公开(公告)号：EP1461149B1

公开(公告)日：2007-08-15

申请号：EP02793662.4

申请日：2002-12-17

Applicant: GE Healthcare Bio-Sciences AB

Inventor： BERG, Hans, c/o Amersham Biosciences AB ,  CARLSSON, Mats ,  LARSSON, Anders, c/o Amersham Biosciences AB

IPC: B01J20/26 ,  C08J3/16 ,  B01D15/08

CPC classification number: G01N30/482 ,  B01J20/26 ,  B01J20/261 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28019 ,  B01J20/28054 ,  B01J20/28083 ,  B01J20/28092 ,  B01J20/285 ,  B01J20/305 ,  B01J2220/54 ,  C08J3/16 ,  C08J9/16 ,  C08J9/26 ,  C08J2201/042 ,  C08J2201/044

Abstract: The present invention is a method of producing porous beads, which comprises the steps of providing a first liquid phase comprising a bead matrix material and essentially edgy templating particle(s), said particle(s) being treated with a surface modifying agent; providing a second liquid phase which is immiscible with the first liquid phase; contacting the first phase and the second phase under conditions resulting in an emulsion of droplets comprised of the first liquid phase dispersed in the continuous second liquid phase; transforming the droplets to mesoporous beads by solidification of the liquid; and removing the templating particle(s) from the beads without causing any essential change of the surrounding bead, whereby hierarchical networks of pores are provided in the beads.

公开(公告)号：EP1368420A1

公开(公告)日：2003-12-10

申请号：EP02702347.2

申请日：2002-02-06

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： MALETZKO, Christian ,  KEPPELER, Uwe ,  HAHN, Klaus ,  DE GRAVE, Isidor

IPC: C08J9/224 ,  C08J9/26

CPC classification number: C08J9/26 ,  C08J9/224 ,  C08J2201/044 ,  C08J2203/14 ,  C08J2323/02

Abstract: The invention relates to expandable polyolefin particles containing expanding agents, said particles being coated with between 0.01 and 3 wt. % of a salt and/or an ester of a long-chained fatty acid, preferably with calcium stearate, in order to prevent agglutination during expansion.

公开(公告)号：EP2300516B1

公开(公告)日：2012-10-03

申请号：EP09785329.5

申请日：2009-07-14

Applicant: Invibio Limited

Inventor： JARMAN-SMITH, Marcus ,  WHITEHEAD, Tony ,  ELLERAY, Andrew ,  DEVINE, John

IPC: C08J3/20 ,  C08J9/26

CPC classification number: C08J9/26 ,  C08J3/203 ,  C08J2201/044 ,  C08J2201/0442 ,  C08J2201/0444 ,  C08J2371/10 ,  Y10T428/2982

公开(公告)号：EP1042388B1

公开(公告)日：2006-11-15

申请号：EP98964258.2

申请日：1998-12-22

Applicant: METABOLIX, INC.

Inventor： MARTIN, David, P. ,  SKRALY, Frank, A. ,  WILLIAMS, Simon, F.

IPC: C08G63/06 ,  C08G63/91 ,  C08K3/00 ,  C08K5/00 ,  C08J9/26 ,  C08J9/28 ,  C08L67/04 ,  C12P7/62 ,  A61K47/34 ,  A61L17/00 ,  A61L27/00 ,  A61L31/00

CPC classification number: A61L31/06 ,  A61K9/1647 ,  A61K9/204 ,  A61K47/34 ,  A61K47/593 ,  A61L15/26 ,  A61L17/12 ,  A61L24/0042 ,  A61L26/0019 ,  A61L26/009 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L29/06 ,  A61L31/148 ,  C08G63/06 ,  C08G63/60 ,  C08G63/64 ,  C08G63/664 ,  C08G63/6852 ,  C08G63/6882 ,  C08J9/26 ,  C08J2201/044 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C08L101/00 ,  C12P7/625 ,  C08L2666/02

Abstract: Biocompatible polyhydroxyalkanoate compositions, particularly based on biotechnologically produced homo- and copolymers of 4- hydroxybutyric acid, with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives like, for example, pore forming agents to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physioogical conditions. These polyhydroxyalkanoate materials provide a wider range of polyhydroxyalkanoate degradation rates than are currently available. Methods for processing these materials, particularly for therapeutic, prophylactic or diagnostic applications, or into devices which can be implanted or injected, are also described.

