公开(公告)号：US4169963A

公开(公告)日：1979-10-02

申请号：US899665

申请日：1978-04-24

Applicant: Helmut Pieper

Inventor： Helmut Pieper

IPC: F27B3/08 ,  C03B5/027 ,  C03B5/033 ,  C03B5/26 ,  C03B7/088 ,  C03B7/098 ,  F27B14/00 ,  F27B14/06 ,  F27B14/08 ,  F27D21/00 ,  F27D99/00 ,  H05B3/60 ,  C03B5/02

CPC classification number: C03B5/0275 ,  C03B5/0336 ,  C03B5/26 ,  C03B7/088 ,  C03B7/098 ,  F27B14/06 ,  H05B3/60 ,  F27B2014/002 ,  F27B2014/068 ,  F27B2014/0818 ,  F27D2099/0008 ,  F27D21/0021 ,  F27M2001/03

Abstract: An electrically heated melting furnace for the melting of mineral materials, such as frits, (vitreous) enamels and the like, wherein a bath of molten material contained in a tank is heated by means of electrodes contacting the molten material and having a current flowing therethrough which heats the molten material by Joule's heat, wherein a batch is fed onto the melt or molten bath, and the molten product is withdrawn from the bottom of the tank wherein the furnace space or tank having the molten bath has a square or almost square cross-section or the cross-section of a regular polygon; that the depth of the furnace space or tank having the molten material therein corresponds almost to the diameter of the tank; and that a plurality of radiator heating rods are arranged above the batch material and said heating electrodes are positioned in the lower portion of the molten bath above the tank bottom and comprising a bottom outlet including a cylindrical portion or element and a further underlying, concentrically disposed, circular disc-shaped or annular portion or element of a refractory material being conductive at high temperature and acting as an electrical conductor, which elements are conductively coupled to a current supply line.

公开(公告)号：US4107446A

公开(公告)日：1978-08-15

申请号：US754871

申请日：1976-12-27

Applicant: Helmut Pieper

Inventor： Helmut Pieper

IPC: G01K7/16 ,  G01K13/00 ,  H05B3/00 ,  C03B5/02

CPC classification number: H05B3/0023 ,  G01K13/00 ,  G01K7/16

Abstract: The temperature or temperature profile of an electrically conductive molten mass heated by electrodes immersed therein is measured during continuous operation by momentarily cutting off the electrical energy supplied to the heating electrodes, passing measuring currents through the molten mass via the heating electrodes during the momentary cut off, measuring the electrical resistance between pairs of heating electrodes in measuring paths defined by such electrodes and then calculating the temperature existing within the individual measuring paths on the basis of the measure resistance values.

Abstract translation: 在连续操作期间，通过瞬时切断供给到加热电极的电能，在瞬时切断期间通过加热电极使测量电流通过熔融物质，测量由浸入其中的电极加热的导电熔融物质的温度或温度分布 测量由这种电极限定的测量路径中的加热电极对之间的电阻，然后基于测量电阻值计算各个测量路径内存在的温度。

公开(公告)号：US4101671A

公开(公告)日：1978-07-18

申请号：US780903

申请日：1977-03-24

Applicant: Johannes Keck ,  Klaus-Reinhold Noll ,  Helmut Pieper ,  Gerd Kruger ,  Sigfrid Puschmann

Inventor： Johannes Keck ,  Klaus-Reinhold Noll ,  Helmut Pieper ,  Gerd Kruger ,  Sigfrid Puschmann

IPC: A61K31/135 ,  A61K31/19 ,  C07D221/24 ,  C07D295/135 ,  C07C87/28

CPC classification number: C07D295/135 ,  A61K31/135 ,  A61K31/19 ,  C07D221/24

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or aliphatic or aromatic carboxylic acyl,R.sub.2 is hydrogen, chlorine or bromine,R.sub.3 is fluorine, alkyl of 1 to 4 carbon atoms, trifluoromethyl, cyano, carbamoyl, carboxyl, carbalkoxy, alkoxy, acetyl, 1-hydroxyethyl or ##STR2## where R.sub.6 and R.sub.7 are each alkyl, cycloalkyl, hydroxy-cycloalkyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino or morpholino, andR.sub.4 and R.sub.5 are each hydrogen, alkyl of 1 to 5 carbon atoms, mono- or di-hydroxy (alkyl of 1 to 5 carbon atoms), alkenyl of 2 to 4 carbon atoms, cycloalkyl of 5 to 7 carbon atoms, mono- or di-hydroxy (cycloalkyl of 5 to 7 carbon atoms), benzyl, morpholinocarbonylmethyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-methyl-piperazino or camphidino,Provided, however, that when R.sub.3 is carboxyl or carbalkoxy, R.sub.4 and R.sub.5 are other than hydrogen, alkyl, mono- or di-hydroxyalkyl, alkenyl, cycloalkyl, mono- or di-hydroxy-cycloalkyl or benzyl; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics.

