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公开(公告)号:US20240156923A1
公开(公告)日:2024-05-16
申请号:US18207868
申请日:2023-06-09
Inventor: Daniel Fossum Bratbak , Ståle Nordgård
IPC: A61K38/48 , A61B10/02 , A61B17/34 , A61K9/00 , A61M5/20 , A61M5/24 , A61M5/28 , A61M5/32 , A61N1/372 , A61P25/06 , A61P27/02
CPC classification number: A61K38/4893 , A61B10/0233 , A61B17/3403 , A61K9/0019 , A61M5/20 , A61M5/24 , A61M5/28 , A61M5/3286 , A61N1/372 , A61P25/06 , A61P27/02 , A61B2017/00199
Abstract: A device for interventions within the body, the device comprising: an end piece 6 for insertion into the body at a distal end thereof, the end piece 6 including a rigid lumen for holding an instrument 10 and guiding the instrument 10 to the distal end of the end piece; and a body section 4 supporting the lumen and being rigidly connected thereto, the body section including a navigation array 14 for guidance of the device using a surgical navigation system and/or including an anchor point 20 for a standard navigation array.
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公开(公告)号:US11780734B2
公开(公告)日:2023-10-10
申请号:US16471381
申请日:2017-12-18
Inventor: Jafar Safarian , Gabriella Tranell
IPC: C01B33/023 , C01B33/037
CPC classification number: C01B33/023 , C01B33/037
Abstract: A process for preparing a highly pure silicon by reduction of a calcium silicate slag using a source of aluminum is disclosed. The process involves forming a molten calcium silicate slag, reducing the calcium silicate slag to Si metal and forming a calcium aluminate slag, and separating the Si metal from the calcium aluminate slag.
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公开(公告)号:US20230151725A1
公开(公告)日:2023-05-18
申请号:US17802282
申请日:2021-02-25
Inventor: Sigve Hovda , Sigbjorn Sangesland , Asbjorn Djupdal , Magnus Jahre
CPC classification number: E21B44/00 , E21B37/00 , E21B45/00 , E21B47/04 , E21B2200/20
Abstract: A method for modelling a drillstring in a wellbore, the method comprising providing a model of the drillstring, the model representing the drillstring by a sequence of alternating springs and elements, where each element describes the mass and/or the moment of inertia of a corresponding part of the drillstring and each spring represents at least one of: axial, torsional and/or bending stiffnesses of one of the corresponding parts of the drillstring, wherein the model describes one or more forces on each element by one or more systems of ordinary equations of first or second order, where each equation comprise a linear part that comprises constant coefficients and a non-linear part that includes one or more of: one or more non-linear terms, one or more non-smooth terms, one or more time dependent terms and/or one or more coupled terms; and the method comprises recalculating the model for a plurality of time steps, wherein recalculating the model for the respective time step comprises calculating one, two or three dimensional positions, orientations and/or associated derivatives of all of the elements for the respective time step based on one, two or three dimensional positions, orientations and/or associated derivatives of all element at a previous time step, by describing the non-linear part by a form of expansion with respect to time and solving the system of equations either analytically or by the use of exponential integrators for the duration of the respective time step. Also described is a method of cleaning a wellbore using the model from the above method.
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公开(公告)号:US20220348615A1
公开(公告)日:2022-11-03
申请号:US17724712
申请日:2022-04-20
Applicant: Norwegian University of Science and Technology (NTNU) , UNIVERSITÄT ULM , NORWEGIAN UNIVERSITY OF LIFE SCIENCES , DANMARKS TEKNISKE UNIVERSITET , UNIVERSITÄT DES SAARLANDES
Inventor: Gerd Michael SEIBOLD , Christoph WITTMANN , Dzung DIEP , Nadav BAR , Christian U. REIDEL , Dominik WEIXLER , Oliver GOLDBECK
IPC: C07K14/34
Abstract: The present invention relates to the production of bacteriocins, and in particular the production of bacteriocins of class I or II by recombinant expression in coryneform bacteria as the bacterial cell host. Also provided are modified coryneform bacteria for use as production hosts for production of bacteriocins.
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公开(公告)号:US11413044B2
公开(公告)日:2022-08-16
申请号:US16881889
申请日:2020-05-22
Inventor: Lars Cato Rekstad , Brynjulf Ystgaard
IPC: A61B17/072 , A61B17/115
Abstract: A surgical stapler includes a proximal end and a distal end and an anvil at the distal end for providing resistance to staples during the stapling operation of the surgical stapler. The anvil may include a number of segments arranged end-to-end. The anvil is elongated in the collapsed state, the anvil being elongated generally in a first direction D1. The anvil is configured such that the segments rotate about a rotation axis along a perpendicular second direction D2 when the anvil is actuated between the deployed and the collapsed states. The anvil is configured such that adjacent segments pivot relative to each other about a pivot axis along a third direction D3 when the anvil is actuated between the deployed and collapsed states. The stapler also includes an actuator mechanism, wherein the actuator mechanism is configured to be controlled from a location on the surgical stapler towards the proximal end.
