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    Medical devices and applications of polyhydroxyalkanoate polymers
    72.
    发明授权
    Medical devices and applications of polyhydroxyalkanoate polymers 有权
    聚羟基链烷酸酯聚合物的医疗装置和应用

    公开(公告)号：US06838493B2

    公开(公告)日：2005-01-04

    申请号：US10082954

    申请日：2002-02-26

    Applicant: Simon F. Williams ,  David P. Martin ,  Frank A. Skraly

    Inventor： Simon F. Williams ,  David P. Martin ,  Frank A. Skraly

    IPC: A61B17/58 ,  A61F2/84 ,  A61K45/00 ,  A61L15/64 ,  A61L17/00 ,  A61L17/12 ,  A61L27/00 ,  A61L27/18 ,  A61L27/58 ,  A61L31/06 ,  A61L31/14 ,  C08G63/06 ,  C08K5/00 ,  C12P7/62 ,  C08L67/04 ,  A61F13/00

    CPC classification number: A61L27/58 ,  A61F2/07 ,  A61F2210/0004 ,  A61K31/715 ,  A61L17/12 ,  A61L27/18 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08G63/06 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C12P7/625 ,  Y10S606/911

    Abstract: Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

    Abstract translation: 由生物相容性聚羟基链烷酸酯形成或包括生物相容性聚羟基链烷酸酯的设备具有受控的降解速率，优选在生理条件下小于一年。 优选的装置包括缝线，缝线紧固件，弯液面修复装置，铆钉，钉，钉，螺钉（包括干涉螺钉），骨板和骨电镀系统，外科手术网，修复贴片，吊索，心血管贴片，矫形针 材料），粘附屏障，支架，引导组织修复/再生装置，关节软骨修复装置，神经导管，肌腱修复装置，房间隔缺损修复装置，心包块，填充剂和填充剂，静脉瓣，骨髓支架，半月板再生 装置，韧带和腱移植物，眼细胞植入物，脊髓融合笼，皮肤替代物，硬脑膜替代物，骨移植物替代物，骨榫，伤口敷料和止血剂。 聚羟基链烷酸酯可以含有由单体的混合物形成的添加剂，或者在其主链中包括侧基或修饰，或者可以化学改性，以改变降解速率。 聚羟基链烷酸酯组合物还在生理条件下的期望时间范围内提供有利的机械性能，生物相容性和降解时间。

    Polyhydroxyalkanoate compositions having controlled degradation rates
    73.
    发明申请
    Polyhydroxyalkanoate compositions having controlled degradation rates 有权
    具有受控降解速率的聚羟基链烷酸酯组合物

    公开(公告)号：US20030236320A1

    公开(公告)日：2003-12-25

    申请号：US10403942

    申请日：2003-03-28

    Applicant: Metabolix, Inc.

    Inventor： David P. Martin ,  Frank Skraly ,  Simon F. Williams

    IPC: C08K003/00

    CPC classification number: C08G63/912 ,  A61K9/1647 ,  A61K47/593 ,  A61K47/6957 ,  A61L15/26 ,  A61L17/10 ,  A61L17/12 ,  A61L24/0042 ,  A61L26/0019 ,  A61L26/009 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L29/06 ,  A61L31/06 ,  A61L31/148 ,  C08G63/06 ,  C08G63/64 ,  C08G63/6852 ,  C08G63/6882 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C12N5/0068 ,  C12N2533/30 ,  C12P7/625 ,  C08L67/04

    Abstract: Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. For example, as demonstrated by the examples, porous polyhydroxyalkanoates can be made using methods that creates pores, voids, or interstitial spacing, such as an emulsion or spray drying technique, or which incorporate leachable or lyophilizable particles within the polymer. Examples describe poly(4HB) compositions including foams, coatings, meshes, and microparticles. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physioogical conditions. These polyhydroxyalkanoate materials provide a wider range of polyhydroxyalkanoate degradation rates than are currently available. Methods for processing these materials, particularly for therapeutic, prophylactic or diagnostic applications, or into devices which can be implanted or injected, are also described.

