公开(公告)号：WO1998026086A1

公开(公告)日：1998-06-18

申请号：PCT/US1997023127

申请日：1997-12-11

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  WILLIAMS, Ralph, C.

IPC: C12P21/04

CPC classification number: C07K16/42 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/4208 ,  Y10S530/866 ,  Y10S530/868

Abstract: The subject invention concerns a method for therapeutically treating a patient afflicted with autoimmune disorders or disease. The subject method comprises administering to a patient a purified antibody composition that is capable of binding to and inhibiting self-reactive pathogenic antibodies present within the patient. Specifically exemplified is a method for treating systemic lupus erythematosis wherein the antibody composition administered to the patient comprises purified anti-DNA anti-idiotypic antibodies. The subject invention further concerns a method for purifying from pooled human gamma globulin preparations anti-idiotype antibodies useful in the present therapeutic method. The present invention further concerns the purified antibody composition used in the present therapeutic method.

Abstract translation: 本发明涉及用于治疗患有自身免疫性疾病或疾病的患者的方法。 本发明方法包括向患者施用能够结合并抑制存在于患者内的自身反应性病原性抗体的纯化抗体组合物。 具体举例说明的是用于治疗系统性红斑狼疮的方法，其中向患者施用的抗体组合物包含纯化的抗DNA抗独特型抗体。 本发明还涉及从本发明的治疗方法中有用的合并的人γ球蛋白制剂抗独特型抗体中纯化的方法。 本发明还涉及本治疗方法中使用的纯化抗体组合物。

公开(公告)号：WO1998023639A3

公开(公告)日：1998-06-04

申请号：PCT/US1997022096

申请日：1997-11-26

Applicant: UNIVERSITY OF FLORIDA ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  BACHEM BIOSCIENCE, INC. ,  BIOMOLECULAR RESEARCH INSTITUTE

Inventor： UNIVERSITY OF FLORIDA ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  BACHEM BIOSCIENCE, INC. ,  BIOMOLECULAR RESEARCH INSTITUTE ,  KEM, William, R. ,  PENNINGTON, Michael, W. ,  NORTON, Raymond, S. ,  CHANDY, George, K. ,  KALMAN, Katalin

IPC: C07K14/435

公开(公告)号：WO1998016632A1

公开(公告)日：1998-04-23

申请号：PCT/US1997017032

申请日：1997-09-23

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  PECK, Ammon, B. ,  SIDHU, Harmeet

IPC: C12N9/10

CPC classification number: C12N9/10 ,  C12N9/1014 ,  C12N9/1022 ,  C12N9/88 ,  C12Q1/04 ,  C12Q1/48 ,  C12Q1/527 ,  C12Q1/689 ,  G01N2333/9104 ,  G01N2333/988

Abstract: The subject invention concerns the novel use of formyl-CoA transferase enzyme together with oxalyl-CoA decarboxylase enzyme for the detection and measurement of oxalate in biological samples. The use of the enzyme system according to the subject invention results in the conversion of oxalate into carbon dioxide and formate. Because the production of formate is directly correlated to the concentration of oxalate present in a sample, the determination of the resulting formate concentration provides an accurate, sensitive and rapid means for detecting even low levels of oxalate. The subject invention further concerns the cloning, sequencing and expression of the genes that encode the formyl-CoA transferase enzyme and the oxalyl-CoA decarboxylase enzyme of Oxalobacter formigenes. The subject invention also concerns methods for detecting the presence of Oxalobacter formigenes organisms in a sample, and the polynucleotide probes and primers used in the detection method.

Abstract translation: 本发明涉及甲酰辅酶A转移酶与草酰辅酶A脱羧酶一起用于生物样品中草酸盐的检测和测量的新用途。 根据本发明的酶系统的使用导致草酸盐转化为二氧化碳和甲酸盐。 因为甲酸盐的生产与样品中存在的草酸盐浓度直接相关，因此所得甲酸盐浓度的测定为检测甚至低含量草酸盐提供了准确，灵敏和快速的方法。 本发明还涉及克隆，测序和表达编码甲醛 - 辅酶A转移酶和草酸 - 辅酶A脱羧酶酶的生物素。 本发明还涉及用于检测样品中生物形态产杆菌生物体的存在的方法，以及用于检测方法中的多核苷酸探针和引物。

公开(公告)号：WO1998010916A1

公开(公告)日：1998-03-19

申请号：PCT/US1997016172

申请日：1997-09-12

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  PARK, Chang-Won ,  WALKER, James, K.

