公开(公告)号：US11219686B2

公开(公告)日：2022-01-11

申请号：US16722124

申请日：2019-12-20

Applicant: The Catholic University of America

Inventor： Venigalla B. Rao

IPC: A61K39/02 ,  C07K14/24 ,  C07K14/32 ,  C07K14/005 ,  A61K39/385 ,  A61K39/07 ,  C07K19/00 ,  A61K39/295 ,  A61K39/00

Abstract: Bivalent immunogenic compositions against anthrax and plague are disclosed herein. One bivalent immunogenic composition comprises a triple fusion protein containing three antigens, F1 and V from Yersinia pestis and PA antigen from Bacillus anthracis fused in-frame and retaining structural and functional integrity of all three antigens. Another bivalent immunogenic composition comprises bacteriophage nanoparticles arrayed with these three antigens on the capsid surface of the bacteriophage nanoparticles. These bivalent immunogenic compositions are able to elicit robust immune response in a subject administered said the bivalent immunogenic compositions and provide protection to the subject against sequential or simultaneous challenge with both anthrax and plague pathogens.

公开(公告)号：US11155835B2

公开(公告)日：2021-10-26

申请号：US16990289

申请日：2020-08-11

Applicant: The Catholic University of America

Inventor： Venigalla B. Rao ,  Jingen Zhu

IPC: C12N15/86

Abstract: Described is hybrid viral vector comprising: a first virus such as bacteriophage T4; one or more second virus such as adeno-associated virus (AAV) attached to the first virus through cross-bridges, such as avidin-biotin cross-bridges; one or more DNA molecules packaged in the first virus; one or more nucleic acid molecules packaged in the second virus; and one or more proteins displayed on the surface of the first virus. Also described are methods of making and using such a hybrid viral vector.

公开(公告)号：US10441940B2

公开(公告)日：2019-10-15

申请号：US14412892

申请日：2013-08-20

Applicant: UNIVERSITY OF MARYLAND ,  THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： Chanel Tissot ,  Aaron Barkatt ,  Mohamad I. Al-Sheikhly

IPC: B01J20/00 ,  B01J20/30 ,  G21F9/12 ,  C22B60/02 ,  B01J20/26 ,  B01J20/32 ,  B01J20/34 ,  B01J20/28 ,  C02F1/28 ,  C08G69/00 ,  C02F101/00 ,  C02F1/68 ,  C02F103/08

Abstract: Complexing or chelating agents that offer strong, selective bonding with uranium as well as a broad pH range of effectiveness, specifically including the pH range around 8.2, together with the acrylic double bonds required for radiation-induced grafting on polymers to remove uranium from a solution such as seawater. The novel adsorbing species are phosphorus-containing molecules, in particular organic phosphates, phosphonates and phosphoric acids. Organic phosphorus compounds, for example, organic phosphates, phosphonates, and phosphoric acids, are attached to polymer fibers to form fibers, fiber fabrics or membranes that are effective, or show activity, in uranium adsorption.

公开(公告)号：US20170336534A1

公开(公告)日：2017-11-23

申请号：US15600020

申请日：2017-05-19

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： Kevin F. Forbes ,  Ernest M. Zampelli

IPC: G01W1/10 ,  G06F17/30 ,  G06F15/18 ,  G06F17/10 ,  G01W1/00

CPC classification number: G01W1/10 ,  F05B2260/8211 ,  G01W2001/006 ,  G01W2201/00 ,  G01W2203/00 ,  G06F16/23 ,  G06F17/10 ,  G06F17/18 ,  G06N20/00 ,  G06Q10/04 ,  G06Q50/06

Abstract: A computer system and method for improving the accuracy of predictions of the amount of renewable energy, such as solar energy and wind energy, available to an electric utility, and/or refine such predictions, by providing improved integration of meteorological forecasts. Coefficient values are calculated for a renewable energy generation model by performing a regression analysis with the forecasted level of renewable energy posted by the utility, forecasted weather conditions and measures of seasonality as explanatory variables. Accuracy is further enhanced through the inclusion of a large number of time series variables that reflect the systematic nature of the energy/weather system. The model also uses the original forecast posted by the system operator as well as variables to control for season.

公开(公告)号：US20170334779A1

公开(公告)日：2017-11-23

申请号：US15597227

申请日：2017-05-17

Applicant: The Catholic University of America

Inventor： Weiliang GONG ,  Hui XU ,  Werner LUTZE ,  Ian PEGG

IPC: C04B28/00 ,  C04B22/08 ,  C04B24/26 ,  C09K8/42 ,  E21B33/14 ,  C04B22/06 ,  C04B14/22 ,  C04B103/22 ,  C04B103/12 ,  C04B103/32 ,  C04B111/00

CPC classification number: C04B28/006 ,  C04B14/22 ,  C04B22/062 ,  C04B22/08 ,  C04B24/26 ,  C04B2103/12 ,  C04B2103/22 ,  C04B2103/32 ,  C04B2111/00146 ,  C09K8/42 ,  C09K8/467 ,  E21B33/14 ,  Y02P40/165 ,  Y02W30/92 ,  Y02W30/94 ,  Y02W30/95 ,  C04B12/04 ,  C04B18/08 ,  C04B2103/24 ,  C04B14/047 ,  C04B14/062 ,  C04B14/106 ,  C04B14/14 ,  C04B14/18 ,  C04B18/141 ,  C04B18/146 ,  C04B18/162 ,  C04B22/066 ,  C04B22/008