Abstract translation: 已经开发了具有可控降解速率的生物相容性聚羟基链烷酸酯组合物，特别是基于生物技术生产的4-羟基丁酸均聚物和共聚物的组合物。 在一个实施方案中，聚羟基链烷酸酯含有添加剂，例如成孔剂以改变降解速率。 在另一个实施方案中，聚羟基链烷酸酯由单体混合物形成或在其骨架中包含侧基或修饰以改变其降解速率。 在又一个实施方案中，聚羟基链烷酸酯是化学改性的。 制造增加孔隙率或暴露表面积的装置的方法可用于改变可降解性。 如实施例所证实的，这些聚羟基链烷酸酯组合物具有非常有利的机械性能，并且在理疗条件下在所需的时间范围内具有生物相容性和降解性。 这些聚羟基链烷酸酯材料提供比目前可获得的更宽范围的聚羟基链烷酸酯降解速率。 还描述了用于处理这些材料的方法，特别是用于治疗，预防或诊断应用，或者可以植入或注射的装置。

公开(公告)号：EP1659142A1

公开(公告)日：2006-05-24

申请号：EP06075303.5

申请日：1998-12-22

Applicant: METABOLIX, INC.

Inventor： The designation of the inventor has not yet been filed

IPC: C08G63/06 ,  C08G63/91 ,  C08K3/00 ,  C08K5/00 ,  C08J9/26 ,  C08J9/28 ,  C08L67/04 ,  C12P7/62 ,  A61K47/34 ,  A61L17/00 ,  A61L27/00 ,  A61L31/00

CPC classification number: A61L31/06 ,  A61K9/1647 ,  A61K9/204 ,  A61K47/34 ,  A61K47/593 ,  A61L15/26 ,  A61L17/12 ,  A61L24/0042 ,  A61L26/0019 ,  A61L26/009 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L29/06 ,  A61L31/148 ,  C08G63/06 ,  C08G63/60 ,  C08G63/64 ,  C08G63/664 ,  C08G63/6852 ,  C08G63/6882 ,  C08J9/26 ,  C08J2201/044 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C08L101/00 ,  C12P7/625 ,  C08L2666/02

Abstract: Biocompatible polyhydroxyalkanoate compositions, particularly based on biotechnologically produced homo- and copolymers of 4- hydroxybutyric acid, with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives like, for example, pore forming agents to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physioogical conditions. These polyhydroxyalkanoate materials provide a wider range of polyhydroxyalkanoate degradation rates than are currently available. Methods for processing these materials, particularly for therapeutic, prophylactic or diagnostic applications, or into devices which can be implanted or injected, are also described.

Abstract translation: 已经开发了具有可控降解速率的生物相容性聚羟基链烷酸酯组合物，特别是基于生物技术生产的4-羟基丁酸均聚物和共聚物的组合物。 在一个实施方案中，聚羟基链烷酸酯含有添加剂，例如成孔剂以改变降解速率。 在另一个实施方案中，聚羟基链烷酸酯由单体混合物形成或在其骨架中包含侧基或修饰以改变其降解速率。 在又一个实施方案中，聚羟基链烷酸酯是化学改性的。 制造增加孔隙率或暴露表面积的装置的方法可用于改变可降解性。 如实施例所证实的，这些聚羟基链烷酸酯组合物具有非常有利的机械性能，并且在理疗条件下在所需的时间范围内具有生物相容性和降解性。 这些聚羟基链烷酸酯材料提供比目前可获得的更宽范围的聚羟基链烷酸酯降解速率。 还描述了用于处理这些材料的方法，特别是用于治疗，预防或诊断应用，或者可以植入或注射的装置。

公开(公告)号：EP1427577A2

公开(公告)日：2004-06-16

申请号：EP02766099.2

申请日：2002-08-23

Applicant: Radiant Holdings, LLC

Inventor： FERGUSON, Terrell, W.

IPC: B29C31/00

CPC classification number: C08J9/00 ,  A61F2/12 ,  C08J2201/044 ,  C08J2201/046 ,  C08J2383/04

Abstract: A foam material is provided that is formed from a body of silicone having a cellular structure formed by a plurality of interconnected voids. The voids have a relatively high volume of between about 0.06545 to about 268.0832 mm3 and more typically about 65.45 to about 179.5948 mm3. The foam material displays unique tactile properties.

公开(公告)号：EP0899290B1

公开(公告)日：2001-07-25

申请号：EP98116140.9

申请日：1998-08-26

Applicant: Rengo Co., Ltd.

