公开(公告)号：US20240035975A1

公开(公告)日：2024-02-01

申请号：US18265361

申请日：2021-12-17

Applicant: Carl Zeiss Jena GmbH

Inventor： Alexandre Gatto ,  Michael Totzeck

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01N2201/0873 ,  G01N2021/0346

Abstract: A lab-on-a-chip system (100) comprises an optical detection waveguide (122) that has an at least partially periodic structure (123, 501, 502, 503, 504) that is configured to couple light (152) from surroundings of the optical detection waveguide (122) into the optical detection waveguide (122). The lab-on-a-chip system (100) furthermore also comprises a microfluidic network (212), wherein the microfluidic network (212) has multiple lines and at least one reaction chamber (211, 211-1, 211-2, 211-3).

公开(公告)号：US09989467B2

公开(公告)日：2018-06-05

申请号：US15432696

申请日：2017-02-14

Applicant: International Business Machines Corporation

Inventor： Yann A. N. Astier ,  Ning Li ,  Devendra K. Sadana ,  Joshua T. Smith ,  William T. Spratt

IPC: H01L31/16 ,  G01N21/64 ,  G02B6/132 ,  H01L33/32 ,  G02B6/122 ,  G02B6/12 ,  H01L33/00 ,  H01L31/0304 ,  H01L27/14 ,  H01L27/15

CPC classification number: G01N21/6454 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0654 ,  G01N15/1436 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/6428 ,  G01N21/645 ,  G01N2015/1006 ,  G01N2021/6439 ,  G01N2021/6482 ,  G01N2201/0873 ,  G02B6/12004 ,  G02B6/122 ,  G02B6/131 ,  G02B6/132 ,  G02B6/136 ,  G02B2006/12078 ,  G02B2006/12123 ,  H01L27/14 ,  H01L27/15 ,  H01L31/03044 ,  H01L31/16 ,  H01L33/007 ,  H01L33/32

Abstract: A semiconductor structure includes a first optical waveguide and a second optical waveguide located on a sapphire substrate. The first optical waveguide and the second optical waveguide each include a core portion of gallium nitride (GaN), and a cladding layer laterally surrounding the core portion. The cladding layer includes a material having a refractive index less than a refractive index of the sapphire substrate.

公开(公告)号：US09915612B2

公开(公告)日：2018-03-13

申请号：US15451305

申请日：2017-03-06

Applicant: Pacific Biosciences of California, Inc.

Inventor： Annette Grot ,  Ravi Saxena ,  Paul Lundquist

IPC: G01N21/64 ,  H01L27/146 ,  G02B6/136 ,  G01N21/77 ,  G02B6/132 ,  G02B6/12

CPC classification number: G01N21/6454 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/7703 ,  G01N21/78 ,  G01N2021/6439 ,  G01N2021/6478 ,  G01N2021/7756 ,  G01N2021/7786 ,  G01N2201/068 ,  G01N2201/0873 ,  G02B5/1895 ,  G02B5/201 ,  G02B5/285 ,  G02B6/132 ,  G02B6/136 ,  G02B27/4238 ,  G02B27/4244 ,  G02B2006/12102 ,  G02B2006/12109 ,  H01L27/14621 ,  H01L27/14627 ,  H01L27/14685

Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.

公开(公告)号：US20170322156A1

公开(公告)日：2017-11-09

申请号：US15600668

申请日：2017-05-19

Applicant: Pacific Biosciences of California, Inc.

Inventor： Ravi SAXENA ,  Michael Tzu RU ,  Takashi Whitney ORIMOTO ,  Annette GROT ,  Mathieu FOQUET ,  Hou-Pu CHOU

IPC: G01N21/64 ,  G02B6/02 ,  G02B6/12 ,  G02B6/124 ,  G02B6/136 ,  G02B5/18 ,  B29D11/00 ,  C12Q1/68 ,  B29D17/00 ,  B29L11/00

CPC classification number: G02B6/12004 ,  B29D11/0073 ,  B29D17/007 ,  B29L2011/005 ,  B29L2011/0066 ,  B29L2011/0075 ,  C12Q1/6869 ,  G01N21/6454 ,  G01N21/648 ,  G01N2021/6478 ,  G01N2201/0873 ,  G02B5/189 ,  G02B6/02123 ,  G02B6/124 ,  G02B6/136 ,  G02B2006/12038 ,  G02B2006/12109

Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.

