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    Gastric retention controlled drug delivery system
    81.
    发明公开
    Gastric retention controlled drug delivery system 有权
    魔术师系统，战胜Wirkstoffabgabe

    公开(公告)号：EP2238975A1

    公开(公告)日：2010-10-13

    申请号：EP10165807.8

    申请日：2002-07-04

    Applicant: Sun Pharma Advanced Research Company Ltd

    Inventor： Dudhara, Kamlesh Mohanlal ,  Dharmadhikari, Nitin Bhalachandra ,  Dhavse, Vaishali Vijay

    IPC: A61K9/22 ,  A61K9/28 ,  A61K47/38 ,  A61K31/197

    CPC classification number: A61K9/0007 ,  A61K9/0065 ,  A61K9/209 ,  A61K31/197

    Abstract: The present invention provides a gastric retention controlled drug delivery system comprising: (a) a controlled release core comprising a drug, a highly swellable polymer and a gas generating agent, said core being capable of swelling and achieving floatation rapidly while maintaining its physical integrity in gastrointestinal fluids for prolonged periods, and (b) a rapidly releasing coat composition comprising the same drug as in the core and pharmaceutically acceptable excipients, wherein the coating composition surrounds the core such that the system provides a biphasic release of the drug in gastrointestinal fluids.

    Abstract translation: 本发明提供了一种胃滞留控制药物递送系统，包括：（a）包含药物，高度可溶胀聚合物和气体发生剂的控释核心，所述核心能够在保持其物理完整性的同时膨胀并实现浮选 胃肠道液体延长的时间，和（b）快速释放的包衣组合物，其包含与核心和药学上可接受的赋形剂相同的药物，其中所述包衣组合物包围所述核心，使得所述系统提供所述药物在胃肠道液体中的双相释放。

    DRUG LOADED NANORESIN PARTICLES
    83.
    发明公开
    DRUG LOADED NANORESIN PARTICLES 审中-公开

    公开(公告)号：EP3943072A1

    公开(公告)日：2022-01-26

    申请号：EP21195946.5

    申请日：2016-07-27

    Applicant: Sun Pharma Advanced Research Company Ltd

    Inventor： KHOPADE, Ajay Jaysingh ,  HALDER, Arindam ,  UPADHYAY, Shivam Umeshkumar

    IPC: A61K9/14 ,  A61K9/10 ,  A61K9/06

    Abstract: The present invention relates to nano-resin particles that are suitable for pharmaceutical use and their use in the pharmaceutical field. The present invention provides nano-sized resin particles having a particle size distribution characterized in that D 90 value is between 200 nanometers to 900 nanometer and D 10 value is not less than 50 nanometers, wherein the nano-resin particles are in pure form and safe for pharmaceutical use. The present invention further relates to pharmaceutical compositions comprising these purified nano-resin particles and their use in the treatment of diseases.
    The present invention further provides a process for preparing purified, nano-sized resin particles that are suitable for pharmaceutical use, the process comprising steps of: (i) washing an ion exchange resin and suspending in an aqueous liquid, (ii) subjecting the suspension of (i) to wet milling for a period such that the particles have a particle size distribution characterized in that the D 90 value is between 200 nanometers to 900 nanometers and D 10 value is not less than 50 nanometers, (iii) subjecting the suspension of (ii) to purification to remove impurities, (iv) drying the purified suspension to obtain nano-resin particles in the form of dry powder.

    DRY POWDER INHALATION COMPOSITION
    89.
    发明公开
    DRY POWDER INHALATION COMPOSITION 审中-公开
    TROCKENPULVERINHALATIONSZUSAMMENSETZUNG

    公开(公告)号：EP2571486A1

    公开(公告)日：2013-03-27

    申请号：EP11783170.1

    申请日：2011-05-13

    Applicant: Sun Pharma Advanced Research Company Ltd

    Inventor： BHOWMICK, Subhas ,  KANE, Prashant ,  S, Ganesh ,  PATEL, Tarun ,  CHUDIWAL, Swapnil

    IPC: A61K9/00 ,  A61K31/137

    CPC classification number: A61K31/137 ,  A61K9/0075 ,  A61K9/145

    Abstract: The dry powder inhalation composition comprising (1) salmeterol xinafoate having mean particle size in range of 2.0μ-6μ microns and a tapped density in the range of 0.20 g·cm−3 to 0.45 g·cm−3 and (2) optionally, one or more other active ingredients and pharmaceutically acceptable carrier.

    Abstract translation: 所述干粉吸入组合物包含（1）平均粒径为2.0μ-6μ微米的海洛英醇海绵酸新甲酯，并且在0.20g·cm -3〜0.45g·cm -3的范围内的抽头密度和（2）任选地， 一种或多种其它活性成分和药学上可接受的载体。

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