公开(公告)号：WO2002062396A3

公开(公告)日：2002-08-15

申请号：PCT/US2002/003819

申请日：2002-02-08

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  RUTGERS, THE STATE OF UNIVERSITY OF NEW JERSEY ,  PARANJP, Pankaj ,  STEIN, Stanley ,  LEIBOWITZ, Michael, J. ,  SINKO, Patrick, J. ,  MINKO, Tamara ,  WILLIAMS, Gregory, C. ,  ZHANG, Goubao ,  POOYAN, Shahrair ,  PARK, Seong Hee ,  QIU, Bo ,  RAMANATHAN, Srinivasan

Inventor： PARANJP, Pankaj ,  STEIN, Stanley ,  LEIBOWITZ, Michael, J. ,  SINKO, Patrick, J. ,  MINKO, Tamara ,  WILLIAMS, Gregory, C. ,  ZHANG, Goubao ,  POOYAN, Shahrair ,  PARK, Seong Hee ,  QIU, Bo ,  RAMANATHAN, Srinivasan

IPC: A61K47/48

Abstract: The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from on eboldily comparment to one or more other bodily compartment bz administering one of the following conjugates: a polmer having multiple functional groups at least one of which is covalentyl bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at lest one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.

公开(公告)号：WO1996014095A1

公开(公告)日：1996-05-17

申请号：PCT/US1995014308

申请日：1995-11-07

Applicant: THE UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY

Inventor： THE UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  SILVER, Frederick, H. ,  KATO, Yasushi, Pedro

IPC: A61L27/00

CPC classification number: D01F4/00 ,  A61F2/08 ,  A61F2310/00365 ,  A61L27/24 ,  A61L27/48 ,  A61L27/58 ,  C08L89/06

Abstract: An improved biodegradable and biocompatible reconstituted monofilament collagen fiber having increased strength and elasticity is disclosed. The method of manufacture of the fiber, comprising a water bath step following a dehydration step, is also disclosed. Several embodiments of the collagen fiber are disclosed, including grafts, prosthetic devices, bundles of the fibers where the fibers of the bundle are tensioned and fail substantially in unison, and methods thereof. The fibers of the invention, or the embodiments of the fibers, may be coated or embedded in a polymer to protect the fibers and to bind them together. Additionally, proteoglycans may be incorporated into the fibers to enhance the ultimate tensile strength of the fibers.

Abstract translation: 公开了具有增强的强度和弹性的改进的可生物降解和生物相容性重建单丝胶原纤维。 还公开了包含脱水步骤后的水浴步骤的纤维的制造方法。 公开了胶原纤维的几个实施方案，包括移植物，假体装置，纤维束，其中束的纤维被张紧并且基本上一致地失效，以及其方法。 本发明的纤维或纤维的实施方案可以被涂覆或嵌入聚合物中以保护纤维并将它们结合在一起。 此外，蛋白多糖可以并入纤维中以增强纤维的极限拉伸强度。

公开(公告)号：WO1992022667A1

公开(公告)日：1992-12-23

申请号：PCT/US1992004987

申请日：1992-06-12

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW ... ,  MOYLE, William, R. ,  BERNARD, Michael ,  MYERS, Rebecca

Inventor： UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW ...

IPC: C12Q01/00

CPC classification number: C07K14/723 ,  C07K2319/00 ,  C07K2319/033 ,  C07K2319/32

Abstract: In one embodiment, the present invention pertains to a protein having binding affinity to human chorionic gonadotrophin (hCG), luteinizing hormone (LH), and follicle stimulating hormone (FSH), comprising an amino acid sequence of 341 amino acids, wherein the protein is a chimera having an amino acid sequence homologous to the amino acid sequence of residues 1-92 of FSHR, an amino acid sequence homologous to the amino acid sequence of residues 93-170 of LHR, and an amino acid sequence homologous to the amino acid sequence of residues 171-341 of FSHR, wherein the protein is a chain of amino acids that is not naturally occurring as a binding protein. (LH numbering system). In another embodiment, the present invention pertains to a glycoprotein hormone receptor having binding affinity to human chorionic gonadotrophin (hCG), luteinizing hormone (LH), and follicle stimulating hormone (FSH), wherein the receptor comprises a transmembrane region and an extracellular N-terminus region, wherein the N-terminus region is a chimera containing an amino acid sequence of 341 amino acids comprising an amino acid sequence homologous to the amino acid sequence of residues 1-92 of FSHR, an amino acid sequence homologous to the amino acid sequence of residues 93-170 of LHR, and an amino acid sequence homologous to the amino acid sequence of residues 171-341 of FSHR, wherein the receptor is a chain of amino acids that is not naturally occurring as a receptor. (LH nmbering system).

