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公开(公告)号：IL225463D0
公开(公告)日：2013-06-27
申请号：IL22546313
申请日：2013-03-24
Applicant: UNIV PENNSYLVANIA , VENTIRX PHARMACEUTICALS INC
IPC: A61K20060101
Abstract: The present invention is directed generally to formulations of a TLR agonist preferably a TLR8 agonist, and its use in the treatment of various diseases, including combination therapies for treating cancer.
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公开(公告)号：SG189071A1
公开(公告)日：2013-05-31
申请号：SG2013021803
申请日：2011-10-03
Applicant: VENTIRX PHARMACEUTICALS INC , UNIV PENNSYLVANIA
Inventor： HERSHBERG ROBERT , COUKOS GEORGE , DIETSCH GREGORY , FACCIABENE ANDREA , MANJARREZ KRISTI , RANDALL TRESSA D
Abstract: The present invention is directed generally to formulations of a TLR agonist preferably a TLR8 agonist, and its use in the treatment of various diseases, including combination therapies for treating cancer.
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公开(公告)号：CA2824786A1
公开(公告)日：2012-07-19
申请号：CA2824786
申请日：2012-01-12
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC
Inventor： HOWBERT JAMES JEFFRY , HERSHBERG ROBERT , BURGESS LAURANCE E , DOHERTY GEORGE A , EARY CHARLES TODD , GRONEBERG ROBERT D , JONES ZACHARY , LYSSIKATOS JOSEPH P , YANG HONG WOON
IPC: C07D403/10 , A61K31/55 , A61P37/00 , C07D223/14 , C07D403/12
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
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公开(公告)号：CA2771484A1
公开(公告)日：2011-02-24
申请号：CA2771484
申请日：2010-08-18
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC
Inventor： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY C TODD , GRONEBERG ROBERT D , JONES ZACHARY
IPC: C07D403/10 , A61K31/4025 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D401/14 , C07D403/14
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll- like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
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公开(公告)号：MX383893B
公开(公告)日：2025-03-14
申请号：MX2018005544
申请日：2018-05-02
Applicant: VENTIRX PHARMACEUTICALS INC
Inventor： DIETSCH GREGORY N
IPC: A61K31/55 , A61K31/704 , A61K39/395 , A61P35/00
Abstract: La solicitud se refiere a métodos para inducir respuestas inmunes antitumorales en un sujeto que tiene cáncer; en algunas modalidades, se proveen métodos para administrar a un sujeto que lo necesita un agonista de TLR8 y un antagonista de PD1-1/PD-L1, opcionalmente incluyendo uno o más agentes terapéuticos adicionales.
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Patent Agency Ranking
公开(公告)号：BR112012003757A2
公开(公告)日：2020-08-11
申请号：BR112012003757
申请日：2010-08-18
Applicant: ARRAY BIOPHARMA INC , VENTIRX PHARMACEUTICALS INC
Inventor： BRAD NEWHOUSE , GREGORY DIETSCH , HONG WOON YANG , JAMES JEFFRY HOWBERT , JOSEPH P LYSSIKATOS , LAURENCE E BURGESS , ROBERT HERSHBERG
IPC: C07D223/14 , A61K31/4025 , A61K31/454 , A61K31/55 , A61P31/00 , A61P35/00 , C07D401/14 , C07D403/10
Abstract: benzoazepinas substítuidas como moduladores de receptor tipo dobre de sino. são fornecidos composições e métodos úteis para a modulação de sinalização através des receptores tipo dobre de sino tlr7 e/ou tlr8. as composições e métodos têm uso no tratamento ou prevenção de doença, incluindo câncer, doença autoimune, doença infecciosa, distúrbio inflamatório, rejeição a enxerto, e doença de enxerto versus hospedeiro.
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公开(公告)号：CA2824779C
公开(公告)日：2020-01-14
申请号：CA2824779
申请日：2012-01-12
Applicant: ARRAY BIOPHARMA INC , VENTIRX PHARMACEUTICALS INC
Inventor： HOWBERT JAMES JEFFRY , HERSHBERG ROBERT , BURGESS LAURENCE E , YANG HONG WOON
IPC: C07D223/16 , A61K31/55 , A61P29/00 , A61P35/00 , C07D403/10
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
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公开(公告)号：HK1252816A1
公开(公告)日：2019-06-06
申请号：HK18112122
申请日：2018-09-20
Applicant: VENTIRX PHARMACEUTICALS INC
Inventor： DIETSCH GREGORY N
IPC: A61K20060101
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公开(公告)号：BR112013007681A2
公开(公告)日：2019-05-14
申请号：BR112013007681
申请日：2011-10-03
Applicant: UNIV PENNSYLVANIA , VENTIRX PHARMACEUTICALS INC
Inventor： ANDREA FACCIABENE , GEORGE COUKOS , GREGORY DIETSCH , KRISTI MANJARREZ , ROBERT HERSHBERG , TRESSA D RANDALL
IPC: A61K9/127 , A61K9/48 , A61K31/122 , A61K31/55 , A61P35/00
Abstract: uso terapêutico de um agonista trl e terapia de combinação a presente invenção é direcionada em geral a formulações de um agonista trl preferivelmente um agonista trl8, e o seu uso no tratamento de várias doenças, incluindo terapias de combinação para tratar câncer.
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公开(公告)号：PL2467380T3
公开(公告)日：2017-09-29
申请号：PL10810564
申请日：2010-08-18
Applicant: VENTIRX PHARMACEUTICALS INC , ARRAY BIOPHARMA INC
Inventor： HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY C TODD , GRONEBERG ROBERT D , JONES ZACHARY
IPC: C07D403/10 , A61K31/4025 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D401/14 , C07D403/14
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