公开(公告)号：ZA200100241B

公开(公告)日：2002-06-26

申请号：ZA200100241

申请日：2001-01-09

Applicant: ID LELYSTAD INST VOOR DIERHOUDERIJ EN DIERGEZONDHEID B V

Inventor： ARNOUD LEONARD JOSEF GIELKENS ,  OLAV SVEN DE LEEUW ,  GUUS KOCH ,  BERNARDUS PETRUS HUBERTUS PEETERS

IPC: C12N15/09 ,  A61K39/17 ,  A61K48/00 ,  A61P31/12 ,  C07K14/125 ,  C12N7/00 ,  C12N7/01 ,  C12N15/45 ,  C12N15/86 ,  C12Q1/70

Abstract: The invention relates to the process for generating infectious Newcastle disease virus (NDV) entirely from cloned full-length cDNA and to the use of vaccines and diagnostic assays generated with and derived from said process. The process offers the possibility to modify the NDV genome by means of genetic modification and allows the introduction of mutations, deletions, and/or insertions. The process can be used to modify the virulence of NDV, thereby generating new attenuated live vaccines with enhanced properties. The process can be used to modify the antigenic make-up of NDV, thus allowing the generation of live NDV marker vaccines which can be serologically distinguished from NDV field strains.

公开(公告)号：CA2428278A1

公开(公告)日：2002-05-16

申请号：CA2428278

申请日：2001-11-06

Applicant: ID LELYSTAD INST DIERHOUDERIJ

Inventor： SMITH HILDA ELIZABETH

IPC: A61K38/00 ,  A61K38/16 ,  C07K14/315 ,  C07K16/12 ,  C12N1/21 ,  C12N15/31

Abstract: The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci. The invention provides a method for modulating virulence of a Streptococcus comprising modifying a genomic fragment of said Streptococcus wherein said genomic fragment comprises at least a functional part of a fragment identifiable by hybridisation in Streptococcus suis to a nucleic acid or fragment thereof as shown in figure 5.

公开(公告)号：AU9439501A

公开(公告)日：2002-03-26

申请号：AU9439501

申请日：2001-09-11

Applicant: ID LELYSTAD INST DIERHOUDERIJ

Inventor： MELOEN ROBERT HANS ,  OONK HENDRICA BERENDINA ,  TURKSTRA JOUWERT ANNE

IPC: A61K39/00 ,  A61K38/00 ,  A61P15/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/575 ,  C07K14/72 ,  C07K16/00 ,  C07K16/26

公开(公告)号：AU8386201A

公开(公告)日：2002-01-08

申请号：AU8386201

申请日：2001-06-15

Applicant: BAYER AG ,  ID LELYSTAD B V

Inventor： SCHLAPP TOBIAS ,  RIJSEWIJK FRANCISCUS ANTONIUS

IPC: C12N15/09 ,  A61K39/15 ,  A61P31/12 ,  C07K14/18 ,  C12N5/02 ,  C12N7/00 ,  C12N7/01 ,  C12N7/04 ,  C12N15/40 ,  C12N15/869 ,  A61K39/12

Abstract: The present invention relates to bovine viral diarrhea virus (BVDV) virus-like particles, a polycistronic RNA and DNA corresponding thereto encoding a polyprotein of BVDV structural proteins that are sufficient to form BVDV virus-like particles, a viral vector encoding factors and structural proteins for the assembly of BVDV virus-like particles, a vaccine comprising BVDV virus-like particles, a diagnostic kit and methods for preparing BVDV virus-like particles.

公开(公告)号：CA2409209A1

公开(公告)日：2001-11-29

申请号：CA2409209

申请日：2001-05-21

Applicant: ID LELYSTAD INST DIERHOUDERIJ

Inventor： VERHEIJE MONIQUE HELENE ,  MEULENBERG JOHANNA JACOBA MARI

IPC: C12N15/09 ,  A61K39/00 ,  A61K39/12 ,  A61P11/00 ,  A61P15/00 ,  A61P31/14 ,  C07K14/08 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/00 ,  C12N7/01 ,  C12N7/04 ,  C12N15/40 ,  C12N15/86

Abstract: The invention relates to the field for Arteriviruses and vaccines directed against infections caused by these viruses. The invention provides an Arteriviruses-like particle comprising at least a first structural protein derived from a first Arterivirus and a second structural protein wherein sai d second structural protein is at least partly not derived from said first Arterivirus.

公开(公告)号：CA2379059A1

公开(公告)日：2001-01-18

申请号：CA2379059

申请日：2000-07-13

Applicant: ID LELYSTAD INST DIERHOUDERIJ

Inventor： BOOT HENDRIK JOHANNIS ,  PEETERS BERNARDUS PETRUS HUBER ,  TER HUURNE ANNA AGNES HENDRIKA

IPC: A61K39/00 ,  A61K39/12 ,  C07K14/08 ,  C12N7/00 ,  C12N7/01 ,  C12N7/04 ,  C12N15/40

Abstract: The invention relates to recombinant Infectious Bursal Disease Virus (IBDV) and vaccines derived thereof. The invention provides infectious recombinant Infectious Bursal Disease Virus (rIBDV) essentially incapable of growing in a cell that is not derived from a bursa cell, or an infectious rIBDV having retained at least part of the very virulent characteristics of a very virule nt Infectious Bursal Disease Virus (vvIBDV).

