公开(公告)号：EP2501671A1

公开(公告)日：2012-09-26

申请号：EP10778650.1

申请日：2010-11-15

Applicant: Ferrer Internacional, S.A. ,  Nicox S.A.

Inventor： ANGLADA, Luis ,  PALOMER, Albert ,  SOBRAL, Luis

IPC: C07C201/02 ,  C07C203/04

CPC classification number: C07C51/347 ,  C07C201/02 ,  C07C203/04

Abstract: This invention relates to a new process for preparing 4-nitro-oxy-methyl- benzoic acid, comprising the following steps: a) reaction of 4-chloromethyl-benzoic acid with silver nitrate and in the presence of an acid as a catalyst in acetonitrile at reflux temperature, followed by cooling and adding of a polar aprotic solvent; b) separation of the silver salts by filtration, followed by washout with a polar aprotic solvent; c) precipitation of the 4-nitro-oxy-methyl-benzoic acid with water from the filtrate obtained in step b); and d) drying of the 4-nitro-oxy-methyl-benzoic acid.

公开(公告)号：EP2222628B1

公开(公告)日：2012-07-18

申请号：EP08864709.4

申请日：2008-12-19

Applicant: DSM Fine Chemicals Austria Nfg GmbH & Co KG

Inventor： BRAUNE, Sascha ,  STEINHOFER, Stefan ,  POECHLAUER, Peter ,  REINTJENS, Rafael Wilhelmus Elisabeth Ghislain ,  LINSSEN, Nicole Theodora Wilhelmina ,  THATHAGAR, Mehul

IPC: C07C201/02 ,  C07C203/04

CPC classification number: B01J19/0093 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00966 ,  B01J2219/00984 ,  C07C201/02 ,  C07C203/04

Abstract: A process for the continuous production of a compound of Formula (II), HO-R1-ONO2 (II) wherein R1 is a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formula (I), HO-R1-OH (I) wherein R1 is as defined above, with nitric acid in the presence of a first solvent, wherein the compound of Formula (II) is continuously extracted into a second solvent, and the reaction is carried out in a mixing microreactor which provides a power loss of at least 1.3 times the power loss provided under identical conditions by a circular cross-section straight-channel microreactor having an internal diameter equal to the average hydraulic diameter of the mixing microreactor and a length equal to the length of the mixing microreactor.

公开(公告)号：EP2288590A2

公开(公告)日：2011-03-02

申请号：EP09766209.2

申请日：2009-06-18

Applicant: Nicox S.A.

Inventor： ALLEGRINI, Pietro ,  SCUBLA, Tiziano ,  TONIUTTI, Nicoletta ,  RIVOLTA, Romano ,  DELAHAIQUE, Thierry

IPC: C07C203/04

CPC classification number: C07C203/04 ,  C07C201/02

Abstract: The present invention relates to a method for purifying naproxcinod comprising the steps of : a) dissolving or dispersing a mixture containing naproxcinod in an amount higher than 90% by weight in a solvent; b) cooling the solution or two phases dispersion under stirring to a temperature ranging from -20°C to 10°C c) optionally seeding the solution with crystals of naproxcinod d) stirring, by maintaining the temperature in the range from - 40°C to 10°C e) collecting the formed solid by maintaining the temperature under 15°C A further object of the invention is a crystalline form of naproxcinod.

公开(公告)号：EP1792891A1

公开(公告)日：2007-06-06

申请号：EP06023304.6

申请日：2006-11-09

Applicant: Josef Meissner GmbH & Co. KG

Inventor： Pöhlmann, Jürgen, Dr. ,  Pottharst, Frank ,  Hermann, Heinrich, Dr. ,  Konieczny, Peter, Dr. ,  Händel, Mirko, Dr. ,  Gebauer, Jürgen

IPC: C07C201/02 ,  C07C203/04

CPC classification number: C07C201/02 ,  C07C203/04

Abstract: Gegenstand der Erfindung ist ein Verfahren zur Herstellung von Salpetersäureestem (Nitroestern) von einwertigen Alkoholen, bei dem ein einwertiger Alkohol oder eine Mischung einwertiger Alkohole mit Salpetersäure in Gegenwart von Schwefelsäure unter adiabatischen Reaktionsbedingungen umgesetzt wird.

