公开(公告)号：CA1229617A

公开(公告)日：1987-11-24

申请号：CA488579

申请日：1985-08-13

Applicant: CIBA GEIGY AG

Inventor： BAUMANN MARCUS ,  BREITENSTEIN WERNER

IPC: C07D307/60 ,  C07C51/56 ,  C07C51/567 ,  C07D401/04 ,  C07D417/04

Abstract: Process for the preparation of dimethylmaleic anhydride The reaction of maleic acid, fumaric acid and/or maleic anhydride in the presence of N-acylated heterocyclic amidines and at elevated temperature affords dimethylmaleic anhydride in good yield. Catalytic amounts of the amidine employed are sufficient for said reaction.

公开(公告)号：CA1229616A

公开(公告)日：1987-11-24

申请号：CA488578

申请日：1985-08-13

Applicant: CIBA GEIGY AG

Inventor： BAUMANN MARCUS ,  BREITENSTEIN WERNER

IPC: C07D307/60 ,  B01J31/00 ,  B01J31/02 ,  C07B61/00 ,  C07C51/56 ,  C07C51/567

Abstract: Process for the preparation of dimethylmaleic anhydride The reaction of maleic acid, fumaric acid and/or maleic anhydride at elevated temperature and in the presence of catalytic amounts of a heterocyclic amidine or a salt thereof with protonic acids affords dimethylmaleic anhydride in good yield.

公开(公告)号：BR8502224A

公开(公告)日：1986-01-14

申请号：BR8502224

申请日：1985-05-10

Applicant: CIBA GEIGY AG

Inventor： BAUMANN MARCUS ,  BOSSHARD HANS ,  GREUTER HANS

IPC: C07D235/28 ,  C07D277/74

Abstract: The reaction of 2-mercapto-benzothiazole or -benzimidazole with alpha , beta -unsaturated carboxylic acid derivatives in a strongly acid reaction medium gives compounds of the formula I I in which X is sulfur or NH, each radical R independently of one another is H, alkyl, halogenalkyl, alkoxy, alkylthio, alkylsulfonyl, phenyl, alkylphenyl, phenylalkyl, cycloalkyl, halogen, NO2, CN, COOH, COOalkyl or a tertiary amino or carbamoyl group and R1, R2 and R3 independently of one another are H, alkyl, halogenalkyl, hydroxyalkyl, alkoxyalkyl unesterified or esterified carboxyl or carboxylalkyl, carbamyol, carbamyolalkyl or unsubstituted or substituted aryl or aralkyl, or R1 and R2 together are straight-chain or branched alkylene, which can be substituted by 1 or 2 carboxyl groups, R4 is unsubstituted or substituted amino, alkoxy, cycloalkoxy, aryloxy or aralkyloxy, or R2 and R4 together are CH2-CO-O- or -CH2CO-NR5- or R3 and R4 together are -CO-O- or -CO-NR5-, forming an anhydride or imide ring, wherein R5 is unsubstituted or substituted alkyl, cycloalkyl, aryl, aralkyl or hydrogen.

公开(公告)号：HUT35655A

公开(公告)日：1985-07-29

申请号：HU154584

申请日：1984-04-20

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BAUMANN MARCUS ,  BREITENSTEIN WERNER

IPC: C07D307/83 ,  C07D405/04

Abstract: Prodn. of benzofuranones of formula (I) (and their salts, tautomers and/or isomers) comprises converting X in cpds. (II) (or their salts) to OH, opt. followed by conversion of salts to free bases (or vice versa) and/or sepn.of isomers. - R1 = H or aliphatic gp. R2 = amino substd. by a divalent hydrocarbyl gp. ring A may contain other substitis.

公开(公告)号：HUT35243A

公开(公告)日：1985-06-28

申请号：HU352483

申请日：1983-10-12

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: C07C69/157 ,  A61K31/05 ,  A61K31/085 ,  A61K31/11 ,  A61P25/04 ,  A61P29/00 ,  C07C27/00 ,  C07C39/02 ,  C07C41/00 ,  C07C43/178 ,  C07C45/00 ,  C07C45/46 ,  C07C47/27 ,  C07C59/76 ,  C07C67/00 ,  C07C213/00 ,  C07C215/76 ,  C07C219/34 ,  C07D207/32 ,  C07D207/325 ,  C07D295/096 ,  C07D295/112 ,  C07D295/155 ,  C07D307/83 ,  C07D405/04 ,  C07D471/04 ,  C07C87/62

Abstract: Novel phenol derivatives, in particular those of the general formula in which R0 represents hydrogen or an acyl radical, R1 denotes hydroxymethyl, esterified or etherified hydroxymethyl, formyl or acetalised formyl, R2 represents hydrogen or an aliphatic radical, R3 represents an amino group which is disubstituted by two monovalent hydrocarbon radicals or by a divalent hydrocarbon radical which may be interrupted by at least one hetero atom and the aromatic ring A can additionally be substituted, and their salts and isomers, a process for their preparation and pharmaceutical preparations containing them and their use as active pharmaceutical compounds and/or in preparing pharmaceutical preparations.

