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    POSITION DETECTION OF MECHANICAL RESONANT SCANNER MIRROR
    71.
    发明申请
    POSITION DETECTION OF MECHANICAL RESONANT SCANNER MIRROR 审中-公开
    机械共振扫描仪的位置检测

    公开(公告)号：WO1998013719A1

    公开(公告)日：1998-04-02

    申请号：PCT/US1997016588

    申请日：1997-09-18

    Applicant: UNIVERSITY OF WASHINGTON

    Inventor： UNIVERSITY OF WASHINGTON ,  MELVILLE, Charles, D.

    IPC: G02B26/08

    CPC classification number: G02B26/105 ,  G01P15/09 ,  G02B7/1821 ,  G02B27/017 ,  Y10S359/90

    Abstract: Two piezoelectric sensors (78, 80) are mounted on the back of a spring-plate (14) of a mechanical resonance scanner (10) on respective sides of a center line coinciding with an axis of rotation (16). As the scanner mirror (12) rotates back and forth the two sensors are accelerated and decelerated at a 180 DEG phase difference. Each sensor's output voltage crosses a zero level when the acceleration is unchanging. A differential amplifier (88) detects the zero-crossings for motion along the axis of rotation. Common mode rejection eliminates the non-rotational accelerations associated with external vibrations and shocks, and prevents masking the mirror's zero-crossings.

    Abstract translation: 两个压电传感器（78,80）安装在与旋转轴线（16）重合的中心线的相应侧上的机械共振扫描器（10）的弹簧板（14）的后部。 当扫描器反射镜（12）来回旋转时，两个传感器以180°的相位差被加速和减速。 当加速度不变时，每个传感器的输出电压都会超过零电平。 差分放大器（88）检测沿着旋转轴线的运动的过零点。 共模抑制消除了与外部振动和冲击相关的非旋转加速度，并防止遮蔽镜的过零点。

    ABSORPTION-ENHANCED DIFFERENTIAL EXTRACTION DEVICE
    73.
    发明申请
    ABSORPTION-ENHANCED DIFFERENTIAL EXTRACTION DEVICE 审中-公开
    吸收增强的差异提取装置

    公开(公告)号：WO1997047390A1

    公开(公告)日：1997-12-18

    申请号：PCT/US1997010307

    申请日：1997-06-13

    Applicant: UNIVERSITY OF WASHINGTON

    Inventor： UNIVERSITY OF WASHINGTON ,  YAGER, Paul ,  BRODY, James, P.

    IPC: B03B05/28

    CPC classification number: G01N30/0005 ,  A61M1/3679 ,  B01J19/0093 ,  B01J2219/00828 ,  B01J2219/00952 ,  B01J2219/00995 ,  B03B5/00 ,  G01N30/02 ,  G01N30/6095 ,  G01N2030/582 ,  Y10S366/01 ,  B01D15/3804

    Abstract: This invention provides an extraction device and method for extracting desired particles from a sample stream (2) containing the desired particles. The device comprises a sample stream inlet (1); an extraction stream inlet (5); an extraction channel (7) in fluid communication with the sample stream inlet (1) and the extraction stream inlet (5) for receiving a sample stream (2) from the sample stream inlet (1) in adjacent laminar flow with an extraction stream (4) from the extraction stream inlet (5); a sequestering material within the extraction channel (7) for capturing desired particles (18) in the extraction stream (9); a by-product stream outlet (15) in fluid communication with the extraction channel (7) for receiving a by-product stream (12) comprising at least a portion of the sample stream (2) from which desired particles (18) have been extracted; and a product outlet (14) in fluid communication with the extraction channel (7) for receiving a product comprising the sequestering material and at least a portion of the desired particles (18).

