公开(公告)号：WO2002072822A2

公开(公告)日：2002-09-19

申请号：PCT/CA2002/000147

申请日：2002-02-12

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA ,  JAPAN SCIENCE AND TECHNOLOGY CORPORATION ,  HADANO, Shinji ,  IKEDA, Joh-E ,  HAYDEN, Michael, R.

Inventor： HADANO, Shinji ,  IKEDA, Joh-E ,  HAYDEN, Michael, R.

IPC: C12N15/12

CPC classification number: C12Q1/6883 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4702 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6896 ,  G01N2800/28

Abstract: A human gene associated with amyotrophic lateral sclerosis type 2(ALS2) is provided. The gene is present in the second chromosome q33 region. Also provided are mutant versions of the gene as well as isolated nucleic acids derived from the gene and peptides encoded thereby. Methods for the diagnosis of ALS2 are alos provided.

Abstract translation: 候选基因导致肌萎缩性侧索硬化症2型（ALS2），编码推定的GTP交换因子（GEF）或GTPase调节因子。

公开(公告)号：WO2002038762A1

公开(公告)日：2002-05-16

申请号：PCT/JP2001002764

申请日：2001-03-30

Applicant: JAPAN SCIENCE AND TECHNOLOGY CORPORATION ,  ASASHIMA, Makoto ,  ONUMA, Yasuko

Inventor： JAPAN SCIENCE AND TECHNOLOGY CORPORATION

IPC: C12N15/12

CPC classification number: C12N9/14

Abstract: A method of acquiring a gene specifically expressed in the head or nerve at the early development stage; and the gene specific to the nerve formation of a vertebrate which is obtained by this method. A cDNA library prepared from cells capable of inducing the head structure, which are obtained by treating a non-prospective germ layer piece of a Xenopus-origin blastula with 100 ng/ml of activin for 1 hour and then pre-incubating for 7 to 10 hours, is hybridized with [32P]-labeled cDNA which is prepared in the same manner from a gastrula at the stage before the formation of the nerve induction (stage 10). Unhybridized clones (negative clones) are selected and cDNAs of the obtained clones are subjected to the homology examination. By eliminating known genes, a gene specific to the nerve formation of a vertebrate, which is expressed in the head structure at the early development stage, can be obtained.

Abstract translation: 在早期发育阶段获得在头部或神经中特异性表达的基因的方法; 以及通过该方法获得的脊椎动物神经形成特异性的基因。 从能够诱导头部结构的细胞制备的cDNA文库，其通过用100ng / ml的活化素处理非洲爪蟾原始囊胚的非前瞻性胚层，1小时，然后预孵育7至10 小时，与[32 P]标记的cDNA杂交，其在神经诱导形成前阶段以相同的方式从胃肠中制备（阶段10）。 选择未杂交的克隆（阴性克隆），并对获得的克隆的cDNA进行同源性检验。 通过消除已知的基因，可以获得在早期发育阶段在头部结构中表达的对脊椎动物的神经形成特异性的基因。

公开(公告)号：WO2001057852A1

公开(公告)日：2001-08-09

申请号：PCT/JP2001000647

申请日：2001-01-31

Applicant: JAPAN SCIENCE AND TECHNOLOGY CORPORATION ,  NAKADAI, Kazuhiro ,  OKUNO, Hiroshi ,  KITANO, Hiroaki ,  MATSUI, Tatsuya

Inventor： JAPAN SCIENCE AND TECHNOLOGY CORPORATION

IPC: G10L21/02

CPC classification number: G10L21/0208 ,  B25J13/003 ,  G10L2021/02163 ,  G10L2021/02165

Abstract: A hearing system (10) of a robot, especially the one of human or animal type, capable of collecting sound from an external target and actively hearing it without being influenced by the noise produced by, e.g. a drive mechanism in the robot. The system comprises a pair of external microphones (16) provided at the ear parts outside the sound-insulating shell (13), a pair of internal microphones (17) for collecting noise provided inside the shell, noise removers (23, 24) for removing noise signals from an inside noise source from the acoustic signals from the external microphones, pitch extracting sections (25, 26) for extracting acoustic data (DL, DR) about the time, frequency and power from the left and right acoustic signals from the noise removers by frequency analysis, a left/right channel relating section (27) for determining the direction from which sound comes on the basis of the harmonic structure involving the pitches of the left/right acoustic data extracted by the pitch extracting section, and a sound source separating section (28) for separating acoustic data into acoustic data sets of respective sound sources according to the information on the sound direction determination.

