公开(公告)号：EP2903715B1

公开(公告)日：2020-07-22

申请号：EP13844181.1

申请日：2013-09-13

Applicant: Flodesign Sonics Inc.

Inventor： LIPKENS, Bart ,  DIONNE, Jason ,  PRESZ, Jr., Walter ,  KENNEDY, III, Thomas J.

IPC: B01D17/04 ,  C02F1/36 ,  C02F1/40

公开(公告)号：EP3658909A1

公开(公告)日：2020-06-03

申请号：EP18817634.1

申请日：2018-06-13

Applicant: Flodesign Sonics, Inc.

Inventor： LIPKENS, Bart ,  MUSIAK, Ronald ,  MEALEY, Dane ,  ARTIS, John ,  SHAJII, Ali

IPC: G01N29/34 ,  B01D17/00 ,  C12N13/00

公开(公告)号：EP3341102A1

公开(公告)日：2018-07-04

申请号：EP16770116.8

申请日：2016-08-26

Applicant: Flodesign Sonics Inc.

Inventor： LIPKENS, Bart ,  PRESZ JR, Walter M. ,  KING, Jeffrey ,  BARNES, Jason ,  MEALEY, Dane ,  MCCARTHY, Brian ,  ROSS-JOHNSRUD, Benjamin ,  CHITALE, Kedar

IPC: B01D21/28 ,  C02F1/36 ,  B06B1/06 ,  G01N33/15 ,  A61M1/36

CPC classification number: B01D21/283 ,  A61M1/3678 ,  B06B1/0622 ,  G10K11/28 ,  G10K11/34 ,  G10K15/00

Abstract: Devices (100) for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber (107), a fluid outlet at a top end of the acoustic chamber (114), a concentrate outlet at a bottom end of the acoustic chamber (116), and an inlet (112) on a first side end (122) of the acoustic chamber (107). An ultrasonic transducer (106) on a side wall of the acoustic chamber and reflector at the opposite side wall create a multi-dimensional acoustic standing wave in the acoustic chamber (107) that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet (114), and the particulates are collected via the concentrate outlet (116). The device is a large-scale device that is able to process liters/hour, and has a large interior volume.

公开(公告)号：EP3288660A1

公开(公告)日：2018-03-07

申请号：EP16732365.8

申请日：2016-04-29

Applicant: Flodesign Sonics Inc.

Inventor： LIPKENS, Bart ,  PRESZ, Walter M. Jr. ,  CHITALE, Kedar ,  KENNEDY, Thomas J. III ,  ROSS-JOHNSRUD, Ben

IPC: B01D21/28 ,  B01J19/10 ,  A61M1/36

CPC classification number: C12N13/00 ,  A61M1/3678 ,  B01D21/283 ,  B01L3/502761 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0436 ,  B01L2400/0439 ,  C12M47/04 ,  G01N15/1484 ,  G01N2015/0053 ,  G01N2015/1006 ,  G01N2015/149

Abstract: Devices for separating materials from a host fluid are disclosed. The devices include a flow chamber, an ultrasonic transducer, and a reflector. The ultrasonic transducer and reflector create an angled acoustic standing wave oriented at an angle relative to the direction of mean flow through the flow chamber. The angled acoustic standing wave results in an acoustic radiation force having an axial force component that deflects the materials, so that the materials and the host fluid can thus be separated. The angled acoustic standing wave can be oriented at an angle of about 20° to about 70° relative to the direction of mean flow through the flow chamber to deflect, collect, differentiate, or fractionate the materials from the fluid flowing through the device at flow rates of about 400 mL/min up to about 700 mL/min.

公开(公告)号：EP3126028A1

公开(公告)日：2017-02-08

申请号：EP15733002.8

申请日：2015-04-03

Applicant: Flodesign Sonics Inc.

Inventor： MCCARTHY, Brian ,  ROSS-JOHNSRUD, Ben ,  LIPKENS, Bart

IPC: B01D21/28 ,  B01D49/00 ,  B06B1/06

CPC classification number: B06B1/0644 ,  B01D21/283 ,  G10K11/20

Abstract: An apparatus includes a flow chamber having at least one inlet and at least one outlet. At least one ultrasonic transducer is located on a wall of the flow chamber, which operates to create a multi-dimensional acoustic standing wave in the flow chamber. A reflector is located on the wall on the opposite side of the flow chamber from the at least one ultrasonic transducer. The reflector is formed from a thin structure that provides a pressure release boundary, such as a plastic film/air interface.

