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    PROTEIN INTERACTION METHOD AND COMPOSITION
    6.
    发明申请
    PROTEIN INTERACTION METHOD AND COMPOSITION 审中-公开
    蛋白质相互作用方法与组合

    公开(公告)号：WO03091273A2

    公开(公告)日：2003-11-06

    申请号：PCT/CA0300602

    申请日：2003-04-24

    Applicant: HELIX BIOPHARMA CORP ,  CHAO HEMAN ,  WONG WAH ,  TIAN BAOMIN ,  SEGAL DONALD ,  MCELROY JERRY

    Inventor： CHAO HEMAN ,  WONG WAH ,  TIAN BAOMIN ,  SEGAL DONALD ,  MCELROY JERRY

    IPC: G01N27/62 ,  C12M1/00 ,  C12N15/09 ,  C12P21/02 ,  C40B30/04 ,  C40B40/10 ,  G01N33/15 ,  G01N33/483 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/566 ,  G01N33/68 ,  G01N37/00 ,  C07K

    CPC classification number: C40B30/04 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00725 ,  C40B40/10 ,  G01N33/543 ,  G01N33/54333 ,  G01N33/54366 ,  G01N33/68

    Abstract: A protein interaction method and composition are described. The method and composition are useful for a number of purposes including: reconstituting multisubunit protein complexes, identifying known binding subunits, detrmining the kinetics and order of self assembly of a multsubunit protein complex, and drug screening. The method involves contacting a conjugate with a solid surface having an immobilized first coil-forming peptide characterized by a selected charge and an ability to interact with a second, oppositely carged coil-forming peptide to form a stable alpha-helical coiled-coil heterodimer, where the conjugate comprises (a) the second, oppositely charged coil-forming peptide, and (b) a first subunit polypeptide which is one of a plurality of subunit polypeptides in a multisubunit complex. By said contacting the conjugate is bound to the solid surface. Other subunit of the complex are added under conditions effective to promote self-assembly of the subunit complex or the solid surface.

    Abstract translation: 描述了蛋白质相互作用方法和组合物。 该方法和组合物可用于许多目的，包括：重构多亚基蛋白复合物，鉴定已知的结合亚单位，限制多亚基蛋白复合物的自组装的动力学和顺序以及药物筛选。 该方法包括使缀合物与具有固定的第一螺旋形成肽的固体表面接触，其特征在于所选择的电荷和与第二相对成熟的缠绕螺旋形成肽相互作用的能力以形成稳定的α-螺旋螺旋线圈异二聚体， 其中缀合物包含（a）第二个带相反电荷的卷曲形成肽，和（b）第一亚基多肽，其是多亚基复合物中的多个亚基多肽之一。 通过所述接触，缀合物与固体表面结合。 在有效促进亚单位复合体或固体表面的自组装的条件下加入复合物的其它亚基。

    PROTEIN INTERACTION SYSTEM FOR MULTISUBUNIT COMPLEXES
    7.
    发明申请
    PROTEIN INTERACTION SYSTEM FOR MULTISUBUNIT COMPLEXES 审中-公开

    公开(公告)号：WO2003091273A3

    公开(公告)日：2003-11-06

    申请号：PCT/CA2003/000602

    申请日：2003-04-24

    Applicant: HELIX BIOPHARMA CORP. ,  CHAO, Heman ,  WONG, Wah ,  TIAN, Baomin ,  SEGAL, Donald ,  McELROY, Jerry

    Inventor： CHAO, Heman ,  WONG, Wah ,  TIAN, Baomin ,  SEGAL, Donald ,  McELROY, Jerry

    IPC: C12N15/10

    Abstract: A protein interaction method and composition are described. The method and composition are useful for a number of purposes including: reconstituting multisubunit protein complexes, identifying known binding subunits, detrmining the kinetics and order of self assembly of a multsubunit protein complex, and drug screening. The method involves contacting a conjugate with a solid surface having an immobilized first coil-forming peptide characterized by a selected charge and an ability to interact with a second, oppositely carged coil-forming peptide to form a stable α-helical coiled-coil heterodimer, where the conjugate comprises (a) the second, oppositely charged coil-forming peptide, and (b) a first subunit polypeptide which is one of a plurality of subunit polypeptides in a multisubunit complex. By said contacting the conjugate is bound to the solid surface. Other subunit of the complex are added under conditions effective to promote self-assembly of the subunit complex or the solid surface.

    USE OF UREASE FOR INHIBITING CANCER CELL GROWTH
    10.
    发明申请
    USE OF UREASE FOR INHIBITING CANCER CELL GROWTH 审中-公开
    使用UREASE抑制癌细胞生长

    公开(公告)号：WO2004009112A1

    公开(公告)日：2004-01-29

    申请号：PCT/CA2003/001061

    申请日：2003-07-16

    Applicant: HELIX BIOPHARMA CORP.

    Inventor： CHAO, Herman ,  WONG, Wah ,  SEGAL, Donald ,  McELROY, Jerry ,  DOCHERTY, John ,  DICKSTEIN, Jodi

    IPC: A61K38/50

    CPC classification number: B82Y5/00 ,  A61K38/50 ,  A61K47/60 ,  A61K47/66 ,  A61K47/6851 ,  A61K47/6891 ,  A61K47/6911 ,  A61K48/00 ,  Y02A50/395

    Abstract: A pharmaceutical composition and method for use in inhibiting growth of cancer cells in a mammalian subject are disclosed. The composition includes a urease enzyme, and associated therewith, a chemical entity effective to enhance the delivery of the enzyme to cancer cells, when the composition is administered to the subject. Also disclosed are a method of enhancing the effectiveness of weakly basic anti-tumor compounds, a method assessing the presence, size or condition a solid tumor in a subject, and a gene therapy composition for treating a cancer in a subject.

    Abstract translation: 公开了用于抑制哺乳动物受试者中癌细胞生长的药物组合物和方法。 组合物包含脲酶，并且与其相关联，当向受试者施用组合物时，有效地增强酶向癌细胞递送的化学实体。 还公开了提高弱碱性抗肿瘤化合物的有效性的方法，评估受试者中实体瘤的存在，大小或状况的方法，以及用于治疗受试者的癌症的基因治疗组合物。

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