    Abstract translation: 本发明提供了一种从含有所需颗粒的样品流（2）中提取所需颗粒的提取装置和方法。 该装置包括样品流入口（1）; 提取流入口（5）; 与样品流入口（1）和提取流入口（5）流体连通的提取通道（7），用于从相邻层流中的样品流入口（1）接收样品流（2），其中提取流入口 4）从提取流入口（5）中取出; 提取通道（7）内的螯合材料，用于捕获提取流（9）中的所需颗粒（18）; 与所述提取通道（7）流体连通的副产物流出口（15），用于接收副产物流（12），所述副产物流包含至少一部分样品流（2），所述样品流从所述至少一部分从所述样品流 提取; 以及与所述提取通道（7）流体连通的产品出口（14），用于接收包含隔离材料和至少一部分所需颗粒（18）的产品。

    VIRTUAL RETINAL DISPLAY WITH EXPANDED EXIT PUPIL
    75.
    发明申请
    VIRTUAL RETINAL DISPLAY WITH EXPANDED EXIT PUPIL 审中-公开
    虚拟终极显示与扩展退出PUPIL

    公开(公告)号：WO1997037339A1

    公开(公告)日：1997-10-09

    申请号：PCT/US1997003302

    申请日：1997-02-27

    Applicant: UNIVERSITY OF WASHINGTON

    Inventor： UNIVERSITY OF WASHINGTON ,  KOLLIN, Joel, S. ,  JOHNSTON, Richard, S. ,  MELVILLE, Charles, D.

    IPC: G09G05/00

    CPC classification number: G02B26/101 ,  G02B27/0081 ,  G02B27/017 ,  G02B27/0172

    Abstract: A display device (10) is achieved using an optical system which generates an expanded exit pupil (21) without compromising magnification or resolution. Modulated light from a source (12) is converged toward a focal point by an optics subsystem (14). A scanning subsystem (16) deflects the converging light, and thus the focal point, along a raster pattern to define a curved intermediate image plane (15). An exit pupil expanding apparatus (18) defines a curved surface which coincides with the curved image plane (15). Impinging light rays at a given instant in time span a given incidence angle ( theta i). Exiting light rays span a larger angle ( theta o). The exiting light spans a larger surface area of an ensuing eyepiece (20). In turn an expanded exit pupil (21) occurs beyond the eyepiece. Exit pupil expanding embodiments include a curved diffractive optical element (300), fiber optic face plate (320), lens array (340) and diffuser (360). The diffractive optical element generates multiple exit pupils (304-316), while the other embodiments generate enlarged exit pupils.

    Abstract translation: 使用在不损害放大率或分辨率的情况下产生扩展出射光瞳（21）的光学系统实现显示装置（10）。 来自光源（12）的调制光通过光学子系统（14）会聚到焦点。 扫描子系统（16）沿着光栅图案偏转会聚光，从而偏转焦点，以限定弯曲的中间像平面（15）。 出射光瞳扩张装置（18）限定与曲面像平面（15）重合的曲面。 在给定的瞬间，在给定的入射角（θi）中引发光线。 退出光线跨越较大的角度（θo）。 出射光横跨随后的目镜（20）的较大表面积。 反过来，扩展的出射光瞳（21）发生在目镜之外。 退出光瞳扩展实施例包括弯曲衍射光学元件（300），光纤面板（320），透镜阵列（340）和漫射器（360）。 衍射光学元件产生多个出射光瞳（304-316），而其他实施例产生放大的出射光瞳。

    FLUORESCENT REPORTER BEADS FOR FLUID ANALYSIS
    76.
    发明申请
    FLUORESCENT REPORTER BEADS FOR FLUID ANALYSIS 审中-公开
    用于流体分析的荧光报告珠

    公开(公告)号：WO1997035189A1

    公开(公告)日：1997-09-25

    申请号：PCT/US1997004099

    申请日：1997-03-14

    Applicant: UNIVERSITY OF WASHINGTON

    Inventor： UNIVERSITY OF WASHINGTON ,  VAN DEN ENGH, Ger ,  WEIGL, Bernhard, H.

