公开(公告)号：US20090310138A1

公开(公告)日：2009-12-17

申请号：US12311042

申请日：2007-09-17

Applicant: Jarmo Vanhanen ,  Marcus Rinkiö ,  Päivi Törmä ,  Jouko Korppi-Tommola ,  Kari Loberg ,  Jukka Elfström

Inventor： Jarmo Vanhanen ,  Marcus Rinkiö ,  Päivi Törmä ,  Jouko Korppi-Tommola ,  Kari Loberg ,  Jukka Elfström

IPC: G01N21/00

CPC classification number: G01N21/8507 ,  G01N21/15 ,  G01N33/2888 ,  G01N2201/0662

Abstract: The invention relates to a method for monitoring the condition of a medium, based on the transmission/emission of light in a channel, in which a light is conducted through a medium layer defined by a measuring gap in a measuring head pushed in from an opening in the wall of the channel, the intensity of the light, or a variable proportional to it is measured through the medium layer, and the condition of the medium is evaluated, using measuring electronics, from the intensity of the change, according to set criteria. The measurement is performed using a sensor with a compact measuring head, in which the measuring electronics are essentially outside the channel, and in which the light is conducted to the measuring gap and away from the measuring gap by optical-fibre means. In addition, the invention also relates to a corresponding device.

Abstract translation: 本发明涉及一种基于通道中的光的透射/发射来监测介质的状态的方法，其中光通过由从开口推入的测量头中的测量间隙限定的介质层传导 在通道的壁上，通过介质层测量光的强度或与之成比例的变量，并且根据设定的标准，使用测量电子学根据变化的强度来评估介质的状况 。 使用具有紧凑测量头的传感器进行测量，其中测量电子器件基本上在通道外，并且光通过光纤装置传导到测量间隙并远离测量间隙。 此外，本发明还涉及相应的装置。

公开(公告)号：US20080123094A1

公开(公告)日：2008-05-29

申请号：US11792097

申请日：2005-12-01

Applicant: Henrik Vilstrup Juhl

Inventor： Henrik Vilstrup Juhl

IPC: G01J3/427

CPC classification number: G01N21/0303 ,  G01N21/31 ,  G01N2021/036 ,  G01N2201/066 ,  G01N2201/0662 ,  G01N2201/1293

Abstract: A spectrophotometer (2) comprising a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b) is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest withiA spectrophotometer (2) comprise a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b) is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest within the retained sample can be obtained.

Abstract translation: 一种分光光度计（2），包括辐射源（6），优选光辐射，被设置成朝向样品保持器（4）中的样品发射多个波长的辐射;以及检测装置8，用于在与 例子。 样品保持器（4）适于对通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的强度相关输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 多个不同的路径长度并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，通过该值，用分光光度计（2）存在感兴趣的物质的指示包括辐射源（6） 优选地，光辐射被设置为发射多个波长的辐射朝向样本保持器（4）中的样本;以及检测装置8，用于在与样本相互作用之后检测辐射。 样品保持器（4）适于对通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的强度相关输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 多个不同的路径长度，并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，由此可以获得在保留的样本内存在感兴趣的物质的指示。

公开(公告)号：US07248911B2

公开(公告)日：2007-07-24

申请号：US10802920

申请日：2004-03-18

Applicant: Kye-jin Jeon ,  Gil-won Yoon ,  In-duk Hwang ,  Sang-joon Han

Inventor： Kye-jin Jeon ,  Gil-won Yoon ,  In-duk Hwang ,  Sang-joon Han

IPC: A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/0053 ,  A61B5/107 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B2560/0223 ,  G01N21/359 ,  G01N2021/036 ,  G01N2021/3144 ,  G01N2201/0662

Abstract: In an apparatus and method of noninvasively measuring a concentration of a blood component, the method includes (a) varying a thickness of a body part of a subject, measuring absorption spectrums at different thicknesses of the body part, obtaining a first differential absorption spectrum between the absorption spectrums measured at different thicknesses, actually measuring concentrations of the blood component, and establishing a statistical model using the first differential absorption spectrum and the actually measured concentrations; and (b) estimating the concentration of the blood component using a second differential absorption spectrum obtained with respect to the body part based on the statistical model.

