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公开(公告)号：JP2014142657A
公开(公告)日：2014-08-07
申请号：JP2014054023
申请日：2014-03-17
Inventor： PEYMAN NAJMABADI , GREGORY J CRANDALL , AARON ALAN STEARRETT , DIRK G SOENKSEN , LEE CHRISTOPHER ADAM , CYNTHIA PERZ
CPC classification number: G02B21/0084 , G01N21/64 , G01N21/6458 , G01N2021/6471 , G02B21/00 , G02B21/002 , G02B21/0076 , G02B21/16 , G06K9/00134 , G06T7/30 , G06T2207/10056 , G06T2207/10064 , G06T2207/30024 , H04N5/3692
Abstract: PROBLEM TO BE SOLVED: To provide a whole slide fluorescence digital pathology system using a monochrome TDI line scan camera.SOLUTION: The fluorescence digital pathology system is particularly useful in fluorescence scanning where a signal is typically much weaker than in brightfield microscopy. The system uses oblique brightfield illumination for fast and accurate tissue finding and employs a unique double sweep focus scoring and objective lens height averaging technique to identify focus points and create a focus map that can be followed during subsequent scanning, to provide autofocusing capability. The system also scans and analyzes image data to determine an optimal line rate for the TDI line scan camera to use during subsequent scanning of the digital slide image and it also creates a light profile to compensate for loss of illumination light due to roll off.
Abstract translation: 要解决的问题：提供使用单色TDI线扫描照相机的整个幻灯片荧光数字病理系统。解决方案：荧光数字病理系统在荧光扫描中特别有用，其中信号通常比明场显微镜弱得多。 该系统使用斜光场照明来快速准确的组织发现，并采用独特的双重扫描焦点评分和物镜高度平均技术来识别焦点，并创建可以在后续扫描中遵循的焦点图，以提供自动对焦功能。 该系统还扫描和分析图像数据，以确定在数字幻灯片图像的后续扫描期间TDI线扫描相机使用的最佳线速率，并且还产生光轮廓以补偿由于滚降而引起的照明光的损失。
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公开(公告)号：JP2014078247A
公开(公告)日：2014-05-01
申请号：JP2013241131
申请日：2013-11-21
Inventor： SOENKSEN DIRK G , KATHY ZIRKER-SMITH , OLE EICHHORN
CPC classification number: G06F19/3425 , G06F19/321 , G16H80/00
Abstract: PROBLEM TO BE SOLVED: To provide a system and method to facilitate consultations between a referral source (e.g., labs, pathologists and patients) and a consultant (e.g., pathologist, radiologist, or other digital image analyst).SOLUTION: Links between the various referral sources and consultants are established through a scanning center via a data communication network such as the Internet. The referral source sends a slide to the scanning center where the corresponding digital slide is posted for review and analysis by the consultant. Upon completion of the analysis and report, a digital slide conference is conducted through the scanning center that provides a venue for direct communication regarding the consultation. The scanning center may also facilitate payment from the referral source to the consultant.
Abstract translation: 要解决的问题：提供一种系统和方法，以便于转诊来源（例如实验室，病理学家和患者）与顾问（例如病理学家，放射科医师或其他数字图像分析师）之间的协商。解决方案：各种 通过扫描中心通过数据通信网络（如互联网）建立转介来源和顾问。 推荐来源将幻灯片发送到扫描中心，其中相应的数字幻灯片发布供顾问进行审查和分析。 完成分析报告后，通过扫描中心进行数字幻灯片会议，为会议提供直接沟通的场所。 扫描中心也可以方便从推荐来源向顾问付款。
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3.发明专利System and method for creating and visualizing three dimensional virtual slide 有权用于创建和可视化三维虚拟幻灯片的系统和方法
公开(公告)号：JP2013239185A
公开(公告)日：2013-11-28
申请号：JP2013128959
申请日：2013-06-19
Inventor： EICHHORN OLE , CRANDALL GREG J , HASHAGEN STEVEN , SOENKSEN DIRK G , WRENN MARK
CPC classification number: G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/0495
Abstract: PROBLEM TO BE SOLVED: To provide a systems and a method for creating and visualizing a three dimensional virtual slide.SOLUTION: One or more microscope slides are disposed in an image acquisition device that scans specimens on the slides and makes two dimensional images at medium resolution or high resolution. These two dimensional images are provided to an image visualizing workstation where these images are visualized by an operator. The operator pans and zooms the two dimensional image and selects an area of interest for scanning at a plurality of depth levels (Z-planes). The image acquisition device receives a set of parameters for scanning at the plurality of depth level scans including a location and depth. The image acquisition device then scans the specimen at a location in a series of Z-plane images where each Z-plane image corresponds to a depth level portion of the specimen within a depth parameter.