    Abstract translation: 已经开发了具有受控降解速率的生物相容性聚羟基链烷酸酯组合物。 在一个实施方案中，聚羟基链烷酸酯含有改变降解速率的添加剂。 在另一个实施方案中，聚羟基链烷酸酯由单体的混合物形成或包括侧链基团或其主链中的修饰以改变其降解速率。 在另一个实施方案中，聚羟基链烷酸酯被化学改性。 用于制造增加孔隙率或暴露表面积的装置的方法可用于改变降解性。 例如，如通过实施例所证明的，多孔聚羟基链烷酸酯可以使用产生孔，空隙或间隙的方法，例如乳液或喷雾干燥技术，或者在聚合物内含有可浸出或可冷冻干燥的颗粒。 实例描述了包括泡沫，涂层，网格和微粒的聚（4HB）组合物。 如实施例所示，这些聚羟基链烷酸酯组合物具有非常有利的机械性能，并且在生理条件下在期望的时间范围内是生物相容的和降解的。 这些聚羟基链烷酸酯材料提供比目前可获得的更广泛的聚羟基链烷酸酯降解速率。 还描述了用于处理这些材料的方法，特别是用于治疗，预防或诊断应用，或可植入或注射的装置。

    Method for production of expansible macromolecular material and porous macromolecular membrane
    74.
    发明授权
    Method for production of expansible macromolecular material and porous macromolecular membrane 失效
    生产可膨胀大分子材料和多孔高分子膜的方法

    公开(公告)号：US4753761A

    公开(公告)日：1988-06-28

    申请号：US102853

    申请日：1987-09-30

    Applicant: Makoto Suzuki

    Inventor： Makoto Suzuki

    IPC: A61F2/08 ,  A61F2/68 ,  B25J9/00 ,  B25J9/10 ,  C08J9/28 ,  B05B3/00 ,  B29C35/02

    CPC classification number: C08J9/28 ,  A61F2/08 ,  A61F2/68 ,  B25J9/0012 ,  B25J9/1095 ,  A61F2002/0894 ,  C08J2201/0482 ,  C08J2201/0484 ,  C08J2201/0502

    Abstract: An expansible macromolecular material is produced by a method which comprises mixing an aqueous polyvinyl alcohol solution, an acidic aqueous macromolecular electrolyte solution, and a basic aqueous macromolecular electrolyte solution thereby preparing a composite polymer and subjecting this composite polymer to at least one cycle of alternate freezing and defrosting treatments. A macromolecular membrane constituted of said expansible macromolecular material and containing numerous through holes is obtained by mixing, freezing, and defrosting the aforementioned three mixed aqueous solutions under specific conditions.

    Abstract translation: 通过包括将聚乙烯醇水溶液，酸性高分子电解质水溶液和碱性高分子电解质水溶液混合从而制备复合聚合物并使该复合聚合物经受至少一个交替冷冻循环的方法制备可膨胀的高分子材料 和除霜治疗。 通过在特定条件下混合，冷冻和除霜上述三种混合水溶液，获得由所述可膨胀大分子材料构成并含有许多通孔的高分子膜。

    METHOD OF AEROGEL SYNTHESIS
    76.
    发明公开
    METHOD OF AEROGEL SYNTHESIS 审中-公开
    VERFAHREN ZUR AEROGELSYNTHESE

    公开(公告)号：EP2999736A4

    公开(公告)日：2017-02-22

    申请号：EP14801072

    申请日：2014-02-10

    Applicant: NEXOLVE CORP

    Inventor： RODMAN DAVID L ,  POE GARRETT D ,  FARMER BRANDON S ,  SMITH JOSEPH C

    IPC: C08G73/10 ,  C08J9/28

    CPC classification number: C08J9/286 ,  C08J9/28 ,  C08J2201/0482 ,  C08J2201/0502 ,  C08J2201/0543 ,  C08J2205/026 ,  C08J2379/08

    Abstract: The present disclosure provides a method for producing an aerogel, the method comprising reacting at least one acid monomer with at least one diamino monomer in a first solvent under conditions appropriate to form a polyimide polymer; conducting a solvent exchange wherein the first solvent is exchanged for a second solvent, said second solvent having a freezing point, wherein said solvent exchange further comprises (1) submersing the polyimide polymer in the second solvent in a pressure vessel and (2) creating a high pressure environment inside the pressure vessel for a first period of time; cooling the polyimide polymer to a first temperature below the freezing point of the second solvent; and subjecting cooled polyimide polymer to a first vacuum for a second period of time at a second temperature.