Abstract translation: 在非侵入性地测量血液成分浓度的装置和方法中，该方法包括：（a）改变被检体的身体部位的厚度，测量身体部位的不同厚度的吸收光谱，获得第一差异吸收光谱， 在不同厚度下测量的吸收光谱，实际测量血液成分的浓度，并使用第一个差示吸收光谱和实际测量的浓度建立统计模型; 和（b）基于统计模型使用相对于身体部位获得的第二差分吸收光谱估计血液成分的浓度。

公开(公告)号：US5482842A

公开(公告)日：1996-01-09

申请号：US224054

申请日：1994-04-07

Applicant: Klaus W. Berndt

Inventor： Klaus W. Berndt

IPC: C12M1/34 ,  C12Q1/04 ,  G01N21/27 ,  G01N21/35 ,  G01N21/59 ,  G06Q50/00

CPC classification number: G01N21/274 ,  C12M41/46 ,  G01N2021/5969 ,  G01N21/3504 ,  G01N2201/06106 ,  G01N2201/066 ,  G01N2201/0662 ,  Y10S435/808

Abstract: Methods and apparatus for detecting biological activity within a sample are disclosed. The present invention provides a combination of a first and a second infrared light source arranged on the side of a sample vial, and a first and a second narrow-band infrared detector similarly arranged on the side of the vial approximately opposite the sources. The disclosed arrangement cancels the sources of error while measuring the carbon dioxide content of the headspace gas above the sample. In operation, the present invention sequentially measures the photocurrents generated at each detector with no source turned on, with the first source turned on, and with the second source turned on and the first source turned off. The CO.sub.2 absorption coefficient of the vial headspace gas is then calculated based on the photocurrents measured. This present invention allows compensation for source aging, detector aging, and vial wall thickness changes. Moreover, the present invention permits a determination of the absolute absorption coefficient at a selected wavelength, most preferably about 4.26 .mu.m, which is the CO.sub.2 absorption characteristic wavelength. The determination of the absolute CO.sub.2 concentration within the headspace permits the detection of bacterial growth processes. Additionally, the disclosed source/detector combination can be produced at low cost. Thus, in preferred embodiments, the apparatus of the present invention comprises a plurality of vials that are simultaneously monitored by providing each of the plurality of vials with its own source/detector combination and activating and deactivating the sources and detectors using a multiplexer/demultiplexer arrangement.

Abstract translation: 公开了用于检测样品内生物活性的方法和装置。 本发明提供了布置在样品瓶侧面的第一和第二红外光源的组合，以及类似地布置在大致与源相对的小瓶侧面上的第一和第二窄带红外检测器。 所公开的布置在测量样品上方的顶空气体的二氧化碳含量的同时消除误差源。 在操作中，本发明顺序地测量在每个检测器处产生的光电流，其中第一源被接通，并且第二源被接通，并且第一源被关断。 然后基于测量的光电流计算出瓶顶空气体的CO 2吸收系数。 本发明允许补偿源老化，检测器老化和小瓶壁厚变化。 此外，本发明允许确定选定波长的绝对吸收系数，最优选约4.26μm，这是CO 2吸收特性波长。 顶部空间中绝对二氧化碳浓度的测定允许细菌生长过程的检测。 另外，所公开的源/检测器组合可以以低成本生产。 因此，在优选实施例中，本发明的装置包括多个小瓶，其通过向多个小瓶中的每一个提供自己的源/检测器组合来同时监视，并使用多路复用器/解复用器布置来激活和去激活源和检测器 。

公开(公告)号：US5371020A

公开(公告)日：1994-12-06

申请号：US050100

申请日：1993-05-07

Applicant: Peter A. Frischauf

Inventor： Peter A. Frischauf

IPC: G01N21/05 ,  G01N21/03 ,  G01N21/31 ,  G01N35/10

CPC classification number: G01N21/0303 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3129 ,  G01N2035/1062 ,  G01N21/314 ,  G01N2201/0662

Abstract: A method of photometric in vitro determination of the content of an analyte in a sample is disclosed. The sample is located in a measuring chamber which has a radiation path length and has at least one at least partially transparent wall part. The measuring chamber is in optical communication with an optical system adapted for the analyte which includes a radiation source and a radiation detector. The measuring chamber is adjustable in shape which enables the radiation path length across the measuring chamber to be changed. In a first measuring step an unknown first radiation path length across the measuring chamber is set and radiation at at least two wavelengths is transmitted from the radiation source through the measuring chamber and to the radiation detector. In a second step, the measuring chamber is adjusted in shape thereby setting a second unknown path length across the measuring chamber. Radiation at the same wavelengths as during the first step is again transmitted from the radiation source through the measuring chamber and to the radiation detector. The analyte content is then determined on the basis of radiation detected in each of the measuring steps.