Abstract translation: 在一个实施方案中，本发明涉及对人绒毛膜促性腺激素（hCG），黄体生成激素（LH）和促卵泡激素（FSH））具有结合亲和力的蛋白质，其包含341个氨基酸的氨基酸序列，其中所述蛋白质是 具有与FSHR的残基1-92的氨基酸序列同源的氨基酸序列的嵌合体，与LHR的残基93-170的氨基酸序列同源的氨基酸序列和与氨基酸序列同源的氨基酸序列 的FSHR的残基171-341，其中所述蛋白质是不是天然存在的结合蛋白质的氨基酸链。 （LH编号系统）。 在另一个实施方案中，本发明涉及对人绒毛膜促性腺激素（hCG），黄体生成激素（LH）和促卵泡激素（FSH）具有结合亲和力的糖蛋白激素受体，其中所述受体包含跨膜区和细胞外N- 其中所述N末端区域是包含341个氨基酸的氨基酸序列的嵌合体，其包含与FSHR的残基1-92的氨基酸序列同源的氨基酸序列，与氨基酸序列同源的氨基酸序列 的LHR的残基93-170和与FSHR的残基171-341的氨基酸序列同源的氨基酸序列，其中受体是不天然存在的受体的氨基酸链。 （LH nmbering系统）。

公开(公告)号：WO1985004413A1

公开(公告)日：1985-10-10

申请号：PCT/US1985000504

申请日：1985-03-27

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW ...

Inventor： UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW ... ,  SILVER, Frederick, H. ,  BERG, Richard, A. ,  BIRK, David, E. ,  WEADOCK, Kevin ,  WHYNE, Conrad

IPC: C08L89/06

CPC classification number: A61L15/425 ,  A61K9/70 ,  A61L15/325 ,  A61L15/44 ,  A61L15/64 ,  A61L26/0033 ,  A61L27/24 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/254 ,  A61L2300/404 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/434 ,  C08L89/06 ,  Y10S128/08 ,  Y10S514/801

Abstract: Processes for preparaing biodegradable collagen-based matrices in sponge or sheet form wherein in one embodiment a collagen-based material including a collagen selected from the group consisting of types I, II and III collagens is freeze dried to form a collagen-based sponge which is contacted with a crosslinking agent selected from the group consisting of a carbodiimide or a succinimidyl active ester to form an intermediate collagen-based matrix which is subsequently subjected to conditions of severe dehydration to form the collagen-based matrix in sponge or sheet form. In another embodiment, a collagen-based sponge or sheet is first subjected to conditions of severe dehydration followed by contacting the thus formed intermediate collagen-based matrix with a carbodiimide crosslinking compound to form the collagen-based matrix in sponge or sheet form. In still another embodiment of the present invention the cross-linking agent is admixed with the collagen-based material prior to formation of the collagen-based sponge or sheet followed by processing steps of severe dehydration. In a paticularly preferred form of the invention, a carrier compound is incorporated during processing to form a collagen-based matrix in sponge or sheet form impregnated with a carrier compound wherein the carrier compound is selected from the group consisting of types IV and V collagen, fibronecting, laminin, hyaluronate, proteoglycan, epidermal growth factor, platelet derived growth factor, angiogenesis factor, antibiotic, antifungal agent, spermacidal agent, enzyme and enzyme inhibitor.