Abstract translation: 制备一价醇的硝酸酯（硝酸酯）包括在绝热反应条件下，在硫酸存在下使一价醇或其混合物与硝酸酯反应。

公开(公告)号：EP0931052B1

公开(公告)日：2002-04-10

申请号：EP97937734.8

申请日：1997-09-01

Applicant: QinetiQ Limited

Inventor： COLCLOUGH, Martin, Eamon,Defence Evaluation Agency ,  PELTER, Andrew,Defence Eval.and Research Agency

IPC: C07C201/02 ,  C07C203/04

CPC classification number: C07F7/1852 ,  C07C201/02 ,  C07C203/04

Abstract: A process for preparing 1,2- and 1,3-dinitrate esters from polyols containing 1,2- or 1,3-diol fragments involves using an alkyl or aryl boronic acid to form a cyclic boronate ester derivative which is then reacted with dinitrogen pentoxide to directly generate the dinitrate ester. In the cyclic ester form the 1,2- or 1,3-hydroxyl groups are protected and other reactions may then be carried out on other parts of the molecule of which the fragment forms a part, leaving the dinitrate ester to be produced subsequently in the final step. High yields are obtained at both stages.

公开(公告)号：EP1038862A3

公开(公告)日：2000-11-15

申请号：EP00105136.6

申请日：2000-03-10

Applicant: Dinamite Dipharma S.p.A.

Inventor： Beltrame, Andrea ,  Scubla, Tiziano

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C07D493/04 ,  C07C203/04

Abstract: A process for the preparation of nitric monoesters of dihydroxyalkyl, dihydroxycycloalkyl or dihydroxy(poly)cycloalkyl compounds starting from the respective nitric diesters of dihydroxyalkyl, dihydroxycycloalkyl or dihydroxy(poly)cycloalkyl compounds, which comprises the hydrogenation of the nitric diesters with a platinum (0) catalyst.

Abstract translation: 一种由二羟基烷基，二羟基环烷基或二羟基（多）环烷基化合物的各自的二硝基二酯制备二羟基烷基，二羟基环烷基或二羟基（多）环烷基化合物的硝酸单酯的方法，该方法包括用铂 ）催化剂。

公开(公告)号：EP0129995B1

公开(公告)日：1987-05-13

申请号：EP84303752.4

申请日：1984-06-04

Applicant: AECI LIMITED

Inventor： Stiff, Anthony John

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C07C203/04

公开(公告)号：EP0170506A3

公开(公告)日：1986-12-30

申请号：EP85305343

申请日：1985-07-26

Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED

Inventor： MINAI, MASAYOSHI ,  UEDA, YUJI

IPC: C07C45/64 ,  C07C45/67 ,  C07C49/707 ,  C07C203/08 ,  C07C309/63 ,  C07C77/02

CPC classification number: C07C201/02 ,  C07B2200/07 ,  C07C45/64 ,  C07C45/673 ,  C07C303/28 ,  C07C2601/08 ,  C07C49/707 ,  C07C203/08 ,  C07C309/66

公开(公告)号：EP1560805B1

公开(公告)日：2007-07-04

申请号：EP03778304.0

申请日：2003-11-06

Applicant: Dipharma Francis S.r.l.

Inventor： SCUBLA, Tiziano ,  FRANCESCUTTI, Nevio ,  GORASSINI, Fausto ,  CASTALDI, Graziano

IPC: C07C201/02 ,  C07C203/04

CPC classification number: C07C203/04 ,  C07C201/02

Abstract: A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.

公开(公告)号：EP1537070A1

公开(公告)日：2005-06-08

申请号：EP03790866.2

申请日：2003-08-06

Applicant: Nicox S.A.

Inventor： DEL SOLDATO, Piero ,  SANTUS, Giancarlo ,  BENEDINI, Francesca

IPC: C07C203/04 ,  C07C201/02

CPC classification number: C07C269/06 ,  C07C67/10 ,  C07C69/734 ,  C07C201/02 ,  C07C203/04 ,  C07C271/28 ,  C07C303/28 ,  C07C309/73

Abstract: The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R-COOZ (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.