公开(公告)号：WO2002092678A1

公开(公告)日：2002-11-21

申请号：PCT/US2002/012524

申请日：2002-04-18

Applicant: NANOSYSTEMS RESEARCH INC. ,  NEDELJKO, Gvozdic

Inventor： NEDELJKO, Gvozdic

IPC: C08J9/26

CPC classification number: C08J9/26 ,  C08J2201/0446

Abstract: What is disclosed herein are physically cross-linked, cellular hydrogels and methods for their preparation. The cellular materials are highly resilient, hydrophilic materials having broad uses. The cellular materials are prepared by the physical crosslinking of frothed polymers and providing materials that have cellular pores provided by the uses of removable materials during the formation of the cellular materials.

Abstract translation: 本文公开的是物理交联的，细胞水凝胶及其制备方法。 多孔材料是具有广泛用途的高弹性亲水材料。 多孔材料通过发泡聚合物的物理交联并通过在形成细胞材料期间通过可移除材料的使用而提供的具有细孔的材料来制备。

公开(公告)号：EP3280464A1

公开(公告)日：2018-02-14

申请号：EP16777342.3

申请日：2016-04-08

Applicant: President and Fellows of Harvard College

Inventor： ALI, Omar Abdel-Rahman ,  MOONEY, David J.

IPC: A61L27/54 ,  A61L27/56 ,  A61L27/36 ,  C08J9/26 ,  A61K35/12 ,  A61K35/13 ,  A61K35/14 ,  A61K35/15 ,  A61K35/17

CPC classification number: G01N33/545 ,  A61K35/15 ,  A61K35/17 ,  A61L31/06 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/438 ,  A61L2300/62 ,  C08J9/0004 ,  C08J9/122 ,  C08J9/26 ,  C08J2201/032 ,  C08J2201/0422 ,  C08J2201/0446 ,  C08J2203/06 ,  C08J2203/08 ,  C08J2205/044 ,  C08J2205/05 ,  C08J2207/10 ,  C08J2305/00 ,  C08J2305/04 ,  C08J2305/08 ,  C08J2305/12 ,  C08J2325/04 ,  C08J2329/04 ,  C08J2333/04 ,  C08J2339/00 ,  C08J2339/06 ,  C08J2367/00 ,  C08J2367/04 ,  C08J2371/02 ,  C08J2385/02 ,  C08J2389/00 ,  C08J2389/04 ,  G01N33/56972 ,  G01N33/5743 ,  G01N2800/042 ,  Y02A50/463 ,  Y02A50/475 ,  Y02A50/48

Abstract: Embodiments herein described provide devices for identifying and collecting rare cells or cells which occur at low frequency in the body of a subject, such as, antigen-specific cells or disease-specific cells. More specifically, the devices are useful for trapping immune cells and the devices contain a physiologically-compatible porous polymer scaffold, a plurality of antigens, and an immune cell-recruiting agent, wherein the plurality of antigens and the immune cell recruiting agent attract and trap the immune cell in the device. Also provided are pharmaceutical compositions, kits, and packages containing such devices. Additional embodiments relate to methods for making the devices, compositions, and kits/packages. Further embodiments relate to methods for using the devices, compositions, and/or kits in the diagnosis or therapy of diseases such as autoimmune diseases or cancers.

公开(公告)号：EP2338532A2

公开(公告)日：2011-06-29

申请号：EP10382243.3

申请日：2010-09-10

Applicant: Fundacion Inasmet

Inventor： Olalde Graells, Beatriz ,  Jurado Oñate, María, Jesús

IPC: A61L27/18 ,  A61L27/56 ,  C08J9/26 ,  C08J9/28

CPC classification number: A61L27/18 ,  A61L27/56 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0422 ,  C08J2201/0444 ,  C08J2201/0446 ,  C08J2201/052 ,  C08J2205/05 ,  C08J2207/10 ,  C08J2371/12 ,  Y10T428/249953 ,  Y10T428/249986 ,  C08L71/00

Abstract: The present invention refers to a porous PEEK-type polymer article comprising a porous PEEK-type polymer structure and presenting at least a trimodal pore distribution. The invention describes a process for the production of said porous PEEK-type polymer article comprising: a) contacting a PEEK-type polymer with a composition comprising at least a organic solvent, b) heating at a temperature at which the PEEK-type polymer is dissolved, c) adding at least a porogen agent, d) cooling the mixture obtained in c) at a temperature at least equal or lower than the temperature at which the PEEK-type polymer precipitates, e) forming said cooled mixture into a shaped article, f) removing the organic solvent and the porogen agent, and g) recovering the PEEK-type polymer article.