公开(公告)号：US09739709B2

公开(公告)日：2017-08-22

申请号：US14889839

申请日：2014-05-08

Applicant: Colorado State University Research Foundation

Inventor： Kevin Lear ,  Timothy Erickson

IPC: G02B6/00 ,  G01N21/41 ,  G02B6/028 ,  G02B27/56 ,  G02B6/122 ,  G02B6/42 ,  G02B6/12

CPC classification number: G01N21/4133 ,  G01M11/33 ,  G01N33/1833 ,  G01N2021/4166 ,  G01N2201/0873 ,  G02B6/028 ,  G02B6/12004 ,  G02B6/1221 ,  G02B6/4291 ,  G02B27/56 ,  G02B2006/12123 ,  G02B2006/12138 ,  Y02A20/206

Abstract: A chip-scale, reusable sensor can detect aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), rapidly in water without sample preparation. The device is capable of real-time, continuous monitoring for BTEX solutes, which diffuse into a film, such as a polymer, on the sensors surface. In operation, BTEX analytes concentrate in the film, causing an increase in refractive index, which modulates evanescent coupling into the chips integrated photodetector array. Integration of the photodetector array simplifies system instrumentation and permits incorporation of an on-chip photocurrent reference region in the immediate vicinity of the sensing region, reducing drift due to temperature fluctuations. In some examples, the chip responds linearly for BTEX concentrations between 1 ppm and 30 ppm, with a limit of detection of 359 ppb, 249 ppb, and 103 ppb for benzene, toluene, and xylene in water, respectively.

公开(公告)号：US20170205350A1

公开(公告)日：2017-07-20

申请号：US15432719

申请日：2017-02-14

Applicant: International Business Machines Corporation

Inventor： Yann A. N. Astier ,  Ning Li ,  Devendra K. Sadana ,  Joshua T. Smith ,  William T. Spratt

IPC: G01N21/64 ,  G02B6/132 ,  G02B6/13 ,  H01L31/16 ,  G02B6/12 ,  H01L33/32 ,  H01L33/00 ,  H01L31/0304 ,  G02B6/136 ,  G02B6/122

CPC classification number: G01N21/6454 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0654 ,  G01N15/1436 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/6428 ,  G01N21/645 ,  G01N2015/1006 ,  G01N2021/6439 ,  G01N2021/6482 ,  G01N2201/0873 ,  G02B6/12004 ,  G02B6/122 ,  G02B6/131 ,  G02B6/132 ,  G02B6/136 ,  G02B2006/12078 ,  G02B2006/12123 ,  H01L27/14 ,  H01L27/15 ,  H01L31/03044 ,  H01L31/16 ,  H01L33/007 ,  H01L33/32

Abstract: A method of forming a semiconductor structure includes forming a first optical waveguide and a second optical waveguide on a sapphire substrate. The first optical waveguide and the second optical waveguide each include a core portion of gallium nitride (GaN), and a cladding layer laterally surrounding the core portion. The cladding layer includes a material having a refractive index less than a refractive index of the sapphire substrate. The method further includes etching a portion of the cladding layer to form a microfluidic channel therein and forming a capping layer on a top surface of the first optical waveguide, the second optical waveguide and the microfluidic channel.

公开(公告)号：US09588289B1

公开(公告)日：2017-03-07

申请号：US15002041

申请日：2016-01-20

Applicant: International Business Machines Corporation

Inventor： Yann A. N. Astier ,  Ning Li ,  Devendra K. Sadana ,  Joshua T. Smith ,  William T. Spratt

IPC: G02B6/13 ,  G02B6/12 ,  G02B6/136 ,  G02B6/132

CPC classification number: G01N21/6454 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0654 ,  G01N15/1436 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/6428 ,  G01N21/645 ,  G01N2015/1006 ,  G01N2021/6439 ,  G01N2021/6482 ,  G01N2201/0873 ,  G02B6/12004 ,  G02B6/122 ,  G02B6/131 ,  G02B6/132 ,  G02B6/136 ,  G02B2006/12078 ,  G02B2006/12123 ,  H01L27/14 ,  H01L27/15 ,  H01L31/03044 ,  H01L31/16 ,  H01L33/007 ,  H01L33/32

Abstract: A method of forming a semiconductor structure includes forming a first optical waveguide and a second optical waveguide on a sapphire substrate. The first optical waveguide and the second optical waveguide each include a core portion of gallium nitride (GaN), and a cladding layer laterally surrounding the core portion. The cladding layer includes a material having a refractive index less than a refractive index of the sapphire substrate. The method further includes etching a portion of the cladding layer to form a microfluidic channel therein and forming a capping layer on a top surface of the first optical waveguide, the second optical waveguide and the microfluidic channel.

Abstract translation: 形成半导体结构的方法包括在蓝宝石衬底上形成第一光波导和第二光波导。 第一光波导和第二光波导均包括氮化镓（GaN）的核心部分和横向包围核心部分的包层。 包覆层包括折射率小于蓝宝石衬底的折射率的材料。 该方法还包括蚀刻包层的一部分以在其中形成微流体通道，并在第一光波导，第二光波导和微流体通道的顶表面上形成覆盖层。

公开(公告)号：US09372308B1

公开(公告)日：2016-06-21

申请号：US13920037

申请日：2013-06-17

Applicant: Pacific Biosciences of California, Inc.

