公开(公告)号：US20150001421A1

公开(公告)日：2015-01-01

申请号：US14212496

申请日：2014-03-14

Applicant: KLA-Tencor Corporation

Inventor： Romain Sappey

IPC: G01N21/64 ,  G01N21/88

CPC classification number: G01N21/6489 ,  G01N21/8806 ,  G01N21/9501 ,  G01N2021/6495 ,  G01N2021/8845 ,  G01N2201/06113 ,  G01N2201/0662

Abstract: Defect detection and photoluminescence measurement of a sample directing a beam of oblique-illumination wavelength light onto a portion of the sample, directing a beam of normal-illumination wavelength light for causing one or more photoluminescing defects of the sample to emit photoluminescent light onto a portion of the sample, collecting defect scattered radiation or photoluminescence radiation from the sample, separating the radiation from the sample into a first portion of radiation in the visible spectrum, a second portion of radiation including the normal-illumination wavelength light, and at least a third portion of radiation including the oblique-illumination wavelength light, measuring one or more characteristics of the first portion, the second portion or the third portion of radiation; detecting one or more photoluminescence defects or one or more scattering defects based on the measured one or more characteristics of the first portion, the second portion or the third portion of radiation.

Abstract translation: 样品的缺陷检测和光致发光测量将倾斜照明波长的光束引导到样品的一部分上，引导正常照明波长的光束，以使样品的一个或多个光致发光缺陷发射光致发光光到一部分上 收集来自样品的缺陷散射辐射或光致发光辐射，将来自样品的辐射分离成可见光谱中的辐射的第一部分，包括正常照明波长的光的第二部分辐射，以及至少三分之一 测量包括倾斜照明波长光的辐射部分，测量第一部分，第二部分或第三部分辐射的一个或多个特性; 基于所测量的第一部分，第二部分或第三部分辐射的一个或多个特性来检测一个或多个光致发光缺陷或一个或多个散射缺陷。

公开(公告)号：US08908184B2

公开(公告)日：2014-12-09

申请号：US13305970

申请日：2011-11-29

Applicant: Ralf Bernhard ,  Achim Gahr

Inventor： Ralf Bernhard ,  Achim Gahr

IPC: G01N21/00 ,  G01N21/17 ,  G01N21/85 ,  G01N21/59

CPC classification number: G01N21/8507 ,  G01N21/59 ,  G01N2201/0662

Abstract: An absorption measurement system, flexibly usable over a large measuring range, for measuring at least one property of a medium reflected in its absorption behavior, especially a property such as an absorption coefficient (μ). The absorption measurement system comprises: a measuring chamber filled with the medium in measurement operation, in which radiatable beam paths usable as measuring paths and of different lengths, extend completely through the medium; a transmitting unit, which transmits radiation along the measuring paths through measuring chamber in measurement operation; a measuring and receiving unit, which receives radiation passing through measuring chamber on the measuring paths and measures its radiation intensities dependent on the property of the medium and the lengths of the measuring paths; and a measuring electronics, which determines the property based on the measured radiation intensities and the lengths of measuring paths.

Abstract translation: 一种吸收测量系统，可在大的测量范围内灵活使用，用于测量其吸收行为反映的介质的至少一种性质，特别是吸收系数（μ）等特性。 吸收测量系统包括：在测量操作中填充介质的测量室，其中可用作测量路径和不同长度的可辐射光束路径完全延伸穿过介质; 发射单元，其在测量操作中通过测量室沿着测量路径传输辐射; 测量和接收单元，其接收通过测量路径上的测量室的辐射，并根据介质的性质和测量路径的长度测量其辐射强度; 以及测量电子器件，其基于测量的辐射强度和测量路径的长度来确定特性。

