公开(公告)号：WO1997012983A1

公开(公告)日：1997-04-10

申请号：PCT/US1996015921

申请日：1996-10-03

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  SCHMIDT, Robert, R. ,  MILLER, Philip

IPC: C12N15/53

CPC classification number: C12N9/0016 ,  C12N15/8241 ,  C12N15/8261 ,  C12N15/8271 ,  Y02A40/146

Abstract: Amino acid and nucleotide sequences relating to the glutamate dehydrogenase (GDH) enzyme are described. The GDH enzymes described herein were discovered in the alga Chlorella sorokiniana in the form of seven different inducible isoenzymes. These isoenzymes are found in the algae as chloroplast-localized hexamers composed of alpha- and beta-subunits. Plants transformed with nucleotide sequences encoding the alpha- or beta-subunits of the enzyme show improved properties, for example, increased growth and improved stress tolerance. A heterohexamer having both alpha - and beta -subunits can have higher aminating:deaminating activity ratio than alpha -homohexamers or beta -homohexamers.

Abstract translation: 描述了与谷氨酸脱氢酶（GDH）酶相关的氨基酸和核苷酸序列。 本文所述的GDH酶以七种不同诱导型同工酶的形式在藻类小球藻中发现。 这些同工酶在藻类中被发现是由α-和β-亚基组成的叶绿体定位的六聚体。 用编码酶的α-或β-亚基的核苷酸序列转化的植物显示改善的性质，例如增加的生长和改善的胁迫耐受性。 具有α - 和β - 亚单位的异构六聚体可以具有比α-低聚己胺或β-低聚己胺更高的氨化：脱氨活性比。

公开(公告)号：WO1996036384A1

公开(公告)日：1996-11-21

申请号：PCT/US1996006797

申请日：1996-05-14

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  SKIMMING, Jeffrey, W. ,  BLANCH, Paul, B.

IPC: A61M15/00

CPC classification number: A61M16/12 ,  A61M16/0833 ,  A61M16/085 ,  A61M2016/1035 ,  A61M2202/0275 ,  B01F5/06 ,  B01F5/0682

Abstract: The present invention relates to gas mixing devices (20) for use with breathing circuit assemblies (10) for use with breathing devices, such as respiratory therapy devices and ventilators and to methods for administering gases, such as breathable gases, like nitric oxide, in combination with other gases in a manner which facilitates the establishment of reliably delivery standards for the gases, which facilitates adequate mixing of the gases, and which reduces exposure time of the gases to one another so as to eliminate or minimize the production of toxic byproducts generated from such gas mixtures.

Abstract translation: 本发明涉及用于与呼吸装置（例如呼吸治疗装置和呼吸机）一起使用的呼吸回路组件（10）的气体混合装置（20），以及用于向诸如一氧化氮的呼吸气体 与其他气体的组合以便于建立可靠的气体输送标准，促进气体的充分混合，并减少气体彼此的暴露时间，从而消除或最小化所产生的有毒副产物的产生 从这种气体混合物。

公开(公告)号：WO1995031592A1

公开(公告)日：1995-11-23

申请号：PCT/US1995005992

申请日：1995-05-12

Applicant: UNIVERSITY OF FLORIDA ,  ADAIR, James, H. ,  SINGH, Rajiv, K.

Inventor： UNIVERSITY OF FLORIDA

IPC: C30B29/04

CPC classification number: C23C16/0272 ,  C30B25/02 ,  C30B29/04

Abstract: A method for creating a uniform thin film of a high surface energy material on a substrate comprising the steps of providing an oppositely charged surface on the substrate, if such does not exist, from that of particles of the high surface energy material, exposing the substrate to an aqueous colloidal suspension of particles composed of the high surface energy material to adsorb seed particles onto the surface of the substrate, and then depositing a uniform thin film of the high surface energy material by chemical vapor deposition onto the seeded substrate.

