公开(公告)号：US20120302892A1

公开(公告)日：2012-11-29

申请号：US13338920

申请日：2011-12-28

Applicant: Niyom Lue ,  Michael Feld ,  Ishan Barman ,  Narahara Chari Dingari ,  Ramachandra Dasari ,  David Feld ,  Alison Hearn ,  Jonathan Feld

Inventor： Niyom Lue ,  Michael Feld ,  Ishan Barman ,  Narahara Chari Dingari ,  Ramachandra Dasari ,  David Feld ,  Alison Hearn ,  Jonathan Feld

IPC: A61B6/00

CPC classification number: A61B5/0091 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/42 ,  A61B5/4312 ,  G01N21/64 ,  G01N2021/4742 ,  G01N2021/656 ,  G01N2201/0639

Abstract: A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment.

Abstract translation: 用于疾病诊断的组织光谱扫描的多模式探针系统。 该系统可以使用漫反射光谱，荧光光谱和拉曼光谱法检测癌组织，如组织边缘评估。

公开(公告)号：US20080304048A1

公开(公告)日：2008-12-11

申请号：US12095326

申请日：2006-11-28

Applicant: Stig Tormod

Inventor： Stig Tormod

IPC: G01N21/33 ,  G01N21/59

CPC classification number: G01N21/33 ,  G01N21/05 ,  G01N21/274 ,  G01N30/74 ,  G01N2021/0193 ,  G01N2030/746 ,  G01N2201/062 ,  G01N2201/0624 ,  G01N2201/0639

Abstract: The present invention relates to methods and apparatus for detecting and measuring the concentration of a substance in a solution, the substance having an absorption at 300 nm or less. The methods and apparatus have particular utility in detecting and measuring the concentration of proteins and nucleic acids.

Abstract translation: 本发明涉及用于检测和测量溶液中物质浓度的方法和装置，该物质在300nm以下具有吸收。 该方法和装置在检测和测量蛋白质和核酸的浓度方面具有特殊的用途。

公开(公告)号：US07394535B1

公开(公告)日：2008-07-01

申请号：US11726083

申请日：2007-03-20

Applicant: Zhigang Chen ,  Hanyou Chu ,  Shifang Li

Inventor： Zhigang Chen ,  Hanyou Chu ,  Shifang Li

IPC: G01N21/00

CPC classification number: G01N21/9501 ,  B82Y20/00 ,  G01B11/2518 ,  G01N21/94 ,  G01N21/95607 ,  G01N2201/0639 ,  H01L22/12

Abstract: An inspection area on a semiconductor wafer can be examined using a photonic nanojet. The photonic nanojet, an optical intensity pattern induced at a shadow-side surface of a dielectric microsphere, is generated. The inspection area is scanned with the photonic nanojet. A measurement is obtained of the retroreflected light from the dielectric microsphere as the photonic nanojet scans the inspection area. The existence of a structure in the inspection area is determined with the obtained measurement of the retroreflected light.

Abstract translation: 可以使用光子纳米喷嘴来检查半导体晶片上的检查区域。 产生光子纳米喷墨，在电介质微球的阴影侧表面处引起的光强度图案。 用光子纳米喷枪扫描检查区域。 当光子纳米喷墨扫描检查区域时，获得来自电介质微球的回射光的测量。 通过获得的回射光的测量来确定检查区域中的结构的存在。

公开(公告)号：US06842243B2

公开(公告)日：2005-01-11

申请号：US10315142

申请日：2002-12-10

Applicant: Eugene Tokhtuev ,  Christopher Owen ,  Anatoly Skirda ,  Viktor Slobodyan ,  José Goin

Inventor： Eugene Tokhtuev ,  Christopher Owen ,  Anatoly Skirda ,  Viktor Slobodyan ,  José Goin

IPC: G01N21/53 ,  G01N21/00

CPC classification number: G01N21/53 ,  G01N2201/0639

Abstract: A small size turbidity sensor for underwater in-situ measurements in the wide range of turbidity values is disclosed that may be integrated into a housing with other underwater sensors. The turbidity sensor incorporates micro focusing devices and light stop that gives no divergence excitation beam with convergence less than 1.5 degrees and the measuring angle between the optical axis of the incident radiation and mat of the diffused radiation 90 ±2.5 degrees. Another embodiment includes internal and external optical calibrators that allows the sensor to work longer without human intervention.