Abstract translation: 以海绵或片状形式制备可生物降解的胶原基质的方法，其中在一个实施方案中，将包含选自I，II和III型胶原蛋白的胶原蛋白的胶原基材料冷冻干燥以形成基于胶原的海绵， 与选自碳二亚胺或琥珀酰亚胺基活性酯的交联剂接触以形成中间胶原基质，随后经历严重脱水的条件以形成海绵或片状形式的基于胶原的基质。 在另一个实施方案中，基于胶原的海绵或片材首先经受严重脱水的条件，然后使由此形成的中间胶原基质与碳二亚胺交联化合物接触以形成海绵或片状形式的基于胶原的基质。 在本发明的另一个实施方案中，在形成基于胶原的海绵或片材之前将交联剂与基于胶原的材料混合，然后进行严重脱水的加工步骤。 在本发明的特别优选形式中，在加工过程中加入载体化合物以形成浸渍有载体化合物的海绵或片状形式的基于胶原的基质，其中载体化合物选自IV型和V型胶原， 纤连蛋白，层粘连蛋白，透明质酸，蛋白多糖，表皮生长因子，血小板衍生生长因子，血管生成因子，抗生素，抗真菌剂，精子拮抗剂，酶和酶抑制剂。

公开(公告)号：WO2013106761A2

公开(公告)日：2013-07-18

申请号：PCT/US2013/021300

申请日：2013-01-11

Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  TAXIS PHARMACEUTICALS, INC. ,  LAVOIE, Edmond J. ,  PARHI, Ajit ,  PILCH, Daniel S. ,  ZHANG, Youngzheng ,  KAUL, Malvika

Inventor： LAVOIE, Edmond J. ,  PARHI, Ajit ,  PILCH, Daniel S. ,  ZHANG, Youngzheng ,  KAUL, Malvika

IPC: A61K31/131 ,  A61K31/14 ,  A61K31/155 ,  A61K31/417 ,  A61P31/04

CPC classification number: C07D417/06 ,  A61K31/135 ,  A61K31/14 ,  A61K31/155 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/425 ,  A61K31/427 ,  A61K31/428 ,  A61K31/44 ,  A61K31/495 ,  C07C211/27 ,  C07C211/64 ,  C07C279/04 ,  C07C279/08 ,  C07C279/10 ,  C07D213/58 ,  C07D233/60 ,  C07D277/28 ,  C07D277/64 ,  C07D295/096 ,  Y02A50/401 ,  Y02A50/475 ,  Y02A50/481

Abstract: The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a compound of formula I: [formula should be inserted here] wherein A, B, and X have any of the meanings defined in the specification; or a pharmaceutically acceptable salt thereof, as well as novel compounds of formula I and salts thereof and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明提供了治疗哺乳动物中的细菌感染的方法，包括给哺乳动物施用式I的化合物：[其中A，B和X具有任何含义 在说明书中定义; 或其药学上可接受的盐，以及新的式I化合物及其盐和包含式I化合物或其药学上可接受的盐的药物组合物。

公开(公告)号：WO2013089888A3

公开(公告)日：2013-06-20

申请号：PCT/US2012/057888

申请日：2012-09-28

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  STEVENS INSTITUTE OF TECHNOLOGY ,  DAI, Xiaoguang ,  MARRAS, Salvatore, A.E. ,  LIBERA, Matthew

Inventor： DAI, Xiaoguang ,  MARRAS, Salvatore, A.E. ,  LIBERA, Matthew

IPC: C12Q1/68

Abstract: The present invention relates to surface-patterned microgels to which molecular beacon probes are immobilized. The immobilized molecular beacon probes exhibit both low non-specific background and high specific fluorescence. Also disclosed are related arrays, related detection methods, and preparation methods.

公开(公告)号：WO2013082295A1

公开(公告)日：2013-06-06

申请号：PCT/US2012/067087

申请日：2012-11-29

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY

Inventor： LIN, Sheldon, Suton ,  PAGLIA, David, Naisby ,  O'CONNOR, John, Patrick ,  BENEVENIA, Joseph ,  WEY, Aaron ,  SUBRAMANIAN, Sangeeta ,  CHIRICHELLA, Paul ,  VIVES, Michael, J.

IPC: A61K33/24 ,  A61K35/32

CPC classification number: A61K33/24 ,  A61K9/0024 ,  A61K33/04 ,  A61K33/30 ,  A61K33/32 ,  A61K35/32 ,  A61K38/179 ,  A61K38/1793 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1875 ,  A61K38/2026 ,  A61K38/2066 ,  A61K38/2086 ,  A61K38/29 ,  A61K45/06 ,  A61L27/54 ,  A61L2430/38 ,  A61K2300/00

Abstract: Methods of promoting bone healing or regeneration by locally administering insulin mimetic agents to patients in need thereof and new uses of insulin-mimetic compounds for accelerating bone-healing processes are disclosed. Bone injury treatment and void filler devices, products and kit suitable for local administration of insulin-mimetic agents or compositions thereof to patients in need of such treatment are also disclosed.

