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公开(公告)号：NO992876L
公开(公告)日：1999-12-13
申请号：NO992876
申请日：1999-06-11
Applicant: HOFFMANN LA ROCHE
Inventor： ADAM GEO , CESURA ANDREA , JENCK FRANCOIS , KOLCZEWSKI SABINE , ROEVER STEPHAN , WICHMANN JUERGEN
IPC: A61K20060101 , A61K31/00 , C07D401/04 , A61K31/395 , A61K31/40 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/445 , A61P3/04 , A61P3/12 , A61P9/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/36 , A61P43/00 , C07D20060101 , C07D207/00 , C07D209/00 , C07D211/00 , C07D221/00 , C07D271/00 , C07D277/00 , C07D401/00 , C07D401/14 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/10 , C07D471/20 , C07D487/12 , C07D498/10 , C07D513/10
Abstract: The present invention relates to compounds of the general formula wherein R is C6-10-cycloalkyl, optionally substituted by lower alkyl or -C(O)O-lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; decahydro-azulen-2-yl; bicycloÄ6.2.0Üdec-9-yl; acenaphthen-1-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl or octahydro-inden-2-yl; R is hydrogen; lower alkyl; =O or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; A &cir& is cyclohexyl or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; X is -CH(OH)-; -C(O)-; -CHR -; -CR =; -O-; -S-; -CH(COOR )- or - C(COOR )=; Y is -CH2-; -CH=; -CH(COOR )-, -C(COOR )=; or -C(CN)-; R is hydrogen or lower alkoxy; R is lower alkyl, cycloalkyl, phenyl, or benzyl and either a or b is optionally an additional bond, and to pharmaceutically acceptable acid addition salts thereof. The compounds are agonists and/or antagonists of the orphanin FQ (QFQ) receptor and therefore useful in the treatment of diseases, related to this receptor.
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公开(公告)号：NO992873A
公开(公告)日：1999-12-13
申请号：NO992873
申请日：1999-06-11
Applicant: HOFFMANN LA ROCHE
Inventor： ADAM GEO , CESURA ANDREA , JENCK FRANCOIS , KOLCZEWSKI SABINE , ROEVER STEPHAN , WICHMANN JUERGEN
IPC: C07D401/00 , A61K31/00 , A61K31/438 , A61P3/04 , A61P9/10 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D471/10 , A61K31/395
CPC classification number: C07D471/10
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公开(公告)号：CA2274201A1
公开(公告)日：1999-12-12
申请号：CA2274201
申请日：1999-06-09
Applicant: HOFFMANN LA ROCHE
Inventor： ROEVER STEPHAN , KOLCZEWSKI SABINE , CESURA ANDREA , JENCK FRANCOIS , WICHMANN JUERGEN , ADAM GEO
IPC: C07D401/04 , A61K20060101 , A61K31/00 , A61K31/395 , A61K31/40 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/445 , A61P3/04 , A61P3/12 , A61P9/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/36 , A61P43/00 , C07D20060101 , C07D207/00 , C07D209/00 , C07D211/00 , C07D221/00 , C07D271/00 , C07D277/00 , C07D401/00 , C07D401/14 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/10 , C07D471/20 , C07D487/12 , C07D498/10 , C07D513/10
Abstract: The present invention relates to compounds of the general formula (see formula I) wherein R1 is C6-10-cycloalkyl, optionally substituted by lower alkyl or -C(O)O-lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; decahydro-azulen-2-yl; bicyclo¢6.2.0!dec-9-yl; acenaphthen-1-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl or octahydro-inden-2-yl; R2 is hydrogen; lower alkyl; =O or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; is cyclohexyl or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; X is -CH(OH)-; -C(O)-; -CHR3-; -CR3=; -O-; -S-; -CH(COOR4)- or C(COOR4)=; Y is -CH2-; -CH=; -CH(COOR4)-, -C(COOR4)=; or -C(CN)-; R3 is hydrogen or lower alkoxy; R4 is lower alkyl, cycloalkyl, phenyl, or benzyl and either a or b is optionally an additional bond, and to pharmaceutically acceptable acid addition salts thereof. The compounds are agonists and/or antagonists of the orphanin FQ (QFQ) receptor and therefore useful in the treatment of diseases, related to this receptor.
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公开(公告)号：NO992876D0
公开(公告)日：1999-06-11
申请号：NO992876
申请日：1999-06-11
Applicant: HOFFMANN LA ROCHE
Inventor： ADAM GEO , CESURA ANDREA , JENCK FRANCOIS , KOLCZEWSKI SABINE , ROEVER STEPHAN , WICHMANN JUERGEN
IPC: A61K20060101 , A61K31/00 , C07D401/04 , A61K31/395 , A61K31/40 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/445 , A61P3/04 , A61P3/12 , A61P9/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/36 , A61P43/00 , C07D20060101 , C07D207/00 , C07D209/00 , C07D211/00 , C07D221/00 , C07D271/00 , C07D277/00 , C07D401/00 , C07D401/14 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/10 , C07D471/20 , C07D487/12 , C07D498/10 , C07D513/10
Abstract: The present invention relates to compounds of the general formula wherein R is C6-10-cycloalkyl, optionally substituted by lower alkyl or -C(O)O-lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; decahydro-azulen-2-yl; bicycloÄ6.2.0Üdec-9-yl; acenaphthen-1-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl or octahydro-inden-2-yl; R is hydrogen; lower alkyl; =O or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; A &cir& is cyclohexyl or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; X is -CH(OH)-; -C(O)-; -CHR -; -CR =; -O-; -S-; -CH(COOR )- or - C(COOR )=; Y is -CH2-; -CH=; -CH(COOR )-, -C(COOR )=; or -C(CN)-; R is hydrogen or lower alkoxy; R is lower alkyl, cycloalkyl, phenyl, or benzyl and either a or b is optionally an additional bond, and to pharmaceutically acceptable acid addition salts thereof. The compounds are agonists and/or antagonists of the orphanin FQ (QFQ) receptor and therefore useful in the treatment of diseases, related to this receptor.