IPC: B29D11/00

CPC classification number: B29D11/00682 ,  B29C47/0014 ,  B29C47/24

Abstract: The present invention is a continuous process of producing an object with radially-varying material properties. These objects can be cylindrical forms made from polymeric materials. This process requires a novel device. The device can be used to produce high bandwidth gradient-index plastic optical fiber (GRIN-POF). This fiber is highly advantageous for use in high speed local area networks (LANs) as well as other short-range optical communication applications. The device can also be used to produce GRIN lenses which can be used in the focusing and transmission of images.

Abstract translation: 本发明是一种生产具有径向变化材料特性的物体的连续方法。 这些物体可以是由聚合材料制成的圆柱形形状。 这个过程需要一个新颖的设备。 该器件可用于生产高带宽梯度折射率塑料光纤（GRIN-POF）。 该光纤对于用于高速局域网（LAN）以及其他短距离光通信应用是非常有利的。 该设备还可用于生产可用于图像聚焦和传输的GRIN透镜。

公开(公告)号：WO1998007834A2

公开(公告)日：1998-02-26

申请号：PCT/US1996013585

申请日：1996-08-22

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  GIROUX, Michael ,  HANNAH, L., Curtis

IPC: C12N09/00

CPC classification number: C12N9/1241 ,  C12N15/8245 ,  C12N15/8261 ,  Y02A40/146

Abstract: The subject invention pertains to novel variants of the maize gene, Shrunken2 (Sh2) and a method of using that gene. The variant gene, Sh2-m1Rev6, encodes a subunit of the ADP-glucose pyrophosphorylase (AGP) enzyme that has additional amino acids inserted in or near the allosteric binding site of the protein. Corn seed expressing the Sh2-m1Rev6 gene has a 15 % weight increase over wild type seed. The increase in seed weight is not associated simply with an increase in percentage starch content of the seed.

Abstract translation: 本发明涉及玉米基因Shrunken2（Sh2）的新变体和使用该基因的方法。 变体基因Sh2-m1Rev6编码ADP-葡萄糖焦磷酸化酶（AGP）酶的亚基，其具有插入蛋白质的变构结合位点内或附近的额外的氨基酸。 表达Sh2-m1Rev6基因的玉米种子比野生型种子具有15％的重量增加。 种子重量的增加与种子淀粉含量百分比的增加无关。

公开(公告)号：WO1998004724A1

公开(公告)日：1998-02-05

申请号：PCT/US1997013094

申请日：1997-07-25

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  POLSTON, Jane, E. ,  HIEBERT, Ernest ,  ABOUZID, Ahmed

IPC: C12N15/82

CPC classification number: C07K14/005 ,  C12N15/8283 ,  C12N2750/12022

Abstract: The subject invention pertains to modified plant virus genes which confer resistance on plants against geminivirus infection. A modified AV1 gene of tomato mottle geminivirus, was subcloned into an appropriate expression vector and transformed into tobacco plants. Expression of the modified gene conferred resistance against viral infection to the plant in which it was expressed. The present invention further concerns a method for conferring viral resistance on a plant. The invention also concerns modified coat protein genes, and fragments thereof, which confer viral resistance on a plant.

Abstract translation: 本发明涉及赋予植物抵抗双重病毒感染的抗性的修饰的植物病毒基因。 将番茄斑驳双系病毒的修饰的AV1基因亚克隆到合适的表达载体中并转化到烟草植物中。 修饰基因表达赋予其表达的植物对病毒感染的抗性。 本发明还涉及赋予植物病毒抗性的方法。 本发明还涉及赋予植物病毒抗性的改良外壳蛋白基因及其片段。

公开(公告)号：WO1997033623A1

公开(公告)日：1997-09-18

申请号：PCT/US1997004019

申请日：1997-03-14

Applicant: UNIVERSITY OF FLORIDA ,  WIELBO, Donna ,  PHILLIPS, M., Ian

Inventor： UNIVERSITY OF FLORIDA

IPC: A61K48/00

CPC classification number: C12N15/113 ,  A61K38/00 ,  C07H21/00 ,  C12N2310/311 ,  C12N2310/315 ,  C12N2310/3511 ,  C12N2310/3535 ,  C12N2799/021

Abstract: Oligonucleotides, and compositions thereof, are disclosed which can be administered to human subjects to inhibit the expression of angiotensinogen to thereby control angiotensinogen induced hypertension.