Abstract: Three pumpable geopolymer compositions for well sealing application is disclosed herein. One pumpable geopolymer composition comprises: (i) less reactive aluminosilicate; (ii) more reactive aluminosilicate; (iii) alkaline silicate activator solution with a very low SiO2/M2O. Another pumpable geopolymer composition comprises: (i) less reactive aluminosilicate; (ii) more reactive aluminosilicate; (iii) alkaline silicate-free activator solution that may contain an alkali salt; and (iv) powdered alkali silicate glass. The third pumpable geopolymer composition comprises (i) less reactive aluminosilicate; (ii) more reactive aluminosilicate; (iii) alkaline low silicate activator solution; and (iv) powdered alkali silicate glass.

公开(公告)号：US20140329891A1

公开(公告)日：2014-11-06

申请号：US14337545

申请日：2014-07-22

Applicant: The Catholic University of America

Inventor： Venigalla B. RAO

IPC: C12N15/85

CPC classification number: C12N15/87 ,  C07K2319/10 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2795/10122 ,  C12N2795/10123 ,  C12N2795/10142 ,  C12N2810/6009 ,  C12N2810/85 ,  C12N2810/859

Abstract: Described is T4 DNA packaging machine comprising: one or more DNA molecules packaged in a head of the T4 DNA packaging machine, one or more Hoc-fused proteins displayed on the head of the T4 DNA packaging machine, and one or more Soc-fused proteins displayed on the head of the T4 DNA packaging machine. Also described are methods of making and using such a T4 DNA packaging machine.

公开(公告)号：US20010044643A1

公开(公告)日：2001-11-22

申请号：US09737546

申请日：2000-12-18

Applicant: The Catholic University of America

Inventor： Theodore A. Litovitz

IPC: A61N001/00

CPC classification number: A61N1/40 ,  A61N2/02

Abstract: Methods and apparatus are described for the treatment of diseases by exposures to electromagnetic fields. Also, apparatus is described for focusing the biological effectiveness of such fields on specific cells, tissues or organs of a human or animal body.

Abstract translation: 描述了通过暴露于电磁场来治疗疾病的方法和装置。 此外，描述了将这些领域的生物学效力聚焦在人或动物体的特定细胞，组织或器官上的装置。

公开(公告)号：US12037597B2

公开(公告)日：2024-07-16

申请号：US17488542

申请日：2021-09-29

Applicant: The Catholic University of America

Inventor： Venigalla B. Rao ,  Jingen Zhu

IPC: C12N15/86

CPC classification number: C12N15/86 ,  C12N2750/14133 ,  C12N2750/14134 ,  C12N2795/10133 ,  C12N2795/10134

Abstract: Described is hybrid viral vector comprising: a first virus such as bacteriophage T4; one or more second virus such as adeno-associated virus (AAV) attached to the first virus through cross-bridges, such as avidin-biotin cross-bridges; one or more DNA molecules packaged in the first virus; one or more nucleic acid molecules packaged in the second virus; and one or more proteins displayed on the surface of the first virus. Also described are methods of making and using such a hybrid viral vector.

公开(公告)号：US20210054410A1

公开(公告)日：2021-02-25

申请号：US16990289

申请日：2020-08-11

Applicant: The Catholic University of America

Inventor： Venigalla B. RAO ,  Jingen ZHU

IPC: C12N15/86

Abstract: Described is hybrid viral vector comprising: a first virus such as bacteriophage T4; one or more second virus such as adeno-associated virus (AAV) attached to the first virus through cross-bridges, such as avidin-biotin cross-bridges; one or more DNA molecules packaged in the first virus; one or more nucleic acid molecules packaged in the second virus; and one or more proteins displayed on the surface of the first virus. Also described are methods of making and using such a hybrid viral vector.

公开(公告)号：US20200147207A1

公开(公告)日：2020-05-14

申请号：US16722124

申请日：2019-12-20

Applicant: The Catholic University of America

Inventor： Venigalla B. RAO

IPC: A61K39/295 ,  A61K39/02 ,  C07K19/00 ,  A61K39/07 ,  A61K39/385 ,  C07K14/005 ,  C07K14/32 ,  C07K14/24

Abstract: Bivalent immunogenic compositions against anthrax and plague are disclosed herein. One bivalent immunogenic composition comprises a triple fusion protein containing three antigens, F1 and V from Yersinia pestis and PA antigen from Bacillus anthracis fused in-frame and retaining structural and functional integrity of all three antigens. Another bivalent immunogenic composition comprises bacteriophage nanoparticles arrayed with these three antigens on the capsid surface of the bacteriophage nanoparticles. These bivalent immunogenic compositions are able to elicit robust immune response in a subject administered said the bivalent immunogenic compositions and provide protection to the subject against sequential or simultaneous challenge with both anthrax and plague pathogens.