Abstract translation: 一种机器人的听觉系统（10），特别是人类或动物类型的听力系统（10），能够收集来自外部目标的声音并主动听到它，而不受例如噪音所产生的噪音的影响。 机器人中的驱动机构。 该系统包括设置在隔音壳体外部的耳部的一对外部麦克风（16），用于收集设置在壳体内的噪声的一对内部麦克风（17），用于 从来自外部麦克风的声学信号中去除来自内部噪声源的噪声信号，音调提取部分（25,26），用于从左侧和右侧声音信号中提取关于时间，频率和功率的声学数据（DL，DR） 通过频率分析的噪声去除器，用于基于包括由音调提取部分提取的左/右声学数据的音调的谐波结构确定声音的方向的左/右声道相关部分（27），以及 声源分离部（28），用于根据关于声音方向确定的信息将声学数据分离成各个声源的声学数据集。

公开(公告)号：WO2001032555A1

公开(公告)日：2001-05-10

申请号：PCT/JP2000007556

申请日：2000-10-27

Applicant: JAPAN SCIENCE AND TECHNOLOGY CORPORATION ,  ESASHI, Masayoshi

Inventor： JAPAN SCIENCE AND TECHNOLOGY CORPORATION

IPC: B81C5/00

CPC classification number: H01L21/6835 ,  H01L21/486 ,  H01L2221/68377 ,  H01L2224/48463 ,  H05K3/06 ,  H05K3/4038 ,  H05K2201/09563 ,  H05K2203/0369

Abstract: A substrate used for a package of a microdevice has flat front and back surfaces and a wiring extending between the surfaces and conduct electricity between the surfaces through the wiring.

Abstract translation: 用于微型装置的封装的基板具有平坦的前后表面和在表面之间延伸的布线，并且通过布线在表面之间导电。

公开(公告)号：WO2001014528A1

公开(公告)日：2001-03-01

申请号：PCT/JP2000004977

申请日：2000-07-26

Applicant: JAPAN SCIENCE AND TECHNOLOGY CORPORATION ,  YADA, Ayumi ,  MATSUMURA, Kimio ,  ONO, Masao ,  AIBA, Setsuya ,  TAKAI, Toshiyuki

Inventor： JAPAN SCIENCE AND TECHNOLOGY CORPORATION

IPC: C12N5/06

CPC classification number: C12N5/0639 ,  A61K2039/5154 ,  C12N2501/998 ,  C12N2710/10011 ,  C12N2710/10211

Abstract: A method of preparing dendritic cells capable of quickly and efficiently inducing a specific immune response to a specific antigen; an immunopotentiator comprising the above dendritic cells capable of quickly and efficiently inducing a specific immune response to a specific antigen; and a method of diagnosing an immunodeficiency disease by using dendritic cells sensitized with an immune complex. Dendritic cells are treated with the use of an immune complex of a specific antigen with an antibody against this antigen and thus the immune complex is incorporated into the cells via immunoglobulin Fc receptor on the dendritic cells, thereby give dendritic cells capable of inducing an antigen-specific immune response. These dendritic cells are usable as an immunopotentiator. An immune deficiency disease can be diagnosed by using dendritic cells sensitized with an immune complex and measuring the antibody titer thereof.

Abstract translation: 一种能够快速有效地诱导特异性抗原特异性免疫应答的树突状细胞的制备方法; 包含能够快速且有效地诱导特异性抗原的特异性免疫应答的上述树突状细胞的免疫增强剂; 以及通过使用用免疫复合物敏化的树突状细胞来诊断免疫缺陷病的方法。 使用特异性抗原的免疫复合物与针对该抗原的抗体处理树突状细胞，由此免疫复合物通过树突状细胞上的免疫球蛋白Fc受体并入细胞中，由此得到能够诱导抗原 - 特异性免疫反应。 这些树突状细胞可用作免疫增强剂。 可以通过使用用免疫复合物敏化的树突状细胞并测量抗体滴度来诊断免疫缺陷病。

公开(公告)号：WO2000036175A1

公开(公告)日：2000-06-22

申请号：PCT/JP1999006976

申请日：1999-12-13

Applicant: JAPAN SCIENCE AND TECHNOLOGY CORPORATION ,  INOUE, Akihisa

Inventor： JAPAN SCIENCE AND TECHNOLOGY CORPORATION

IPC: C22C45/10

CPC classification number: C22C45/10

Abstract: An amorphous zirconium alloy with excellent corrosion resistance which has a composition represented by the formula Zr¿1-a-b-cA¿a[(Fe, Co, Ni)Cu]¿bNb¿c, the formula Zr¿1-a-b-cA¿a[(Fe, Co, Ni)Cu]¿bTa¿c, or the formula Zr¿1-a-b-cA¿a[(Fe, Co, Ni)Cu]¿bTi¿c [wherein A is one or two elements selected between Al and Ga; a to c indicate atomic proportion; a is 5 to 20; b is 15 to 45; the ratio of (Ni, Co, Fe) to Cu is from 1/8 to 2/1; c satisfies 0