公开(公告)号：US20120140228A1

公开(公告)日：2012-06-07

申请号：US13305970

申请日：2011-11-29

Applicant: Ralf Bernhard ,  Achim Gahr

Inventor： Ralf Bernhard ,  Achim Gahr

IPC: G01N21/59

CPC classification number: G01N21/8507 ,  G01N21/59 ,  G01N2201/0662

Abstract: An absorption measurement system, flexibly usable over a large measuring range, for measuring at least one property of a medium reflected in its absorption behavior, especially a property such as an absorption coefficient (μ). The absorption measurement system comprises: a measuring chamber filled with the medium in measurement operation, in which radiatable beam paths usable as measuring paths and of different lengths, extend completely through the medium; a transmitting unit, which transmits radiation along the measuring paths through measuring chamber in measurement operation; a measuring and receiving unit, which receives radiation passing through measuring chamber on the measuring paths and measures its radiation intensities dependent on the property of the medium and the lengths of the measuring paths; and a measuring electronics, which determines the property based on the measured radiation intensities and the lengths of measuring paths.

Abstract translation: 一种吸收测量系统，可在大的测量范围内灵活使用，用于测量其吸收行为反映的介质的至少一种性质，特别是吸收系数（μ）等特性。 吸收测量系统包括：在测量操作中填充介质的测量室，其中可用作测量路径和不同长度的可辐射光束路径完全延伸穿过介质; 发射单元，其在测量操作中通过测量室沿着测量路径传输辐射; 测量和接收单元，其接收通过测量路径上的测量室的辐射，并根据介质的性质和测量路径的长度测量其辐射强度; 以及测量电子器件，其基于测量的辐射强度和测量路径的长度来确定特性。

公开(公告)号：US20040186364A1

公开(公告)日：2004-09-23

申请号：US10802920

申请日：2004-03-18

Inventor： Kye-jin Jeon ,  Gil-won Yoon ,  In-duk Hwang ,  Sang-joon Han

IPC: A61B005/00

CPC classification number: A61B5/14532 ,  A61B5/0053 ,  A61B5/107 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B2560/0223 ,  G01N21/359 ,  G01N2021/036 ,  G01N2021/3144 ,  G01N2201/0662

Abstract: In an apparatus and method of noninvasively measuring a concentration of a blood component, the method includes (a) varying a thickness of a body part of a subject, measuring absorption spectrums at different thicknesses of the body part, obtaining a first differential absorption spectrum between the absorption spectrums measured at different thicknesses, actually measuring concentrations of the blood component, and establishing a statistical model using the first differential absorption spectrum and the actually measured concentrations; and (b) estimating the concentration of the blood component using a second differential absorption spectrum obtained with respect to the body part based on the statistical model.

Abstract translation: 在非侵入性地测量血液成分浓度的装置和方法中，该方法包括：（a）改变被检体的身体部位的厚度，测量身体部位的不同厚度的吸收光谱，获得第一差异吸收光谱， 在不同厚度下测量的吸收光谱，实际测量血液成分的浓度，并使用第一个差示吸收光谱和实际测量的浓度建立统计模型; 和（b）基于统计模型使用相对于身体部位获得的第二差分吸收光谱估计血液成分的浓度。

公开(公告)号：US4966462A

公开(公告)日：1990-10-30

申请号：US310128

申请日：1989-02-15

Applicant: Vincent J. Novick

Inventor： Vincent J. Novick

IPC: G01F1/66 ,  G01F1/74 ,  G01N15/00 ,  G01N15/06 ,  G01N21/53 ,  G01N21/85

CPC classification number: G01N15/06 ,  G01F1/661 ,  G01F1/74 ,  G01N21/534 ,  G01N2015/0046 ,  G01N21/85 ,  G01N2201/0662

Abstract: A method and apparatus for using the light extinction measurements from two or more light cells positioned along a gasflow chamber in which the gas volumetric rate is known to determine particle number concentration and mass concentration of an aerosol independent of extinction coefficient and to determine estimates for particle size and mass concentrations. The invention is independent of particle size. This invention has application to measurements made during a severe nuclear reactor fuel damage test.