公开(公告)号：NO20006406D0

公开(公告)日：2000-12-15

申请号：NO20006406

申请日：2000-12-15

Applicant: ID LELYSTAD INST DIERHOUDERIJ

Inventor： PEETERS BERNARDUS PETRUS HUBER ,  LEEUW OLAV SVEN DE ,  KOCH GUUS ,  GIELKENS ARNOUD LEONARD JOSEF

IPC: C12N15/09 ,  A61K39/17 ,  A61K48/00 ,  A61P31/12 ,  C07K14/125 ,  C12N7/00 ,  C12N7/01 ,  C12N15/45 ,  C12N15/86 ,  C12Q1/70 ,  C12N

Abstract: The invention relates to the process for generating infectious Newcastle disease virus (NDV) entirely from cloned full-length cDNA and to the use of vaccines and diagnostic assays generated with and derived from said process. The process offers the possibility to modify the NDV genome by means of genetic modification and allows the introduction of mutations, deletions, and/or insertions. The process can be used to modify the virulence of NDV, thereby generating new attenuated live vaccines with enhanced properties. The process can be used to modify the antigenic make-up of NDV, thus allowing the generation of live NDV marker vaccines which can be serologically distinguished from NDV field strains.

公开(公告)号：CA2364686A1

公开(公告)日：2000-08-17

申请号：CA2364686

申请日：2000-02-09

Applicant: ID LELYSTAD INST DIERHOUDERIJ

Inventor： BOSSERS ALEXANDER ,  SCHREUDER BRAM EDWARD CORNELIS ,  LANGEVELD JOANNES PIETER MARIA ,  JACOBS JORG GUNTHER ,  SMITS MARINUS ADRIANUS ,  GARSSEN GERRIT JAN ,  VAN KEULEN LUCIEN JOHANNES MAT

IPC: C12Q1/37 ,  G01N33/68

Abstract: The invention is related to diagnostic methods for detecting transmissible spongiform encephalopathies (TSEs) such as BSE and scrapie and related disea se in humans. The invention provides use of guanidine thiocyanate (gdnSCN) or a functional equivalent thereof for treating at least one sample derived from a mammal, including humans for reducing the risk of scoring a false-positive test result in testing said sample for the presence or absence of aberrant prion protein.

公开(公告)号：CZ300760B6

公开(公告)日：2009-08-05

申请号：CZ20004707

申请日：1999-06-17

Applicant: ID LELYSTAD

Inventor： PEETERS BERNARDUS PETRUS HUBERTUS ,  DE LEEUW OLAV SVEN ,  KOCH GUUS ,  GIELKENS ARNOUD LEONARD JOSEF

IPC: C12N15/09 ,  C12N15/45 ,  A61K39/17 ,  A61K48/00 ,  A61P31/12 ,  C07K14/125 ,  C12N7/00 ,  C12N7/01 ,  C12N15/86 ,  C12Q1/70

Abstract: cDNA ptacího paramyxoviru obsahující alespon sekvenci nukleové kyseliny odpovídající 5' konci genomu viru Newcastleské choroby drubeže jak je videt z obrázku 6, umožnující prípravu infekcní kopie ptacího paramyxoviru. Zpusob prípravy infekcního viru Newcastleské choroby (NDV) klonováním cDNA úplné délky a užití vakcín a diagnostických testu vytvorených a odvozených behem zpusobu prípravy infekcní cástice NDV. Zpusob nabízí možnost modifikace genomu NDV pomocí genetických modifikací a umožnuje zavedení mutací, delecí a/nebo insercí. Zpusob umožnuje prípravu živých NDV markerových vakcín, které lze sérologicky odlišit od polních kmenu NDV.

公开(公告)号：AU2003202826B9

公开(公告)日：2008-06-19

申请号：AU2003202826

申请日：2003-01-13

Applicant: ID LELYSTAD INSTITUUT VOOR DIERHOUDERIJ EN DIERGEZONDHEID B V

Inventor： WESTERVEEN SJOUKJE FETSJE ,  THOLE JELLE EGBERTUS RUDOLFUS ,  ZIJDERVELD FRED GOVERT VAN ,  WILLEMSEN PETRUS THEODORUS JOH ,  BAKKER DOUWE

IPC: G01N33/53 ,  A61K39/00 ,  A61K39/005 ,  A61K39/02 ,  A61K39/04 ,  A61K39/085 ,  A61K39/09 ,  A61K39/108 ,  A61K39/135 ,  A61K39/145 ,  A61K39/155 ,  A61K39/215 ,  A61K39/245 ,  A61P31/04 ,  A61P31/06 ,  A61P31/12 ,  C07K14/35 ,  C07K16/12 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/31 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/68 ,  G01N33/569

Abstract: The present invention relates to nucleic acid sequences encoding Mycobacterium avium subspecies paratuberculosis proteins, to parts of such nucleic acid sequences that encode an immunogenic fragment of such proteins, to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to Mycobacterium avium subspecies paratuberculosis proteins and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, proteins or immunogenic parts thereof and antibodies against such proteins or immunogenic parts thereof. Also, the invention relates to the use of said proteins in vaccines and for the manufacture of vaccines. Moreover, the inventions relates to the use of said nucleic acid sequences, proteins, or antibodies for diagnostic or vaccination purposes. Also, the invention relates to methods for the preparation of such vaccines. Finally the invention relates to diagnostic kits comprising such nucleic acids, proteins or antibodies against such proteins.