公开(公告)号：WO2012158960A3

公开(公告)日：2012-11-22

申请号：PCT/US2012/038425

申请日：2012-05-17

Applicant: H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC. ,  INTEZYNE TECHNOLOGIES INC. ,  ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  GILLIES, Robert, J. ,  MORSE, David, L. ,  BARKEY, Natalie, M. ,  SILL, Kevin, N. ,  VAGNER, Josef ,  TAFRESHI, Narges, K. ,  SESSLER, Jonathan, L. ,  PREIHS, Christian

Inventor： GILLIES, Robert, J. ,  MORSE, David, L. ,  BARKEY, Natalie, M. ,  SILL, Kevin, N. ,  VAGNER, Josef ,  TAFRESHI, Narges, K. ,  SESSLER, Jonathan, L. ,  PREIHS, Christian

IPC: C07K7/06 ,  C07K7/08 ,  C07K5/10 ,  A61K38/08 ,  A61K38/10 ,  A61K9/127 ,  G01N33/574 ,  A61P35/00

Abstract: The subject invention pertains to a modified MCIR peptide ligand comprising a peptide that is a melanocortin 1 receptor (MCIR) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MCIR peptide ligand can be coupled, e.g. , via a click reaction with a complementary click functionality attached, to a moiety to form an MClR-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MCIR. The subject invention also pertains to a MCIR peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MCIR or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.

公开(公告)号：WO2010042206A1

公开(公告)日：2010-04-15

申请号：PCT/US2009/005541

申请日：2009-10-09

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  ZHONG, Guangming

Inventor： ZHONG, Guangming

IPC: C07K14/00 ,  A61K39/118

CPC classification number: C07K14/295 ,  A61K39/00 ,  G01N33/56927

Abstract: Disclosed are isolated Chlamydia trachomatis proteins, methods of fusion protein and associated antibody production, and methods of using isolated proteins and antibodies in diagnosis and detection. Also disclosed are compositions comprising isolated proteins, wherein the compositions can further comprising pharmaceutically acceptable carriers, an adjuvant and/or an immunostimulant, and methods using the pharmaceutical compositions for treating or preventing an infection by Chlamydia in a subject. The compositions may also comprise a protein or immunogenic fragment of a pathogenic organism other than Chlamydia trachomatis.

Abstract translation: 公开了分离的沙眼衣原体蛋白，融合蛋白和相关抗体产生的方法，以及在诊断和检测中使用分离的蛋白质和抗体的方法。 还公开了包含分离的蛋白质的组合物，其中所述组合物还可包含药学上可接受的载体，佐剂和/或免疫刺激剂，以及使用该药物组合物治疗或预防受试者中衣原体感染的方法。 组合物还可以包含沙眼衣原体以外的致病生物体的蛋白质或免疫原性片段。

公开(公告)号：WO2009006607A1

公开(公告)日：2009-01-08

申请号：PCT/US2008/069226

申请日：2008-07-03

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  BURGER, Douglas, C. ,  KECKLER, Stephen, W. ,  MCDONALD, Robert ,  GRATZ, Paul ,  RANGANATHAN, Nitya ,  SETHUMADHAVAN, Lakshminarasimhan ,  SANKARALINGAM, Karthikeyan ,  NAGARAJAN, Ramadass ,  KIM, Changkyu ,  LIU, Haiming

Inventor： BURGER, Douglas, C. ,  KECKLER, Stephen, W. ,  MCDONALD, Robert ,  GRATZ, Paul ,  RANGANATHAN, Nitya ,  SETHUMADHAVAN, Lakshminarasimhan ,  SANKARALINGAM, Karthikeyan ,  NAGARAJAN, Ramadass ,  KIM, Changkyu ,  LIU, Haiming

IPC: G06F1/00

CPC classification number: G06F9/3885 ,  G06F9/3836 ,  G06F9/3897 ,  G06F12/0875 ,  G06F15/7867 ,  Y02D10/12 ,  Y02D10/13

Abstract: A method, system and computer program product for dynamically composing processor cores to form logical processors. Processor cores are composable in that the processor cores are dynamically allocated to form a logical processor to handle a change in the operating status. Once a change in the operating status is detected, a mechanism may be triggered to recompose one or more processor cores into a logical processor to handle the change in the operating status. An analysis may be performed as to how one or more processor cores should be recomposed to handle the change in the operating status. After the analysis, the one or more processor cores are recomposed into the logical processor to handle the change in the operating status. By dynamically allocating the processor cores to handle the change in the operating status, performance and power efficiency is improved.