Abstract translation: 公开了寡核苷酸及其组合物，其可以施用于人受体以抑制血管紧张素原的表达，从而控制血管紧张素原诱导的高血压。

公开(公告)号：WO1997033607A1

公开(公告)日：1997-09-18

申请号：PCT/US1997003794

申请日：1997-03-12

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  SOOS, Jeanne, M. ,  SCHIFFENBAUER, Joel ,  JOHNSON, Howard, M.

IPC: A61K38/21

CPC classification number: C07K14/555 ,  A61K38/212 ,  C07K14/56 ,  C07K16/249 ,  C07K2319/00 ,  C07K2319/02 ,  Y10S930/142 ,  A61K2300/00

Abstract: The present invention includes interferon-tau (IFN tau ) pharmaceutical compositions useful for oral administration to treat cancers, autoimmune disorders (particularly multiple sclerosis), cell proliferative disorders and viral disease.

Abstract translation: 本发明包括可用于口服给药以治疗癌症，自身免疫性疾病（特别是多发性硬化症），细胞增殖性病症和病毒性疾病的干扰素τ（IFNτ）药物组合物。

公开(公告)号：WO1997028262A1

公开(公告)日：1997-08-07

申请号：PCT/US1997001748

申请日：1997-01-31

Applicant: UNIVERSITY OF FLORIDA ,  KINGSMORE, Stephen, F. ,  BARBOSA-ALLEYNE, Maria, D., F., S.

Inventor： UNIVERSITY OF FLORIDA

IPC: C12N15/12

CPC classification number: C07K14/47 ,  A01K2217/05 ,  A61K38/00

Abstract: Disclosed are compositions comprising murine Lyst1 and Lyst2 genes and human LYST1 and LYST2 genes. Also disclosed are the Lyst1, Lyst2, LYST1, and LYST2 proteins encoded by these genes, respectively. Also disclosed are methods of using these genes in identifying patients with Chediak-Higashi Syndrome and detecting CHS-related nucleic acid and/or protein sequences. Also disclosed are methods for the recombinant expression of LYST1, Lyst1, LYST2, and Lyst2 polypeptides, antibodies raised against these polypeptides, and therapeutic approaches to treatment of autoimmune diseases and certain types of tumors. Assays for detection of the gene mutations resulting in CH Syndrome, as well as diagnostic probes for the detection of Lyst1, Lyst2, LYST1, and LYST2 genes are also provided.

Abstract translation: 公开了包含鼠Lyst1和Lyst2基因和人LYST1和LYST2基因的组合物。 还公开了分别由这些基因编码的Lyst1，Lyst2，LYST1和LYST2蛋白。 还公开了使用这些基因鉴定Chediak-Higashi综合征患者并检测CHS相关核酸和/或蛋白质序列的方法。 还公开了用于重组表达LYST1，Lyst1，LYST2和Lyst2多肽的方法，针对这些多肽产生的抗体，以及用于治疗自身免疫性疾病和某些类型的肿瘤的治疗方法。 还提供了用于检测导致CH综合征的基因突变的检测以及用于检测Lyst1，Lyst2，LYST1和LYST2基因的诊断探针。

公开(公告)号：WO1997016453A2

公开(公告)日：1997-05-09

申请号：PCT/US1996017280

申请日：1996-10-28

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  HUDLICKY, Tomas ,  KONIGSBERGER, Kurt ,  MCLAMORE, Sherita, D. ,  RAKESH, Maurya

IPC: C07D491/04

CPC classification number: C07D491/04 ,  C07D203/26 ,  C07D317/54 ,  C07D317/58 ,  C07D317/60

Abstract: Disclosed are novel pancratistatins and methods for their total asymmetric synthesis. In particular embodiments, processes for the total asymmetric synthesis of (+)-pancratistatin, (-)-pancratistatin, (+)-7-deoxypancratistatin, (-)-7-deoxypancratistatin, truncated pancratistatins, and related derivatives are provided.

Abstract translation: 公开了它们的全不对称合成的新颖的pancratistatin和方法。 在特定的实施方案中，提供了（+） - 泛酸盐抑制素，（ - ） - 泛磷酸抑制素，（+） - 7-脱氧胰​​蛋白酶抑制剂，（ - ） - 7-脱氧胰​​蛋白酶抑制剂，截短的pancratistatin和相关衍生物的全不对称合成方法。