    IPC: G01N31/22

    CPC classification number: G01N31/225 ,  G01N15/14 ,  G01N21/6428 ,  G01N21/6458 ,  G01N31/221 ,  G01N31/223 ,  G01N33/5005 ,  G01N33/54313 ,  G01N2015/1018 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/14 ,  Y10T436/15 ,  Y10T436/16 ,  Y10T436/20 ,  Y10T436/207497

    Abstract: The present invention provides a method and apparatus for rapid measurements of a fluid bulk analyte, requiring only microscale volumes. Several fluid bulk analytes can be measured simultaneously and, for biological samples, the cell content can also be measured simultaneously. The invention comprises reporter beads for chemical analysis of fluid bulk properties such as pH, oxygen saturation and ion content. Each reporter bead comprises a substrate bead having a plurality of at least one type of fluorescent reporter molecules immobilized thereon. The fluorescent properties of the reporter bead are sensitive to a corresponding analyte. Reporter beads are added to a fluid sample and the analyte concentration is determined by measuring fluorescence of individual beads, for example in a flow cytometer. Alternatively, reporter molecules which change absorbance as a function of analyte concentration can be employed.

    Abstract translation: 本发明提供了一种仅需要微量体积的用于快速测量流体体分析物的方法和装置。 可以同时测量几种流体体分析物，并且对于生物样品，也可以同时测量细胞含量。 本发明包括用于化学分析流体体积特性如pH，氧饱和度和离子含量的报道珠。 每个报道珠包含具有固定在其上的多个至少一种类型的荧光报道分子的底物珠。 报道珠的荧光性质对相应的分析物敏感。 将报道珠添加到流体样品中，并且通过测量各个珠的荧光来测定分析物浓度，例如在流式细胞仪中。 或者，可以使用改变作为分析物浓度的函数的吸光度的报道分子。

    DIABETES MELLITUS 37 kD AUTOANTIGEN PROTEIN-TYROSINE PHOSPHATASE
    77.
    发明申请
    DIABETES MELLITUS 37 kD AUTOANTIGEN PROTEIN-TYROSINE PHOSPHATASE 审中-公开
    糖尿病Mellitus 37 kD自动蛋白酪氨酸磷酸酶

    公开(公告)号：WO1997032984A1

    公开(公告)日：1997-09-12

    申请号：PCT/US1997003532

    申请日：1997-03-05

    Applicant: ZYMOGENETICS, INC. ,  UNIVERSITY OF WASHINGTON

    Inventor： ZYMOGENETICS, INC. ,  UNIVERSITY OF WASHINGTON ,  KINDSVOGEL, Wayne ,  JELINEK, Laura ,  SHEPPARD, Paul, O. ,  HAGOPIAN, William ,  LAGASSE, James

    IPC: C12N15/55

    CPC classification number: C07K14/4713 ,  A61K38/00 ,  C12N9/16

    Abstract: A mammalian islet cell antigen polypeptide involved in the development of insulin-dependent diabetes mellitus (IDDM) is disclosed. This islet cell antigen polypeptide, 1851, was found to contain regions of homology to the protein-tyrosine phosphatase family. Methods for diagnosis and treatment, including use in immunoprecipitation assays and the induction of immune tolerance using the recombinant mammalian polypeptides and antibodies specific to mammalian islet cell antigen 1851 polypeptides are presented.

    Abstract translation: 公开了涉及胰岛素依赖性糖尿病（IDDM）发展的哺乳动物胰岛细胞抗原多肽。 该胰岛细胞抗原多肽1851被发现含有与蛋白质 - 酪氨酸磷酸酶家族同源的区域。 提出了用于诊断和治疗的方法，包括在免疫沉淀测定中的应用和使用重组哺乳动物多肽和对哺乳动物胰岛细胞抗原1851多肽特异的抗体诱导免疫耐受。

    SILICON MICROCHANNEL OPTICAL FLOW CYTOMETER
    78.
    发明申请
    SILICON MICROCHANNEL OPTICAL FLOW CYTOMETER 审中-公开
    硅微通道光流量计