Inventor： Ravi Saxena ,  Michael Tzu Ru ,  Takashi Whitney Orimoto ,  Annette Grot ,  Mathieu Foquet ,  Hou-Pu Chou

IPC: G02B6/136 ,  B29D17/00 ,  G02B6/02

CPC classification number: G02B6/12004 ,  B29D11/0073 ,  B29D17/007 ,  B29L2011/005 ,  B29L2011/0066 ,  B29L2011/0075 ,  C12Q1/6869 ,  G01N21/6454 ,  G01N21/648 ,  G01N2021/6478 ,  G01N2201/0873 ,  G02B5/189 ,  G02B6/02123 ,  G02B6/124 ,  G02B6/136 ,  G02B2006/12038 ,  G02B2006/12109

Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.

Abstract translation: 提供了集成分析设备阵列及其生产方法。 阵列可用于高密度高分复用的光学反应，包括生化反应，如核酸测序反应。 集成器件允许使用诸如光谱，幅度和时间分辨率之类的特征或其组合来对光信号进行高灵敏度鉴别。 本发明的阵列和方法利用为电子工业开发的硅芯片制造和制造技术，并且非常适合于小型化和高吞吐量。

公开(公告)号：US20160116403A1

公开(公告)日：2016-04-28

申请号：US14889839

申请日：2014-05-08

Applicant: Colorado State University Research Foundation

Inventor： Kevin LEAR ,  Timothy ERICKSON

IPC: G01N21/41 ,  G02B6/42 ,  G02B6/12

CPC classification number: G01N21/4133 ,  G01M11/33 ,  G01N33/1833 ,  G01N2021/4166 ,  G01N2201/0873 ,  G02B6/028 ,  G02B6/12004 ,  G02B6/1221 ,  G02B6/4291 ,  G02B27/56 ,  G02B2006/12123 ,  G02B2006/12138 ,  Y02A20/206

Abstract: A chip-scale, reusable sensor can detect aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), rapidly in water without sample preparation. The device is capable of real-time, continuous monitoring for BTEX solutes, which diffuse into a film, such as a polymer, on the sensors surface. In operation, BTEX analytes concentrate in the film, causing an increase in refractive index, which modulates evanescent coupling into the chips integrated photodetector array. Integration of the photodetector array simplifies system instrumentation and permits incorporation of an on-chip photocurrent reference region in the immediate vicinity of the sensing region, reducing drift due to temperature fluctuations. In some examples, the chip responds linearly for BTEX concentrations between 1 ppm and 30 ppm, with a limit of detection of 359 ppb, 249 ppb, and 103 ppb for benzene, toluene, and xylene in water, respectively.

Abstract translation: 芯片级的可重复使用的传感器可以在没有样品制备的情况下快速检测芳烃，如苯，甲苯，乙苯和二甲苯（BTEX）。 该装置能够实时，连续地监测传感器表面上扩散到薄膜（如聚合物）中的BTEX溶质。 在操作中，BTEX分析物集中在膜中，引起折射率的增加，其调节到芯片集成光电检测器阵列中的渐逝耦合。 光电检测器阵列的集成简化了系统仪器，并且允许在感测区域附近并入片上光电流参考区域，从而减少由于温度波动引起的漂移。 在一些实例中，芯片对于1ppm和30ppm之间的BTEX浓度线性反应，分别对苯，苯和二甲苯的检测限为359ppb，249ppb，103ppb。

公开(公告)号：US20160061740A1

公开(公告)日：2016-03-03

申请号：US14836629

申请日：2015-08-26

Applicant: Pacific Biosciences of California, Inc.

Inventor： Annette GROT ,  Ravi SAXENA ,  Paul LUNDQUIST

IPC: G01N21/78 ,  G02B27/42 ,  G02B5/28 ,  G02B5/18 ,  G02B5/20

CPC classification number: G01N21/6454 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/7703 ,  G01N21/78 ,  G01N2021/6439 ,  G01N2021/6478 ,  G01N2021/7756 ,  G01N2021/7786 ,  G01N2201/068 ,  G01N2201/0873 ,  G02B5/1895 ,  G02B5/201 ,  G02B5/285 ,  G02B6/132 ,  G02B6/136 ,  G02B27/4238 ,  G02B27/4244 ,  G02B2006/12102 ,  G02B2006/12109 ,  H01L27/14621 ,  H01L27/14627 ,  H01L27/14685

Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.

Abstract translation: 提供了集成分析设备阵列及其生产方法。 阵列可用于高密度高分复用的光学反应，包括生化反应，如核酸测序反应。 这些器件允许使用诸如光谱，幅度和时间分辨率之类的特征或其组合来对光信号进行高灵敏度鉴别。 这些器件包括集成的衍射光束成形元件，其提供从光学反应发射的光的空间分离。