Abstract translation: 其中R 1是氢或脂族或芳族羧酰基，R 2是氢，氯或溴，R 3是氟，1-4个碳原子的烷基，三氟甲基，氰基，氨基甲酰基，羧基，烷氧基，烷氧基， 乙酰基，1-羟乙基或者其中R 6和R 7各自为烷基，环烷基，羟基 - 环烷基，或彼此连接的氮原子，与它们相连的氮原子，吡咯烷子基，哌啶子基或吗啉代，R 4和R 5各自为 氢，1至5个碳原子的烷基，一或二羟基（1至5个碳原子的烷基），2至4个碳原子的烯基，5至7个碳原子的环烷基，一或二羟基（环烷基 5至7个碳原子），苄基，吗啉代羰基甲基或彼此连接的氮原子，吡咯烷基，哌啶子基，六亚甲基亚氨基，吗啉代，N-甲基 - 哌嗪子基或樟脑酸，提供，但是当R3 是羧基或烷氧基，R4和R5不同于氢 烷基，单 - 或二 - 羟基烷基，烯基，环烷基，单 - 或二 - 羟基 - 环烷基或苄基; 和无毒的，药学上可接受的酸加成盐。 化合物及其盐可用作抗溃疡发生剂。

公开(公告)号：USRE29628E

公开(公告)日：1978-05-09

申请号：US746954

申请日：1976-12-02

Applicant: Johannes Keck ,  Klaus-Reinhold Noll ,  Helmut Pieper ,  Gerd Kruger ,  Sigfrid Puschmann

Inventor： Johannes Keck ,  Klaus-Reinhold Noll ,  Helmut Pieper ,  Gerd Kruger ,  Sigfrid Puschmann

IPC: A61K31/135 ,  A61K31/19 ,  C07D221/24

CPC classification number: A61K31/19 ,  A61K31/135 ,  C07D221/24

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or aliphatic or aromatic carboxylic acyl,R.sub.2 is hydrogen, chlorine or bromine,R.sub.3 is fluorine, alkyl of 1 to 4 carbon atoms, trifluoromethyl, cyano, carbamoyl, carboxyl, carbalkoxy, alkoxy, acetyl, 1-hydroxyethyl or ##STR2## where R.sub.6 and R.sub.7 are each alkyl, cycloalkyl, hydroxy-cycloalkyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino or morpholino, andR.sub.4 and R.sub.5 are each hydrogen, alkyl of 1 to 5 carbon atoms, mono- or di-hydroxy (alkyl of 1 to 5 carbon atoms), alkenyl of 2 to 4 carbon atoms, cycloalkyl of 5 to 7 carbon atoms, mono- or di-hydroxy(cycloalkyl of 5 to 7 carbon atoms), benzyl, morpholinocarbonylmethyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-methyl-piperazino or camphidino, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as anti-ulcerogenics, secretolytics, .[.antitussive,.]. .Iadd.antitussives .Iaddend.and stimulants of the production of the surfactant or antiatelectasis factor of the alveoli.

公开(公告)号：US3950393A

公开(公告)日：1976-04-13

申请号：US458099

申请日：1974-04-05

Applicant: Johannes Keck ,  Klaus-Reinhold Noll ,  Helmut Pieper ,  Gerd Kruger ,  Sigfrid Puschmann

Inventor： Johannes Keck ,  Klaus-Reinhold Noll ,  Helmut Pieper ,  Gerd Kruger ,  Sigfrid Puschmann

IPC: C07C211/52 ,  A61K31/135 ,  A61K31/19 ,  C07C209/10 ,  C07C209/50 ,  C07C209/62 ,  C07C209/74 ,  C07C211/29 ,  C07C211/49 ,  C07C211/53 ,  C07C221/00 ,  C07C225/22 ,  C07C231/12 ,  C07C233/43 ,  C07C255/58 ,  C07D221/24 ,  C07D295/135 ,  C07C101/48 ,  C07C101/68

CPC classification number: C07D295/135 ,  A61K31/135 ,  A61K31/19 ,  C07D221/24 ,  Y10S514/849

Abstract: Compounds of the formula ##SPC1##WhereinR.sub.1 is hydrogen or aliphatic or aromatic carboxylic acyl,R.sub.2 is hydrogen, chlorine or bromine,R.sub.3 is fluorine, alkyl of 1 to 4 carbon atoms, trifluoromethyl, cyano, carbamoyl, carboxyl, carbalkoxy, alkoxy, acetyl, 1-hydroxyethyl or ##EQU1## where R.sub.6 and R.sub.7 are each alkyl, cycloalkyl, hydroxy-cycloalkyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino or morpholino, andR.sub.4 and R.sub.5 are each hydrogen, alkyl of 1 to 5 carbon atoms, mono- or di-hydroxy (alkyl of 1 to 5 carbon atoms), alkenyl of 2 to 4 carbon atoms, cycloalkyl of 5 to 7 carbon atoms, mono- or di-hydroxy(cycloalkyl of 5 to 7 carbon atoms), benzyl, morpholinocarbonylmethyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-methyl-piperazino or camphidino,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as anti-ulcergenics, secretolytics, antitussive, and stimulants of the production of the surfactant or antiatelectasis factor of the alveoli.

Abstract translation: 式WHEREIN R 1的化合物是氢或脂族或芳族羧酸酰基，R 2是氢，氯或溴，R 3是氟，1至4个碳原子的烷基，三氟甲基，氰基，氨基甲酰基，羧基，烷氧基，烷氧基，乙酰基， 羟乙基或R6 -CH2-N ANGLE R7，其中R6和R7各自为烷基，环烷基，羟基 - 环烷基或彼此连接的氮原子，吡咯烷基，哌啶子基或吗啉代，R4和R5各自为 氢，1至5个碳原子的烷基，一或二羟基（1至5个碳原子的烷基），2至4个碳原子的烯基，5至7个碳原子的环烷基，一或二羟基（环烷基 5至7个碳原子），苄基，吗啉代羰基甲基或彼此连接的氮原子，吡咯烷基，哌啶子基，六亚甲基亚氨基，吗啉代，N-甲基哌嗪基或卡宾多，以及非毒性，药理学上可接受的 其添加量： 化合物作为其生物利用作为抗生素，秘密，抗生素和生物活性成分或抗生素因子的有效途径。