中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

57 records (took 0.032 seconds)

    Contrast agent for diagnostic imaging with prolonged blood retention
    1.
    发明专利
    Contrast agent for diagnostic imaging with prolonged blood retention 有权
    对比剂用于诊断成像具有延长的血液保留

    公开(公告)号：JP2008189683A

    公开(公告)日：2008-08-21

    申请号：JP2008095587

    申请日：2008-04-01

    Applicant: Epix Pharmaceuticals Inc ,  エピックス ファーマシューティカルズ,インコーポレイテッド

    Inventor： MCMURRY THOMAS J ,  SAJIKI HIRONAO ,  SCOTT DANIEL M ,  LAUFFER RANDALL B

    IPC: A61K49/00 ,  A61B5/055 ,  A61B6/00 ,  A61B8/00 ,  A61K49/04 ,  A61K49/08 ,  A61K49/18 ,  A61K51/00 ,  C07F9/09 ,  G01R33/28

    CPC classification number: A61K49/085 ,  A61B6/507 ,  A61K49/0002 ,  A61K49/10 ,  A61K49/103 ,  A61K49/106 ,  C07F9/091

    Abstract: PROBLEM TO BE SOLVED: To provide a contrast agent for diagnostic imaging which exhibits improved blood retention. SOLUTION: The contrast agent for diagnostic imaging comprises (a) an image enhancing moiety (IEM), (b) a plasma protein binding moiety (PPBM), and (c) a blood half-life extending moiety (BHEM) and demonstrates at least about 10% binding to plasma protein and demonstrates, in a rat plasma pharmacokinetic experiment, an area under the plasma concentration versus time curve from 0 to 10 minutes which is at least about 20% greater than that observed for the combination of the IEM and PPBM alone without the BHEM. This agent may be targeted to the blood pool or any other biological component. Since this agent is lost less rapidly from the bloodstream, lower doses can be used at a higher margin of safety. COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题：提供显示出改善的血液保持性的用于诊断成像的造影剂。 解决方案：用于诊断成像的造影剂包括（a）图像增强部分（IEM），（b）血浆蛋白结合部分（PPBM）和（c）血液半衰期延长部分（BHEM）和 证明至少约10％与血浆蛋白的结合，并且在大鼠血浆药代动力学实验中证明在0至10分钟的血浆浓度对时间曲线下的面积比对于组合的观察到的至少大约20％ IEM和PPBM单独没有BHEM。 该试剂可能靶向血液池或任何其他生物成分。 由于该药剂从血液中的损失不那么快，因此可以以更高的安全边际使用较低的剂量。 版权所有（C）2008，JPO＆INPIT

    Peptide aggregate
    2.
    发明专利
    Peptide aggregate 审中-公开
    肽聚集

    公开(公告)号：JP2007008954A

    公开(公告)日：2007-01-18

    申请号：JP2006210376

    申请日：2006-08-01

    Applicant: Epix Pharmaceuticals Inc ,  エピックス ファーマシューティカルズ, インコーポレイテッド

    Inventor： ELLISON JEFFREY J

    IPC: A61K49/00 ,  C07K7/06 ,  A61B5/055 ,  A61K49/14 ,  C07F5/00 ,  C07K7/04 ,  C07K7/08 ,  G01R33/28

    CPC classification number: C07K7/06 ,  A61K49/14 ,  C07K7/08 ,  G01R33/281

    Abstract: PROBLEM TO BE SOLVED: To provide a peptide aggregate which, when compared with a single monomeric assembling peptide which makes an aggregate by assembling, can have a plurality of paramagnetic metal cores, exhibits an increased size, an increased solubility, and a higher MR relaxivity, and is capable of being quickly eliminated from the patient to be examined because of its in vivo enzymatic degradability of the peptide portion of the molecule.
    SOLUTION: The peptide aggregate is a peptide aggregate containing two or more assembling peptides, wherein at least one of the assembling peptides contains a metal-binding moiety.
    COPYRIGHT: (C)2007,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种肽聚集体，当与通过组装制备聚集体的单个单体组装肽相比时，可以具有多个顺磁金属芯，表现出增加的尺寸，增加的溶解度和 更高的MR弛豫性，并且由于其分子的肽部分的体内酶促降解性，能够快速地从患者中消除待检查。 肽聚集体是含有两个或更多个组装肽的肽聚集体，其中至少一个组装肽含有金属结合部分。 版权所有（C）2007，JPO＆INPIT

