公开(公告)号：US20170248574A1

公开(公告)日：2017-08-31

申请号：US15594978

申请日：2017-05-15

Applicant: CELLOMICS, INC.

Inventor： Richik Niloy Ghosh ,  Dirk John VandenBerg, III ,  Keith Rao Heffley ,  Monica Jo Tomaszewski ,  Jeffrey Robert Haskins

IPC: G01N33/487 ,  G01N21/31 ,  G02B5/02 ,  G02B21/16 ,  G02B21/36 ,  G01N21/64 ,  G01N35/00

CPC classification number: G01N33/487 ,  F21Y2105/10 ,  F21Y2105/14 ,  G01N21/253 ,  G01N21/255 ,  G01N21/31 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6458 ,  G01N21/6486 ,  G01N35/00029 ,  G01N2021/6439 ,  G01N2021/6491 ,  G01N2035/00158 ,  G01N2201/0627 ,  G01N2201/0631 ,  G01N2201/064 ,  G02B5/0278 ,  G02B5/0294 ,  G02B21/16 ,  G02B21/367

Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.

公开(公告)号：US09726604B2

公开(公告)日：2017-08-08

申请号：US14924815

申请日：2015-10-28

Applicant: Hiroyoshi Sekiguchi ,  Shintaroh Kida ,  Kohji Oshikiri ,  Izumi Itoh

Inventor： Hiroyoshi Sekiguchi ,  Shintaroh Kida ,  Kohji Oshikiri ,  Izumi Itoh

IPC: G01N21/55 ,  B60Q1/08 ,  B60S1/08 ,  B60R16/023 ,  G01N21/552 ,  G01N21/94 ,  G01N21/958

CPC classification number: G01N21/55 ,  B60Q1/085 ,  B60R16/023 ,  B60S1/0844 ,  G01N21/552 ,  G01N21/94 ,  G01N2021/945 ,  G01N2021/9586 ,  G01N2201/061 ,  G01N2201/063 ,  G01N2201/064

Abstract: An adhering detection apparatus includes a light source to emit probe light to a light translucent object during an emission period, and to stop an emission of the probe light to the light translucent object during a non-emission period, a light receiver to receive light coming from the light translucent object during the emission period and the non-emission period of the light source, and an adhering detection processor to perform an adhering detection processing for detecting a substance adhering to the light translucent object based on light quantity of the light coming from the light translucent object and received by the light receiver, and to output a detection result of the adhering detection processing. The adhering detection processor selectively performs one or more processes depending on the light quantity of the light received by the light receiver during the non-emission period of the light source.

公开(公告)号：US09638624B2

公开(公告)日：2017-05-02

申请号：US14434171

申请日：2013-10-07

Applicant: EMPA EIDGENÖSSISCHE MATERIALPRÜFUNGS- UND FORSCHUNGSANSTALT

Inventor： Markus Mangold ,  Bela Tuzson ,  Lukas Emmenegger

IPC: G01N21/03 ,  G01N21/3504

CPC classification number: G01N21/031 ,  G01N21/3504 ,  G01N2201/064

Abstract: A Multi-pass optical cell (1) with an internal space (11) for laser spectroscopy is described, which is able to reduce or eliminate interference fringes appearing by performing laser absorption spectroscopy in the multi-pass optical cells (1) leading to improved absorption spectra. This is achieved by using a multi-pass optical cell (1) comprising an absorption mask (3) which is permanently or removable mountable in the internal space (11) in a rotatably fixed manner, where in a mask wall (30) a plurality of m apertures (300) is formed, in which the position of each aperture (300) is adapted to a predefinable propagation path of a main optical beam and/or the resulting reflection spot pattern (211) defined by the geometry of the multi-pass optical cell (1) and the used angle of incidence of an initial beam (20), so that each aperture (300) is traversable by the main optical beam from a first side (301) to a second side (302).

