a binding site of the ERAP1 polypeptide to the PHB2 polypeptide, and a pharmaceutical composition comprising the peptide. In addition, provided is a method for screening a drug candidate for treating and/or preventing cancer using inhibition of the binding of the ERAP1 polypeptide to PP1± polypeptide, PKA polypeptide or PKB polypeptide as an index.