    System and method for targeting magnetic resonance imaging of vascular system
    4.
    发明专利
    System and method for targeting magnetic resonance imaging of vascular system 审中-公开
    用于瞄准血管系统磁共振成像的系统和方法

    公开(公告)号：JP2006006962A

    公开(公告)日：2006-01-12

    申请号：JP2005218095

    申请日：2005-07-27

    Applicant: Epix Pharmaceuticals Inc ,  エピックス ファーマシューティカルズ,インコーポレイテッド

    Inventor： WEISSKOFF ROBERT M ,  CARAVAN PETER D ,  WITTE SONIA ,  LAUFFER RANDALL B ,  CARPENTER ALAN P JR

    IPC: A61B5/055 ,  G01R33/28 ,  A61K49/00

    CPC classification number: A61B5/416 ,  A61B5/055

    Abstract: PROBLEM TO BE SOLVED: To provide a system and a method for a targeting magnetic resonance imaging of vascular system which are cost-effective and safe and identify the presence, position, and size of a CVD (celebrovascular disease) target in a vascular system correctly by using a simple method. SOLUTION: A method to decide presence or absence of a static target in the vascular system of a mammal comprises (a) a process to administer a targeting MRI (magnetic resonance imaging) contrast agent to this mammal, (b) a process to acquire a first MRI data set including an image of this vascular system, and (c) a process to acquire a second MRI data set. This targeting MRI contrast agent has a specific affinity for this static target, and furthermore, this targeting MRI contrast agent can provide contrast enhancement of the vascular system of this static target and this mammal. This second MRI data set comprises a process to be acquired in suitable hours in order to provide contrast enhancement of this static target at an observable level for the reinforcement of blood and tissue of a background when this static target is present. COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 要解决的问题：提供一种用于血管系统的靶向磁共振成像的系统和方法，所述系统和方法是成本有效和安全的，并且识别CVD（血管性脑血管疾病）靶的存在，位置和大小 血管系统正确使用简单的方法。 决定哺乳动物血管系统中静止靶的存在或不存在的方法包括（a）向该哺乳动物施用靶向MRI（磁共振成像）造影剂的方法，（b） 以获取包括该血管系统的图像的第一MRI数据集，以及（c）获取第二MRI数据集的处理。 该靶向MRI造影剂对该静态靶具有特异性亲和性，此外，该靶向MRI造影剂可以提供该静态靶和该哺乳动物的血管系统的对比度增强。 该第二MRI数据集包括在合适的时间内获取的过程，以便当存在该静态目标时，以可观察的水平提供该静态目标的对比度增强以加强背景的血液和组织。 版权所有（C）2006，JPO＆NCIPI

    Contrast-enhanced diagnostic imaging method for monitoring interventional therapy
    5.
    发明专利
    Contrast-enhanced diagnostic imaging method for monitoring interventional therapy 审中-公开
    用于监测传统治疗的对比增强诊断成像方法

    公开(公告)号：JP2006077020A

    公开(公告)日：2006-03-23

    申请号：JP2005276942

    申请日：2005-09-22

    Applicant: Epix Pharmaceuticals Inc ,  エピックス ファーマシューティカルズ,インコーポレイテッド

    Inventor： LAUFFER RANDALL B ,  DUNHAM STEPHEN O

    IPC: A61K49/00 ,  G01R33/48 ,  A61B5/055 ,  A61K49/06 ,  A61K49/08 ,  G01N21/27 ,  G01R33/28

    CPC classification number: A61K49/10 ,  A61K49/0052 ,  A61K49/085 ,  A61K49/103 ,  A61K49/106