Abstract translation: 一种用于动态组成处理器内核以形成逻辑处理器的方法，系统和计算机程序产品。 处理器核心是可组合的，因为处理器核心被动态地分配以形成逻辑处理器来处理操作状态的改变。 一旦检测到操作状态的改变，则可以触发一种机制来将一个或多个处理器核重组到逻辑处理器中以处理操作状态的变化。 可以执行关于如何重组一个或多个处理器核来处理操作状态的变化的分析。 在分析之后，将一个或多个处理器核重新组合到逻辑处理器中以处理操作状态的改变。 通过动态分配处理器核以处理运行状态的变化，提高了性能和功率效率。

公开(公告)号：WO2009006595A1

公开(公告)日：2009-01-08

申请号：PCT/US2008/069207

申请日：2008-07-03

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  BURGER, Douglas C. ,  KECKLER, Stephen W. ,  MCDONALD, Robert ,  SETHUMADHAVAN, Lakshminarasimhan ,  ROESNER, Franziska

Inventor： BURGER, Douglas C. ,  KECKLER, Stephen W. ,  MCDONALD, Robert ,  SETHUMADHAVAN, Lakshminarasimhan ,  ROESNER, Franziska

IPC: G06F15/00

CPC classification number: G06F9/3826 ,  G06F9/3824 ,  G06F9/383 ,  G06F9/3855

Abstract: A method and processor for providing full load/store queue functionality to an unordered load/store queue for a processor with out-of-order execution. Load and store instructions are inserted in a load/store queue in execution order. Each entry in the load/store queue includes an identification corresponding to a program order. Conflict detection in such an unordered load/store queue may be performed by searching a first CAM for all addresses that are the same or overlap with the address of the load or store instruction to be executed. A further search may be performed in a second CAM to identify those entries that are associated with younger or older instructions with respect to the sequence number of the load or store instruction to be executed. The output results of the Address CAM and Age CAM are logically ANDed.

Abstract translation: 一种方法和处理器，用于向具有无序执行的处理器的无序加载/存储队列提供满载/存储队列功能。 加载和存储指令以执行顺序插入到加载/存储队列中。 加载/存储队列中的每个条目包括与程序顺序相对应的标识。 可以通过在第一CAM中搜索与要执行的加载或存储指令相同或重叠的所有地址来执行这种无序加载/存储队列中的冲突检测。 可以在第二CAM中执行进一步的搜索以识别与要执行的加载或存储指令的序列号相关联的与较年或更旧的指令相关联的那些条目。 地址CAM和Age CAM的输出结果在逻辑上为AND。

公开(公告)号：WO2008144067A1

公开(公告)日：2008-11-27

申请号：PCT/US2008/006499

申请日：2008-05-21

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  BOSE, Santanu ,  CHATTERJEE, Bandana

Inventor： BOSE, Santanu ,  CHATTERJEE, Bandana

IPC: A61K39/12 ,  A61K45/00

CPC classification number: A61K45/06 ,  A61K35/768 ,  A61K38/00 ,  A61K38/177 ,  A61K38/19 ,  A61K38/208 ,  A61K38/45 ,  A61K39/12 ,  A61K39/155 ,  C07K14/535 ,  C12N2760/18532 ,  A61K2300/00

Abstract: The present invention relates generally to methods and compositions employing the oncolytic activity of respiratory syncytial virus (RSV) to treat cancer and other neoplastic disorders.

Abstract translation: 本发明一般涉及使用呼吸道合胞病毒（RSV）的溶瘤活性治疗癌症和其它肿瘤性疾病的方法和组合物。

公开(公告)号：WO2007149211A1

公开(公告)日：2007-12-27

申请号：PCT/US2007/013161

申请日：2007-06-05

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  PHILLIPS, Margaret ,  RATHOD, Pradipsinh, K. ,  BALDWIN, Jeffery ,  GUJJAR, Ramesh

Inventor： PHILLIPS, Margaret ,  RATHOD, Pradipsinh, K. ,  BALDWIN, Jeffery ,  GUJJAR, Ramesh

IPC: A61K31/47 ,  C07D215/02

CPC classification number: C07D487/04

Abstract: Pharmaceutical compositions comprising compounds of the formula (I) where R 1 , R 2 , and R 3 are described here, have therapeutic utility in selectively inhibiting P. falciparum dihydroorotate dehydrogenase. Accordingly, such compositions have use in the treatment and prevention of malaria.

Abstract translation: 包含其中R 1，R 2和R 3的式（I）化合物的药物组合物在此描述具有选择性的治疗效用 抑制恶性疟原虫二氢乳清酸脱氢酶。 因此，这些组合物可用于治疗和预防疟疾。

公开(公告)号：WO2007011629A2

公开(公告)日：2007-01-25

申请号：PCT/US2006/027127

申请日：2006-07-13

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  DE BRABANDER, Jef ,  JIANG, Xin

Inventor： DE BRABANDER, Jef ,  JIANG, Xin

IPC: C07D407/06 ,  C07D309/10 ,  A61K31/365 ,  A61K31/351

CPC classification number: C07D407/06 ,  C07D309/10

Abstract: The invention relates to the synthesis and complete stereochemical assignments of cytotoxic compounds such as compound 28-a and its stereoisomers. The invention further provides processes for making the compounds, their synthetic intermediates, and for methods of using the compounds and their pharmaceutical compositions for the treatment of neoplastic diseases.

