PULSED-MULTILINE EXCITATION FOR COLOR-BLIND FLUORESCENCE DETECTION
    85.
    发明公开
    PULSED-MULTILINE EXCITATION FOR COLOR-BLIND FLUORESCENCE DETECTION 审中-公开
    脉冲多行THRILLS FOR THE色盲荧光检测器

    公开(公告)号:EP1432966A1

    公开(公告)日:2004-06-30

    申请号:EP02757433.4

    申请日:2002-08-28

    Abstract: The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity : (1) optimal excitation of all fluorophores in the genomic assay and (2) 'color-blind' detection, which collects considerably more light than standard wavelength resolved detection. This technology differs significantly from the current state-of-the-art DNA sequencing instrumentation, which features single source excitation and color dipersion for DNA sequence identification. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.

    Light emitting devices
    86.
    发明公开
    Light emitting devices 失效
    GerätefürLichtemission。

    公开(公告)号:EP0343782A2

    公开(公告)日:1989-11-29

    申请号:EP89303873.7

    申请日:1989-04-19

    CPC classification number: F21V15/04 G21H3/02 H01J65/08

    Abstract: A light emitting device in which annular self luminous light sources are supported intermediate the ends of a resilient rod. In an illustrated embodiment a plurality of the rods are located concentrically within a transparent tube between end caps which close the ends of the tube.

    Abstract translation: 一种发光装置,其中环形自发光光源被支撑在弹性杆的端部的中间。 在所示实施例中,多个杆同心地位于封闭管端部的端盖之间的透明管内。

    Structured light active localization microscopy

    公开(公告)号:US09921161B1

    公开(公告)日:2018-03-20

    申请号:US14991016

    申请日:2016-01-08

    Inventor: Daniel Feldkhun

    Abstract: Methods and systems are provided for estimating locations of sub-wavelength-sized emitters, which may be sparsely arrayed among inactive emitters, in one or more dimensions to synthesize a super-resolved image. The emitter emits light in response to structured illumination, which may be acousto-optically generated. The structured illumination is translated, and a detector, such as a camera pixel, senses the emitted linear or nonlinear response, producing a periodic signal. A processor computes a phase of the signal using phase shifting interferometry and uses it to estimate the emitter location with resolution finer than a quarter of the illumination wavelength. Modulation depth and/or amplitude of the signal may be used to estimate emitter size and/or evaluate location fidelity. Optical sectioning or extended depth of field may be provided by controlling spatial coherence of the illumination. Encoding and decoding emitter locations with non-periodic patterns is also described.

    Luminescent, ultraviolet protected automotive interior members
    88.
    发明授权
    Luminescent, ultraviolet protected automotive interior members 有权
    发光,紫外线防护汽车内部构件

    公开(公告)号:US09187034B2

    公开(公告)日:2015-11-17

    申请号:US13833396

    申请日:2013-03-15

    Abstract: A component of a motor vehicle comprising a photoluminescent interior member formed of a plastic composition, wherein the plastic composition comprises at least one polymer and a plurality of additives comprising at least one photoluminescent material and at least a first ultraviolet protector, wherein the at least one photoluminescent material absorbs electromagnetic radiation in a first ultraviolet range of an electromagnetic spectrum, and thereafter emits electromagnetic radiation in a visible radiation range of the electromagnetic spectrum, and wherein the first ultraviolet protector is an ultraviolet absorber, wherein the ultraviolet absorber absorbs electromagnetic radiation in a second ultraviolet range of the electromagnetic spectrum and does not absorb electromagnetic radiation in the first ultraviolet range of the electromagnetic spectrum.

    Abstract translation: 一种机动车辆的组件,包括由塑料组合物形成的光致发光内部构件,其中塑料组合物包含至少一种聚合物和多种添加剂,其包含至少一种光致发光材料和至少第一紫外线保护剂,其中至少一种 光致发光材料在电磁光谱的第一紫外线范围内吸收电磁辐射,然后在电磁光谱的可见光辐射范围内发射电磁辐射,其中第一紫外线保护器是紫外线吸收剂,其中紫外线吸收剂吸收电磁辐射 电磁波谱的第二紫外线范围,并且不吸收电磁波谱的第一紫外线范围内的电磁辐射。

    Method for the quantitative determination of the concentration of fluorophores of a substance in a sample and apparatus for carrying out the same
    90.
    发明授权
    Method for the quantitative determination of the concentration of fluorophores of a substance in a sample and apparatus for carrying out the same 有权
    用于定量测定样品中物质的荧光团的浓度的方法和用于进行该物质的装置的方法

    公开(公告)号:US08334522B2

    公开(公告)日:2012-12-18

    申请号:US12616811

    申请日:2009-11-12

    Applicant: Rafael Egger

    Inventor: Rafael Egger

    CPC classification number: G01N21/278 G01N21/6428

    Abstract: The invention concerns methods and apparatuses for quantitatively determining the concentration of fluorophores of a substance in a sample. A constant portion of the reference light of a reference light wave length (λr) emitted by a reference light source is coupled in by an optical element in the direction of a receiving element. A first value corresponding to the portion of the reference light coupled in which is incident on the receiving element is detected. The sample is irradiated with the excitation light of an excitation wave length (λex) emitted by an excitation light source. A second value corresponding to the portion of the fluorescent light of an emission wave length (λem) emitted by the sample which is incident on the receiving element. The ratio of the second value to the first value is determined. The number of fluorophores in the substance is determined based on the ratio.

    Abstract translation: 本发明涉及用于定量测定样品中物质的荧光团浓度的方法和装置。 由参考光源发射的参考光波长(λr)的参考光的恒定部分通过光学元件沿接收元件的方向耦合。 检测对应于其中入射在接收元件上的参考光的部分的第一值。 用激发光源发射的激发波长(λex)的激发光照射样品。 对应于由入射在接收元件上的样品发射的发射波长(λem)的荧光的部分的第二值。 确定第二值与第一值的比率。 该物质中荧光团的数量是根据比例来确定的。

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