Abstract translation: 一种用于在衬底上形成高表面能材料的均匀薄膜的方法，包括以下步骤：在所述衬底上提供相反电荷的表面，如果不存在，则与所述高表面能材料的颗粒的表面相比，暴露所述衬底 涉及由高表面能材料构成的颗粒的水性胶体悬浮液，以将种子颗粒吸附到基材的表面上，然后通过化学气相沉积将均匀的高表面能材料薄膜沉积到接种的基底上。

公开(公告)号：WO1995031478A1

公开(公告)日：1995-11-23

申请号：PCT/US1995006111

申请日：1995-05-15

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  BRADY, L., Jeannine

IPC: C07K14/315

CPC classification number: C07K14/315 ,  A61K39/00

Abstract: The subject invention concerns the genetic manipulation of the gene encoding a group B streptococcal (GBS) surface protein known as the beta antigen. The beta antigen is known to bind to the Fc region of IgA immunoglobulins in a non-immune manner. The portion of beta antigen gene which encodes the IgA binding function has been identified and removed using genetic engineering techniques. The novel polypeptide encoded by the altered beta antigen gene does not bind to IgA but does immunoreact with monospecific anti-beta antigen antisera raised against the wild-type beta antigen protein. This non-IgA binding form of the beta antigen may be used as a component in a human vaccine to protect against GBS infections.

Abstract translation: 本发明涉及编码被称为β抗原的B组链球菌（GBS）表面蛋白的基因的遗传操作。 已知β抗原以非免疫的方式结合IgA免疫球蛋白的Fc区。 已经使用基因工程技术鉴定和去除了编码IgA结合功能的β抗原基因部分。 由改变的β抗原基因编码的新多肽不与IgA结合，但与针对野生型β抗原蛋白产生的单特异性抗β抗原抗体进行免疫反应。 β抗原的非IgA结合形式可以用作人类疫苗中的组分以防止GBS感染。

公开(公告)号：WO1995025430A1

公开(公告)日：1995-09-28

申请号：PCT/US1995003572

申请日：1995-03-21

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  STIMAC, Jerry, L. ,  PEREIA, Roberto

IPC: A01N63/04

CPC classification number: C12R1/645 ,  A01N25/006 ,  A01N63/04 ,  Y10S435/911

Abstract: The subject invention concerns novel biopesticides and their use to control cockroaches, carpenter ants, and pharaoh ants. Specifically, highly virulent isolates of Beauveria bassiana in an agricultural composition, can be used to effectively control these pests. Exemplified are Beauveria bassiana No. 447, ATCC 20872, and Beauveria bassiana SP111, ATCC 74038. Also described are unique formulations which are highly effective for delivering biocontrol agents to target pests. By using these novel compositions, target pests can be controlled without the environmental and public safety hazards presented by chemical control agents.

Abstract translation: 本发明涉及新型生物杀虫剂及其用于控制​​蟑螂，木蚁和法老蚂蚁的用途。 具体来说，在农业组合物中高效毒性的白僵菌分离物可用于有效控制这些害虫。 例子是白僵菌487号，ATCC 20872号，和Beauveria bassiana SP111，ATCC 74038.还描述了对于将生物防治剂递送到目标害虫方面非常有效的独特配方。 通过使用这些新型组合物，可以控制目标害虫，而不会由化学防治剂引起的环境和公共安全危害。

公开(公告)号：WO1994005288A1

公开(公告)日：1994-03-17

申请号：PCT/US1993008192

申请日：1993-08-31

Applicant: UNIVERSITY OF FLORIDA ,  KEM, William, R. ,  ZOLTEWICZ, John, A. ,  MEYER, Edwin, M.

Inventor： UNIVERSITY OF FLORIDA

IPC: A61K31/435

CPC classification number: C07D401/04 ,  C07D211/82 ,  C07D405/14

Abstract: Novel anabaseine and anabasine derivatives are useful for stimulating brain cholinergic transmission, and have utility in the treatment of degenerative diseases of the nervous system.

Abstract translation: 新颖的阿那霉素和阿那巴星衍生物可用于刺激脑胆碱能传递，并且可用于治疗神经系统的退行性疾病。

公开(公告)号：WO1993018018A1

公开(公告)日：1993-09-16

申请号：PCT/US1993002193

申请日：1993-03-10

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  RAO, Koppaka, V.

IPC: C07D305/14

CPC classification number: C07D305/14

Abstract: Taxol, 10-deacetyltaxol and other taxane derivatives are prepared from naturally occurring taxane-7-xylosides by the oxidative cleavage of the 7-xyloside moieties.