公开(公告)号：US20170115209A1

公开(公告)日：2017-04-27

申请号：US15292414

申请日：2016-10-13

Applicant: Nix Sensor Ltd.

Inventor： Matthew Sheridan

IPC: G01N21/25 ,  G01N21/01 ,  G01N33/08

CPC classification number: G01N21/251 ,  G01J3/50 ,  G01J3/501 ,  G01N21/01 ,  G01N21/03 ,  G01N21/255 ,  G01N33/08 ,  G01N2021/4757 ,  G01N2021/4769 ,  G01N2201/0221 ,  G01N2201/062 ,  G01N2201/064 ,  G01N2201/08

Abstract: The present concept is a method of preparing an egg to determine the color of the egg using an egg yolk cover. The egg yolk cover is dome-shaped with a base edge and inspection area. The egg yolk cover eliminates ambient light from impinging on the egg yolk and is used in combination with a light sensor to determine the color of egg yolks. The light sensor includes a single flat printed circuit board with a top and bottom side which includes at least one LED light and one color sensor, at least one light pipe receiving light from the LED and transmitting it onto a substrate at an angle theta and a tube frame including an optical tube for receiving light reflections from the substrate. The light pipes and the tube frame are compression fit between the printed circuit board and a lower housing. To determine the color of the egg yolk, the egg is first cracked onto a flat surface. The egg yolk cover is then placed over the egg yolk and the color sensor is placed onto the inspection area to measure the color.

公开(公告)号：US09506870B2

公开(公告)日：2016-11-29

申请号：US13926679

申请日：2013-06-25

Applicant: CANON KABUSHIKI KAISHA

Inventor： Makoto Ogusu

IPC: G01N21/75 ,  G01N21/05 ,  B01L3/00 ,  G01N21/00

CPC classification number: G01N21/75 ,  B01L3/502707 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/168 ,  G01N21/05 ,  G01N2021/056 ,  G01N2201/064 ,  Y10T436/143333

Abstract: The present invention provides a flow-channel device for detecting light emission, which suppresses a noise originating in unnecessary light emission, and can be simply bonded with the use of an organic material. The flow-channel device having a flow channel is structured by the bonding of at least two substrates, wherein at least any one substrate has a first groove which constitutes the flow channel, and a second groove for arranging an adhesive therein which contains an organic material, and a light-shielding layer is provided on an inner wall of the second groove so as to block a light emitted from the second groove from penetrating into the first groove.

Abstract translation: 本发明提供了一种用于检测发光的流路装置，其抑制源自不必要的发光的噪声，并且可以使用有机材料简单地结合。 具有流动通道的流动通道装置通过至少两个基板的结合而构成，其中至少一个基板具有构成流动通道的第一凹槽，以及用于在其中布置粘合剂的第二凹槽，其中包含有机材料 并且在所述第二槽的内壁上设置有遮光层，以阻挡从所述第二凹槽发射的光穿透到所述第一凹槽中。

公开(公告)号：US20160266044A1

公开(公告)日：2016-09-15

申请号：US15031866

申请日：2014-10-15

Applicant: TecSense Gmbh

Inventor： Volker RIBITSCH ,  Johannes KROTTMAIER

IPC: G01N21/77

CPC classification number: G01N21/77 ,  G01J3/0202 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/4406 ,  G01N21/6428 ,  G01N21/643 ,  G01N21/645 ,  G01N21/7703 ,  G01N2021/6419 ,  G01N2021/6432 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2021/7786 ,  G01N2021/7793 ,  G01N2021/7796 ,  G01N2201/064

Abstract: An optochemical sensor comprises a measuring element excitable by the light of an excitation light source and in contact with a medium to be measured, and a measuring arrangement including at least one excitation light source and a detector as well as a hood separating the measuring arrangement from the measuring element, wherein the excitation light source and the detector are fixed to a base plate arranged in parallel with the measuring element, the hood, the excitation light source and the detector are separated from one another by at least a portion of the material thickness of the hood, and light from the excitation light source through an optical waveguide impinges on the measuring element at such an angle that fluorescence light emitted by the measuring element impinges perpendicularly on the detector.