Inventor： Higashiyama, Akira, c/o Rengo Co., Ltd. ,  Saito, Hidenao, c/o Rengo Co., Ltd.

IPC: C08J5/18 ,  C08J9/08

CPC classification number: C08J9/26 ,  C08J5/18 ,  C08J9/08 ,  C08J2201/044 ,  C08J2301/00 ,  Y10T428/249988 ,  Y10T428/249989

公开(公告)号：US20230203264A1

公开(公告)日：2023-06-29

申请号：US17926776

申请日：2021-05-27

Applicant: University of Florida Research Foundation, Inc.

Inventor： Peng Jiang ,  Calen Leverant ,  Yifan Zhang

IPC: C08J9/26 ,  B42D25/36 ,  G01N21/78 ,  C08J9/36 ,  C08F222/10

CPC classification number: C08J9/26 ,  B42D25/36 ,  G01N21/78 ,  C08J9/36 ,  C08F222/102 ,  C08J2201/044 ,  C08J2201/0462 ,  C08J2335/02

Abstract: Provided herein are methods for fabricating a porous polymer material, methods for revealing hidden anti-counterfeiting patterns, chromogenic sensors having hidden anti-counterfeiting patterns, and the like. Chromogenic sensors including porous polymer materials are provided. The chromogenic sensors can reveal hidden patterns such as anti-counterfeiting patterns and the pattern can be re-hidden.

公开(公告)号：US20180250640A1

公开(公告)日：2018-09-06

申请号：US15756759

申请日：2016-08-31

Applicant: Tokyo Ohka Kogyo Co., Ltd.

Inventor： Tsukasa SUGAWARA

IPC: B01D67/00 ,  B01D71/34 ,  B01D71/68 ,  B01D71/64 ,  B01D69/12 ,  B01D69/02 ,  C08J9/26 ,  H01M2/16 ,  H01M10/0525

CPC classification number: B01D67/003 ,  B01D67/002 ,  B01D69/02 ,  B01D69/12 ,  B01D71/34 ,  B01D71/64 ,  B01D71/68 ,  B01D2325/021 ,  C08J9/0066 ,  C08J9/26 ,  C08J2201/044 ,  C08J2327/16 ,  C08J2379/08 ,  C08J2381/06 ,  H01M2/1653 ,  H01M2/166 ,  H01M10/0525

Abstract: Provided are a porous film having excellent surface smoothness and a method for producing the same. The surface roughness of a porous film of polyvinylidene fluoride, polyethersulfone, polyimide and/or polyamide-imide is Ra 30,000 Å or less. The opening diameter of the porous film is preferably from 100 nm to 5000 nm. The method for producing a porous film preferably includes a step for kneading a varnish containing fine particles and at least one resin selected from the group consisting of polyvinylidene fluoride, polyether sulfone, polyamic acid, polyimide, polyamide-imide precursor, and polyamide-imide. The varnish preferably has a viscosity at 25° C. of 0.1-3 Pa·s, a solids fraction concentration of 10-50 mass %, and a fine particle average particle size of 10-5000 nm.

公开(公告)号：US20180126041A1

公开(公告)日：2018-05-10

申请号：US15797063

申请日：2017-10-30

Applicant: DANKOOK UNIVERSITY CHEONAN CAMPUS INDUSTRY ACADEMIC COOPERATION FOUNDATION

Inventor： Jung Keun Hyun ,  Jong-Wan Kim ,  Young-Jin Son ,  Min Soo Kim ,  Hong Sun Ahn

IPC: A61L27/56 ,  A61L27/58 ,  A61L27/18 ,  C08J9/26 ,  C08J9/28 ,  A61L27/36 ,  A61F2/00 ,  A61F2/02

CPC classification number: A61L27/56 ,  A61B17/1128 ,  A61F2/0077 ,  A61F2/02 ,  A61F2002/0081 ,  A61F2002/0086 ,  A61L27/18 ,  A61L27/3604 ,  A61L27/3675 ,  A61L27/383 ,  A61L27/58 ,  A61L2400/08 ,  A61L2430/32 ,  A61L2430/38 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/044 ,  C08J2201/0544 ,  C08J2205/044 ,  C08J2205/06 ,  C08J2207/10 ,  C08J2367/04 ,  C08L67/04

Abstract: The present invention relates to a method for preparing a nerve conduit containing cells, more particularly to a method for preparing a porous nerve conduit containing cells, having micropores formed in microchannels, wherein the nerve conduit containing cells prepared according to the present invention can be usefully used in in-vitro and in-vivo researches on nerves.