Abstract translation: 具有优良耐腐蚀性的无定形锆合金具有式Zr1-ab-cAa [（Fe，Co，Ni）Cu] bNbc，式Zr1-ab-cAa [（Fe，Co，Ni）Cu] bTac或式Zr1-ab-cAa [（Fe，Co，Ni）Cu] bTic [其中A是在Al和Ga之间选择的一种或两种元素; a至c表示原子比例; a是5到20; b为15至45; （Ni，Co，Fe）与Cu的比例为1/8〜2/1; 对于Nb，Ta和Ti，c分别满足0

公开(公告)号：WO2000017340A1

公开(公告)日：2000-03-30

申请号：PCT/JP1999005185

申请日：1999-09-22

Applicant: JAPAN SCIENCE AND TECHNOLOGY CORPORATION ,  THE INSTITUTE OF PHYSICAL AND CHEMICAL RESEARCH ,  TAGUCHI, Kazunori ,  FUKUI, Toshiaki ,  DOI, Yoshiharu

Inventor： JAPAN SCIENCE AND TECHNOLOGY CORPORATION ,  THE INSTITUTE OF PHYSICAL AND CHEMICAL RESEARCH

IPC: C12N15/09

CPC classification number: C12P7/625

Abstract: A process for producing a poly-3-hydroxyalkanoic acid characterized by transferring a poly-3-hydroxyalkanoic acid polymerase gene and a fatty acid synthase gene into a host microorganism to thereby transform the host, proliferating the resultant transformant microorganism in the presence of a carbon source, and then isolating and purifying the poly-3-hydroxyalkanoic acid from the thus proliferated microorganism; and a transformant microorganism constructed by transferring a poly-3-hydroxyalkanoic acid polymerase gene and a fatty acid synthase gene into a host microorganism. Thus, a highly pure poly-3-hydroxyalkanoic acid, which is useful as a material for producing substitute plastics etc., can be conveniently and economically produced in a large amount.

Abstract translation: 一种生产聚-3-羟基链烷酸的方法，其特征在于将聚-3-羟基链烷酸聚合酶基因和脂肪酸合酶基因转移到宿主微生物中，从而转化宿主，在碳存在下使得到的转化体微生物增殖 来源，然后从这样增殖的微生物中分离和纯化聚-3-羟基链烷酸; 以及通过将聚-3-羟基链烷酸聚合酶基因和脂肪酸合酶基因转移到宿主微生物中构建的转化体微生物。 因此，作为制造替代塑料等的材料可以使用的高纯度的聚-3-羟基链烷酸可以大量地方便，经济地生产。

公开(公告)号：WO2000014102A1

公开(公告)日：2000-03-16

申请号：PCT/JP1999004898

申请日：1999-09-09

Applicant: JAPAN SCIENCE AND TECHNOLOGY CORPORATION ,  SAITO, Isao ,  DOHNO, Chikara ,  FUJISAWA, Kazuhiko ,  NAKATANI, Kazuhiko ,  NAKAMURA, Takashi

Inventor： JAPAN SCIENCE AND TECHNOLOGY CORPORATION

IPC: C07H21/00

CPC classification number: C07H21/00 ,  C07H19/04 ,  Y02P20/55

Abstract: Photoresponsive substances for introducing photoresponsive nucleosides into strands of DNA without structural freedom and easily. Specifically, nucleic acids bearing photoresponsive groups linked thereto by triple bonds or reactive derivatives of the same, preferably nucleic acids substituted with groups represented by general formula (I), (wherein R is hydrogen or cyano) or reactive derivatives of the same; nucleic acid oligomers containing the above nucleic acids; phosphoramidite reagents comprising phosphoramidite derivatives of the above nucleic acids; and a process for the preparation of nucleic acid oligomers by using the phosphoramidite reagents.