Abstract translation: 一种用于使用沿着气流室定位的两个或更多个光单元的消光测量的方法和装置，其中已知气体体积速率确定独立于消光系数的气溶胶的粒子数浓度和质量浓度，并且确定颗粒的估计值 大小和质量浓度。 本发明独立于粒度。 本发明适用于在严重核反应堆燃料损坏试验期间进行的测量。

公开(公告)号：US11971341B2

公开(公告)日：2024-04-30

申请号：US16196479

申请日：2018-11-20

Applicant: MINITÜB GMBH

Inventor： Georg Wippenbeck ,  Christian Simmet

IPC: B01L3/00 ,  C12Q1/06 ,  G01N15/06 ,  G01N15/10 ,  G01N15/14 ,  G01N15/1404 ,  G01N21/03 ,  G02B21/34 ,  G02B21/16

CPC classification number: G01N15/1404 ,  B01L3/5027 ,  C12Q1/06 ,  G01N15/06 ,  G02B21/34 ,  B01L2200/021 ,  B01L2200/026 ,  B01L2200/14 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/0662 ,  G02B21/16

Abstract: The present invention relates to a method for analyzing samples comprising spermatozoa, said method comprising the use of a flow-through counting compartment, wherein the time period between the end of loading and closing is carried out in a controlled and specified time period. The present invention further relates to a counting compartment or chamber suitable for said method and to a counting device comprising said counting compartment.

公开(公告)号：US11808758B2

公开(公告)日：2023-11-07

申请号：US17082483

申请日：2020-10-28

Applicant: S.D. SIGHT DIAGNOSTICS LTD.

Inventor： Joseph Joel Pollak ,  Sarah Levy Schreier ,  Yochay Shlomo Eshel ,  Amir Zait ,  Sharon Pecker ,  Trevor Ruggiero

IPC: G01N33/50 ,  G01N21/31 ,  G01N21/59 ,  G01N21/64 ,  G01N21/03

CPC classification number: G01N33/50 ,  G01N21/0303 ,  G01N21/31 ,  G01N21/59 ,  G01N21/64 ,  G01N2201/0662

Abstract: Apparatus and methods are described including placing a sample into a sample carrier that comprises a plurality of regions having upper and lower surfaces, having respective heights that are different from each other, and being configured such that cells form a monolayer, the monolayer within respective regions of the sample carrier having respective, different densities from each other, due to the respective regions of the sample carrier having respective heights that are different from each other. Microscopic images are acquired of each of the plurality of regions. Measurements are performed upon cell types that have a relatively high density upon microscopic images of a region of the sample chamber having a relatively low height, and measurements are performed upon cell types that have a relatively low density upon microscopic images of a region of the sample chamber having a relatively great height. Other applications are also described.

公开(公告)号：US20170003203A1

公开(公告)日：2017-01-05

申请号：US15112792

申请日：2015-06-30

Applicant: Dale Lee HEINTZELMAN, JR. ,  Beacon Technologies, LLC

Inventor： Dale Lee Heintzelman, JR.

IPC: G01N1/14 ,  B01L3/02 ,  G01N21/01 ,  G01N35/10

CPC classification number: B01L3/0275 ,  B01L3/021 ,  B01L9/543 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2300/0654 ,  B01L2300/0858 ,  B01L2300/123 ,  B01L2300/168 ,  G01N1/14 ,  G01N21/01 ,  G01N21/0303 ,  G01N21/13 ,  G01N21/59 ,  G01N35/10 ,  G01N2021/0367 ,  G01N2035/1062 ,  G01N2201/0662

Abstract: This disclosure is directed to exemplary embodiments of systems, methods, techniques, processes, products and product components that can facilitate users making improved absorbance or fluorescence measurements in the field of spectroscopy with reduced (minimal) sample waste, and increased throughput, particularly in the study of biological sciences. A measuring system is provided having: a base unit with a means for locating a pipette tip; a pipette tip designed to interact with the base unit for purposes of accurate pipette tip positioning; at least one light supplying unit positioned to supply light to a liquid sample in the pipette tip and at least one light collecting unit positioned to collect light from a liquid sample in the pipette tip.