Abstract translation: 一种装置包括具有至少一个入口和至少一个出口的流动室。 至少一个超声换能器位于流动室的壁上，其操作以在流动室中产生多维声驻波。 反射器位于流动室的与至少一个超声波换能器相反的一侧的壁上。 反射器由提供压力释放边界的薄结构形成，例如塑料膜/空气界面。

公开(公告)号：EP3065795A1

公开(公告)日：2016-09-14

申请号：EP14812011.6

申请日：2014-11-05

Applicant: Flodesign Sonics Inc.

Inventor： LIPKENS, Bart ,  BARNES, Jason ,  MEALEY, Dane ,  PRESZ, Walter M. Jr ,  KOWALSKI, Stanley, III ,  MASI, Louis ,  KENNEDY, Thomas J., III ,  MCCARTHY, Brian ,  ROSS-JOHNSRUD, Ben

IPC: A61M1/36 ,  C12M1/26 ,  C12M1/00 ,  B60B1/00

CPC classification number: C12M47/02 ,  A61M1/3678 ,  B01D21/0045 ,  B01D21/283 ,  B06B1/06 ,  C12M33/08 ,  C12M47/10

Abstract: An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.

Abstract translation: 公开了一种由模块化部件组成的消声装置。 本文公开了多个模块，包括超声换能器模块，输入/输出模块，收集井模块和各种连接器模块。 这些允许构建具有用于从流体分离颗粒（例如生物细胞）的适当流体动力学的不同系统。

公开(公告)号：EP2838582A1

公开(公告)日：2015-02-25

申请号：EP13721179.3

申请日：2013-04-19

Applicant: Flodesign Sonics Inc.

Inventor： DUTRA, Brian ,  LIPKENS, Bart

IPC: A61M1/38

CPC classification number: A61M1/3681 ,  A61M1/363 ,  A61M1/3678 ,  A61M2202/08 ,  B01D21/283

Abstract: A system for removing lipids from blood during cardiopulmonary bypass surgery is disclosed. The system uses an acoustophoretic separator having improved trapping force. The transducer of the acoustophoretic seperator includes a ceramic crystal. Blood flows through the separator, and lipids are trapped and removed.

Abstract translation: 公开了一种在体外循环手术期间从血液中除去脂质的系统。 该系统使用具有改进的捕获力的声学分离器。 声波分离器的换能器包括陶瓷晶体。 血液流过分离器，脂质被捕获并除去。

公开(公告)号：EP2825279A1

公开(公告)日：2015-01-21

申请号：EP13760840.2

申请日：2013-03-15

Applicant: Flodesign Sonics Inc.

Inventor： LIPKENS, Bart ,  DIONNE, Jason ,  KENNEDY, III, Thomas J. ,  MASI, Louis ,  KOWALSKI, III, Stanley

IPC: B01D43/00

CPC classification number: B01D43/00 ,  B06B1/0644 ,  C12M47/02

Abstract: A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.

公开(公告)号：EP3914695A1

公开(公告)日：2021-12-01

申请号：EP20745494.3

申请日：2020-01-21

Applicant: FloDesign Sonics, Inc.

Inventor： ROSS-JOHNSRUD, Benjamin ,  LIPKENS, Bart

IPC: C12N5/00 ,  C12M1/42 ,  C12M1/00 ,  C12M1/36

公开(公告)号：EP3737738A1

公开(公告)日：2020-11-18

申请号：EP19738317.7

申请日：2019-01-09

Applicant: FloDesign Sonics, Inc.

Inventor： LIPKENS, Bart ,  TOSTOES, Rui ,  PRESZ, JR., Walter, M. ,  ROSS-JOHNSRUD, Benjamin ,  CHITALE, Kedar ,  KENNEDY, III, Thomas, J. ,  DUTRA, Brian ,  MCCARTHY, Brian ,  SALOIO, Jack

IPC: C12M1/00 ,  C12N5/078 ,  C12N13/00 ,  B01D21/28 ,  B02C19/00 ,  B02C19/18