公开(公告)号：US20180356342A1

公开(公告)日：2018-12-13

申请号：US16060720

申请日：2016-12-05

Applicant: BAE SYSTEMS plc

Inventor： LESLIE CHARLES LAYCOCK

IPC: G01N21/64 ,  G01K11/20 ,  G01L11/02 ,  G02B26/06

CPC classification number: G01N21/643 ,  G01K11/20 ,  G01L11/02 ,  G01N21/63 ,  G01N21/6489 ,  G01N2021/1793 ,  G01N2201/06193 ,  G01S7/4802 ,  G01S7/481 ,  G01S7/4811 ,  G01S7/497 ,  G01S17/74 ,  G01S17/95 ,  G02B5/126 ,  G02B26/06 ,  Y02A90/19

Abstract: A system for remotely sensing light from within a monitored environment containing one or more retro-reflective optical elements. The system includes an illuminator including a light source and a reflector unit comprising a deformable mirror arranged to receive light from the light source and to reflect the received light. This outputs illumination light from the illuminator for illuminating the optical element(s) within the monitored environment. A detector is arranged to receive light returned by the one or more retro-reflective optical elements in response to the illumination light. The detector determines a wavefront of the returned light and detects a property of the monitored environment according to the returned light. The reflector unit is arranged to deform the deformable mirror according to the determined wavefront such that light from the light source is reflected by the deformable mirror so deformed to output illumination light with a modified wavefront.

公开(公告)号：US20180120228A1

公开(公告)日：2018-05-03

申请号：US15620945

申请日：2017-06-13

Applicant: President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc.

Inventor： Catherine Racowsky ,  Manqi Deng ,  Daniel Needleman

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2201/06193

Abstract: The invention provides novel non-invasive in vitro methods for assessing the metabolic condition of oocytes and/or embryos with fluorescence lifetime imaging microscope, that can be used, for example, in assessment of oocytes and embryos in assisted reproductive technologies.

公开(公告)号：US09921155B2

公开(公告)日：2018-03-20

申请号：US14553113

申请日：2014-11-25

Applicant: BAKER HUGHES INCORPORATED

Inventor： Mary Jane Felipe ,  Corina Sandu ,  David N. Fulmer ,  Bing Bing Guo

IPC: G01N21/64 ,  C02F5/10

CPC classification number: G01N21/64 ,  C02F5/10 ,  C02F2103/023 ,  C02F2103/08 ,  C02F2303/08 ,  C02F2303/22 ,  G01N33/18 ,  G01N33/1826 ,  G01N2201/06193

Abstract: Water-soluble polymers may be added to an aqueous system to inhibit or decrease scale deposition within the aqueous system. In a non-limiting embodiment, the water-soluble polymer(s) may be or include polymaleates, polyacrylates, copolymers thereof, and combinations thereof. The treated aqueous system may include a decreased amount of scale deposition as compared to an otherwise identical aqueous system absent the water-soluble polymer(s).

公开(公告)号：US20180029085A1

公开(公告)日：2018-02-01

申请号：US15708743

申请日：2017-09-19

Applicant: Timothy L. JUSTICE ,  JOHAN CALCOEN ,  DIRK Adams ,  GERALD R. RICHERT

Inventor： Timothy L. JUSTICE ,  JOHAN CALCOEN ,  DIRK Adams ,  GERALD R. RICHERT

IPC: B07C5/342 ,  G01N21/89 ,  G01N21/88

CPC classification number: B07C5/342 ,  B07C5/34 ,  B07C5/3422 ,  B07C5/3425 ,  B07C2501/0018 ,  B07C2501/0081 ,  G01N21/85 ,  G01N21/8806 ,  G01N21/89 ,  G01N2201/06113 ,  G01N2201/06193 ,  G01N2201/062 ,  G01N2201/0636

Abstract: A method and apparatus for sorting objects is described, and which provides high-speed image data acquisition to fuse multiple data streams in real-time, while avoiding destructive interference when individual sensors or detectors are utilized in providing data regarding internal and external features and characteristics and qualities of products being inspected.

