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    Induction of rev and tat specific cytotoxic t-cells for prevention and treatment of human immunodeficiency virus (hiv) infection
    6.
    发明专利
    Induction of rev and tat specific cytotoxic t-cells for prevention and treatment of human immunodeficiency virus (hiv) infection 审中-公开
    诱导用于预防和治疗人类免疫缺陷病毒（HIV）感染的特异性细胞因子T细胞

    公开(公告)号：JP2006265255A

    公开(公告)日：2006-10-05

    申请号：JP2006093367

    申请日：2006-03-30

    Applicant: Erasmus Univ Rotterdam ,  エラスムス ユニヴァーシテイト ロッテルダムErasmus Universiteit Rotterdam

    Inventor： BAALEN CAREL A VAN ,  OSTERHAUS ALBERTUS D M E

    IPC: A61K39/21 ,  G01N33/569 ,  A61K35/76 ,  A61K39/00 ,  A61K48/00 ,  A61P31/18 ,  C07K14/16 ,  C12N15/09 ,  C12Q1/02

    CPC classification number: C07K14/005 ,  A61K39/00 ,  C12N2740/16322

    Abstract: PROBLEM TO BE SOLVED: To provide a method and composition (including immunologic composition such as vaccine) targeting prevention and treatment of AIDS.
    SOLUTION: The presence of cytotoxic T-cells to the Rev and/or Tat protein in samples from a subject infected with immunodeficiency virus, particularly HIV in humans, is an indication of a stable disease condition and a favorable prognosis of lack of progression of disease. Immunogenic compositions containing at least one cytotoxic T-cell epitope of the Rev and/or Tat protein of an immunodeficiency virus, particularly HIV, or a vector encoding the T-cell epitope, may be used to prevent infection by disease caused by the immunodeficiency virus, by inducing, in the host, a specific cytotoxic T-cell response specific for the respective Rev and/or Tat proteins.
    COPYRIGHT: (C)2007,JPO&INPIT

    Abstract translation: 要解决的问题：提供靶向预防和治疗艾滋病的方法和组合物（包括免疫组合物如疫苗）。 解决方案：感染免疫缺陷病毒，特别是人类艾滋病毒的受试者的样品中，对Rev和/或Tat蛋白的细胞毒性T细胞的存在是指示稳定的疾病状况和缺乏的有利的预后 疾病进展 包含免疫缺陷病毒，特别是HIV的Rev和/或Tat蛋白的至少一种细胞毒性T细胞表位或编码T细胞表位的载体的免疫原性组合物可用于预防由免疫缺陷病毒引起的疾病的感染 通过在宿主中诱导针对相应的Rev和/或Tat蛋白特异性的特异性细胞毒性T细胞应答。 版权所有（C）2007，JPO＆INPIT

    Molecular detection of chromosome aberrations
    7.
    发明专利
    Molecular detection of chromosome aberrations 审中-公开
    分子检测染色体异常

    公开(公告)号：JP2009148291A

    公开(公告)日：2009-07-09

    申请号：JP2009048603

    申请日：2009-03-02

    Applicant: Erasmus Univ Rotterdam ,  エラスムス ユニフェルシテイト ロッテルダムErasmus Universiteit Rotterdam

    Inventor： VAN DONGEN JACOBUS JOHANNES MA ,  LANGERAK ANTHONIE WILLEM

    IPC: C12N15/09 ,  C12Q1/68 ,  C12Q1/02

    CPC classification number: C12Q1/6876 ,  C12Q1/6841 ,  C12Q1/6886 ,  C12Q2600/156

    Abstract: PROBLEM TO BE SOLVED: To provide nucleic-acid probes that can be used in hybridization techniques for the detection of chromosomal aberrations and other gene rearrangements, for example, such as immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangements.
    SOLUTION: A pair of nucleic-acid probes detects at least one chromosomal aberration in interphase nuclei by in-situ hybridization. Each of the nucleic-acid probes hybridizes to a sequence such that the pair of nucleic-acid probes would flank a potential breakpoint in a chromosome upon hybridization to the chromosome and the pair of nucleic-acid probes would not overlap with a breakpoint cluster region in the chromosome. The pair of nucleic-acid probes is configured such that each of the nucleic-acid probes hybridizes at a genomic distance of ≤100 kb between the nucleic-acid probes resulting in colocalization of the reporter molecule signals if no chromosome aberration is present.
    COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 要解决的问题：提供可用于检测染色体畸变和其他基因重排的杂交技术中的核酸探针，例如免疫球蛋白（Ig）和T细胞受体（TCR）基因重排 。 解决方案：一对核酸探针通过原位杂交检测间期核中的至少一种染色体畸变。 每个核酸探针与序列杂交，使得一对核酸探针在与染色体杂交后将位于染色体中的潜在断点，并且该对核酸探针不会与断点簇区域重叠 染色体。 这对核酸探针被配置成使得每个核酸探针在核酸探针之间的基因组距离≤100kb处杂交，导致报告分子信号的共定位，如果不存在染色体畸变。 版权所有（C）2009，JPO＆INPIT

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