Abstract translation: PCT No.PCT / DK92 / 00280 Sec。 371日期：1993年5月7日 102（e）日期1993年5月7日PCT 1991年9月17日PCT公布。 出版物WO93 / 06456 日期：1993年4月1日。公开了一种光度测定样品中分析物含量的方法。 样品位于具有辐射路径长度并具有至少一个至少部分透明的壁部分的测量室中。 测量室与适用于包括辐射源和辐射探测器的分析物的光学系统光学通信。 测量室的形状可调节，使测量室上的辐射路径长度可以改变。 在第一测量步骤中，设置跨越测量室的未知的第一辐射路径长度，并且至少两个波长的辐射从辐射源通过测量室和辐射探测器传输。 在第二步骤中，测量室的形状被调节，从而在测量室上设置第二未知路径长度。 与第一步骤相同的波长的辐射再次从辐射源通过测量室和辐射探测器传输。 然后基于在每个测量步骤中检测到的辐射来确定分析物含​​量。

公开(公告)号：US5214593A

公开(公告)日：1993-05-25

申请号：US610416

申请日：1990-11-07

Applicant: Haakon T. Magnussen, Jr. ,  Roy P. Moeller

Inventor： Haakon T. Magnussen, Jr. ,  Roy P. Moeller

IPC: G01N21/27 ,  G01N21/85 ,  G01N30/74

CPC classification number: G01N21/274 ,  G01N21/85 ,  G01N2201/0662 ,  G01N2201/126 ,  G01N30/74

Abstract: A method and accompanying apparatus for automatically extending the linear dynamic absorbance range of absorbance detectors including multi-lightpath flow cells. The absorbance of a reference beam in a relatively short reference path is multiplied by a ratio of the absorbance of a sample beam in a relatively long sample path to the reference path absorbance in developing a relative absorbance for the sample path beyond its linear dynamic range.

Abstract translation: 一种用于自动扩展包括多光路流动池的吸光度检测器的线性动态吸光度范围的方法和伴随装置。 在相对较短的参考路径中的参考光束的吸光度乘以相对长的取样通道中的样品光束的吸光度与参考光路的吸光度之比，使得样品路径的相对吸光度超过其线性动态范围。

公开(公告)号：US4990781A

公开(公告)日：1991-02-05

申请号：US276603

申请日：1988-11-28

Applicant: Theodor Heller

Inventor： Theodor Heller

IPC: G01N21/3504 ,  G01N21/3554

CPC classification number: G01N21/3554 ,  G01N2021/354 ,  G01N2201/0636 ,  G01N2201/0662

Abstract: In a spectroscopically operating infrared hygrometer, beams emitted by the beam source and formed by the lens arrangement disposed in front thereof, are reflected via two pairs of rotating lenses, fixed in two parallel planes which are at a fixed distance from each other, and via a fixed mirror, to the lens arrangement placed in front of the detector and are directed by this lens arrangement to the detector. In this infrared hygrometer the absorption distance change takes place very rapidly, so that it is possible during measurements over longer perids of time, for example, during measurements taken from an airplane, to relate with small time constants the individual measurement values for the two absorption distances continuously. Furthermore, intermediate calibration is not required with this infrared hygrometer.

Abstract translation: 在光谱操作的红外湿度计中，由光束源发射并由设置在其前面的透镜装置形成的光束经由两对旋转透镜反射，两对旋转透镜固定在彼此处于固定距离的两个平行平面中，并且经由 固定的镜子，放置在放置在检测器前面的透镜装置，并被该透镜装置导向检测器。 在这种红外线湿度计中，吸收距离的变化非常快速地发生，因此在长时间的测量中可能会发生，例如在飞机测量期间，与小时间常数相关的两个吸收的各个测量值 距离不断。 此外，该红外湿度计不需要中间校准。

公开(公告)号：WO2013150102A1

公开(公告)日：2013-10-10

申请号：PCT/EP2013/057112

申请日：2013-04-04

Applicant: DRÄGER MEDICAL GMBH

Inventor： BUCHTAL, Ralf ,  DREYER, Peter ,  FORNASIERO, Livio

IPC: G01J3/26 ,  G01J3/42 ,  G01J3/433 ,  G01N21/35

CPC classification number: G01N21/3504 ,  G01J3/26 ,  G01J3/42 ,  G01J3/433 ,  G01N2201/061 ,  G01N2201/0662 ,  G01N2201/068