Abstract translation: 本公开涉及系统，方法，技术，方法，产品和产品组件的示例性实施方案，其可以促进用户在减少（最小）样品废物和增加的产量的光谱学领域中进行改进的吸光度或荧光测量，特别是在 生物科学研究。 提供了一种测量系统，其具有：具有用于定位移液管尖端的装置的基座单元; 移液管尖端设计为与基座单元相互作用，用于精确移液管尖端定位; 至少一个供光单元，其被定位成向移液管尖端中的液体样品提供光，以及至少一个聚光单元，定位成收集来自移液管尖端中的液体样品的光。

公开(公告)号：US08947668B2

公开(公告)日：2015-02-03

申请号：US13617478

申请日：2012-09-14

Applicant: A Keith Hulme ,  John Hammond ,  Nathan Hulme

Inventor： A Keith Hulme ,  John Hammond ,  Nathan Hulme

IPC: G01N21/00 ,  G01N21/11 ,  G01N21/27

CPC classification number: G01N21/11 ,  G01N21/274 ,  G01N21/278 ,  G01N2201/0662 ,  G01N2201/1286

Abstract: A for traceably determining an unknown optical path length of a sample in an optical measuring device comprises the steps of: providing a drop analyzer connected to a standard spectrophotometer; providing a certified reference material contained in first and second closed high accuracy cuvettes; measuring absorbance of the certified reference material to obtain a first absorbance measurement for the first specified path length; measuring absorbance of the certified reference material for a second path length to obtain a second absorbance measurement; using a dropping device to drop a specified volume of the solvent on an optical surface so that the path length of the specified volume can be determined by reference to the first and second absorbance measurement; and using the dropping device to drop the same volume of sample as the specified volume of solvent on the optical measuring device.

Abstract translation: A，用于在光学测量装置中用于可追溯性地确定样品的未知光程长度包括以下步骤：提供连接到标准分光光度计的液滴分析仪; 提供包含在第一和第二封闭高精度比色杯中的认证参考材料; 测量认证参考材料的吸光度，以获得第一指定路径长度的第一吸光度测量; 测量第二路径长度的认证参考材料的吸光度以获得第二吸光度测量; 使用滴下装置将特定体积的溶剂落在光学表面上，使得可以参照第一和第二吸光度测量来确定指定体积的路径长度; 并使用滴液装置将相同体积的样品与特定体积的溶剂一起放在光学测量装置上。

公开(公告)号：US07796265B2

公开(公告)日：2010-09-14

申请号：US12109254

申请日：2008-04-24

Applicant: Michael Tkachuk

Inventor： Michael Tkachuk

IPC: G01N21/00

CPC classification number: G01N21/3504 ,  G01N2201/0662 ,  G01N2201/0668

Abstract: An optical absorption gas analyzer for determining the concentration of a target gas in a sample is disclosed. The analyzer comprises a chamber for containing the sample in use; a radiation source assembly arranged to emit radiation into the chamber; a first radiation detector assembly arranged to detect radiation transmitted along a first optical path through the chamber and a second radiation detector assembly arranged to detect radiation transmitted along a second optical path through the chamber, wherein the length of the second optical path which the sample can intercept is shorter than that of the first optical path. The analyzer further comprises a processor adapted to generate a sensing signal SS based on the detected radiation transmitted along the first optical path and a reference signal SR based on the detected radiation transmitted along the second optical path. The processor determines the concentration of the target gas in the sample based on a comparison of the sensing signal with the reference signal.

Abstract translation: 公开了一种用于测定样品中目标气体浓度的光吸收气体分析仪。 分析仪包括用于容纳使用中的样品的室; 辐射源组件，被布置成将辐射发射到所述腔室中; 第一辐射检测器组件，被布置成检测沿着通过所述室的第一光路传输的辐射;以及第二辐射检测器组件，其布置成检测沿着通过所述室的第二光路传输的辐射，其中所述样品可以 截距比第一光路的截距短。 分析器还包括处理器，其适于基于沿着第一光路传输的检测到的辐射和基于沿着第二光路传输的检测到的辐射的参考信号SR生成感测信号SS。 处理器基于感测信号与参考信号的比较来确定样品中目标气体的浓度。