Abstract translation: 光化学传感器包括由激发光源的光可激发并与待测介质接触的测量元件，以及包括至少一个激发光源和检测器的测量装置以及将测量装置与 所述测量元件，其中所述激发光源和所述检测器固定到与所述测量元件平行设置的基板，所述罩，所述激发光源和所述检测器通过所述材料厚度的至少一部分彼此分离 并且来自激发光源的通过光波导的光以这样的角度照射在测量元件上，使得由测量元件发射的荧光垂直照射在检测器上。

公开(公告)号：US20160161410A1

公开(公告)日：2016-06-09

申请号：US15040545

申请日：2016-02-10

Applicant: Howard Hughes Medical Institute

Inventor： Philipp Johannes Keller

IPC: G01N21/64 ,  G02B21/16 ,  G02B27/10 ,  G02B21/00 ,  G02B21/36 ,  G01N33/483 ,  G02B21/06

CPC classification number: G01N21/6486 ,  A61B5/0071 ,  A61B2503/42 ,  G01N21/64 ,  G01N33/4833 ,  G01N2021/1736 ,  G01N2201/06193 ,  G01N2201/064 ,  G02B21/0004 ,  G02B21/0048 ,  G02B21/06 ,  G02B21/16 ,  G02B21/361 ,  G02B21/362 ,  G02B21/367 ,  G02B27/1013

Abstract: A live biological specimen is imaged by generating a plurality of light sheets; directing the plurality of light sheets along an illumination axis through the biological specimen such that the light sheets spatially and temporally overlap within the biological specimen along an image plane, and optically interact with the biological specimen within the image plane; and recording, at each of a plurality of views, images of the fluorescence emitted along a detection axis from the biological specimen due to the optical interaction between the light sheets and the biological specimen. The temporal overlap is within a time shift that is less than a resolution time that corresponds to a spatial resolution limit of the microscope.

Abstract translation: 通过生成多个光片对活体生物样本进行成像; 沿着照明轴线引导多个光片通过生物样本，使得光片沿着图像平面在空间和时间上在生物样本内重叠，并与图像平面内的生物样本光学相互作用; 并且在多个视图的每一个处，由于光片和生物样本之间的光学相互作用，沿着检测轴从生物样本记录荧光的图像。 时间重叠在时间偏移之内，其小于对应于显微镜的空间分辨率极限的分辨率时间。

公开(公告)号：US20160131579A1

公开(公告)日：2016-05-12

申请号：US14924815

申请日：2015-10-28

Applicant: Hiroyoshi SEKIGUCHI ,  Shintaroh KIDA ,  Kohji OSHIKIRI ,  Izumi ITOH

Inventor： Hiroyoshi SEKIGUCHI ,  Shintaroh KIDA ,  Kohji OSHIKIRI ,  Izumi ITOH

IPC: G01N21/55 ,  B60Q1/08 ,  B60S1/08 ,  B60R16/023

CPC classification number: G01N21/55 ,  B60Q1/085 ,  B60R16/023 ,  B60S1/0844 ,  G01N21/552 ,  G01N21/94 ,  G01N2021/945 ,  G01N2021/9586 ,  G01N2201/061 ,  G01N2201/063 ,  G01N2201/064

Abstract: An adhering detection apparatus includes a light source to emit probe light to a light translucent object during an emission period, and to stop an emission of the probe light to the light translucent object during a non-emission period, a light receiver to receive light coming from the light translucent object during the emission period and the non-emission period of the light source, and an adhering detection processor to perform an adhering detection processing for detecting a substance adhering to the light translucent object based on light quantity of the light coming from the light translucent object and received by the light receiver, and to output a detection result of the adhering detection processing. The adhering detection processor selectively performs one or more processes depending on the light quantity of the light received by the light receiver during the non-emission period of the light source.