公开(公告)号：WO1993010794A1

公开(公告)日：1993-06-10

申请号：PCT/US1992010495

申请日：1992-12-02

Applicant: UNIVERSITY OF FLORIDA ,  BODOR, Nicholas, S.

Inventor： UNIVERSITY OF FLORIDA

IPC: A61K31/70

CPC classification number: B82Y5/00 ,  A61K31/55 ,  A61K47/6951 ,  C08B37/0015 ,  Y10S514/964

Abstract: The invention provides compositions for use in improving the oral bioavailability of carbamazepine comprising, in oral dosage form, a therapeutically effective amount of carbamazepine complexed with cyclodextrin selected from the group consisting of hydroxypropyl and hydroxyethyl derivatives of β- and η-cyclodextrin, the complex comprising at least 2 molecules of cyclodextrin per molecule of carbamazepine; and a non-toxic pharmaceutically acceptable carrier therefor. Also provided are compositions comprising, in oral dosage form, a therapeutically effective amount of carbamazepine in an aqueous solution comprising from about 20 % to about 50 % cyclodextrin selected from the group consisting of hydroxypropyl and hydroxyethyl derivatives of β- and η-cyclodextrin. The invention makes it possible to achieve greater, more rapid and less variable delivery of carbamazepine by the oral route.

公开(公告)号：WO1993005473A1

公开(公告)日：1993-03-18

申请号：PCT/US1992007151

申请日：1992-08-28

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  FU, Li, Min

IPC: G06F15/18

CPC classification number: G06N3/0427

Abstract: A rule-based expert system (14) is generated from a neural network (10). The neural network (10) is trained in such a way to avoid redundancy (50) and to select input weights to the various processing elements in such a way as to nullify the input weights which have smaller absolute values. The neural network is translated into a set of rules (12) by a heuristic search technique. Additionally, the translation distinguishes between positive and negative attributes (56, 58) for efficiency and can adequately explore rule size exponential with a given parameter. Both explicit and implicit knowledge of adapted neural networks (54) are decoded and represented as if - then rules (54, 50).

Abstract translation: 从神经网络（10）生成基于规则的专家系统（14）。 以避免冗余（50）的方式对神经网络（10）进行训练，并且以使绝对值较小的输入权重无效的方式选择各种处理元件的输入权重。 通过启发式搜索技术将神经网络转换为一组规则（12）。 另外，翻译区分正负属性（56,58）以获得效率，并且可以用给定参数充分地探索规则大小指数。 对适应神经网络（54）的显式和隐性知识进行解码，并表示为 - 然后规则（54,50）。

公开(公告)号：WO1992017180A1

公开(公告)日：1992-10-15

申请号：PCT/US1992002503

申请日：1992-04-03

Applicant: UNIVERSITY OF FLORIDA

Inventor： UNIVERSITY OF FLORIDA ,  SLOAN, Kenneth, B. ,  BEALL, Howard, D.

IPC: A61K31/505

CPC classification number: A61K31/505

Abstract: A pharmaceutical composition in unit dosage form adapted for topical administration to a human or non-human animal in need thereof comprising a pharmacologically effective amount of a prodrug of 5-fluorouracil having formula (I), wherein R1 and R2 may be the same or different and are selected from the group consisting of H, R3CO- and R4-O-CO with the proviso that both R1 and R2 may not be H; or a non-toxic pharmaceutically acceptable salt, adduct, oxide or other derivative thereof; a pharmaceutically acceptable, topically administratable carrier therefor; and a method for topically applying the composition. R3 and R4 comprise groups such that the prodrug (1) has an enhanced delivery across topical membranes and (2) hydrolyzes after delivery to 5-fluorouracil.

Abstract translation: 适于局部施用于有需要的人或非人动物的单位剂量形式的药物组合物，其包含药理学有效量的具有式（I）的5-氟尿嘧啶的前药，其中R 1和R 2可以相同或不同 并且选自H，R 3 CO-和R 4 -O-CO，条件是R 1和R 2可以不是H; 或其无毒的药学上可接受的盐，加合物，氧化物或其它衍生物; 药学上可接受的，可局部施用的载体; 以及用于局部施用组合物的方法。 R3和R4包含基团，使得前药（1）在局部膜上具有增强的递送，和（2）在递送至5-氟尿嘧啶之后水解。