公开(公告)号：US09063007B2

公开(公告)日：2015-06-23

申请号：US12938224

申请日：2010-11-02

Applicant: Claudia B. Jaffe ,  Steven M. Jaffe ,  Michieal L. Jones

Inventor： Claudia B. Jaffe ,  Steven M. Jaffe ,  Michieal L. Jones

IPC: G01J3/10 ,  G01N21/25 ,  G01N21/64 ,  G01N21/47 ,  G01N21/51 ,  G01N21/53

CPC classification number: G01J3/10 ,  G01N21/253 ,  G01N21/255 ,  G01N21/4788 ,  G01N21/51 ,  G01N21/53 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6469 ,  G01N2021/6484 ,  G01N2201/06193

Abstract: The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.

Abstract translation: 本发明涉及用于用存在于检测体积中的分子照射一种或多种所选波长的光并将荧光，吸光度，透射率，散射引导到一个或多个检测器上的光源。 与光的分子相互作用允许使用物理或化学标签（最常见的荧光和发色团标记）在反应中鉴定和定量参与的化学部分。 本发明还可以使用光源单独地并且同时用一个或多个选择的波长的光照射多个毛细管或其它流动约束结构，并且分别并且同时检测在毛细管或其它流动限制结构内产生的荧光。 在各种实施方案中，流动限制结构可以允许分子的分离或运输，并且包括毛细管，微孔和毫里流系统。 毛细血管用于分离用适当荧光或发色团组化学标记的分子。

公开(公告)号：US08988679B2

公开(公告)日：2015-03-24

申请号：US12596089

申请日：2008-04-18

Applicant: Michael J. Natan

Inventor： Michael J. Natan

IPC: G01J3/44 ,  G01N33/566 ,  G01N21/65 ,  B82Y30/00 ,  C40B70/00 ,  B82Y20/00

CPC classification number: C40B70/00 ,  B01J2219/00572 ,  B01J2219/00576 ,  B01J2219/00722 ,  B01J2219/00725 ,  B82Y20/00 ,  B82Y30/00 ,  G01N21/658 ,  G01N2201/06193 ,  Y10S977/773

Abstract: A method of producing a surface enhanced Raman scattering spectrum which is useful for certain types of assays, in particular proximity assays. The method includes providing two SERS-active nanoparticles. The first SERS-active nanoparticle will absorb a photon at a first wavelength and emit a Raman-shifted photon at a second wavelength. The second SERS-active nanoparticle will absorb a photon at the second wavelength and emit a Raman-shifted photon at a third wavelength. Accordingly, when the first and second SERS-active nanoparticles are proximate to one another and the first SERS-active nanoparticle is illuminated at the first wavelength a Raman-shifted photon at the second wavelength may be emitted. This photon can be absorbed by the second SERS-active nanoparticle causing detectable emission of a second Raman-shifted photon at the third wavelength. Various assays may be designed based upon the above. Proximity assays using two SERS-active nanoparticles will have advantageous background signal characteristics.

Abstract translation: 一种产生表面增强拉曼散射光谱的方法，其可用于某些类型的测定，特别是邻近测定。 该方法包括提供两种SERS活性纳米粒子。 第一SERS活性纳米颗粒将吸收第一波长的光子并且在第二波长处发射拉曼移动的光子。 第二SERS活性纳米颗粒将吸收第二波长的光子并在第三波长处发射拉曼光子。 因此，当第一和第二SERS活性纳米颗粒彼此靠近并且第一SERS活性纳米颗粒在第一波长被照射时，可以发射第二波长的拉曼移动的光子。 该光子可被第二SERS活性纳米粒子吸收，导致在第三波长处的第二拉曼移位光子的可检测发射。 可以基于上述设计各种测定。 使用两种SERS活性纳米颗粒的接近测定将具有有利的背景信号特征。

