公开(公告)号：US10751368B2

公开(公告)日：2020-08-25

申请号：US15873943

申请日：2018-01-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair Reisner ,  Esther Bachar-Lustig ,  Shlomit Reich-Zeliger

IPC: A61K35/17 ,  C07K16/28 ,  A61P35/00 ,  A61K35/28 ,  A61K39/395

Abstract: A method of transplantation is disclosed. The method comprising administering to a subject in need of transplantation of cells in suspension, a therapeutically effective amount of tolerance inducing anti-third party cytotoxic T-lymphocytes (CTLs), wherein the tolerance inducing anti-third party CTLs are generated by directing T-lymphocytes of a donor against a third party antigen or antigens, the tolerance inducing anti-third party CTLs being substantially depleted of T-lymphocytes capable of developing into alloreactive CTLs, and wherein the tolerance inducing anti-third party CTLs do not comprise cells having a central memory T-lymphocyte (Tcm) phenotype, wherein the cells in suspension comprise non-hematopoietic cells or hematopoietic cells which are not stem cells. Methods of treating and kits are also provided.

公开(公告)号：US10730976B2

公开(公告)日：2020-08-04

申请号：US16064498

申请日：2016-12-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob Klein ,  Weifeng Lin ,  Ronit Goldberg

IPC: C07F9/10 ,  C08F130/02 ,  A61K9/127 ,  A61K9/08 ,  A61P19/02 ,  A61K9/00 ,  A61K47/69

Abstract: A polymeric compound is disclosed herein, having the general formula I: wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.

公开(公告)号：US10688330B2

公开(公告)日：2020-06-23

申请号：US15535050

申请日：2015-12-10

Applicant: Yeda Research and Development Co. Ltd. ,  University of Washington

Inventor： Dan S. Tawfik ,  Haim Leader ,  Yaacov Ashani ,  Izhack Cherny ,  Moshe Goldsmith ,  Per Jr. Greisen ,  Sagar D. Khare ,  Gustav Oberdorfer ,  David Baker ,  Sarel Fleishman ,  Adi Goldenzweig ,  Nidhi Aggarwal

IPC: C12N9/16 ,  A61P25/00 ,  A62D3/02 ,  A62D101/02 ,  A62D101/26

Abstract: A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.

公开(公告)号：US20200131232A1

公开(公告)日：2020-04-30

申请号：US16726290

申请日：2019-12-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ada YONATH ,  Zohar EYAL ,  Donna MATZOV ,  Haim ROZENBERG ,  Ella ZIMMERMAN ,  Anat BASHAN

IPC: C07K14/31 ,  C07H17/08 ,  C07D263/20 ,  C07D211/54 ,  G16C20/50 ,  G16B15/00 ,  G16B30/00

Abstract: A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.

公开(公告)号：US20200095984A1

公开(公告)日：2020-03-26

申请号：US16495487

申请日：2018-03-07

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Jacob Karni ,  Leon Karni

IPC: F03G6/06 ,  F24S10/30 ,  F24S23/77 ,  F24S60/10

Abstract: The present invention relates to the utilization of solar energy for generation of electricity and/or production of clean fuels or other chemicals, as a means for long term, transportable storage of inherently intermittent solar energy.

公开(公告)号：US10557852B2

公开(公告)日：2020-02-11

申请号：US15307011

申请日：2015-04-28

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David Margulies ,  Leila Motiei ,  Naama Mankovski ,  Yael Nissinkorn

IPC: G01N33/58 ,  G01N33/68

Abstract: This invention is directed to monomolecular sensors, comprising a selective binder, a non-selective binder and a fluorophore, which can track changes that occur on the surface of labeled proteins. This invention is further directed to the use of such sensors for identifying binding partners of specific proteins. This invention is further directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins.

公开(公告)号：US20190388064A1

公开(公告)日：2019-12-26

申请号：US16478507

申请日：2018-01-19

Applicant: New York University ,  Yeda Research And Development Co., Ltd.

Inventor： Itay KEZURER ,  Achiau LUDOMIRSKY ,  Yaron LIPMAN

IPC: A61B8/08 ,  G06T7/00 ,  G06T7/62 ,  G06T7/194 ,  G06T17/20 ,  G06N3/08 ,  G06N20/00

Abstract: An exemplary system, method and computer-accessible medium for detecting an anomaly(ies) in an anatomical structure(s) of a patient(s) can be provided, which can include, for example, receiving imaging information related to the anatomical structure(s) of the patient(s), classifying a feature(s) of the anatomical structure(s) based on the imaging information using a neural network (s), and detecting the anomaly(ies) based on data generated using the classification procedure. The imaging information can include at least three images of the anatomical structure(s).

公开(公告)号：US10468507B2

公开(公告)日：2019-11-05

申请号：US15527711

申请日：2015-11-19

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Oren Tal ,  Ran Vardimon ,  Marina Klionsky

IPC: H01L29/66 ,  B82Y25/00 ,  H01F1/00 ,  B82Y10/00 ,  H01L29/76 ,  H01L29/84 ,  H01L29/06 ,  H01F10/32 ,  H01L29/82

Abstract: The present invention is in the field of spintronics, and relates to a highly efficient spin filter device, such as a spin-polarizer or a spin valve, and a method for fabrication thereof.

公开(公告)号：US20190316087A1

公开(公告)日：2019-10-17

申请号：US16313486

申请日：2017-06-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Noga OR-GEVA ,  Rotem GIDRON BUDOVSKY ,  Esther BACHAR-LUSTIG ,  Assaf LASK ,  Sivan KAGAN

IPC: C12N5/0783 ,  C12N5/00 ,  A61K35/17 ,  A61K39/00

Abstract: A method of generating an isolated population of non graft versus host disease (GvHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) providing a population of at least 70% memory T cells; (b) contacting the population of memory T cells with an antigen or antigens so as to allow enrichment of antigen reactive cells; and (c) culturing the cells resulting from step (b) in the presence of cytokines so as to allow proliferation of cells comprising the Tcm phenotype. Cells generated by the method, pharmaceutical compositions and methods of treatment are also disclosed.

公开(公告)号：US20190314312A1

公开(公告)日：2019-10-17

申请号：US16316639

申请日：2017-07-11

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ayelet EREZ ,  Noa STETTNER

IPC: A61K31/198 ,  A61K31/366 ,  A61P1/00 ,  A61P35/00

Abstract: Provided are uses of a therapeutically effective amount of citrulline for the manufacture of a medicament for treatment of a subject having an inflammatory bowel disease (IBD) and/or colon cancer. Also provided are pharmaceutical compositions comprising a therapeutic effective amount of citrulline and a therapeutically effective amount of a flavonoid for the treatment of an inflammatory bowel disease (IBD) and/or colon cancer and kits comprising same.