    公开(公告)号：WO1997012223A1

    公开(公告)日：1997-04-03

    申请号：PCT/US1996015566

    申请日：1996-09-27

    Applicant: UNIVERSITY OF WASHINGTON

    Inventor： UNIVERSITY OF WASHINGTON ,  ALTENDORF, Eric, H. ,  YAGER, Paul

    IPC: G01N15/14

    CPC classification number: B01L3/502715 ,  B01L2200/0636 ,  B01L2300/0654 ,  B01L2300/0822 ,  B01L2300/0851 ,  B01L2300/0877 ,  G01N15/1056 ,  G01N15/1404 ,  G01N2015/1075 ,  G01N2021/058

    Abstract: The present invention provides a flow cytometer made of two components: a flow cytometer optical head and a disposable flow module. The flow module utilizes a V-groove flow channel micromachined in a silicon wafer. The optical head comprises a laser to provide an illuminating beam and small and large angle photodetectors. Anisotropically etched facets of the V-groove reflect the illuminating beam. Small angle scattered light is also reflected by the V-groove wall and is collected by the small angle photodetector. Large angle scattered light and fluorescent light can exit the channel without reflection and are collected by the large angle photodetector. In addition, fluorescent light can be back-reflected by the V-groove, which enhances the collection efficiency. This invention further includes a method of analyzing a particle-containing fluid and a method of measuring the velocity of a particle in a fluid flow.

    Abstract translation: 本发明提供一种由两个组分制成的流式细胞仪：流式细胞仪光学头和一次性流动模块。 流动模块利用在硅晶片中微加工的V形槽流动通道。 该光头包括一激光器以提供照明光束和小角度和大角度的光电探测器。 V形槽的各向异性蚀刻面反射照明光束。 小角度散射光也被V形槽壁反射并被小角度光电探测器收集。 大角度散射光和荧光灯可以无反射地离开通道，并由大角度光电探测器收集。 此外，荧光灯可以通过V形槽反向反射，这提高了收集效率。 本发明还包括分析含颗粒流体的方法和测量流体流中颗粒速度的方法。

    METHODS FOR INHIBITING FACTOR XIII ACTIVITY
    79.
    发明申请
    METHODS FOR INHIBITING FACTOR XIII ACTIVITY 审中-公开
    抑制因子XIII活性的方法

    公开(公告)号：WO1997002340A2

    公开(公告)日：1997-01-23

    申请号：PCT/US1996011182

    申请日：1996-06-28

    Applicant: ZYMOGENETICS, INC. ,  UNIVERSITY OF WASHINGTON

    Inventor： ZYMOGENETICS, INC. ,  UNIVERSITY OF WASHINGTON ,  YEE, Vivien, C. ,  TELLER, David, C. ,  KONTOYIANNI, Maria

    IPC: C12N09/10

    CPC classification number: C12N9/1044

    Abstract: Methods for inhibiting Factor XIII activity feature a ligand that forms at least one contact, at a distance of about 5 ANGSTROM or less, with at least one amino acid residue of a Factor XIII monomer. Factor XIII inhibitors are selected or designed using the three-dimensional structure of Factor XIII as a guide. In one approach, inhibitory ligands are selected or designed based on the Factor XIII b-sandwich:core interface. In a second approach, inhibitors are selected or designed based on the catalytic site of Factor XIII. In a third approach, inhibitory ligands are selected or designed based on the Factor XIII dimer interface. In a fourth approach, inhibitory molecules were designed to occupy the Factor XIII binding site, and include an electrophilic moiety susceptible to nucleophilic displacement by the reactive Cys-314.

    Abstract translation: 本发明涉及使用位于单体因子XIII的至少一个氨基酸组的距离等于或小于5埃的配体来抑制因子XIII的方法。 选择因子XIII抑制剂，或使用因子XIII的三维结构作为指导制备。 在一种方法中，根据β-夹层结构域和因子XIII核之间的界面来选择或制造抑制性配体。 根据第二种方法，根据因子XIII的催化位点选择或制备抑制剂。 根据第三种方法，根据因子XIII二聚体界面选择或制备抑制性配体。 根据第四种方法，使抑制分子占据因子XIII结合位点，并且它们包含能够在发生反应的Cys-314的作用下发生亲核置换的亲电子基团。

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