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公开(公告)号：ID21413A
公开(公告)日：1999-06-10
申请号：ID981576
申请日：1998-12-03
Applicant: HOFFMANN LA ROCHE
Inventor： ADAM GEO , CESURA ANDREA , GALLEY GUIDO , JENCK FRANCOIS , ROEVER STEPHAN , WICHMANN JUERGEN
IPC: C07D235/02 , A61K31/00 , A61K31/41 , A61K31/435 , A61K31/438 , A61P3/00 , A61P3/04 , A61P9/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00 , C07D207/04 , C07D233/30 , C07D471/10
Abstract: The present invention relates to compounds of formula I and pharmaceutically acceptable acid addition salts thereof.
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Patent Agency Ranking
公开(公告)号：ZA9811128B
公开(公告)日：1999-06-07
申请号：ZA9811128
申请日：1998-12-04
Applicant: HOFFMANN LA ROCHE
Inventor： ADAM GEO , CESURA ANDREA , GALLEY GUIDO , JENCK FRANCOIS , ROEVER STEPHAN , WICHMANN JUERGEN
IPC: C07D235/02 , A61K31/00 , A61K31/41 , A61K31/435 , A61K31/438 , A61P3/00 , A61P3/04 , A61P9/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00 , C07D207/04 , C07D233/30 , C07D471/10 , C07D , A61K
Abstract: The present invention relates to compounds of formula I and pharmaceutically acceptable acid addition salts thereof.
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公开(公告)号：HU9802807D0
公开(公告)日：1999-02-01
申请号：HU9802807
申请日：1998-12-04
Applicant: HOFFMANN LA ROCHE
Inventor： ADAM GEO , CESURA ANDREA , GALLEY GUIDO , JENCK FRANCOIS , ROEVER STEPHAN , WICHMANN JUERGEN
IPC: C07D235/02 , A61K31/00 , A61K31/41 , A61K31/435 , A61K31/438 , A61P3/00 , A61P3/04 , A61P9/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00 , C07D207/04 , C07D233/30 , C07D471/10
Abstract: The present invention relates to compounds of formula I and pharmaceutically acceptable acid addition salts thereof.
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公开(公告)号：NO985684D0
公开(公告)日：1998-12-04
申请号：NO985684
申请日：1998-12-04
Applicant: HOFFMANN LA ROCHE
Inventor： ADAM GEO , CESURA ANDREA , GALLEY GUIDO , JENCK FRANCOIS , ROEVER STEPHAN , WICHMANN JUERGEN
IPC: C07D235/02 , A61K31/00 , A61K31/41 , A61K31/435 , A61K31/438 , A61P3/00 , A61P3/04 , A61P9/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00 , C07D207/04 , C07D233/30 , C07D471/10 , C07D
Abstract: The present invention relates to compounds of formula I and pharmaceutically acceptable acid addition salts thereof.
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公开(公告)号：TR9800085A2
公开(公告)日：1998-08-21
申请号：TR9800085
申请日：1998-01-20
Applicant: HOFFMANN LA ROCHE
Inventor： ADAM GEO , CESURA ANDREA , GALLEY GUIDO , JENCK FRANCOIS , MONSMA FREDERICK , ROEVER STEPHAN , WICHMANN JURGEN
IPC: C07D233/04 , A61K31/00 , A61K31/41 , A61K31/435 , A61K31/438 , A61K31/445 , A61K31/55 , A61K51/02 , A61P3/04 , A61P3/12 , A61P9/00 , A61P9/12 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , A61P43/00 , C07D215/58 , C07D305/14 , C07D471/00 , C07D471/10 , C07D498/00 , C07D , A61K
CPC classification number: C07D471/10
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公开(公告)号：CZ9800273A3
公开(公告)日：1998-08-12
申请号：CZ27398
申请日：1998-01-29
Applicant: HOFFMANN LA ROCHE
Inventor： ADAM GEO , CESURA ANDREA , GALLEY GUIDO , JENCK FRANCOIS , MONSMA FREDERICK , ROVER STEPHAN , WICHMANN JURGEN
IPC: C07D233/04 , A61K31/00 , A61K31/41 , A61K31/435 , A61K31/438 , A61K31/445 , A61K31/55 , A61K51/02 , A61P3/04 , A61P3/12 , A61P9/00 , A61P9/12 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , A61P43/00 , C07D215/58 , C07D305/14 , C07D471/00 , C07D471/10 , C07D498/00
CPC classification number: C07D471/10
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