Abstract translation: 附着检测装置包括在发光期间将探测光发射到光半透明物体的光源，并且在非发光期间停止将探测光发射到光半透明物体;光接收器，用于接收光 在光源的发光期间和非发光期间的光半透明物体，以及附着检测处理器，其基于来自光源的光的光量进行用于检测附着在所述光半透明物体上的物质的附着检测处理 该光半透明物体并由光接收器接收，并输出粘附检测处理的检测结果。 粘附检测处理器根据在光源的非发光时段期间由光接收器接收的光的光量来选择性地执行一个或多个处理。

公开(公告)号：US20160123875A1

公开(公告)日：2016-05-05

申请号：US14893858

申请日：2014-05-30

Applicant: DURAG GMBH

Inventor： -Ing. Sven Cierullies

IPC: G01N21/49

CPC classification number: G01N21/49 ,  G01N15/0211 ,  G01N21/53 ,  G01N2021/4709 ,  G01N2021/473 ,  G01N2021/536 ,  G01N2201/064

Abstract: A device for measuring scattered light from a measurement volume with compensation for background signals, includes a light sensor having separately evaluable light-sensitive elements, a single imaging optical system, wherein the light-sensitive elements are arranged in the image plane and the measurement volume is arranged in the corresponding object plane of the optical system, a light transmitter with a collimated light beam, this light-sensitive element detects scattered light from the measurement volume and background light from the overlapping visual ranges behind the subject plane, and the other light-sensitive element detects no or significantly less scattered light from the measurement volume and background light from the overlapping visual areas behind the object plane, and a diaphragm that restricts the visual ranges of the light-sensitive elements behind the object plane.

Abstract translation: 一种用于测量来自测量体积的散射光的装置，用于补偿背景信号，包括具有单独可评估的感光元件的光传感器，单个成像光学系统，其中光敏元件布置在图像平面中，并且测量体积 被布置在光学系统的相应物体平面中，具有准直光束的光发射器，该感光元件检测来自测量体积的散射光和来自对象平面后面的重叠视觉范围的背景光，另一个光 敏感元件检测来自测量体积和来自物平面后面的重叠视觉区域的背景光的散射光以及限制光敏元件在物平面后面的视觉范围的光阑。

公开(公告)号：US09291551B2

公开(公告)日：2016-03-22

申请号：US14314603

申请日：2014-06-25

Applicant: DAINIPPON SCREEN MFG. CO., LTD.

Inventor： Sanzo Moriwaki ,  Hiroki Fujimoto

IPC: G01N21/25 ,  G01N21/47

CPC classification number: G01N21/255 ,  G01N21/47 ,  G01N2201/064 ,  G01N2201/0668

Abstract: An imaging apparatus for imaging a two-dimensional image of an imaging object comprises a holder which holds a sample container carrying a biological sample as the imaging object on a carrying surface, a light emitting part which emits light toward the carrying surface, an imager which includes a strip-like light receiving part, receives the light incident on the light receiving part and thereby images an image of a strip-like region of the carrying surface, a strip-like light shield which shields a part of light emitted from the illuminator toward the strip-like region, and a mover which integrally and relatively moves the light emitting part, the light receiving part and the light shield with respect to the sample container.

Abstract translation: 用于对成像对象的二维图像进行成像的成像装置包括：保持器，其将携带作为成像对象的生物样本的样本容器保持在承载表面上;发光部件，朝着承载表面发射光;成像器， 包括条状光接收部分，接收入射在光接收部分上的光，从而对承载表面的条状区域的图像进行成像;带状遮光罩，其屏蔽从照射器发出的光的一部分 朝向条状区域，以及使发光部，光接收部和遮光板相对于样本容器一体地移动的动子。