Abstract translation: 要解决的问题：提供用于创建和可视化三维虚拟幻灯片的系统和方法。解决方案：将一个或多个显微镜幻灯片放置在图像采集装置中，扫描幻灯片上的样本，并以中等分辨率制作二维图像 或高分辨率。 这些二维图像被提供给图像可视化工作站，其中这些图像由操作者可视化。 操作者对二维图像进行平移并放大并选择感兴趣的区域以在多个深度级（Z平面）上进行扫描。 图像采集装置接收用于在包括位置和深度的多个深度级扫描中进行扫描的一组参数。 然后，图像获取装置在一系列Z平面图像中的每个Z平面图像上的位置扫描样本，其中每个Z平面图像在深度参数内对应于样本的深度级部分。
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公开(公告)号：JP2011232762A
公开(公告)日：2011-11-17
申请号：JP2011109646
申请日：2011-05-16
Inventor： DIRK SOENKSEN
CPC classification number: G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
Abstract: PROBLEM TO BE SOLVED: To provide an apparatus for and a method of fully automatically and rapidly scanning and digitizing an entire microscope sample, using a computer controlled microscope slide scanner for composing image strips obtained by continuous scanning of the sample into a single continuous digital image.SOLUTION: An optical microscope system 10 includes a microscope slide scanner 11. All of the microscope slide scanners 11 have a primary connection to a network 42. A preferred sample 12 is a microscope slide. An illumination optics system 32 and an imaging optics system 34 are consistent with a transmission mode optics system optimized for a diffraction-limited digital image.
Abstract translation: 要解决的问题：为了提供一种完全自动且快速地扫描和数字化整个显微镜样品的装置和方法，使用计算机控制的显微镜幻灯片扫描器来组合通过将样品连续扫描获得的图像条形成单个 连续数字图像。 解决方案：光学显微镜系统10包括显微镜幻灯片扫描器11.所有显微镜幻灯片扫描仪11都具有与网络42的主要连接。优选的样品12是显微镜载玻片。 照明光学系统32和成像光学系统34与针对衍射受限数字图像优化的透射模式光学系统一致。 版权所有（C）2012，JPO＆INPIT
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5.发明专利Data management system and method in microscope slide scanner using linear array 有权使用线性阵列的微型幻灯片扫描仪中的数据管理系统和方法
公开(公告)号：JP2011108250A
公开(公告)日：2011-06-02
申请号：JP2010279678
申请日：2010-12-15
Inventor： CRANDALL GREG J , EICHHORN OLE , OLSON ALLEN H , SOENKSEN DIRK G
Abstract: PROBLEM TO BE SOLVED: To provide a data management tool suitable to manage a small number of relatively large (to 200MB) image stripes that are captured by a line scan image striping system. SOLUTION: Large capacity image data is generated by a microscope slide scanner of linear array type and is generated with about 3GB every minute. Data of a series of image stripes which are roughly adjusted and overlapped slightly at a time is received, and the heterogeneity and chromatic aberration of images are corrected to obtain a reference image that is seamless and has no break by arranging the images with precision. The reference image is logically mapped into a plurality of areas with an address attached separately so that the reference image is easily appreciated and operated. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 要解决的问题：提供适合于管理由行扫描图像条带化系统捕获的少量相对大（200MB）的图像条纹的数据管理工具。
解决方案：大容量图像数据由线性阵列型显微镜幻灯片扫描仪生成，每分钟生成约3GB。 接收一次粗略地调整和重叠地重叠的一系列图像条纹的数据，校正图像的异质性和色像差，以通过精确地排列图像来获得无缝的参考图像，并且不会发生断裂。 参考图像被逻辑地映射到具有单独地址的多个区域，使得参考图像容易被识别和操作。 版权所有（C）2011，JPO＆INPIT
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Patent Agency Ranking
公开(公告)号：JP5643210B2
公开(公告)日：2014-12-17
申请号：JP2011533391
申请日：2009-10-23
Applicant: アペリオ・テクノロジーズ・インコーポレイテッドAperio Technologies, Inc. , アペリオ・テクノロジーズ・インコーポレイテッドAperio Technologies, Inc.
