公开(公告)号：CA2360893A1

公开(公告)日：2000-08-10

申请号：CA2360893

申请日：2000-02-04

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： SHETTY RESHMA ,  WALKER CRAIG ,  JONES ROBERT M ,  OLIVERA BALDOMERO M ,  STEELE DOUG ,  JACOBSEN RICHARD ,  HOOPER DAVID

IPC: C12N15/09 ,  A61K38/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P29/00 ,  A61P43/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C12N15/12 ,  C07K14/00 ,  A61K38/10

Abstract: The invention relates to relatively short peptides (termed ~-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

公开(公告)号：CA2361534A1

公开(公告)日：2000-08-03

申请号：CA2361534

申请日：2000-01-28

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： MCINTOSH J MICHAEL ,  JONES ROBERT M ,  HILLYARD DAVID R ,  OLIVERA BALDOMERO M ,  WATKINS MAREN

IPC: C12N15/09 ,  A61K38/00 ,  C07K4/12 ,  C07K14/435 ,  C12N15/12 ,  C07K7/08

Abstract: The invention relates to relatively short peptides (termed .alpha. -conotoxi ns herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

公开(公告)号：AU6415999A

公开(公告)日：2000-04-26

申请号：AU6415999

申请日：1999-10-06

Applicant: COGNETIX INC ,  SALK INSTITUTE THE ,  UNIV UTAH RES FOUND

Inventor： LAYER RICHARD T ,  PEMBERTON-GOODMAN KAREN E ,  JONES ROBERT M ,  GARRETT JAMES L ,  OLIVERA BALDOMERO M ,  MCINTOSH J MICHAEL ,  HILLYARD DAVID R ,  GRILLEY MICHELLE ,  WATKINS MAREN ,  SANTOS AMEURFINA D ,  ZAFARALLA GLENN ,  CRAIG A GREY

IPC: A61K38/00 ,  C07K14/435 ,  C12N15/12 ,  A61K38/12 ,  A61K38/14 ,  A61K38/17

Abstract: The present invention is directed to kappaA (kappaA) conopeptides and the use of these peptides for blocking the flow of potassium ions through voltage-gated potassium channels. The kappaA conopeptides include unglycosylated and O-glycosylated peptides.

公开(公告)号：CA2308115A1

公开(公告)日：1999-05-06

申请号：CA2308115

申请日：1998-10-23

Applicant: UNIV CASE WESTERN RESERVE ,  UNIV UTAH RES FOUND ,  SALK INST ,  COGNETIX INC

Inventor： CARTIER G EDWARD ,  SHEN GREGORY S ,  KOERBER STEVEN C ,  RIVIER JEAN E ,  OLIVERA BALDOMERO M ,  YOSHIKAMI DOJU ,  SHON KI-JOON ,  MCINTOSH J MICHAEL

IPC: G01R33/465 ,  A61K38/00 ,  C07K7/08 ,  C07K14/435 ,  C12N15/09 ,  G01N33/566 ,  G01N33/574 ,  G06F17/30 ,  G06F19/00 ,  G01N24/08 ,  G01N33/68

Abstract: This invention relates to derivatives of the conopeptide MII, an .alpha.-4/7 conotoxin peptide, in which amino acid residues are substituted as described herein while maintaining the basic activity of MII. The present invention also relates to the discovery of the 3-dimensional structure of MII, and the relationship of its structure to its specificity to the .alpha.3.beta.2 subtype of the neuronal nicotinic acetylcholine receptor (nAChR). The present invention also relates to computer based programs for the expression of the three-dimensional structure of MII and peptide analogs, peptide mimetics or non-peptide mimetics thereof. The structural characteristics may be correlated with biological activity to enable the design of .alpha.-4/7 conotoxin peptide analogs and peptide mimetics which demonstrate the same specificity to neuronal nAChR. Such analogs and peptide mimetics are useful as cardiovascular agents and for treating or detecting small-cell lung carcinoma (SCLC).