公开(公告)号：EP1812481A4

公开(公告)日：2010-07-21

申请号：EP05851973

申请日：2005-11-18

Applicant: MAYO FOUNDATION

Inventor： WANG SHANGFENG ,  YASZEMSKI MICHAEL J ,  LU LICHUN ,  CURRIER BRADFORD L

IPC: C08F20/00 ,  A61F2/00 ,  A61L27/42 ,  B32B27/00 ,  C08G63/02 ,  C08G63/08 ,  C08G81/00 ,  C08J9/26 ,  C08K5/00

CPC classification number: A61L27/56 ,  A61L27/18 ,  A61L27/46 ,  B33Y70/00 ,  B33Y80/00 ,  C08G63/08 ,  C08G63/60 ,  C08G2261/126 ,  C08J9/26 ,  C08J2201/024 ,  C08J2201/0446 ,  C08J2367/06 ,  C08L67/06

公开(公告)号：EP1877111A1

公开(公告)日：2008-01-16

申请号：EP06721786.9

申请日：2006-04-07

Applicant: Rimon Therapeutics Ltd.

Inventor： BUTLER, Mark J. ,  SEFTON, Michael Vivian ,  SKARJA, Gary Alan

IPC: A61L27/56 ,  A61L27/14 ,  A61K35/12 ,  A61L27/58 ,  A61L27/60 ,  C08J5/00

CPC classification number: A61L27/16 ,  A61L27/56 ,  A61L27/58 ,  A61L27/60 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2300/10 ,  C08J2333/02 ,  C08L33/08

Abstract: A pro-angiogenic porous polymer scaffold is disclosed. The polymer has at least 20 mol-% monomeric subunits containing acidic functional groups, and has a porosity of at least 40%. The pores in the scaffold are interconnected. A method of making such a scaffold using a novel adaptation to the traditional solvent casting/particulate leaching technique technique is also disclosed. The scaffold may be used for tissue regeneration.

公开(公告)号：EP1812481A2

公开(公告)日：2007-08-01

申请号：EP05851973.7

申请日：2005-11-18

Applicant: Mayo Foundation for Medical Education and Research

Inventor： WANG, Shangfeng ,  YASZEMSKI, Michael, J. ,  LU, Lichun ,  CURRIER, Bradford, L.

IPC: C08F20/00 ,  C08G63/02 ,  A61F2/00 ,  B32B27/00

CPC classification number: A61L27/56 ,  A61L27/18 ,  A61L27/46 ,  B33Y70/00 ,  B33Y80/00 ,  C08G63/08 ,  C08G63/60 ,  C08G2261/126 ,  C08J9/26 ,  C08J2201/024 ,  C08J2201/0446 ,  C08J2367/06 ,  C08L67/06

Abstract: Poly(propylene fumarate) is copolymerized with poly(caprolactone) diol to produce a block copolymer of poly(propylene fumarate) and poly(caprolactone). The biocompatible and bioresorbable block copolymer of poly(propylene fumarate) and poly(caprolactone) is useful in the fabrication of injectable and in­ situ hardening scaffolds for tissue and/or skeletal reconstruction. The block copolymer can be crosslinked by redox or photo-initiation, with or without an additional crosslinker. Thus, the copolymer is both self-crosslinkable (without the use of any crosslinkers) and photocrosslinkable (in the presence of photons such as UV light).

公开(公告)号：EP0556391A1

公开(公告)日：1993-08-25

申请号：EP91918934.0

申请日：1991-11-05

Applicant: KOMATSU LTD.

Inventor： YOKOTA, Akira, Komatsu Ltd. Plastic Division

IPC: C08J9/22

CPC classification number: C08J9/26 ,  B29C45/0001 ,  B29C67/205 ,  B29K2023/0683 ,  C08J9/24 ,  C08J2201/0446 ,  C08J2323/06

Abstract: A porous material of ultrahigh molecular weight polyethylene containing numerous interconnected pores, having permeability and being useful as filters, carriers and so forth; and a process for effectively producing said material. This material comprises minute particles of plasticized ultrahigh molecular weight polyethylene fused with one another so as to form interconnected pores communicating with the outer atmosphere. It is produced by injecting the plasticized ultrahigh molecular weight polyethylene into the cavity of a mold at a shear rate of 5 x 10⁴ sec⁻¹ or above and filling therein in such a manner that the ratio of G₀ to V₀ will be 0.7 g/cm³ or less, wherein G₀ represents product weight (g) and V₀ represents product volume (cm³).

