公开(公告)号：DE19509958A1

公开(公告)日：1996-09-19

申请号：DE19509958

申请日：1995-03-18

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT DR ,  FRETSCHNER ERICH ,  SCHROEDER JUERGEN DR

IPC: C07D231/12 ,  C07D521/00

Abstract: The prepn. of an N-substd. pyrazole deriv. of formula (I) comprises reacting pyrazole deriv. of formula (II) with an alcohol of formula R1OH (III) at 50-400 deg C in the presence of a catalyst. The mole ratio (II): (III) is 0.001-1:1 and reaction is carried out in the liq. phase at a pressure of below atmos. to 250 bar. The catalyst is an acid and/or its alkyl ester or anhydride. The mole ratio catalyst:(II) is 0.0001-0.5:1. R1 = 1-12C alkyl or 7-20C phenylalkyl; R2-R4 = H, 1-12C alkyl, 7-20C phenylalkyl or opt. substd. aryl.

公开(公告)号：ZA9406357B

公开(公告)日：1996-02-22

申请号：ZA9406357

申请日：1994-08-22

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH

IPC: C07B35/04 ,  C07D231/12 ,  C07D521/00 ,  C07D

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

公开(公告)号：AU7536194A

公开(公告)日：1995-03-21

申请号：AU7536194

申请日：1994-08-13

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH

IPC: C07B35/04 ,  C07D231/12 ,  C07D521/00

Abstract: PCT No. PCT/EP94/02708 Sec. 371 Date Feb. 15, 1996 Sec. 102(e) Date Feb. 15, 1996 PCT Filed Aug. 13, 1994 PCT Pub. No. WO95/06036 PCT Pub. Date Mar. 2, 1995A process for preparing pyrazole and its derivatives of the formula I I where R1, R2, R3 and R4 are each hydrogen, halogen, nitro, carboxyl, sulfonyl or C-organic radicals, from alpha,beta-unsaturated carbonyl compounds of the formula II II and hydrazine or hydrazine derivatives of the formula III H2N-NHR4 III wherein, initially without additional diluent, an alpha,beta-unsaturated carbonyl compound of the formula II is reacted with hydrazine or a hydrazine derivative of the formula III, and the resulting reaction mixture is reacted in another step with a mixture of sulfuric acid and iodine or a compound which liberates iodine or hydrogen iodide.

公开(公告)号：ES2062181T3

公开(公告)日：1994-12-16

申请号：ES90110517

申请日：1990-06-02

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT DR ,  FRETSCHNER ERICH

IPC: C07D231/06 ,  C07D231/12

Abstract: Pyrazole and its derivs. (I) are produced by dehydrogenation of the corresp. 2-pyrazoline (II) with the aid of sulphuric acid in the presence of iodine or an iodine cpd. (III) at 50-250 deg.C. (II) is produced in situ in the reaction medium by reaction of glycerol or acrolein or a deriv. thereof with hydrazine or a hydrazine deriv.; amt. of (III) is 0.01-10 mol. equiv. w.r.t. (II) or the corresp. hydrazine; 30-99 wt.% H2SO4 is used.

公开(公告)号：ES2056537T3

公开(公告)日：1994-10-01

申请号：ES91114026

申请日：1991-08-22

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT DR ,  FRETSCHNER ERICH

IPC: B01J27/06 ,  C07B61/00 ,  C07D231/12 ,  C07D521/00

Abstract: Production of 3-methylpyrazole and its derivatives by reacting butenediols or ethynylalkylcarbinols or their acylates in 30 to 100% by weight of sulphuric acid, with optionally substituted hydrazine or its salts, in the presence of catalytic amounts of iodine or of an iodine compound.

公开(公告)号：DK0474037T3

公开(公告)日：1994-08-15

申请号：DK91114026

申请日：1991-08-22

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT DR ,  FRETSCHNER ERICH

IPC: B01J27/06 ,  C07B61/00 ,  C07D231/12 ,  C07D521/00

Abstract: Production of 3-methylpyrazole and its derivatives by reacting butenediols or ethynylalkylcarbinols or their acylates in 30 to 100% by weight of sulphuric acid, with optionally substituted hydrazine or its salts, in the presence of catalytic amounts of iodine or of an iodine compound.

公开(公告)号：AT100799T

公开(公告)日：1994-02-15

申请号：AT90110517

申请日：1990-06-02

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT DR ,  FRETSCHNER ERICH

IPC: C07D231/06 ,  C07D231/12

公开(公告)号：DE4028393A1

公开(公告)日：1992-03-12

申请号：DE4028393

申请日：1990-09-07

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT DR ,  FRETSCHNER ERICH

IPC: B01J27/06 ,  C07B61/00 ,  C07D231/12 ,  C07D521/00

Abstract: Production of 3-methylpyrazole and its derivatives by reacting butenediols or ethynylalkylcarbinols or their acylates in 30 to 100% by weight of sulphuric acid, with optionally substituted hydrazine or its salts, in the presence of catalytic amounts of iodine or of an iodine compound.

公开(公告)号：HU903775D0

公开(公告)日：1990-11-28

申请号：HU377590

申请日：1990-06-08

Applicant: BASF AG

Inventor： MERKLE HANS PETER ,  FRETSCHNER ERICH

IPC: C07D231/06 ,  C07D231/12

Abstract: Pyrazole and its derivs. (I) are produced by dehydrogenation of the corresp. 2-pyrazoline (II) with the aid of sulphuric acid in the presence of iodine or an iodine cpd. (III) at 50-250 deg.C. (II) is produced in situ in the reaction medium by reaction of glycerol or acrolein or a deriv. thereof with hydrazine or a hydrazine deriv.; amt. of (III) is 0.01-10 mol. equiv. w.r.t. (II) or the corresp. hydrazine; 30-99 wt.% H2SO4 is used.

公开(公告)号：CA2294023C

公开(公告)日：2007-07-31

申请号：CA2294023

申请日：1998-06-22

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH

IPC: C07D231/12 ,  C07D20060101 ,  C07D231/10

Abstract: The invention relates to a process for producing pyrazole derivatives of th e formula I : (see formula I) where R1 and R2 are, independently of one another, an unsubstituted or substituted C1-C8-alkyl, C3-C8-cycloalkyl, C6-C14-aryl or phenyl-C1-C4-alkyl group, and R1 can also be hydrogen by reaction of carbonyl compounds of the formula lI R1-C(O)-CH(R2)-CH3 with hydrazine, its hydrate or its salts in 30 to 100 wt per ct sulphuric acid in the presence of catalytic quantities of iodi ne or an iodine compound.