公开(公告)号：US08559006B2

公开(公告)日：2013-10-15

申请号：US13121467

申请日：2009-10-01

Applicant: Stephen John Penney ,  John E. A. Shaw ,  Paul J. Taylor ,  Steven Ian Bennett

Inventor： Stephen John Penney ,  John E. A. Shaw ,  Paul J. Taylor ,  Steven Ian Bennett

IPC: G01N21/00 ,  G01J1/42

CPC classification number: G01N21/53 ,  F21K9/64 ,  F21V7/06 ,  F21V9/30 ,  F21Y2115/10 ,  G01J1/0214 ,  G01J1/0422 ,  G01J1/08 ,  G01N15/0211 ,  G01N2021/3181 ,  G01N2021/4733 ,  G01N2201/06193 ,  G01N2201/0625 ,  G01N2201/0696 ,  G08B17/107 ,  G08B17/113 ,  G08B17/117

Abstract: A particulate detector (10) comprises a radiation source (12) arranged to emit radiation in at least first and second predetermined wavebands towards a sampling region (18) suspected of containing particulates, and a detection element (14), shielded from the radiation source (12), and arranged to detect radiation from the sampling region (18) at least first and second instances. The radiation source (12) is such that the emissions in the wavebands temporarily overlap. The detector is such that, at the instances at which the radiation is detected, the relative contributions from the emissions in each predetermined waveband are distinguishable, thereby allowing characteristics of the particulates to be determined. The radiation source (12) may comprise a light emitting diode (24).

Abstract translation: 微粒检测器（10）包括辐射源（12），辐射源（12）被布置成在至少第一和第二预定波段中向被怀疑含有微粒的采样区域（18）发射辐射;以及检测元件（14），其与辐射源 （12），并且被布置成在至少第一和第二实例中检测来自采样区域（18）的辐射。 辐射源（12）使得波段中的发射暂时重叠。 检测器使得在检测到辐射的情况下，来自每个预定波段中的发射的相对贡献是可区分的，从而允许确定微粒的特性。 辐射源（12）可以包括发光二极管（24）。

公开(公告)号：US20130161851A1

公开(公告)日：2013-06-27

申请号：US13716429

申请日：2012-12-17

Applicant: Pilkington Group Limited

Inventor： Michael R. Ehrick ,  Robert R. Frutig

IPC: C03C17/00

CPC classification number: C03C17/001 ,  B29C45/842 ,  C03C27/10 ,  G01N21/958 ,  G01N2201/06193

Abstract: An apparatus which accurately detects breakage of a tempered glass panel in an encapsulation die during a glass encapsulation process and rapidly reacts to the detection of such breakage to interrupt the encapsulation process, thus minimizing damage to the encapsulation die, and by so doing, reducing process downtime. A method of utilizing the apparatus is also a part of the invention.

Abstract translation: 一种在玻璃封装过程中精确检测密封模具中的钢化玻璃面板断裂的装置，并且迅速地对这种断裂的检测作出反应，以中断封装工艺，从而最小化对封装模具的损害，并且通过这样做，减少了工艺 停机时间 利用该装置的方法也是本发明的一部分。

公开(公告)号：US08364217B2

公开(公告)日：2013-01-29

申请号：US11811083

申请日：2007-06-08

Applicant: Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

Inventor： Ralph Ballerstadt ,  Roger McNichols ,  Ashok Gowda

IPC: A61B5/1455

CPC classification number: A61B5/0066 ,  A61B5/14532 ,  A61B5/1459 ,  G01N21/4795 ,  G01N21/6428 ,  G01N2021/1787 ,  G01N2201/06193 ,  Y10S436/805 ,  Y10T436/144444