Abstract: Die Erfindung betrifft eine Vorrichtung zur Aufnahme eines Absorptionsspektrums eines Fluids mit einer ersten Strahlungsquelle (1), die entlang eines ersten Strahlengangs (11) eine Strahlung in einem ersten Spektralbereich emittiert, mit einer in dem ersten Strahlengang (11) angeordneten ersten Messstrecke (5), entlang derer die Strahlung durch das Fluid tritt, mit einem in dem ersten Strahlengang (11) angeordneten durchstimmbaren Fabry-Perot Interferometer (7), das als ein verschiebbarer Bandpassfilter Strahlung in dem ersten Spektralbereich transmittieren kann, und mit einem ersten Detektor (9; 35) zur Messung der Intensität der Strahlung in dem ersten Spektralbereich. Erfindungsgemäß ist vorgesehen, dass die Vorrichtung ein erstes Etalon (3) zur spektralen Modulation der Strahlung aufweist, das in dem ersten Strahlengang (11) angeordnet ist und das in dem ersten Spektralbereich eine Mehrzahl von Transmissionsmaxima (17) aufweist, und dass das Fabry- Perot (7) dazu eingerichtet ist, dass das von dem Fabry-Perot Interferometer (7) gebildete Bandpassfilter derart über den ersten Spektralbereich verschoben werden kann, dass die spektrale Modulation der Strahlung durch das erste Etalon (3) als eine zeitliche Modulation der Intensität der Strahlung von dem ersten Detektor (9, 35) gemessen werden kann.

Abstract translation: 本发明涉及一种装置，用于记录具有被沿着第一光束路径发射的第一辐射源（1）的流体的吸收光谱（11）具有在第一光谱区中的辐射，布置有在所述第一光路（11），所述第一测量部分（5） 沿着其中发生穿过流体，其在所述第一光路（11）的可调谐的法布里 - 珀罗干涉仪（7）设置有，其可以如在第一光谱范围内的可动的带通滤波器的辐射和第一检测器（9发射辐射; 35），用于测量所述辐射的强度在第一光谱范围内。 根据本发明，提供的是该装置包括用于辐射，其设置在所述第一光束路径（11），并且具有在第一光谱范围内，多个透射峰（17）的频谱调制的第一标准具（3），并且所述法布里 珀罗（7）适于该法布里 - 珀罗干涉仪形成能够经由第一光谱范围内被移动，以便（7）的带通滤波器的，辐射的通过所述第一标准具（3）的强度的时间调制的频谱调制 来自第一检测器（9，35）的辐射可以被测量。

公开(公告)号：WO2013066500A1

公开(公告)日：2013-05-10

申请号：PCT/US2012/054950

申请日：2012-09-12

Applicant: MINE SAFETY APPLIANCES COMPANY

Inventor： STARTA, Christopher, D. ,  UBER, Robert, E. ,  TRAUTZSCH, Thomas ,  SCHULER, Frederick, J.

IPC: G01N21/35 ,  G01N21/31

CPC classification number: G01N21/59 ,  G01N21/3151 ,  G01N21/3504 ,  G01N2201/023 ,  G01N2201/0636 ,  G01N2201/0662

Abstract: A closed path infrared sensor includes an enclosure, a first energy source within the enclosure, at least a second energy source within the enclosure, at least one detector system within the enclosure and a mirror system external to the enclosure and spaced from the enclosure. The mirror system reflects energy from the first energy source to the at least one detector system via a first analytical path and reflects energy from the second energy source to the at least one detector system via a second analytical path. Each of the first analytical path and the second analytical path are less than two feet in length.

Abstract translation: 封闭路径红外传感器包括外壳，外壳内的第一能量源，外壳内的至少第二能量源，外壳内的至少一个检测器系统和外壳外部与外壳隔开的反射镜系统。 反射镜系统经由第一分析路径将来自第一能量源的能量反射到至少一个检测器系统，并且经由第二分析路径将来自第二能量源的能量反射到至少一个检测器系统。 第一分析路径和第二分析路径中的每一条长度小于两英尺。

公开(公告)号：WO2006058741A1

公开(公告)日：2006-06-08

申请号：PCT/EP2005/012820

申请日：2005-12-01

Applicant: FOSS ANALYTICAL A/S ,  JUHL, Henrik, Vilstrup

Inventor： JUHL, Henrik, Vilstrup

IPC: G01N21/03 ,  G01N21/31

CPC classification number: G01N21/0303 ,  G01N21/31 ,  G01N2021/036 ,  G01N2201/066 ,  G01N2201/0662 ,  G01N2201/1293

Abstract: A spectrophotometer (2)comprising a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b)is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest withiA spectrophotometer (2)comprise a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is dapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b)is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest within the retained sample can be obtained.

Abstract translation: 一种分光光度计（2），包括辐射源（6），优选光辐射，被设置成朝向样品保持器（4）中的样品发射多个波长的辐射;以及检测装置8，用于在与 例子。 样品保持器（4）适于对通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的与强度相关的输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，通过该值，用分光光度计（2）存在感兴趣的物质的指示包括辐射源（6）， 优选地，光辐射被设置为以多个波长朝向样品保持器（4）中的样品发射辐射;以及检测装置8，用于在与样品相互作用之后检测辐射。 样品保持器（4）被折叠以对于通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的与强度相关的输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，通过该值，可以获得在保留的样品内存在感兴趣物质的指示。