Inventor： ペイマン ナマバディ , ペイマン ナマバディ , グレゴリー ジェイ． クランドール , グレゴリー ジェイ． クランドール , アーロン アラン スターレット , アーロン アラン スターレット , ディルク ジー． ションクセン , ディルク ジー． ションクセン , クリストファ アダム リー , クリストファ アダム リー , シンシア パーズ , シンシア パーズ
CPC classification number: G02B21/0084 , G01N21/64 , G01N21/6458 , G01N2021/6471 , G02B21/00 , G02B21/002 , G02B21/0076 , G02B21/16 , G06K9/00134 , G06T7/30 , G06T2207/10056 , G06T2207/10064 , G06T2207/30024 , H04N5/3692
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公开(公告)号：JP2012084158A
公开(公告)日：2012-04-26
申请号：JP2011243159
申请日：2011-11-07
Inventor： EICHHORN OLE
CPC classification number: G06T15/00 , G02B21/34 , G02B21/367 , G06T5/50 , G06T15/08 , G06T15/10 , G06T2207/20212 , G06T2207/20224 , G06T2207/30024 , G06T2207/30056
Abstract: PROBLEM TO BE SOLVED: To provide a system and a method for retrieving, operating, and browsing an object of 3D imaging among 3D virtual microscope slide images.SOLUTION: An image library module provides access to image data on a 3D virtual slide and generates the object of 3D imaging which spreads out in the same space at the 3D virtual slide or its 3D sub part. From the object of 3D imaging, a cross layer plane representation which covers various depths of the 3D virtual slide is generated similarly to a 3D prism and other formed image areas. The image library module can slice the object of 3D imaging into horizontal and vertical representations, and a cross layer representation and 3D image areas in a standard and an irregular shape can be distorted for a presentation by a user.
Abstract translation: 要解决的问题：提供一种用于在3D虚拟显微镜幻灯片图像之间检索，操作和浏览3D成像的对象的系统和方法。 解决方案：图像库模块提供对3D虚拟幻灯片上的图像数据的访问，并生成在3D虚拟幻灯片或其3D子部分的相同空间中展开的3D成像对象。 从3D成像的目的来看，覆盖3D虚拟幻灯片的各种深度的交叉层平面表示类似于3D棱镜和其它形成的图像区域而产生。 图像库模块可以将3D成像的对象分割成水平和垂直表示，并且标准和不规则形状的交叉层表示和3D图像区域可能被扭曲以供用户呈现。 版权所有（C）2012，JPO＆INPIT
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公开(公告)号：JP2012093764A
公开(公告)日：2012-05-17
申请号：JP2011246947
申请日：2011-11-10
Inventor： OLSON ALLEN , SALIGRAMA KIRAN , SOENKSEN DIRK G
CPC classification number: G06T7/0012 , G02B21/365 , G06K9/00127 , G06K9/036 , G06T2207/10016 , G06T2207/10056 , G06T2207/30024
Abstract: PROBLEM TO BE SOLVED: To provide systems and methods for assessing virtual microscope slide image quality.SOLUTION: In order to determine whether a virtual slide image has any out of focus areas and is therefore a candidate for manual inspection, the various focus points used to scan the virtual slide image are used to calculate a best fit surface for the virtual slide image. The distance of each focus point from the best fit surface is then calculated and the largest distance is compared to a predetermined value. If the largest distance from a focus point to the best fit surface is larger than the predetermined value, then the virtual slide image is designated as needing a manual inspection and possible re-scan.
