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公开(公告)号：US20190151453A1
公开(公告)日：2019-05-23
申请号：US16259541
申请日：2019-01-28
Applicant: Micell Technologies, Inc.
Inventor： James B. McClain , James P. DeYoung
Abstract: A method of forming a drug/polymer composite material is carried out by combining a drug material with a polymer material under pressure in the presence of a compressed gas solvent (e.g., carbon dioxide) to form the drug/polymer composite material. Drug/polymer composite materials and shaped articles (e.g., subcutaneous drug depots) which may be produced by a process are also described, along with methods of use thereof.
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公开(公告)号：US20190117851A1
公开(公告)日：2019-04-25
申请号：US16217755
申请日：2018-12-12
Applicant: Micell Technologies, Inc.
Inventor： Timothy Charles Kiorpes , James B. McClain
IPC: A61L31/06 , A61K9/20 , A61F2/82 , A61K9/00 , A61L27/18 , A61L31/16 , A61K47/10 , A61L31/14 , A61L31/12 , A61L31/10
Abstract: A drug-eluting product is disclosed comprising an at least partially bioabsorbable element and an active pharmaceutical agent having a morphology, a solubility, and an average particle size which are selected so that the active pharmaceutical agent continues to dissolve during the biodegradation of the bioabsorbable element. The morphology is a crystalline, semi-crystalline or amorphous morphology, the solubility is less than 100 μg/ml and the average particle size is grater that about 100 nm.
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公开(公告)号：US20190111190A1
公开(公告)日：2019-04-18
申请号：US16223552
申请日：2018-12-18
Applicant: Micell Technologies, Inc.
Inventor： James P. DeYoung , Charles Douglas Taylor , James B. McClain , Clint Smoke , Mike Cole
Abstract: A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.
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公开(公告)号：US20180272043A1
公开(公告)日：2018-09-27
申请号：US15960836
申请日：2018-04-24
Applicant: Micell Technologies, Inc.
Inventor： Charles Douglas Taylor , James B. McClain
CPC classification number: A61L31/10 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61L31/16 , C08L67/04
Abstract: Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
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公开(公告)号：US20180228371A1
公开(公告)日：2018-08-16
申请号：US15750096
申请日：2016-08-03
Applicant: Micell Technologies, Inc.
Inventor： James B. McClain
IPC: A61B5/00 , A61B5/0215 , A61B5/024
CPC classification number: A61B5/0028 , A61B5/0002 , A61B5/0022 , A61B5/02007 , A61B5/021 , A61B5/0215 , A61B5/024 , A61B5/02444 , A61B5/026 , A61B5/4839 , A61B5/686 , A61B5/6862 , A61B5/6876 , A61B2560/0214 , A61F2/82
Abstract: An implantable device including a sensing element, transmitter and power element is disclosed. The device may allow for monitoring of one or more body conditions in a minimally invasive manner, while a receiver may receive such information. Methods of utilizing device are also disclosed.
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Patent Agency Ranking
公开(公告)号：US20170065521A1
公开(公告)日：2017-03-09
申请号：US15260579
申请日：2016-09-09
Applicant: Micell Technologies, Inc.
Inventor： Wenda C. Carlyle
CPC classification number: A61K9/1647 , A61K9/1676
Abstract: Drug delivery systems are disclosed which include a drug in dry powder form and a biodegradable or metabolizable carrier having an average particle size of less than about 1 mm for delivery of the drug to a particular location in the body and for providing for the timed elution of the drug at that location, preferably by exhibiting a linear drug elution profile for a sustained drug release period of at least 30 days. Methods for manufacturing these drug delivery systems are also disclosed.
Abstract translation: 公开了药物递送系统，其包括干粉形式的药物和平均粒度小于约1mm的可生物降解或代谢的载体，用于将药物递送至身体中的特定位置，并提供定时洗脱 该药物在该位置，优选通过显示持续药物释放期至少30天的线性药物洗脱曲线。 还公开了制备这些药物递送系统的方法。
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公开(公告)号：US20170049939A1
公开(公告)日：2017-02-23
申请号：US15341160
申请日：2016-11-02
Applicant: Micell Technologies, Inc.