    Abstract: PROBLEM TO BE SOLVED: To provide a diagnostic imaging method for noninvasively and correctly monitoring the state of a specific tissue or tissue component. SOLUTION: The method for contrast-enhanced diagnostic imaging of the specific tissue or tissue component being subjected or having been subjected to an interventional therapy comprises (a) a step for prescribing for a patient a contrast agent capable of binding to a targeted tissue or tissue component and exhibiting a special affinity to the tissue or tissue component, the contrast agent comprising an image-enhancing moiety (IEM) and a state-depending tissue binding moiety (SDTBM); (b) a step for subjecting the patient to one of MRI imaging, ultraviolet imaging, visible light imaging and infrared imaging; and (c) a step for monitoring the characteristic imaged signal of the contrast agent to decide whether the interventional therapy is completed or not. COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 要解决的问题：提供用于非侵入性地正确监测特定组织或组织成分的状态的诊断成像方法。 解决方案：用于进行或已进行介入治疗的特定组织或组织成分的对比度增强诊断成像的方法包括（a）向患者开出能够结合靶向的造影剂的步骤 组织或组织成分并且对组织或组织组分表现出特殊的亲和力，造影剂包含图像增强部分（IEM）和状态依赖性组织结合部分（SDTBM）; （b）使患者进行MRI成像，紫外线成像，可见光成像和红外成像之一的步骤; 和（c）用于监测造影剂的特征成像信号以决定介入治疗是否完成的步骤。 版权所有（C）2006，JPO＆NCIPI

    System and method for targeting magnetic resonance imaging of vascular system
    6.
    发明专利
    System and method for targeting magnetic resonance imaging of vascular system 审中-公开
    用于瞄准血管系统磁共振成像的系统和方法

    公开(公告)号：JP2008220966A

    公开(公告)日：2008-09-25

    申请号：JP2008076834

    申请日：2008-03-24

    Applicant: Epix Pharmaceuticals Inc ,  エピックス ファーマシューティカルズ,インコーポレイテッド

    Inventor： WEISSKOFF ROBERT M ,  CARAVAN PETER D ,  WITTE SONIA ,  LAUFFER RANDALL B ,  CARPENTER ALAN P JR

    IPC: A61B5/055 ,  G01R33/28 ,  A61K49/00

    CPC classification number: A61B5/416 ,  A61B5/055

    Abstract: PROBLEM TO BE SOLVED: To provide a safety and simle method for a targeting magnetic resonance imaging of vascular system which is sufficient in cost-effective and identifies the presence, position and size of a CVD (celebrovascular disease) target in a vascular system correctly by using a simple method. SOLUTION: The method to determine presence or absence of a static target in a vascular system of a mammal comprises: (a) a process to administer a targeting MRI contrast agent to the mammal; (b) a process to acquire a first MRI data set including an image of the vascular system; and (c) a process to acquire a second MRI data set. The second MRI data set includes a process to acquire the second MRI data set in suitable hours for providing contrast enhancement of the static target at an observable level for the reinforcement of blood and tissue of a background when the static target is present. COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题：为了提供血管系统的靶向磁共振成像的安全性和简单方法，其在成本有效的情况下是足够的，并且识别血管中CVD（血管性血管疾病）靶的存在，位置和大小 系统正确使用简单的方法。 确定哺乳动物血管系统中静止靶的存在或不存在的方法包括：（a）向哺乳动物施用靶向MRI造影剂的方法; （b）获取包括血管系统的图像的第一MRI数据集的过程; 和（c）获取第二MRI数据集的过程。 第二MRI数据集包括在适当的小时内获取第二MRI数据集的过程，以在静态目标存在时增强静态目标的血液和组织的可观察水平的静态目标的对比度增强。 版权所有（C）2008，JPO＆INPIT

Patent Agency Ranking