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    DEVICE FOR USE IN THE DETECTION OF BINDING AFFINITIES
    85.
    发明公开
    DEVICE FOR USE IN THE DETECTION OF BINDING AFFINITIES 有权
    设备中使用IN的结合亲和力识别

    公开(公告)号：EP2929326A1

    公开(公告)日：2015-10-14

    申请号：EP13799537.9

    申请日：2013-12-03

    Applicant: F.Hoffmann-La Roche AG

    Inventor： FATTINGER, Christof

    IPC: G01N21/77

    CPC classification number: G01N21/75 ,  G01N21/7703 ,  G01N21/774 ,  G01N2021/752 ,  G01N2021/7776 ,  G01N2021/7793 ,  G01N2201/0438

    Abstract: A device for use in the detection of binding affinities, the device comprising a planar waveguide (2) arranged on a substrate (3), and further comprising an optical coupler (41) having a predetermined length for coupling coherent light (1) of a predetermined wavelength into the planar waveguide (2) such that a parallel beam of coherent light propagates through the planar waveguide (2) with an evanescent field (11) of the coherent light propagating along an outer surface (21) of the planar waveguide (2). The outer surface (21) of the planar waveguide (2) comprises binding sites thereon capable of binding target samples to the binding sites such that light of the evanescent field (11) is diffracted by target samples bound to the binding sites. The binding sites are arranged along a plurality of predetermined straight lines (7) running parallel to one another with a constant distance between adjacent straight lines. The predetermined straight lines (7) are arranged at an angle relative to the direction of propagation of the evanescent field (11) such that the coherent light (12) diffracted by the target samples bound to the binding sites impinges under a diffraction angle relative to the straight lines onto a further optical coupler (8) arranged in a portion (10) of the planar waveguide (2) outside the beam of coherent light propagating through the planar waveguide. The further optical coupler (8) couples the diffracted coherent light (13) out of the planar waveguide (2) such as to interfere at a predetermined detection location (9) with a difference in optical path length which is an integer multiple of the predetermined wavelength.

    VORRICHTUNG UND VERFAHREN ZUR OPTISCHEN CHARAKTERISIERUNG VON MATERIALIEN
    86.
    发明公开
    VORRICHTUNG UND VERFAHREN ZUR OPTISCHEN CHARAKTERISIERUNG VON MATERIALIEN 有权

    公开(公告)号：EP2619547A1

    公开(公告)日：2013-07-31

    申请号：EP11760701.0

    申请日：2011-09-09

    Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

    Inventor： HARTRUMPF, Matthias

    IPC: G01N21/21 ,  G01N21/85

    CPC classification number: G01N21/21 ,  G01N15/1434 ,  G01N15/1463 ,  G01N15/1475 ,  G01N21/84 ,  G01N2015/144 ,  G01N2021/845 ,  G01N2201/0438 ,  G01N2201/06113

    Abstract: The present invention relates to an apparatus for optically characterizing a sample and/or the material(s) of the latter, having an illumination unit which is oriented or can be oriented to illuminate a sample space section, into which the sample can be introduced, with incident light, having a detection unit which is oriented or can be oriented to image the sample, which has been introduced into the sample space section, by receiving light reflected by the sample and is designed to detect at least two different, preferably two orthogonal, polarization components in the reflected light, and having an evaluation unit which can be used to identify, in the image data recorded by the detection unit, those imaged surface elements (reflection elements) of the sample, the reflected received light of which is based on reflection of the incident light at the sample, and can be used to evaluate the detected different polarization components for these reflection elements for the purpose of the optical characterization.

    Abstract translation: 本发明涉及一种用于对样品和/或其材料进行光学表征的装置，该装置具有照明单元，该照明单元可以被定向为用入射光照射样品空间部分，样品可以被引入其中， 检测单元，其被定向或可以被定向以通过接收由样本反射的光成像引入到样本空间部分中的样本，并且被配置为检测反射光中的至少两个不同的，优选正交的偏振分量，以及 在由检测单元记录的成像数据中可以识别样品的那些成像表面元件（反射元件）的评估单元，并且可以对这些反射元件的检测到的不同偏振分量进行光学表征。

    DISPOSITIF D'IMAGERIE A BALAYAGE PAR FLUORESCENCE
    87.
    发明公开
    DISPOSITIF D'IMAGERIE A BALAYAGE PAR FLUORESCENCE 审中-公开
    GRID插图DEVICE ON荧光性碱基

    公开(公告)号：EP1955101A1

    公开(公告)日：2008-08-13

    申请号：EP06819303.6

    申请日：2006-11-07

    Applicant: INNOPSYS

    Inventor： BEC, Daniel ,  PAVEAU, Vincent ,  LE BRUN,Stéphane

    IPC: G02B21/00 ,  G02B21/24 ,  G01N21/64

    CPC classification number: G01N21/6452 ,  G01N21/6458 ,  G01N2201/0438 ,  G01N2201/0492 ,  G01N2201/101 ,  G02B21/0076

    Abstract: A device for analysing a specimen by fluorescence comprises a confocal microscope, illumination means capable of emitting a light beam that converges, by means of an objective, on a focal spot, means for successively positioning the focal spot at various points on the specimen (21) during analysis. The confocal microscope includes an objective mounted on a movable rapid-scan carriage driven in a reciprocating linear movement along a transverse direction by a rotating motor by means of a device of the connecting rod type. The specimen (21) is placed on a movable support (20) driven in a longitudinal movement and is able to move along the axis of the objective of the microscope in order to position the specimen relative to the focal spot. The excitation light spectrum is spread over the surface of the specimen (21) in such a way that the excitation light reflected by the specimen and corresponding to the wavelengths close to fluorescence converge on points that are sufficiently distant from a diaphragm positioned in front of a device for measuring the fluorescence.

    Analytic reader device
    88.
    发明公开
    Analytic reader device 失效
    分析读取器设备

    公开(公告)号：EP0359550A3

    公开(公告)日：1991-05-08

    申请号：EP89309302.1

    申请日：1989-09-13

    Applicant: EXOCELL, INC.

    Inventor： Neuman, Robert Glenn

    IPC: G01N21/25 ,  G01N21/75 ,  G01N33/53

    CPC classification number: G01N33/68 ,  G01N21/253 ,  G01N21/78 ,  G01N33/54366 ,  G01N2201/0438 ,  G01N2201/127

    Abstract: An analytical reader device having an elongated fixed standard tray supporting thereon a strip of standard wells and an elongated movable sample tray supporting thereon a strip of sample wells. A track arrangement connects and allows the movable sample tray to slide along the fixed standard tray. A rack gear is secured along the side of the movable sample tray opposite to the track arrangement. A geared dial is rotatably supported on a support plate secured to the fixed standard tray. The teeth of the geared dial mesh with the teeth of the rack gear so that as the movable sample tray slides the dial rotates. When a sample well is positioned adjacent the visually simi­lar standard well, the dial is turned so that the correct concentration reading thereon appears through a fixed readout window.

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