Abstract translation: 要解决的问题：提供评估虚拟显微镜幻灯片图像质量的系统和方法。
解决方案：为了确定虚拟幻灯片图像是否具有任何失焦区域，因此是手动检查的候选者，用于扫描虚拟幻灯片图像的各种对焦点用于计算最佳拟合曲面 虚拟幻灯片图像。 然后计算每个对焦点与最佳拟合表面的距离，并将最大距离与预定值进行比较。 如果从焦点到最佳配合曲面的最大距离大于预定值，则虚拟幻灯片图像被指定为需要手动检查和可能的重新扫描。 版权所有（C）2012，JPO＆INPIT
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公开(公告)号：JP2012059290A
公开(公告)日：2012-03-22
申请号：JP2011268426
申请日：2011-12-07
Inventor： EICHHORN OLE , BRUMME ANNE
CPC classification number: H04L65/403 , G02B21/26 , G02B21/32 , G06F3/1454 , G06F17/241 , G06F17/30905 , G06F19/321 , G06Q50/24
Abstract: PROBLEM TO BE SOLVED: To provide a virtual slide browsing system and a browsing method.SOLUTION: For a storage image containing image data of a plurality of resolutions and annotation data associated with a specific location in relation to a base resolution of an image, a request for a specific region of the storage image and a specific resolution of a request image is confirmed in an image server 30 which receives an image request from a client viewer 70. It is determined that a region requested with the base resolution of the storage image is associated with the annotation data, a coordinate associated with the base resolution of the storage image for the associated annotation data is determined, and the associated annotation data are scaled (enlarged/reduced) from the base resolution to a requested resolution associated with the coordinate in accordance with the coordinate. In providing request image data and associated annotation data scaled for display of the client viewer, the annotation data are indicated on a display as an overlay of request image data on that coordinate.
Abstract translation: 要解决的问题：提供虚拟幻灯片浏览系统和浏览方法。 解决方案：对于包含与图像的基本分辨率相关的多个分辨率和与特定位置相关联的注释数据的图像数据的存储图像，对存储图像的特定区域的请求和特定分辨率 在从客户机查看器70接收图像请求的图像服务器30中确认请求图像。确定以存储图像的基本分辨率请求的区域与注释数据相关联，与基本分辨率相关联的坐标 确定相关联的注释数据的存储图像，并且将相关联的注释数据从基本分辨率缩放（放大/缩小）到根据该坐标与坐标相关联的所请求的分辨率。 在提供请求图像数据和缩放以显示客户端查看器的关联注释数据时，注释数据在显示器上被指示为在该坐标上的请求图像数据的叠加。 版权所有（C）2012，JPO＆INPIT
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10.发明专利
公开(公告)号：JP2011204243A
公开(公告)日：2011-10-13
申请号：JP2011092600
申请日：2011-04-19
Inventor： EICHHORN OLE , CRANDALL GREG J , HASHAGEN STEVEN , SOENKSEN DIRK G , WRENN MARK
CPC classification number: G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/0495
Abstract: PROBLEM TO BE SOLVED: To provide a systems and a method for creating and viewing a three dimensional digital slide.SOLUTION: One or more microscope slides are positioned in an image acquisition device that scans specimens on the slides and makes two dimensional images at a medium or high resolution. These two dimensional digital slide images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at a plurality of depth levels (Z-planes). The image acquisition device receives a set of parameters for a plurality of depth level scans including a location and a depth. The image acquisition device then scans the specimen at a location in a series of Z-plane images where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
Abstract translation: 要解决的问题：提供用于创建和观看三维数字幻灯片的系统和方法。解决方案：将一个或多个显微镜幻灯片放置在图像采集装置中，其对载玻片上的样本进行扫描，并将二维图像置于中等 或高分辨率。 这些二维数字幻灯片图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像并且选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。 图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。 然后，图像采集装置在一系列Z平面图像中的每个Z平面图像的位置扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。
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