Abstract translation: 本发明涉及细胞毒化合物例如化合物28-a及其立体异构体的合成和完全立体化学指定。 本发明进一步提供了制备这些化合物，它们的合成中间体的方法，以及使用这些化合物及其药物组合物治疗肿瘤疾病的方法。

公开(公告)号：WO2006026502A1

公开(公告)日：2006-03-09

申请号：PCT/US2005/030543

申请日：2005-08-26

Applicant: THE DOW CHEMICAL COMPANY ,  BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  HITT, James, E. ,  ROGERS, True, L. ,  GILLESPIE, Ian, B. ,  SCHERZER, Brian, D. ,  GARCIA, Paula, C. ,  BECK, Nicholas, S. ,  TUCKER, Christopher, J. ,  YOUNG, Timothy, J. ,  HAYES, David, A. ,  WILLIAMS, Robert, O., III ,  JOHNSTON, Keith, P. ,  MCCONVILLE, Jason, T. ,  PETERS, Jay, I. ,  TALBERT, Robert ,  BURGESS, David

Inventor： HITT, James, E. ,  ROGERS, True, L. ,  GILLESPIE, Ian, B. ,  SCHERZER, Brian, D. ,  GARCIA, Paula, C. ,  BECK, Nicholas, S. ,  TUCKER, Christopher, J. ,  YOUNG, Timothy, J. ,  HAYES, David, A. ,  WILLIAMS, Robert, O., III ,  JOHNSTON, Keith, P. ,  MCCONVILLE, Jason, T. ,  PETERS, Jay, I. ,  TALBERT, Robert ,  BURGESS, David

IPC: A61K9/12 ,  A61K31/496

CPC classification number: A61K31/496 ,  A61K9/0073 ,  A61K9/008 ,  A61K9/19

Abstract: Inhalable compositions are described. The inhalable compositions comprise one or more respirable aggregates, the respirable aggregates comprising one or more poorly water soluble active agents, wherein at least one of the active agents reaches a maximum lung concentration (C max ) of at least about 0.25 μg/gram of lung tissue and remains at such concentration for a period of at least one hour after being delivered to the lung. Methods for making such compositions and methods for using such compositions are also disclosed.

Abstract translation: 描述了可吸入组合物。 可吸入组合物包含一种或多种可呼吸聚集体，可呼吸聚集体包含一种或多种难溶于水的活性剂，其中至少一种活性剂达到最大肺浓度（C

公开(公告)号：WO2004071405A3

公开(公告)日：2004-08-26

申请号：PCT/US2004/001452

申请日：2004-01-21

Applicant: DUKE UNIVERSITY ,  BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  NEWGARD, Christopher, B. ,  JENSEN, Mette, V. ,  SHERRY, A., Dean ,  BURGESS, Shawn, C.

Inventor： NEWGARD, Christopher, B. ,  JENSEN, Mette, V. ,  SHERRY, A., Dean ,  BURGESS, Shawn, C.

IPC: C12N9/04 ,  C12N15/70 ,  C12N5/08 ,  C12P21/06 ,  C07H21/04 ,  A61K39/395 ,  A61K38/00

Abstract: The present invention provides an isolated nucleic acid encoding a novel lactate dehydrogenase (LDH) as well as the isolated LDH polypeptide. Also provided are methods of enhancing fuel-stimulated insulin secretion, in particular, glucose-stimulated insulin secretion. Further provided are methods of screening for compounds that bind LDH, modulate LDH activity, and/or modulate fuel- or glucose-stimulated insulin secretion and the compounds identified thereby. The invention further provides a method of enhancing insulin secretion by administering a nucleic acid encoding LDH to a subject in a therapeutically effective amount.

公开(公告)号：WO2002081691A2

公开(公告)日：2002-10-17

申请号：PCT/US2001/043823

申请日：2001-11-20

Applicant: TULARIK INC. ,  BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： HOBBS, Helen, H. ,  SHAN, Bei ,  BARNES, Robert ,  TIAN, Hui

IPC: C12N15/12

CPC classification number: G01N33/92 ,  A61K38/00 ,  C07K14/705 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2500/04 ,  G01N2800/044

Abstract: The present invention provides nucleic acids encoding a novel ABC family cholesterol transporter, ABCG8. The herein-disclosed sequences can be used for any of a number of purposes, including for the diagnosis and treatment of cholesterol-associated disorders, including sitosterolemia, and for the identification of molecules that associate with and/or modulate the activity of ABCG8.

Abstract translation: 本发明提供编码新型ABC家族胆固醇转运蛋白ABCG8的核酸。 本文所公开的序列可用于多种目的中的任何一种，包括用于诊断和治疗胆固醇相关疾病，包括静脉曲张，以及用于鉴定与ABCG8的活性相关和/或调节的分子。