Abstract: There are many inventions described and illustrated herein. In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid (for example, a fluid sample) or matrix. The analyte may be glucose or other chemical of interest. The fluid or matrix may be, for example, the fluid or matrix in the body of an animal (for example, human), or any other suitable fluid or matrix in which it is desired to know the concentration of an analyte. In one embodiment, the invention is a system and/or device that includes one or more layers having a plurality of analyte-equivalents and mobile or fixed receptor molecules with specific binding sites for the analyte-equivalents and analytes under analysis (for example, glucose). The receptor molecules, when exposed to or in the presence of analyte (that resides, for example, in a fluid in an animal), bind with the analyte (or vice versa). As such, some or all (or substantially all) of the receptor molecules within a given layer may bind with the analyte, which results in a change in the optical properties of one or more of the layers. These layer(s) may be examined or interrogated, via optical techniques, whereby the optical response of the layers and/or, in particular, the substance within the layer(s), may be measured, evaluated and/or analyzed.

Abstract translation: 这里描述和说明了许多发明。 一方面，本发明是用于感测流体（例如，流体样品）或基质中的分析物的浓度的系统，装置和方法。 分析物可以是葡萄糖或其他感兴趣的化学品。 流体或基质可以是例如动物（例如人）体内的流体或基质，或其中希望了解分析物浓度的任何其它合适的流体或基质。 在一个实施方案中，本发明是一种系统和/或装置，其包括具有多个分析物等价物和具有分析物等同物和分析物分析物的特异性结合位点的可移动或固定受体分子的一个或多个层（例如葡萄糖 ）。 受体分子当被分析物（例如在动物中存在的流体中）暴露或存在时，与分析物结合（反之亦然）。 因此，给定层内的受体分子中的一些或全部（或基本上全部）受体分子可与分析物结合，这导致一个或多个层的光学性质的变化。 可以通过光学技术检查或询问这些层，由此可以测量，评估和/或分析层和/或特别是层内的物质的光学响应。

公开(公告)号：US20100177306A1

公开(公告)日：2010-07-15

申请号：US12596089

申请日：2008-04-18

Applicant: Michael J. Natan

Inventor： Michael J. Natan

IPC: G01J3/44

CPC classification number: C40B70/00 ,  B01J2219/00572 ,  B01J2219/00576 ,  B01J2219/00722 ,  B01J2219/00725 ,  B82Y20/00 ,  B82Y30/00 ,  G01N21/658 ,  G01N2201/06193 ,  Y10S977/773

Abstract: A method of producing a surface enhanced Raman scattering spectrum which is useful for certain types of assays, in particular proximity assays. The method includes providing two SERS-active nanoparticles. The first SERS-active nanoparticle will absorb a photon at a first wavelength and emit a Raman-shifted photon at a second wavelength. The second SERS-active nanoparticle will absorb a photon at the second wavelength and emit a Raman-shifted photon at a third wavelength. Accordingly, when the first and second SERS-active nanoparticles are proximate to one another and the first SERS-active nanoparticle is illuminated at the first wavelength a Raman-shifted photon at the second wavelength may be emitted. This photon can be absorbed by the second SERS-active nanoparticle causing detectable emission of a second Raman-shifted photon at the third wavelength. Various assays may be designed based upon the above. Proximity assays using two SERS-active nanoparticles will have advantageous background signal characteristics.

Abstract translation: 一种产生表面增强拉曼散射光谱的方法，其可用于某些类型的测定，特别是邻近测定。 该方法包括提供两种SERS活性纳米粒子。 第一SERS活性纳米颗粒将吸收第一波长的光子并且在第二波长处发射拉曼移动的光子。 第二SERS活性纳米颗粒将吸收第二波长的光子并在第三波长处发射拉曼光子。 因此，当第一和第二SERS活性纳米颗粒彼此靠近并且第一SERS活性纳米颗粒在第一波长被照射时，可以发射第二波长的拉曼移动的光子。 该光子可被第二SERS活性纳米粒子吸收，导致在第三波长处的第二拉曼移位光子的可检测发射。 可以基于上述设计各种测定。 使用两种SERS活性纳米颗粒的接近测定将具有有利的背景信号特征。