Abstract translation: 公开了通过局部给予有需要的患者的胰岛素模拟物促进骨愈合或再生的方法以及用于加速骨愈合过程的胰岛素模拟化合物的新用途。 还公开了骨损伤治疗和适用于局部给予需要这种治疗的患者胰岛素模拟剂或其组合物的空隙填充装置，产品和试剂盒。

公开(公告)号：WO2013036610A2

公开(公告)日：2013-03-14

申请号：PCT/US2012/053920

申请日：2012-09-06

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  MA, Jianjie ,  WEISLEDER, Noah

Inventor： MA, Jianjie ,  WEISLEDER, Noah

IPC: A61K48/00

CPC classification number: C07K14/4702 ,  A61K48/00

Abstract: Disclosed herein are compositions and methods for the treatment and/or protection of airway cells and/or tissue from damage due to injury to the lungs or complications of underlying respiratory, cardiovascular or infectious diseases, or any combination thereof.

Abstract translation: 本文公开了用于治疗和/或保护气道细胞和/或组织免于由于肺损伤或潜在的呼吸系统并发症，心血管或感染性疾病或任何组合造成的损伤的组合物和方法 物。

公开(公告)号：WO2012149113A1

公开(公告)日：2012-11-01

申请号：PCT/US2012/035129

申请日：2012-04-26

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  MOURADIAN, M., Maral ,  BRAITHWAITE, Steven ,  VORONKOV, Michael

Inventor： MOURADIAN, M., Maral ,  BRAITHWAITE, Steven ,  VORONKOV, Michael

IPC: A61K31/485 ,  C07D221/28

CPC classification number: A61K31/485 ,  A61K31/197 ,  A61K45/06

Abstract: Methods of treating patients with dyskinesias, by administering a therapeutically effective amount of a dual-action mu-opioid receptor antagonist/kappa-opioid receptor agonist or prodrug thereof to a subject in need thereof, sufficient to mitigate the dyskinesia. Alternatively, a combination of both a mu-opioid receptor antagonist or prodrug thereof, and a kappa-opioid receptor agonist or prodrug thereof can be administered, either together or separately.

Abstract translation: 通过向有需要的受试者施用足以减轻运动障碍的治疗有效量的双重作用的μ-阿片样物质受体拮抗剂/κ-阿片受体激动剂或其前体药物来治疗运动障碍患者的方法。 或者，可以一起或分开施用μ-阿片受体拮抗剂或其前药和κ-阿片受体激动剂或其前药的组合。

公开(公告)号：WO2012079024A2

公开(公告)日：2012-06-14

申请号：PCT/US2011/064240

申请日：2011-12-09

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  LIN, Sheldon, Suton ,  PAGLIA, David, Naisby ,  O'CONNOR, John, Patrick ,  BREITBART, Eric ,  BENEVENIA, Joseph

Inventor： LIN, Sheldon, Suton ,  PAGLIA, David, Naisby ,  O'CONNOR, John, Patrick ,  BREITBART, Eric ,  BENEVENIA, Joseph

IPC: A61K31/28 ,  A61K47/04

CPC classification number: A61L31/08 ,  A61K9/0024 ,  A61K9/0092 ,  A61K31/28 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/40 ,  A61L2420/04 ,  A61L2430/02

Abstract: The present invention discloses vanadium-based insulin-mimetic agent composite coatings, application of these coatings onto implantable devices, and use of the implantable devices for accelerating osseous healing. The invention also encompasses methods of manufacturing implantable devices coated with vanadium-based insulin- mimetic agent composite coatings and the implantable devices so manufactured. The implantable devices have wide applications, including but not limited to treating bone fracture, bone trauma, arthrodesis, and other bone deficit conditions, as well as bone injuries incurred in military and sports activities.

Abstract translation: 本发明公开了基于钒的胰岛素模拟剂复合涂层，将这些涂层应用于可植入装置，以及使用可植入装置来加速骨愈合。 本发明还包括制造涂覆有基于钒的胰岛素模拟剂复合涂层的可植入装置和如此制造的可植入装置的方法。 可植入装置具有广泛的应用，包括但不限于治疗骨折，骨创伤，关节固定术和其他骨缺损状况，以及在军事和体育活动中引起的骨损伤。