Abstract translation: 超高分子量聚乙烯的多孔材料包含许多相互连通的孔，具有渗透性并可用作过滤器，载体等; 以及有效地生产所述材料的方法。 该材料包括彼此熔合的增塑超高分子量聚乙烯的微小颗粒，以形成与外部气氛连通的互连孔。 通过将塑化的超高分子量聚乙烯以5×10 4秒-1以上的剪切速率注入到模具的空腔中并以这样的方式填充，从而使G0与 V0为0.7g / cm 3以下，其中G0表示产品重量（g），V0表示产品体积（cm 3）。

公开(公告)号：JP6131538B2

公开(公告)日：2017-05-24

申请号：JP2012154874

申请日：2012-07-10

Applicant: シヤチハタ株式会社

Inventor： 松下 幾三 ,  永田 義明

IPC: B41K1/50

CPC classification number: C08L9/06 ,  B41K1/40 ,  C08J9/00 ,  C08J9/0061 ,  C08J9/0066 ,  C08J9/26 ,  C08L23/06 ,  C08L23/08 ,  C08L31/04 ,  C08L33/00 ,  C08J2201/022 ,  C08J2201/026 ,  C08J2201/0446 ,  C08J2323/04 ,  C08J2323/16 ,  C08J2331/04 ,  C08J2333/08 ,  C08J2409/06 ,  C08J2425/10 ,  C08J2453/02

公开(公告)号：JP5457032B2

公开(公告)日：2014-04-02

申请号：JP2008538238

申请日：2006-11-06

Applicant: ピーピーディー メディテック

Inventor： モーリセット，ダニエル ,  クロトー，パトリック

IPC: C08J9/26

CPC classification number: B32B5/145 ,  A61L27/18 ,  A61L27/48 ,  A61L27/56 ,  B32B5/22 ,  B32B27/00 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2205/05 ,  C08J2371/12 ,  Y10T428/249953 ,  Y10T428/249981 ,  Y10T428/249991 ,  C08L71/00

公开(公告)号：JP2014015003A

公开(公告)日：2014-01-30

申请号：JP2012154874

申请日：2012-07-10

Applicant: Shachihata Inc ,  シヤチハタ株式会社

Inventor： MATSUSHITA IKUZO ,  NAGATA YOSHIAKI

IPC: B41N1/12 ,  B41K1/50

CPC classification number: C08L9/06 ,  B41K1/40 ,  C08J9/00 ,  C08J9/0061 ,  C08J9/0066 ,  C08J9/26 ,  C08J2201/022 ,  C08J2201/026 ,  C08J2201/0446 ,  C08J2323/04 ,  C08J2323/16 ,  C08J2331/04 ,  C08J2333/08 ,  C08J2409/06 ,  C08J2425/10 ,  C08J2453/02 ,  C08L23/06 ,  C08L23/08 ,  C08L31/04 ,  C08L33/00

Abstract: PROBLEM TO BE SOLVED: To provide a porous stamp material capable of burning and evaporating only the resin of a part irradiated with a laser beam in laser engraving to prevent an unnecessary part from being melted and obtaining a clear stamp impression having a sharp edge.SOLUTION: The porous stamp material consists of: at least one thermoplastic resin selected from a low density polyethylene, a linear low density polyethylene, a high density polyethylene, an ethylene-α-olefin copolymer, an ethylene-vinyl acetate copolymer, and an ethylene-acrylic copolymer; at least one thermoplastic elastomer selected from a hydrogenated styrene thermoplastic elastomer; and at least one filler selected from inorganic compounds. The thermoplastic resin and the thermoplastic elastomer have continuous open cells formed by crosslinking.

Abstract translation: 要解决的问题：提供一种能够在激光雕刻中仅用激光束照射的部分的树脂进行燃烧和蒸发的多孔印模材料，以防止不必要的部分熔化，并获得具有锋利边缘的清晰的印模。 多孔印模材料包括：至少一种选自低密度聚乙烯，线型低密度聚乙烯，高密度聚乙烯，乙烯-α-烯烃共聚物，乙烯 - 乙酸乙烯酯共聚物和乙烯 - 丙烯酸共聚物; 至少一种选自氢化苯乙烯热塑性弹性体的热塑性弹性体; 和至少一种选自无机化合物的填料。 热塑性树脂和热塑性弹性体具有通过交联形成的连续开孔。