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    PHARMACEUTICAL COMPOSITION COMPRISING AN HMG-CoA REDUCTASE INHIBITOR AND AN ACE INHIBITOR
    71.
    发明专利
    PHARMACEUTICAL COMPOSITION COMPRISING AN HMG-CoA REDUCTASE INHIBITOR AND AN ACE INHIBITOR 未知

    公开(公告)号：SG10202000597UA

    公开(公告)日：2020-03-30

    申请号：SG10202000597U

    申请日：2016-08-26

    Applicant: SERVIER LAB

    Inventor： FONKNECHTEN GILLES

    Abstract: Fixed pharmaceutical compositions comprising an HMG-CoA reductase inhibitor, atorvastatin, and an antihypertensive agent, perindopril, and use of said compositions for the treatment and prevention of cardiovascular diseases and more particularly coronary events in patients with a history of myocardial infarction and/or of revascularization in combination with primary hypocholesteraemia or mixed hyperlipidaemia.

    ДОЗИРОВАННАЯ ЛЕКАРСТВЕННАЯ ФОРМА, СОДЕРЖАЩАЯ БИСОПРОЛОЛ И ПЕРИНДОПРИЛ
    72.
    发明专利
    ДОЗИРОВАННАЯ ЛЕКАРСТВЕННАЯ ФОРМА, СОДЕРЖАЩАЯ БИСОПРОЛОЛ И ПЕРИНДОПРИЛ 未知

    公开(公告)号：EA032808B1

    公开(公告)日：2019-07-31

    申请号：EA201790772

    申请日：2015-11-04

    Applicant: SERVIER LAB

    Inventor： FONKNECHTEN GILLES

    IPC: A61K9/16 ,  A61K9/24 ,  A61K31/138 ,  A61K31/404

    Abstract: Изобретениеотноситсяк дозированнойлекарственнойформе, содержащейбисопрололилиегофармацевтическиприемлемуюсоль, ихгидратыи кристаллическиеформыи периндоприлилиегофармацевтическиприемлемуюсоль, ихгидратыи кристаллическиеформыв комбинациис однимилинесколькимифармацевтическиприемлемыминаполнителями, причембисопрололи периндоприлразделеныфизически. Лекарственнаяформапонастоящемуизобретениюявляетсяпригоднойдляпримененияв леченииилипрофилактикесердечно-сосудистыхзаболеваний, выбранныхизартериальнойгипертензии, стабильнойишемическойболезнисердцаилихроническойсердечнойнедостаточности.

    Solid pharmaceutical composition for buccal administration of agomelatine
    78.
    发明专利
    Solid pharmaceutical composition for buccal administration of agomelatine 未知

    公开(公告)号：NZ601713A

    公开(公告)日：2014-01-31

    申请号：NZ60171312

    申请日：2012-08-08

    Applicant: SERVIER LAB

    Inventor： PEAN JEAN-MANUEL ,  THARRAULT FRANCOIS ,  FONKNECHTEN GILLES ,  POIRIER CECILE

    IPC: C07C233/17 ,  A61K9/20 ,  A61K31/16 ,  A61K31/165 ,  A61P9/00 ,  A61P25/00 ,  C07C231/00 ,  C07C233/11 ,  C07C233/18

    Abstract: ABSTRACT - 601713 The disclosure relates to a solid buccal pharmaceutical composition intended for systemic action, which is a tablet to be sucked, a pastille to be sucked, a lozenge to be sucked, or a solid obtained by hot-melt extrusion or injection-moulding, comprising agomelatine or one of its hydrates, complexes, co-crystals, crystalline forms, addition salts with a pharmaceutically acceptable acid or base, and one or more excipients selected from diluents, binders, flow agents, lubricants, coating agents, plasticisers, flavourings, counter-irritants and sweeteners, characterised in that it makes it possible to obtain a release time of the active ingredient comprised between 3 and 30 minutes and an absolute bioavailability greater than 25%. These compositions have a slow erosion release of agomelatine and are suitable for the treatment of major depression, seasonal affective disorder, generalized anxiety disorder, obsessional compulsive disorder, bipolar disorders, sleep disorders, cardiovascular pathologies, pathologies of the digestive system, insomnia and fatigue due to jet-lag, appetite disorders and obesity, and any pathology associated with deregulation of circadian rhythms.

    80.
    发明专利
    未知

    公开(公告)号：BR102012020320A2

    公开(公告)日：2013-10-29

    申请号：BR102012020320

    申请日：2012-08-09

    Applicant: SERVIER LAB

    Inventor： THARRAULT FRANCOIS ,  POIRIER CECILE ,  FONKNECHTEN GILLES ,  PEAN JEAN-MANUEL

    IPC: A61K31/165 ,  A61K9/20 ,  A61P3/04 ,  A61P9/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  C07C233/18

    Abstract: Solid oral composition comprises agomelatine or its hydrate, complexes, co-crystals, crystalline forms, addition salts with an acid or a base, and one or more excipients comprising diluents, binders, flowing agents, lubricants, coating agents, plasticizers, flavors, anti-irritants or sweeteners, where the composition has: an absolute bioavailability of greater than 25%; and a bioavailability greater than that obtained for an orodispersible tablet with an oromucosal absorption containing the active principle agomelatine under the same form and at the same dosage. ACTIVITY : Antidepressant; Tranquilizer; Neuroleptic; Hypnotic; Cardiovascular-Gen.; Gastrointestinal-Gen.; CNS-Gen.; Muscular-Gen.; Anorectic. MECHANISM OF ACTION : None given.

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