公开(公告)号：ZA837572B

公开(公告)日：1985-04-24

申请号：ZA837572

申请日：1983-10-12

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: C07C69/157 ,  A61K31/05 ,  A61K31/085 ,  A61K31/11 ,  A61P25/04 ,  A61P29/00 ,  C07C27/00 ,  C07C39/02 ,  C07C41/00 ,  C07C43/178 ,  C07C45/00 ,  C07C45/46 ,  C07C47/27 ,  C07C59/76 ,  C07C67/00 ,  C07C213/00 ,  C07C215/76 ,  C07C219/34 ,  C07D207/32 ,  C07D207/325 ,  C07D295/096 ,  C07D295/112 ,  C07D295/155 ,  C07D307/83 ,  C07D405/04 ,  C07D471/04 ,  C07C ,  C07D ,  A61K

Abstract: Novel phenol derivatives, in particular those of the general formula in which R0 represents hydrogen or an acyl radical, R1 denotes hydroxymethyl, esterified or etherified hydroxymethyl, formyl or acetalised formyl, R2 represents hydrogen or an aliphatic radical, R3 represents an amino group which is disubstituted by two monovalent hydrocarbon radicals or by a divalent hydrocarbon radical which may be interrupted by at least one hetero atom and the aromatic ring A can additionally be substituted, and their salts and isomers, a process for their preparation and pharmaceutical preparations containing them and their use as active pharmaceutical compounds and/or in preparing pharmaceutical preparations.

公开(公告)号：GB2128993A

公开(公告)日：1984-05-10

申请号：GB8326566

申请日：1983-10-04

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: C07C45/46 ,  C07C205/37 ,  C07D295/096 ,  C07D295/112 ,  C07D295/155 ,  C07D295/194 ,  C07D307/79 ,  C07D307/83 ,  C07D405/04 ,  A61K31/40 ,  A61K31/445 ,  A61K31/535 ,  C07D407/04

Abstract: Benzofurans or 2,3-dihydrobenzofurans of the formula (I) in which R1 represents hydrogen or an aliphatic radical, R2 represents an amino group disubstituted by a bivalent aliphatic radical which is optionally interrupted by at least one hetero atom, and the aromatic ring may be additionally substituted, and the salts thereof, have anti-inflammatory and/or analgesic activities.

公开(公告)号：FI841553A0

公开(公告)日：1984-04-18

申请号：FI841553

申请日：1984-04-18

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BAUMANN MARCUS ,  BREITENSTEIN WERNER

IPC: C07D307/83 ,  C07D405/04 ,  C07D

Abstract: Prodn. of benzofuranones of formula (I) (and their salts, tautomers and/or isomers) comprises converting X in cpds. (II) (or their salts) to OH, opt. followed by conversion of salts to free bases (or vice versa) and/or sepn.of isomers. - R1 = H or aliphatic gp. R2 = amino substd. by a divalent hydrocarbyl gp. ring A may contain other substitis.

公开(公告)号：DK202584D0

公开(公告)日：1984-04-18

申请号：DK202584

申请日：1984-04-18

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BAUMANN MARCUS ,  BREITENSTEIN WERNER

IPC: C07D307/83 ,  C07D405/04 ,  C07D307

Abstract: Prodn. of benzofuranones of formula (I) (and their salts, tautomers and/or isomers) comprises converting X in cpds. (II) (or their salts) to OH, opt. followed by conversion of salts to free bases (or vice versa) and/or sepn.of isomers. - R1 = H or aliphatic gp. R2 = amino substd. by a divalent hydrocarbyl gp. ring A may contain other substitis.

公开(公告)号：FI833676A

公开(公告)日：1984-04-14

申请号：FI833676

申请日：1983-10-10

Applicant: CIBA GEIGY AG

Inventor： WENK PAUL ,  BREITENSTEIN WERNER ,  BAUMANN MARCUS

IPC: C07C69/157 ,  A61K31/05 ,  A61K31/085 ,  A61K31/11 ,  A61P25/04 ,  A61P29/00 ,  C07C27/00 ,  C07C39/02 ,  C07C41/00 ,  C07C43/178 ,  C07C45/00 ,  C07C45/46 ,  C07C47/27 ,  C07C59/76 ,  C07C67/00 ,  C07C213/00 ,  C07C215/76 ,  C07C219/34 ,  C07D207/32 ,  C07D207/325 ,  C07D295/096 ,  C07D295/112 ,  C07D295/155 ,  C07D307/83 ,  C07D405/04 ,  C07D471/04 ,  C07D

Abstract: Novel phenol derivatives, in particular those of the general formula in which R0 represents hydrogen or an acyl radical, R1 denotes hydroxymethyl, esterified or etherified hydroxymethyl, formyl or acetalised formyl, R2 represents hydrogen or an aliphatic radical, R3 represents an amino group which is disubstituted by two monovalent hydrocarbon radicals or by a divalent hydrocarbon radical which may be interrupted by at least one hetero atom and the aromatic ring A can additionally be substituted, and their salts and isomers, a process for their preparation and pharmaceutical preparations containing them and their use as active pharmaceutical compounds and/or in preparing pharmaceutical preparations.