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    COMPACT OPTICAL DETECTION SYSTEM
    81.
    发明申请
    COMPACT OPTICAL DETECTION SYSTEM 审中-公开
    紧凑光学检测系统

    公开(公告)号：US20100227386A1

    公开(公告)日：2010-09-09

    申请号：US12438725

    申请日：2007-08-24

    Applicant: Pavel Neuzil ,  Juergen Pipper ,  Lukas Novak

    Inventor： Pavel Neuzil ,  Juergen Pipper ,  Lukas Novak

    IPC: C12M1/34 ,  G01J1/58

    CPC classification number: G01N21/645 ,  B01L3/5088 ,  B01L7/52 ,  B01L2200/147 ,  B01L2300/1827 ,  G01N21/0332 ,  G01N21/6428 ,  G01N21/76 ,  G01N21/763 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/0221 ,  G01N2201/0625 ,  G01N2201/0627 ,  G01N2201/0693

    Abstract: A detection system is provided, the detection system comprising a light source that generates excitation light having a wavelength sufficient to excite a fluorophore in a sample; an excitation filter positioned along a first line along a path of the excitation light, the excitation filter transmitting the excitation light from the light source; a beam splitter positioned along the first line, the beam splitter reflecting the excitation light transmitted by the excitation filter along a second line toward a mirror positioned on one side of the beam splitter, and passing emitted light reflected along the second line; the mirror, positioned to reflect the excitation light from the beam splitter to the fluorophore in the sample along a third line, normal to both the first and second lines, wherein the mirror further reflects emitted light emitted along the third line, along the second line toward the beam splitter; an emission filter positioned along the second line, on a second side of the beam splitter; and a detector that detects the emitted light transmitted by the emission filter.

    Abstract translation: 提供一种检测系统，所述检测系统包括产生具有足以激发样品中的荧光团的波长的激发光的光源; 激励滤光器，其沿着激励光的路径沿着第一线定位，所述激发滤光器透射来自所述光源的激发光; 分束器，沿着第一线定位，分束器将由激励滤光器透射的激发光沿着第二线反射到位于分束器一侧的反射镜，并且使沿着第二线反射的发射光反射; 所述反射镜被定位成将来自分束器的激发光沿着与第一和第二线垂直的第三线反射到样品中的荧光团，其中反射镜还沿着第二条线反射沿着第三条线发射的发射光 朝向分束器; 沿着所述第二线定位在所述分束器的第二侧上的发射滤光器; 以及检测由发射滤波器发射的发射光的检测器。

    SELF-CONTAINED MULTIVARIATE OPTICAL COMPUTING AND ANALYSIS SYSTEMS
    82.
    发明申请
    SELF-CONTAINED MULTIVARIATE OPTICAL COMPUTING AND ANALYSIS SYSTEMS 有权
    自包含多光学计算和分析系统

    公开(公告)号：US20100182600A1

    公开(公告)日：2010-07-22

    申请号：US12513265

    申请日：2007-11-01

    Applicant: Robert P. Freese ,  Terrell K. Teague ,  David L. Perkins ,  William J. Soltmann

    Inventor： Robert P. Freese ,  Terrell K. Teague ,  David L. Perkins ,  William J. Soltmann

    IPC: G01J3/28

    CPC classification number: G01J3/4338 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/0264 ,  G01N21/255 ,  G01N21/31 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/4738 ,  G01N2021/1793 ,  G01N2201/0691 ,  G01N2201/0693 ,  G01N2201/1293

    Abstract: An optical analysis system includes a light source configured to radiate a first light along a first ray path; a modulator disposed in the first ray path, the modulator configured to modulate the first light to a desired frequency; a spectral element disposed proximate the modulator, the spectral element configured to filter the first light for a spectral range of interest of a sample; a cavity in communication with the spectral element, the cavity configured to direct the first light in a direction of the sample; a conical mirror configured to convert the first light reflecting from the sample into a second light, the cavity being further configured to direct the second light; a beamsplitter configured to split the second light into a first beam and a second beam; an optical filter mechanism disposed to receive the first beam, the optical filter mechanism configured to optically filter data carried by the first beam into at least one orthogonal component of the first beam; a first detector mechanism in communication with the optical filter mechanism to measure a property of the orthogonal component to measure the data; a second detector mechanism configured to receive the second beam for comparison of the property of the orthogonal component to the second beam; an accelerometer configured to control the data acquisition such that only detector signals during the period of time when the system is in the proper orientation such that the material sample (e.g., aspirin) is in proximity to the interrogation window are used for calculation; a computer having a data acquisition and conversion card, the computer disposed in the system in communication with the first and second detector mechanisms for signal processing; and a battery and charging system disposed in the system in electrical communication with the system to provide stand-alone operation capability.

    Abstract translation: 光学分析系统包括被配置为沿第一射线路径辐射第一光的光源; 调制器，设置在第一射线路径中，调制器被配置为将第一光调制到期望的频率; 设置在所述调制器附近的光谱元件，所述光谱元件被配置为过滤所述第一光以获得样品的感兴趣的光谱范围; 与所述光谱元件连通的空腔，所述空腔被配置为沿所述样品的方向引导所述第一光; 锥形镜，被配置为将从样品反射的第一光转换成第二光，所述空腔进一步构造成引导第二光; 分束器，被配置为将所述第二光分成第一光束和第二光束; 滤光器机构，设置成接收第一光束，滤光器机构被配置为将由第一光束承载的数据光学滤波成第一光束的至少一个正交分量; 与所述光学滤波器机构通信以测量所述正交分量的属性以测量所述数据的第一检测器机构; 第二检测器机构，其被配置为接收所述第二光束，用于将所述正交分量的属性与所述第二光束进行比较; 加速度计被配置为控制数据采集，使得仅在系统处于正确定向的时间段内的检测器信号才能使材料样品（例如阿司匹林）接近询问窗口进行计算; 具有数据获取和转换卡的计算机，所述计算机设置在与所述第一和第二检测器机构通信以进行信号处理的系统中; 以及设置在系统中与系统电连通以提供独立操作能力的电池和充电系统。

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