    Abstract translation: 本公开提供了一种制备气凝胶的方法，所述方法包括在适合形成聚酰亚胺聚合物的条件下使至少一种酸单体与至少一种二氨基单体在第一溶剂中反应; 进行溶剂交换，其中所述第一溶剂交换为第二溶剂，所述第二溶剂具有凝固点，其中所述溶剂交换进一步包括（1）将聚酰亚胺聚合物浸入第二溶剂中的压力容器中，和（2）形成 压力容器内的高压环境第一段时间; 将聚酰亚胺聚合物冷却至低于第二溶剂凝固点的第一温度; 以及在第二温度下使冷却的聚酰亚胺聚合物经受第一次真空第二段时间。

    Polyhydroxyalkanoate compositions having controlled degradation rates
    80.
    发明公开
    Polyhydroxyalkanoate compositions having controlled degradation rates 有权
    具有可控降解速率的聚羟基链烷酸酯组合物

    公开(公告)号：EP2196484A1

    公开(公告)日：2010-06-16

    申请号：EP10075046.2

    申请日：1998-12-22

    Applicant: Metalbolix Inc.

    Inventor： Martin, David P ,  Skraly, Frank A ,  Williams, Simon F

    IPC: C08G63/06 ,  C08G63/91 ,  C08K3/00 ,  C08K5/00 ,  C08J9/26 ,  C08J9/28 ,  C08L67/04 ,  C12P7/62 ,  A61K47/34 ,  A61L17/00 ,  A61L27/00 ,  A61L31/00

    CPC classification number: A61L31/06 ,  A61K9/1647 ,  A61K9/204 ,  A61K47/34 ,  A61K47/593 ,  A61L15/26 ,  A61L17/12 ,  A61L24/0042 ,  A61L26/0019 ,  A61L26/009 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L29/06 ,  A61L31/148 ,  C08G63/06 ,  C08G63/60 ,  C08G63/64 ,  C08G63/664 ,  C08G63/6852 ,  C08G63/6882 ,  C08J9/26 ,  C08J2201/044 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C08L101/00 ,  C12P7/625 ,  C08L2666/02

    Abstract: The present application provides a biocompatible medical implant comprising poly(4-hydroxybutyrate) homopolymer. Optionally, the implant is sterile. The implant may, for example, be selected from guided tissue regeneration devices, tissue engineering devices, tissue engineering scaffolds, foams, coatings, meshes, microparticles, resorbable wound closure materials such as suturing and stapling materials, controlled release devices, drug delivery devices, cell encapsulation devices, targeted delivery devices, devices with biocompatible coatings, orthopedic devices, prosthetics, bone cements (including adhesives and/or structural fillers), diagnostic devices, rods, bone screws, pins, surgical sutures, stents, patches (such as hernial patches and pericardial patches), devices with vascular applications, and tubes suitable for the passage of bodily fluids. The invention also provides a method for preparing a biocompatible polyhydroxyalkanoate that has a controlled degradation rate of less than one year under physiological conditions, and optionally processing thus prepared polyhydroxyalkanoate into a medical device. The biocompatible polyhydroxyalkanoate used in the method may, for example, be produced by a process selected from the group consisting of fermentation, enzymatic synthesis, chemical synthesis, melt processing, reactive blending, and recombinant techniques. The biocompatible polyhydroxyalkanoate used in the method may, for example, be derived by fermentation (a) using a co-feed, and/or (b) by a fermentation process that uses transgenic bacteria.

    Abstract translation: 本申请提供了包含聚（4-羟基丁酸酯）均聚物的生物相容性医学植入物。 可选地，植入物是无菌的。 植入物可以例如选自引导的组织再生装置，组织工程装置，组织工程支架，泡沫，涂层，网状物，微粒，可再吸收的伤口闭合材料例如缝合和缝合材料，控释装置，药物输送装置， 细胞封装装置，靶向输送装置，具有生物相容性涂层的装置，矫形装置，假体，骨接合剂（包括粘合剂和/或结构填充物），诊断装置，棒，骨螺钉，针，外科缝合线，支架，贴片 贴片和心包贴片），具有血管应用的装置和适于体液通过的管。 本发明还提供了一种用于制备在生理条件下具有小于一年的受控降解速率的生物相容性聚羟基链烷酸酯的方法，并且任选地将如此制备的聚羟基链烷酸酯加工成医疗装置。 用于该方法中的生物相容性聚羟基链烷酸酯可以例如通过选自发酵，酶促合成，化学合成，熔融加工，反应性共混和重组技术的方法生产。 用于该方法中的生物相容性聚羟基链烷酸酯可以例如通过发酵（a）使用共同进料，和/或（b）通过使用转基因细菌的发酵过程来获得。

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