公开(公告)号：CA2261568A1

公开(公告)日：1998-01-29

申请号：CA2261568

申请日：1997-07-21

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC ,  SALK INST

Inventor： WALKER CRAIG ,  ZHOU LI-MING ,  OLIVERA BALDOMERO M ,  CRUZ LOURDES J ,  LAYER RICHARD T ,  ABOGADIE FE C ,  SHEN GREGORY S ,  HILLYARD DAVID R ,  MCCABE R TYLER ,  RIVIER JEAN E ,  COLLEDGE CLARK ,  JIMENEZ ELSIE

IPC: A61P25/04 ,  A61K38/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C12N15/09 ,  C12Q1/68 ,  C12N15/12 ,  C07K5/027 ,  C07H21/04

Abstract: The present invention is directed to conantokin peptides, conantokin peptide derivatives and conantokin peptide chimeras, referred to collectively as conantokins, having 10-30 amino acids, including preferably two or more .gamma.-carboxyglutamic acid residues. The conantokins are useful for the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, neuroprotective agents or analgesic agents.

公开(公告)号：CA2347713C

公开(公告)日：2010-07-13

申请号：CA2347713

申请日：1999-10-20

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND ,  SALK INST

Inventor： CRAIG A GREY ,  GRIFFEN DAVID ,  OLIVERA BALDOMERO M ,  WATKINS MAREN ,  HILLYARD DAVID R ,  IMPERIAL JULITA ,  CRUZ LOURDES J ,  WAGSTAFF JOHN D ,  LAYER RICHARD T ,  JONES ROBERT M ,  MCCABE R TYLER

IPC: C12N15/09 ,  C12N15/12 ,  A61K38/00 ,  A61K38/10 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K7/08 ,  C07K9/00 ,  C07K14/435 ,  C07K14/575

Abstract: The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10-contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.

公开(公告)号：AU2006202549A1

公开(公告)日：2006-07-13

申请号：AU2006202549

申请日：2006-06-14

Applicant: COGNETIX INC ,  UNIV OF UTAH REASEARCH FOUNDATION

Inventor： HILLYARD DAVID R ,  CARTIER G EDWARD ,  LAYER RICHARD T ,  MCINTOSH J MICHAEL ,  OLIVERA BALDOMERA M ,  WATKINS MAREN ,  JONES ROBERT M

IPC: A61K38/00 ,  C07K14/435

公开(公告)号：AU2005203263A1

公开(公告)日：2005-08-18

申请号：AU2005203263

申请日：2005-07-26

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND

Inventor： MCCABE R TYLER ,  MCINTOSH J MICHAEL ,  OLIVERA BALDOMERA M ,  JONES ROBERT M ,  WAGSTAFF JOHN D ,  LAYER RICHARD T ,  GARRETT JAMES E

IPC: A61K38/00 ,  C07K14/00 ,  C07K14/435 ,  C12N15/12

公开(公告)号：HK1039570B

公开(公告)日：2004-10-15

申请号：HK02101114

申请日：2002-02-15

Applicant: COGNETIX INC ,  UNIV UTAH RES FOUND ,  SALK INST BIOLOGICAL STUDIES

Inventor： A GREY CRAIG ,  DAVID GRIFFIN ,  BALDOMERO M OLIVERA ,  MAREN WATKINS ,  DAVID R HILLYARD ,  JULITA IMPERIAL ,  LOURDES J CRUZ ,  JOHN D WAGSTAFF ,  RICHARD T LAYER ,  ROBERT M JONES ,  R TYLER MCCABE

IPC: C07K20060101 ,  C12N15/09 ,  A61K20060101 ,  A61K38/00 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K7/08 ,  C07K9/00 ,  C07K14/435 ,  C07K14/575 ,  C12N20060101 ,  C12N15/12

公开(公告)号：AU768091B2

公开(公告)日：2003-12-04

申请号：AU3223500

申请日：2000-02-04

Applicant: UNIV UTAH RES FOUND ,  COGNETIX INC

Inventor： WALKER CRAIG ,  SHETTY RESHMA ,  OLIVERA BALDOMERO M ,  HOOPER DAVID ,  JACOBSEN RICHARD ,  STEEL DOUG ,  JONES ROBERT M

IPC: C12N15/09 ,  A61K38/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P29/00 ,  A61P43/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C12N15/12 ,  A61K38/10 ,  C07K14/00

Abstract: The invention relates to relatively short peptides (termed tau-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.