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公开(公告)号:US11337427B2
公开(公告)日:2022-05-24
申请号:US16592462
申请日:2019-10-03
Inventor: Marit Otterlei , Siri Bachke
IPC: A01N63/50 , A61K38/17 , A61K38/14 , A61K38/16 , A61L2/16 , C07K14/00 , A61K38/00 , A61K31/165 , A61K31/35 , A61K31/397 , A61K31/43 , A61K31/496 , A61K31/7036 , A61K31/7048 , A61K41/00 , A61K45/06 , A61L2/10 , A01N25/08
Abstract: The present invention provides an agent, or a composition containing an agent, for use in treating or preventing a bacterial infection in a subject, wherein said agent comprises: (i) an oligopeptidic compound comprising a PCNA interacting motif and a domain that facilitates the cellular uptake of said compound, wherein the PCNA interacting motif is X1X2X3X4X5 (SEQ ID NO: 1) and wherein: X1 is a basic amino acid; X2 is an aromatic amino acid; X3 is an uncharged amino acid other than an aromatic amino acid, Glycine (G) and Proline (P); X4 is any amino acid other than Proline (P), an acidic amino acid or an aromatic amino acid; and X5 is a basic amino acid or Proline (P); or (ii) a nucleic acid molecule comprising a sequence encoding the oligopeptidic compound of (i). In certain aspects the agent and compositions of the invention may be used as single agents. In other aspects of the invention agents and compositions of the invention may be used in conjunction with one or more additional active agents, such as antibiotics.
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公开(公告)号:US11261537B2
公开(公告)日:2022-03-01
申请号:US16679832
申请日:2019-11-11
Inventor: Bjørn-Ove Fimland , Dheeraj L. Dasa , Helge Weman
IPC: C30B25/10 , C30B25/18 , C30B29/40 , C30B29/48 , H01L21/02 , H01L29/15 , H01L29/20 , H01L29/22 , C30B29/02 , H01L29/04 , H01L29/16
Abstract: A composition of matter comprising a film on a graphitic substrate, said film having been grown epitaxially on said substrate, wherein said film comprises at least one group III-V compound or at least one group II-VI compound.
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公开(公告)号:US20210015514A1
公开(公告)日:2021-01-21
申请号:US16623027
申请日:2018-06-08
Inventor: Per Even STORLI , Lars Cato REKSTAD , Brynjulf YSTGAARD
Abstract: A surgical retractor tool for removing an object from the stomach or from the oesophagus. The tool includes a flexible steerable tube for insertion into the body via the oral cavity and a gripper at the distal end of the tube for gripping an object in the stomach or the oesophagus in order to allow for removal of the object from the stomach or the oesophagus. The gripper includes first and second rotatable gripper surfaces and a clamping mechanism for moving the gripper surfaces to clamp the object. The rotatable gripper surfaces are arranged to rotate relative to the tube in order to allow a longitudinal axis of a gripped object to move into alignment with a longitudinal axis of the tube.
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公开(公告)号:US20200289121A1
公开(公告)日:2020-09-17
申请号:US16881889
申请日:2020-05-22
Inventor: Lars Cato REKSTAD , Brynjulf YSTGAARD
IPC: A61B17/115 , A61B17/072
Abstract: A surgical stapler includes a proximal end and a distal end and an anvil at the distal end for providing resistance to staples during the stapling operation of the surgical stapler. The anvil may include a number of segments arranged end-to-end. The anvil is elongated in the collapsed state, the anvil being elongated generally in a first direction D1. The anvil is configured such that the segments rotate about a rotation axis along a perpendicular second direction D2 when the anvil is actuated between the deployed and the collapsed states. The anvil is configured such that adjacent segments pivot relative to each other about a pivot axis along a third direction D3 when the anvil is actuated between the deployed and collapsed states. The stapler also includes an actuator mechanism, wherein the actuator mechanism is configured to be controlled from a location on the surgical stapler towards the proximal end.
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公开(公告)号:US10695067B2
公开(公告)日:2020-06-30
申请号:US15551385
申请日:2017-06-28
Inventor: Lars Cato Rekstad , Brynjulf Ystgaard
IPC: A61B17/115 , A61B17/072
Abstract: A surgical stapler includes a proximal end and a distal end and an anvil at the distal end for providing resistance to staples during the stapling operation of the surgical stapler. The anvil may include a number of segments arranged end-to-end. The anvil is elongated in the collapsed state, the anvil being elongated generally in a first direction D1. The anvil is configured such that the segments rotate about a rotation axis along a perpendicular second direction D2 when the anvil is actuated between the deployed and the collapsed states. The anvil is configured such that adjacent segments pivot relative to each other about a pivot axis along a third direction D3 when the anvil is actuated between the deployed and collapsed states. The stapler also includes an actuator mechanism, wherein the actuator mechanism is configured to be controlled from a location on the surgical stapler towards the proximal end.
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