Abstract:
PROBLEM TO BE SOLVED: To provide a medicine for treating an elevated intraocular pressure such as glaucoma.SOLUTION: The invention relates to a therapeutically effective amount of compound selected from the group consisting of: a protein of an antagonist of the frizzled related protein gene product, a peptide, peptidomimetic, and small molecule; and a gene of frizzled related protein gene, antisense, ribozyme, and triplex nucleic acids or the like, for increasing or decreasing a level or biological activity of a Wnt pathway component or a frizzled related protein gene product.
Abstract:
A system and a method for user selectable release modality for a surgical cassette are provided to prevent release of the cassette due to an accident, and to make the release speed balanced. A system for user selectable release modality for a surgical cassette includes the steps of: providing a user interface for enabling a user to select a cassette release mode for a surgical cassette from a cassette release mode set; and measuring whether the release request is performed. The step of releasing the surgical cassette from the surgical device according to the selected cassette release mode includes initiating and completing a cassette release process based on the measurement of whether the release request is performed. A cassette is placed on a cassette receiving vessel.
Abstract:
A fluidic cassette detection mechanism is provided to secure the proper measurement of fluid by accurately positioning a fluidic cassette in a fluidic module. A fluidic cassette detection mechanism includes a fluidic module, a fluidic cassette(12), a detector, and a fluidic module control system. The fluidic cassette is operated to be inserted into the fluidic module and located on the surface of the fluidic module adjacent to a cassette vessel(14). The detector detects the existence of the fluidic cassette. The fluidic module control system receives a cassette detection signal from the detector, and is operated to start a closing command when receiving the detection signal. The detector includes a plurality of mechanical probes, and a plurality of optical interrupt switches. The mechanical probes are extended to the faceplate of the fluidic module. The fluidic module displaces the mechanical probes when the fluidic cassette is inserted into the fluidic module.
Abstract:
PROBLEM TO BE SOLVED: To provide a foldable device material for ophthalmology and otolaryngology.SOLUTION: A soft acrylic material has an elongation of at least 150% and a high refractive index. The material is particularly useful as an intraocular lens material, including an aryl acrylic hydrophobic monomer as a single main device forming monomer material. In addition to the use as an intraocular lens material, the material is suitable for use as other ophthalmological devices or otolaryngological devices such as a contact lens, an artificial cornea, a cornea inlay or cornea ring; an otological ventilation tube, and a nose implant.
Abstract:
PROBLEM TO BE SOLVED: To provide a valve device comprising a valve structure in which a valve is normally closed.SOLUTION: The normally closed valve can comprise a circular valve seal face formed by the underside of a rim of an elastomeric valve boss and a circular valve seat, which is formed by the rim of a through-hole molded into, for example, a plastic cassette, such that the valve seal face, the valve seat, and the through-hole are concentric. The valve boss can be a hollow "mushroom" shaped valve boss, or a conical-shaped valve boss. If no force is applied to the inside surface of the valve boss, no fluid can pass through the valve as the valve seal face rests against the valve seat as a result of the steady free-state load created by the stretch of the valve boss over the slightly longer through-hole. When a force is applied to the inside surface of the valve boss, the valve seal face is displaced from the valve seat, allowing fluid between the valve seal face and valve seat to pass between the valve boss and the inside surface of the through-hole.
Abstract:
PROBLEM TO BE SOLVED: To provide an implantable compact drug delivery device which is simple, inexpensive, and easy to manufacture, and which can respond to implantation into the body of a human or animal for delivering a drug to a wide variety of locations.SOLUTION: An implantable compact drug delivery system 10 enables the transplantation of a machine into the body, thereby enabling the delivery of the drug to the wide variety of locations. The system 10 includes at least one basin 14, well and a hollow space. The basin 14, well, or the hollow space is enframed, sealed, encased, or formed in a core body 12. The basin 14, well or the hollow space within the core body or a basin encasement portion 12 is of sufficient size to contain the desired amount of a medicament needed for prolonged internal treatment of a chronic condition or disease.
Abstract:
PROBLEM TO BE SOLVED: To provide an interfering RNA that targets SAA mRNA, and thereby interferes with SAA mRNA expression.SOLUTION: There is provided RNA interference for inhibition of serum amyloid A mRNA expression in glaucoma involving SAA expression. There is provided a method for attenuating expression of the serum amyloid A mRNA in an eye of a subject including a step of administering to the eye of the subject a composition comprising an effective amount of the interfering RNA having a length of 19 to 49 nucleotides and a pharmaceutically acceptable carrier, the interfering RNA comprising a sense nucleotide sequence, an antisense nucleotide sequence, and a region of at least near-perfect contiguous complementary of at least 19 nucleotides between the sense and antisense sequences.
Abstract:
PROBLEM TO BE SOLVED: To provide an interfering RNA that silences expression of FRP-1 mRNA.SOLUTION: There is provided RNA interference for inhibition of Frizzled related protein-1 mRNA expression, in particular, for treating a patient having glaucoma or at risk of developing the glaucoma. The method includes treating a subject having the glaucoma or at the risk of developing the glaucoma by administering the interfering RNA that silences the expression of the FRP-1 mRNA; thus interfering with the Wnt signaling pathway; and preventing a cascade of events related to the glaucoma and pre-glaucoma cellular activity. The expression of the Frizzled related protein-1 mRNA is attenuated thereby.
Abstract:
PROBLEM TO BE SOLVED: To provide a reliable footswitch that functions to communicate with a surgical system while avoiding potential hazard or a restrictive environment created by entangled cables.SOLUTION: The surgical footswitch includes a base, a pedal, an encoder assembly, a wireless interface, and an internal power generator, and includes a first switch and a second switch. The wireless interface sends control signals from an encoder to a surgical controller and then instructs surgical equipment based on the control signal. This wireless interface eliminates the tangle of wires or tethers, which may be a hazard in a surgical theater. The internal power generator converts footswitch movement into stored energy, in order to eliminate potential failures of the footswitch during a surgery and to overcome the need to replace batteries of the footswitch.
Abstract:
PROBLEM TO BE SOLVED: To provide a reliable footswitch that avoids potential hazards or a regulated environment formed by a tangled cable and simultaneously functions to work on a surgical system.SOLUTION: The present invention provides a surgical footswitch that includes a base, a pedal, an encoder assembly, a wireless interface, and an internal power generator. The wireless interface passes a control signal from the encoder to the surgical console, which then directs the surgical apparatus based on the control signal. This wireless interface eliminates the tangle of wires or tethers, which may be a hazard in the surgical theater. The internal power generator translates footswitch movement into stored energy to eliminate potential failures of the footswitch during a procedure and overcome the need to replace batteries within the footswitch.