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    CEPHALOSPORINS
    88.
    发明专利
    CEPHALOSPORINS 未知

    公开(公告)号：AU533088B2

    公开(公告)日：1983-10-27

    申请号：AU6443880

    申请日：1980-11-17

    Applicant: HOFFMANN LA ROCHE

    Inventor： MONTAVON MARC ,  REINER ROLAND

    IPC: C07D501/00 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D20060101 ,  C07D501/04 ,  C07D501/16 ,  C07D501/36 ,  C07D501/46

    Abstract: For the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A process for the manufacture of acyl derivatives of general formula I see diagramm : EP0030294,P12,F1 in which R represents hydrogen or a readily hydrolyzable ester group, as well as of salts of these compounds and hydrates of these compounds or of their salts by reating a halide of general formula II see diagramm : EP0030294,P12,F2 in which R has the significance given above and Y represents a halogen atom, or a salt of this compound with thiourea and, if desired, converting a compound of formula I obtained into a salt or hydrate or into a hydrate of this salt, characterized in that X signifies one of the groups see diagramm : EP0030294,P13,F3 in which R' represents hydrogen or a readily hydrolysable ether group.

    CEPHALOSPORIN DERIVATIVES
    89.
    发明专利
    CEPHALOSPORIN DERIVATIVES 未知

    公开(公告)号：CA1154009A

    公开(公告)日：1983-09-20

    申请号：CA372901

    申请日：1981-03-12

    Applicant: HOFFMANN LA ROCHE

    Inventor： MONTAVON MARC ,  REINER ROLAND

    IPC: C07D249/12 ,  C07D253/075 ,  C07D501/36

    Abstract: RAN 4410/143 Cephalosporin derivatives of the general formula in which X represents one of the groups (a) (b) wherein R1 represents lower alkyl or (together with the oxygen) a readily hydrolysable ether group, as well as readily hydrolysable esters of the compounds of formula I wherein X represents the group (b) or (a) in which R represents lower alkyl and salts of these compounds and hydrates of the compounds of formula I or of esters and salts thereof. Further, also corresponding preparations, the use of these products in the treatment of illnesses, the manufacture of the active substances as well as intermediates thereby occurring.

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