Abstract translation: 公开了一种用于大范围浊度值的水下原位测量的小尺寸浊度传感器，其可以与其它水下传感器集成到壳体中。 浊度传感器包含微聚焦装置和光停止器，其不产生会聚小于1.5度的发散激发光束，并且入射辐射的光轴与漫射辐射的光束之间的测量角度为90±2.5度。 另一个实施例包括内部和外部光学校准器，其允许传感器在没有人为干预的情况下工作更长时间。

公开(公告)号：US5926271A

公开(公告)日：1999-07-20

申请号：US982256

申请日：1997-12-01

Applicant: Francois Couderc ,  Michel Nertz ,  Georges Nouadje

Inventor： Francois Couderc ,  Michel Nertz ,  Georges Nouadje

IPC: G01N21/63 ,  G01N21/03 ,  G01N21/05 ,  G01N21/64 ,  G01N27/447 ,  G01N30/74 ,  G01J3/30

CPC classification number: G01N21/05 ,  G01N21/6402 ,  G01N21/645 ,  G01N27/44721 ,  G01N30/74 ,  G01N2021/0346 ,  G01N2021/6467 ,  G01N2021/6478 ,  G01N2021/6482 ,  G01N2201/0639

Abstract: A laser-induced fluorescence detector comprises a laser beam emitting device, a dichroic mirror to deviate the laser light orthogonally, a lens with a small numerical aperture, a ball lens, a unique cell within a capillary, the cell receiving a solute containing at least one unknown fluorescent substance at the laser wavelength, the same device collecting the fluorescence emitted by the fluorescent substance, with optical filters, a photomultiplier tube, and a computer for displaying results of the analysis. The ball lens converts the laser beam into a very small divergent beam, which allows a high irradiated volume in the capillary cell. The cell employs controlled geometric contours to prevent laminar mixing and turbulence during liquid flow, and the collecting device is a high numerical aperture device, for example, a ball lens.

Abstract translation: 激光诱导荧光检测器包括激光束发射装置，正交偏转激光的二向色镜，具有小数值孔径的透镜，球透镜，毛细管内的独特细胞，细胞接收至少含有溶质 在激光波长处的一种未知的荧光物质，与荧光物质发射的荧光相同的装置，光学滤光器，光电倍增管和用于显示分析结果的计算机。 球形透镜将激光束转换成非常小的发散光束，这允许毛细管电池中的高照射体积。 电池采用受控的几何轮廓，以防止液体流动期间的层流混合和湍流，并且收集装置是高数值孔径装置，例如球形透镜。

公开(公告)号：US5037199A

公开(公告)日：1991-08-06

申请号：US314462

申请日：1989-02-22

Applicant: Louis Hlousek

Inventor： Louis Hlousek

IPC: G01N21/03 ,  G01N21/25 ,  G01N30/74 ,  G02B3/00 ,  G02B7/02

CPC classification number: G01N21/255 ,  G02B3/00 ,  G02B7/027 ,  G01N2021/0346 ,  G01N2201/0639

Abstract: There is disclosed herein a cell assembly for use in spectrophotometric analysis or detection of a substance within a small sample volume, such as in a capillary sample cell. The assembly comprises a transparent lens having the shape of a ball, sphere or cylinder, referred to as a "ball lens," and which is placed in direct contact or close proximity to the exterior wall of the capillary cell. This lens and cell are mounted together, any may form a removable cell assembly. The small volume may be contained within the ball lens itself. The ball lens serves to concentrate and direct light into the capillary cell. The arrangement also significantly reduces the sensitivity to alignment of replaceable cells thereby permitting easier mounting and replacement of such cells.

Abstract translation: 本文公开了用于分光光度分析或检测小样品体积内的物质的细胞组件，例如在毛细管样品池中。 组件包括具有称为“球形透镜”的球，球或圆筒形状的透明透镜，其被放置成直接接触或紧邻毛细管电池的外壁。 这个透镜和电池被安装在一起，任何一个可以形成一个可拆卸电池组件。 小体积可以包含在球镜本身内。 球透镜用于将光聚集并引导到毛细管中。 该布置还显着降低了可更换电池对准的灵敏度，从而允许更容易地安装和更换这种电池。

公开(公告)号：US3723747A

公开(公告)日：1973-03-27

申请号：US3723747D

申请日：1971-06-03

Applicant: ELECTRO SIGNAL LAB

Inventor： STEELE D

IPC: G01N21/53 ,  G08B17/107 ,  G01N21/26

CPC classification number: G08B17/107 ,  G01N21/53 ,  G01N2201/0639 ,  G08B17/113

Abstract: A smoke detector with a first cell sensing light scattered from matter to be detected and a second compensating cell has an adjustable plug for varying light from a source to the compensating cell and a diffuser for spreading the adjusted light over the same area of the compensating cell as the area of the first cell exposed to scattered light.