Abstract translation: 将光反应性核苷引入DNA链中的光响应物质，无结构自由且容易。 具体而言，含有通过三键或其反应性衍生物连接的光响应基团的核酸，优选被通式（I）表示的基团取代的核酸，其中R是氢或氰基或其反应性衍生物; 含有上述核酸的核酸低聚物; 包含上述核酸的亚磷酰胺衍生物的亚磷酰胺试剂; 以及通过使用亚磷酰胺试剂制备核酸低聚物的方法。

公开(公告)号：WO1998004341A1

公开(公告)日：1998-02-05

申请号：PCT/JP1997002644

申请日：1997-07-30

Applicant: NOF CORPORATION ,  JAPAN SCIENCE AND TECHNOLOGY CORPORATION ,  NAKABAYASHI, Nobuo ,  ISHIHARA, Kazuhiko ,  SHIINO, Daijiro ,  WAKI, Kazunori

Inventor： NOF CORPORATION ,  JAPAN SCIENCE AND TECHNOLOGY CORPORATION

IPC: B01F17/52

CPC classification number: C08F30/02 ,  A61K8/04 ,  A61K8/06 ,  A61K8/553 ,  A61K8/8152 ,  A61K9/0014 ,  A61K47/32 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/10 ,  B01F17/005 ,  B01F17/0064

Abstract: Solubilizers, emulsifiers and dispersants having the effects of moistening the skin when used as detergents and being capable of elevating the concentration of a material to be solubilized, emulsified or dispersed in solvents including water as compared with the case where the material is employed alone, or homogenizing the material in an emulsified or dispersed state to thereby elevate the apparent concentration thereof, which contain as the active ingredient polymers obtained by polymerizing monomer compositions containing hydrophilic monomers (a) having groups represented by general formula (1) in the side chains, wherein R , R and R represent each H or C1-4 alkyl.

Abstract translation: 当与用作洗涤剂的情况相比时，具有润湿皮肤的作用的增溶剂，乳化剂和分散剂，并且与单独使用该材料的情况相比，能够提高要溶解，乳化或分散在包括水的溶剂中的物质的浓度，或者 在乳化或分散状态下使材料均化，从而提高其表观浓度，其含有作为活性成分的聚合物，其通过在侧链中聚合含有由通式（1）表示的基团的亲水性单体（a）的单体组合物而获得，其中 R 1，R 2和R 3各自代表H或C 1-4烷基。

公开(公告)号：WO2001007206A1

公开(公告)日：2001-02-01

申请号：PCT/JP2000004592

申请日：2000-07-10

Applicant: JAPAN SCIENCE AND TECHNOLOGY CORPORATION ,  SHINMURA, Takeo ,  YAMAGUCHI, Hitomi

Inventor： JAPAN SCIENCE AND TECHNOLOGY CORPORATION

IPC: B24B5/40

CPC classification number: B24B1/005 ,  B24B5/40 ,  B24B31/112

Abstract: A magnetic polishing method using a magnetic pin and a device therefor, capable of polishing and work-hardening the surface of a work by means of magnetic particles easily rotated following a rotating magnetic pole even in a uniform magnetic field. The magnetic polishing method comprises the steps of disposing magnetic abrasive grains (5) on the inner surface of a work (4) such as a pipe disposed in a magnetic field and consisting of a non-magnetic element such as ceramics and stainless steel, and rotating the work (4) and the magnetic field relative to each other to thereby polish the inner surface of the work (4), wherein, in addition to the magnetic abrasive grains (5), magnetic particles (a magnetic pin tool having a specified diameter and specified length) (6) in a shape having a magnetic anisotropy is used. Accordingly, even in the case of a fine-diameter polishing requiring a uniform magnetic field, the magnetic particles (5, 6) having a magnetic anisotropy can rotate following a rotating magnetic pole without corotating with the work (4) to thereby make it possible to ultra-precision-polishing the surface of the work (4).

Abstract translation: 一种使用磁销及其装置的磁性抛光方法，其能够通过即使在均匀的磁场中也可以旋转的磁极而易于旋转的磁性粒子来研磨和加工硬化工件的表面。 磁性抛光方法包括以下步骤：将磁性磨粒（5）放置在工件（4）的内表面上，例如设置在磁场中的管，由诸如陶瓷和不锈钢的非磁性元件组成， 相对于彼此旋转工件（4）和磁场，从而抛光工件（4）的内表面，其中除了磁性磨料颗粒（5）之外，磁性颗粒（具有指定的磁性颗粒 直径和规定长度）（6）使用具有磁各向异性的形状。 因此，即使在需要均匀的磁场的微细直径研磨的情况下，具有磁各向异性的磁性粒子（5,6）可以在旋转磁极之后旋转，而不会与工件（4）共旋转，从而使其成为可能 对工件的表面进行超精密抛光（4）。