Abstract:
A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment.
Abstract:
The present invention relates to methods and apparatus for detecting and measuring the concentration of a substance in a solution, the substance having an absorption at 300 nm or less. The methods and apparatus have particular utility in detecting and measuring the concentration of proteins and nucleic acids.
Abstract:
An inspection area on a semiconductor wafer can be examined using a photonic nanojet. The photonic nanojet, an optical intensity pattern induced at a shadow-side surface of a dielectric microsphere, is generated. The inspection area is scanned with the photonic nanojet. A measurement is obtained of the retroreflected light from the dielectric microsphere as the photonic nanojet scans the inspection area. The existence of a structure in the inspection area is determined with the obtained measurement of the retroreflected light.
Abstract:
A small size turbidity sensor for underwater in-situ measurements in the wide range of turbidity values is disclosed that may be integrated into a housing with other underwater sensors. The turbidity sensor incorporates micro focusing devices and light stop that gives no divergence excitation beam with convergence less than 1.5 degrees and the measuring angle between the optical axis of the incident radiation and mat of the diffused radiation 90 ±2.5 degrees. Another embodiment includes internal and external optical calibrators that allows the sensor to work longer without human intervention.
Abstract:
A laser-induced fluorescence detector comprises a laser beam emitting device, a dichroic mirror to deviate the laser light orthogonally, a lens with a small numerical aperture, a ball lens, a unique cell within a capillary, the cell receiving a solute containing at least one unknown fluorescent substance at the laser wavelength, the same device collecting the fluorescence emitted by the fluorescent substance, with optical filters, a photomultiplier tube, and a computer for displaying results of the analysis. The ball lens converts the laser beam into a very small divergent beam, which allows a high irradiated volume in the capillary cell. The cell employs controlled geometric contours to prevent laminar mixing and turbulence during liquid flow, and the collecting device is a high numerical aperture device, for example, a ball lens.
Abstract:
There is disclosed herein a cell assembly for use in spectrophotometric analysis or detection of a substance within a small sample volume, such as in a capillary sample cell. The assembly comprises a transparent lens having the shape of a ball, sphere or cylinder, referred to as a "ball lens," and which is placed in direct contact or close proximity to the exterior wall of the capillary cell. This lens and cell are mounted together, any may form a removable cell assembly. The small volume may be contained within the ball lens itself. The ball lens serves to concentrate and direct light into the capillary cell. The arrangement also significantly reduces the sensitivity to alignment of replaceable cells thereby permitting easier mounting and replacement of such cells.
Abstract:
A smoke detector with a first cell sensing light scattered from matter to be detected and a second compensating cell has an adjustable plug for varying light from a source to the compensating cell and a diffuser for spreading the adjusted light over the same area of the compensating cell as the area of the first cell exposed to scattered light.
Abstract:
An optical sensor may include a sensor head that has an optical window for directing light into a flow of fluid and/or receiving optical energy from the fluid. The optical sensor may also include a flow chamber that includes a housing defining a cavity into which the sensor head can be inserted. In some examples, the flow chamber includes an inlet port defining a flow nozzle that is configured to direct fluid entering the flow chamber against the optical window of the sensor head. In operation, the force of the incoming fluid impacting the optical window may prevent fouling materials from accumulating on the optical window.
Abstract:
A compact lens system for imaging a sample comprising a substrate having a well formed therein. Index matching material is disposed in the well and a lens member is further disposed in the well in optical contact with the index matching material disposed in the well. A spacer member extends from at least one of the substrate and the lower transparent member to define a spacing from a focal point of the lens member, wherein the lens member and index matching material cooperate to image a sample disposed below the lower transparent member.
Abstract:
A compact lens system for imaging a sample comprising a substrate having a well formed therein. Index matching material is disposed in the well and a lens member is further disposed in the well in optical contact with the index matching material disposed in the well. A spacer member extends from at least one of the substrate and the lower transparent member to define a spacing from a focal point of the lens member, wherein the lens member and index matching material cooperate to image a sample disposed below the lower transparent member.