Abstract translation: 具有感测从要检测的物质散发的光的第一单元的烟雾探测器和第二补偿单元具有用于从光源到补偿单元的变化的光的可调节插头和用于将调节的光扩散在补偿单元的相同区域上的扩散器 因为第一个电池的面积暴露于散射光。

公开(公告)号：US09464982B2

公开(公告)日：2016-10-11

申请号：US14642459

申请日：2015-03-09

Applicant: Ecolab USA Inc.

Inventor： Eugene Tokhtuev ,  Christopher J. Owen ,  Anatoly Skirda ,  William M. Christensen

IPC: G01N21/05 ,  G01N21/15 ,  G01N21/64 ,  G02B27/00 ,  B08B3/02 ,  B08B5/02

CPC classification number: G01N21/15 ,  B08B3/02 ,  B08B5/02 ,  G01N21/05 ,  G01N21/645 ,  G01N2021/151 ,  G01N2021/6478 ,  G01N2021/6482 ,  G01N2201/0639 ,  G02B27/0006

Abstract: An optical sensor may include a sensor head that has an optical window for directing light into a flow of fluid and/or receiving optical energy from the fluid. The optical sensor may also include a flow chamber that includes a housing defining a cavity into which the sensor head can be inserted. In some examples, the flow chamber includes an inlet port defining a flow nozzle that is configured to direct fluid entering the flow chamber against the optical window of the sensor head. In operation, the force of the incoming fluid impacting the optical window may prevent fouling materials from accumulating on the optical window.

公开(公告)号：US09304280B2

公开(公告)日：2016-04-05

申请号：US14207852

申请日：2014-03-13

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Mayurachat Ning Gulari ,  Mostafa Ghannad-Rezaie ,  Anurag Tripathi ,  Nikolaos Chronis

IPC: G02B7/02 ,  G02B21/33 ,  G02B3/00 ,  G02B21/36 ,  G01N15/14 ,  G01N21/64

CPC classification number: G02B7/027 ,  G01N15/1436 ,  G01N21/6458 ,  G01N2201/0639 ,  G02B3/0056 ,  G02B21/365

Abstract: A compact lens system for imaging a sample comprising a substrate having a well formed therein. Index matching material is disposed in the well and a lens member is further disposed in the well in optical contact with the index matching material disposed in the well. A spacer member extends from at least one of the substrate and the lower transparent member to define a spacing from a focal point of the lens member, wherein the lens member and index matching material cooperate to image a sample disposed below the lower transparent member.

Abstract translation: 一种用于成像样品的紧凑透镜系统，包括其中良好地形成的衬底。 索引匹配材料设置在井中，并且透镜构件进一步设置在孔中，与设置在井中的折射率匹配材料光学接触。 间隔构件从衬底和下透明构件中的至少一个延伸以限定与透镜构件的焦点的间隔，其中透镜构件和折射率匹配材料协作以对设置在下透明构件下方的样品进行成像。

公开(公告)号：US20140268319A1

公开(公告)日：2014-09-18

申请号：US14207852

申请日：2014-03-13

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Mayurachat Ning GULARI ,  Mostafa GHANNAD-REZAIE ,  Anurag TRIPATHI ,  Nikolaos CHRONIS

IPC: G02B21/00

CPC classification number: G02B7/027 ,  G01N15/1436 ,  G01N21/6458 ,  G01N2201/0639 ,  G02B3/0056 ,  G02B21/365

Abstract: A compact lens system for imaging a sample comprising a substrate having a well formed therein. Index matching material is disposed in the well and a lens member is further disposed in the well in optical contact with the index matching material disposed in the well. A spacer member extends from at least one of the substrate and the lower transparent member to define a spacing from a focal point of the lens member, wherein the lens member and index matching material cooperate to image a sample disposed below the lower transparent member.

Abstract translation: 一种用于成像样品的紧凑透镜系统，包括其中良好地形成的衬底。 索引匹配材料设置在井中，并且透镜构件进一步设置在孔中，与设置在井中的折射率匹配材料光学接触。 间隔构件从衬底和下透明构件中的至少一个延伸以限定与透镜构件的焦点的间隔，其中透镜构件和折射率匹配材料协作以对设置在下透明构件下方的样品进行成像。