Inventor： Charles Douglas Taylor , James B. McClain , Edward Schmitt
CPC classification number: A61L31/10 , A61K31/435 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2420/02 , A61L2420/06 , A61L2420/08 , B05D3/12 , B05D2254/06 , C08G63/06 , C08G63/08 , C08G63/90 , C08G2150/20 , C08G2230/00 , C08J7/047 , C08L67/04 , C09D5/033 , C09D167/04
Abstract: Provided herein is a composition comprising a poly(alpha-hydroxycarboxylic acid) substantially free of acidic impurities wherein the poly(alpha-hydroxycarboxylic acid) is selected from poly(D,L-lactic-co-glycolic acid), poly(L-lactic acid), poly(D-lactic acid) and poly(D,L-lactic acid). Also provided is a device comprising: a substrate, and a coating wherein the coating comprises poly(D,L-lactic-co-glycolic acid) substantially free of acidic impurities.
Abstract translation: 本文提供的是包含基本上不含酸性杂质的聚（α-羟基羧酸）的组合物，其中聚（α-羟基羧酸）选自聚（D，L-乳酸 - 共 - 乙醇酸），聚（L-乳酸 酸），聚（D-乳酸）和聚（D，L-乳酸）。 还提供了一种装置，其包括：基底和涂层，其中所述涂层包含基本上不含酸性杂质的聚（D，L-乳酸 - 共 - 乙醇酸）。
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88.发明申请公开(公告)号：US20160015537A1
公开(公告)日：2016-01-21
申请号：US14718342
申请日：2015-05-21
Applicant: Micell Technologies, Inc.
Inventor： Charles Douglas Taylor , James DeYoung , James B. McClain
CPC classification number: A61F2/86 , A61F2/07 , A61F2002/821 , A61F2240/002 , A61F2250/0067 , A61L31/022 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/606 , A61L2420/08
Abstract: A coated coronary stent, comprising a stainless steel sent framework coated with a p1imer layer of Parylene C, and a rapamycin-polymer coating having substantially uniform thickness disposed on the stent framework, wherein the rapamycin-polymer coating comprises polybutyl methacrylate (PBMA), polyethylene-co-vinyl acetate (PEVA) and rapamycin, wherein substantially all of the rapamycin in the coating is in amorphous form and substantially unifom1ly dispersed within the rapamycin-polymer coating.
Abstract translation: 一种涂覆的冠状动脉支架，包括涂覆有聚对二苯二甲酚的聚合物层的不锈钢送出框架和布置在支架框架上的具有基本均匀厚度的雷帕霉素聚合物涂层，其中雷帕霉素聚合物涂层包括聚甲基丙烯酸丁酯（PBMA），聚乙烯 （PEVA）和雷帕霉素，其中涂层中基本上所有的雷帕霉素都是无定形形式，并且基本上单分散在雷帕霉素聚合物涂层内。
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公开(公告)号：US20150134047A1
公开(公告)日：2015-05-14
申请号：US14402839
申请日：2013-05-21
Applicant: Micell Technologies, Inc.
Inventor： James B. McClain , Charles Douglas Taylor
CPC classification number: A61L31/16 , A61L31/10 , A61L2300/204 , A61L2300/404 , A61L2300/416 , A61L2300/606 , A61L2300/63 , A61L2420/06 , C08L67/04
Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
Abstract translation: 本文提供的装置包括：a。 支架; b。 在所述支架框架上的多个层以形成所述装置; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。
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公开(公告)号：US20210161687A1
公开(公告)日：2021-06-03
申请号：US17157115
申请日：2021-01-25
Applicant: Micell Technologies, Inc.
Inventor： Charles Douglas Taylor , James B. McClain , Mike Cole , James P. DeYoung , Clint Smoke
Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.
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